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Schools are key environments for promoting healthy eating habits, food knowledge and skills, but the systematic implementation of food education is usually lacking. This study aimed to examine the perceptions of primary school headteachers and municipal education directors regarding the key factors influencing the implementation of food education in Finnish primary schools.
Design:
In this qualitative study, the participants took part in research interviews. The interviews were transcribed verbatim and analysed using theory-driven content analysis to identify common categories.
Setting:
Semi-structured one-on-one interviews were conducted.
Participants:
The interviews involved twelve headteachers and five education directors, all of whom had prior experience in implementing food education through the Tasty School project, which supported primary schools in delivering food education.
Results:
In the analysis, the key factors influencing implementation of food education were categorised according to an ecological framework into two levels: the macro level and the school community level, which represents the micro-level interactions within the school’s physical and social environment. The results indicate that successful food education requires a school culture that prioritises it − incorporating curriculum integration, dedicating adequate planning time and ensuring sufficient resources.
Conclusions:
Primary schools would benefit from a school culture that prioritises food education. This includes setting objectives in the curriculum, allocating sufficient time for planning, ensuring resources and creating supportive learning environments. While headteachers play a central role, support from municipal officials is essential for sustained implementation. These findings provide insights to support the implementation of food education at both school and municipal levels.
The performance of elite athletes is at the forefront of attention in sports science, with a predominant focus on technical, physiological, mental, or contextual factors that can be leveraged to optimize athlete performance. Athletes’ off-sports activities, however, remain largely unexplored. What is it that elite athletes do in their off-sports time, and how are their off-sports activities related to sports experiences and outcomes? With this qualitative study, we aim to illuminate athletes’ off-sports activities and their implications for sports outcomes. We collected listings of off-sports activities from 46 professional soccer players and interviewed 15 elite speed skaters about their off-sports activities and their potential to enrich or interfere with their sports domain. The resulting category framework of off-sports activities comprises eight categories, reflecting social, cognitive, and physical off-sports activities. Next, the speed skaters described beneficial spillover experiences for active, high-effort mastery-oriented off-sports activities. However, such activities could also cause fatigue if not balanced with sufficient, more passive, restful activities. In all, athletes did experience spillover from non-sports to sports and their qualitative accounts reveal several antecedents, mechanisms, and outcomes of spillover, supporting the process view of the work–home resources (W-HR) model (Ten Brummelhuis & Bakker, 2012).
Evidence regarding the association between dietary choline intake and mortality in individuals with diabetes remains limited. This study aimed to evaluate the relationship between dietary choline intake and all-cause, CVD and cancer-related mortality among adults with diabetes. A total of 4712 participants with diabetes were included from the National Health and Nutrition Examination Survey 2007–2018 cycles. Dietary choline intake was estimated using two 24-h dietary recalls, and mortality outcomes were ascertained via linkage to National Death Index records through 31 December 2019. Cox proportional hazards models and Kaplan-Meier analyses were employed to assess the associations between choline intake and mortality. Restricted cubic spline models were used to examine potential non-linear relationships, and threshold analyses were conducted to identify inflection points. Over a median follow-up of 6·42 years, 805 deaths were documented, including 267 from CVD and 126 from cancer. A U-shaped association was observed between dietary choline intake and all-cause mortality (Pfor non-linearity < 0·0001). Compared with the lowest quartile, multivariable-adjusted hazard ratios for all-cause mortality were 0·64 (95 % CI 0·47, 0·88) for the second quartile, 0·59 (0·43, 0·82) for the third and 0·69 (0·43, 1·09) for the highest quartile. No significant associations were found between choline intake and either CVD or cancer mortality. These findings indicate a U-shaped relationship between dietary choline intake and all-cause mortality in individuals with diabetes, with intakes between 286·77 and 538·86 mg/d associated with the lowest risk – providing potential implications for dietary guidance in diabetes management.
The Russia-Ukraine war generates fear, depression, loneliness, burnout and substance misuse among civilians. Our study examines mental health among Ukrainian university female students during 3 years of war. A total of 3,467 students were surveyed on three occasions: August to October 2022 (T1, n = 1,416), March to July 2023 (T2, n = 747) and September to November 2024 (T3, n = 1,304). The respondent’s average age was 19.3 years, 25.3% identified as secular and 36.9% were married/partnered. The respondents included 81.2% who were not relocated, 10.7% who were internally displaced and 8.1% who were refugees. Valid and reliable survey instruments were used to gather data. One-way analysis of variance (ANOVA) shows a significant decrease in fear of war, depression and burnout in 2023 compared to 2022; however, there was a marked increase in 2024. Regardless of the survey period, one-way ANOVA shows a significant difference in fear of war and burnout scores associated with depression and loneliness levels. Stepwise regression analysis shows fear of war, depression and loneliness associated with burnout. This study provides usable information for mental health services planning and intervention purposes associated with young women affected by war in Ukraine. Additionally, it has relevance for training to address client and service personnel needs, for academic curriculum development and course instruction, and as a reference source for mental health personnel addressing student needs.
Polyploid Giant Cancer Cells (PGCCs) are a malformed subpopulation of tumor. They play a crucial role in metastasis, recurrence, and therapy resistance. However, the inconsistent model systems and a lack of standardization have hindered mechanistic understanding and clinical translation. This review highlights the pluralistic research for clinical application by methodically analyzing various model systems used in PGCC research to fill the gap in the literature.
Methods
As of November 2025, scholarly literature gathered from Google Scholar, PubMed, and ScienceDirect focused on examining the development, characteristics, and functional involvement of PGCCs in cancer.
Results
In vitro approaches, although limited in their physiological relevance, enable detailed mechanistic studies and facilitate the screening of drugs. Ex vivo tumor explants and organoids preserve patient-specific traits with translational potential, while in vivo models, such as Drosophila and mouse xenografts, provide insight into PGCC function in complex tissue environments. By mapping model capabilities against PGCC research priorities, we demonstrate that no single system comprehensively recapitulates PGCC biology, necessitating integrated, multi-model experimental strategies that we outline in this study. More specifically, integrating patient-derived organoids with lineage-traced xenografts and single-cell omics enables continuous tracking of PGCC development and functional diversity, facilitating mechanistic studies of metastasis, drug resistance, and identification of clinical biomarkers for patient stratification.
Conclusion
Considering the current lack of PGCC-targeted therapies, the convergence of model modification and the development of single-cell and imaging capabilities indicates significant progress toward therapeutically relevant findings. The ongoing development of these models is thus crucial for translating PGCC biology into predictive diagnoses and effective treatment methods.
Suicide is a significant global mental health issue and a leading cause of death, with over half a million lives lost annually. The majority of suicide deaths occur in low- and middle-income countries (LMICs), yet there are limited data on suicidal behavior in these regions, particularly in Ethiopia. Given the rising trends of mental health issues worldwide and the alarming rate of suicide in LMICs, this research addresses a critical gap in knowledge regarding suicidal behavior in Eastern Ethiopia, which is essential to inform local public health strategies. Therefore, the study aimed to assess the prevalence and associated factors of suicidal ideation and attempts among adults in the Kersa, Haramaya and Harar Health and Demographic Surveillance System in Eastern Ethiopia in 2022. A community-based cross-sectional study was conducted among 1,411 participants selected using a multistage sampling technique. Binary logistic regression was employed to identify factors associated with suicidal ideation and attempts.
The findings revealed that 9.8% and 6.2% of participants reported suicidal ideation and attempts, respectively. A history of mental illness [adjusted odds ratio (AOR) = 6.82, 95% confidence interval (CI): 4.63–10.05] and khat use (AOR = 2.34, 95% CI: 1.48–3.69) were factors significantly associated with suicidal ideation. Similarly, rural residence (AOR = 4.32, 95% CI: 2.17–7.58), a history of mental illness (AOR = 6.02, 95% CI: 3.78–9.60) and khat use (AOR = 2.23, 95% CI: 1.29–3.85) were strongly associated with suicide attempts (p < 0.05). The study highlights that nearly one in 10 individuals in the community experienced suicidal ideation or attempts, underscoring the urgent need for attention to these mental health concerns. In conclusion, suicidal ideation and attempts are prevalent in Eastern Ethiopia and are significantly associated with mental illness, khat use and rural residence. Early screening, detection and management of suicidal behavior at the community level are recommended to address this pressing public health issue.
This article addresses the questions of when mental health advance planning documents are created, the points when circumstances which they are intended to address arise and what consequences should flow when such a situation does arise. It addresses these points primarily from the perspective of what the law could/should be at a conceptual level. It looks at three stages: (a) creation of the document; (b) the period between the creation of the document and the point at which the intended circumstances arise; and (c) the point at which the intended circumstances arise. It does not purport to provide solutions at each stage, but rather to frame the dilemmas to aid discussion. In similar vein, it draws upon case studies from England & Wales, not to purport to dictate similarities of approach, but to flesh out dilemmas that have arisen to stimulate consideration.
Neurocognitive assessment is an essential research instrument for autism spectrum disorder (ASD), as the clinical manifestations are rooted in diverse neurocognitive processes that cause variation in clinical presentation. Few instruments comprehensively capture relevant neurocognitive domains, and most require professional assessors. The Penn Computerized Neurocognitive Battery (CNB) is widely used in child and adolescent psychiatry research across cultures. This study adapted and validated the CNB for a clinical ASD cohort in Hong Kong.
Method:
In this Hong Kong version of the CNB (CNB-HK), thirteen cognitive tasks were translated and adapted, with one task for sensorimotor speed and twelve belonging to four specific domains (episodic memory, social cognition, complex cognition, and executive function). The CNB-HK was administered to 636 normal-IQ children with ASD (mean age: 8.4 years, 87.1% male) and 412 children without ASD (mean age: 8.6 years, 55.1% male). Factor structure was examined using factor analyses.
Results:
The CNB-HK had high feasibility for children with ASD, with <7% invalid data across all tasks. The original four-factor and bi-factor structures were replicated with good model fit, and partial scalar invariance was achieved between children with and without ASD. The factor scores correlated positively with estimated IQ in the ASD group. The ASD group had worse performance across all four cognitive domains and the g factor compared to the group without ASD.
Conclusions:
The CNB-HK is a valid, multi-domain cognitive assessment tool for children with ASD in Hong Kong, offering a feasible and reliable approach for research and clinical settings.
Due to the high prevalence of depression and anxiety in people with epilepsy, the International League Against Epilepsy Commission on the Neuropsychiatric Aspects of Epilepsy recommends implementing routine screening for depression and anxiety symptoms. Our epilepsy group began administering three screening questionnaires to all clinic patients in 2016: the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), the Beck Anxiety Inventory (BAI) and the Generalized Anxiety Disorder-7 (GAD-7).
Objective:
We aim to review our experience with this screening approach.
Methods:
We reviewed 2253 sets of questionnaires completed from January 2018 to March 2020 and studied the actions taken by epileptologists in response to a positive screening.
Results:
Thirty-six percent of all assessed patients screened positive on at least one questionnaire: 13.6% screened positive for depression symptoms (NDDI-E ≥ 16), 12.3% for anxiety symptoms (BAI ≥ 22) and 30.3% for GAD symptoms (GAD-7 > 7). Among patients with a positive screening, 36% received a care intervention, 59% did not and 5% declined the neurologist’s recommendation. Among patients for whom an intervention was implemented, 58% were referred to a mental health professional (generally a neuropsychiatrist), 29% had their antiseizure medication adjusted to alleviate their symptoms and 13% received another intervention.
Conclusion:
In our clinic, an important proportion of patients screened positive for depression and/or anxiety symptoms. Fewer than half received a management option to alleviate their symptoms. We conclude that while routine screening increases the detection of depression and anxiety among epilepsy patients, it must be accompanied by effective interventions and access to mental-health professionals.
This study explores how loneliness affects earthquake risk perception and preparedness behaviors among older adults in Japan. Aging is often accompanied by increased vulnerability to natural disasters, and loneliness is hypothesized to compromise effective preparedness. Using the Japanese Older Adult Preparedness Model (JOAPM), which integrates the Protective Action Decision Model (PADM) and cultural context, we examine how loneliness influences both perceived earthquake risk and protective behaviors.
Methods
An online survey conducted in April 2024 gathered responses from adults aged 55 and older across 4 earthquake-prone Japanese prefectures. Measures included demographics, disaster experience, loneliness (UCLA Loneliness Scale), risk perception, and preparedness actions such as household adjustments. Regression and mediation analyses assessed the direct and indirect effects of loneliness on preparedness.
Results
Findings show that loneliness has a significant negative direct effect on disaster preparedness. However, it also slightly increases risk perception, which in turn has a positive relationship with preparedness behaviors, suggesting a modest indirect pathway. Overall, the direct negative effect of loneliness outweighs the indirect benefit.
Conclusion
The results highlight the complex role of psychosocial factors in disaster readiness, suggesting that interventions should address information dissemination, self-efficacy, and the emotional isolation experienced by older adults in high-risk areas.
While the effects of multidisciplinary weight loss (WL) on resting energy expenditure remain unclear in adolescents with obesity, the potential presence of adaptive thermogenesis (AT) has never been explored, which was the objective of the present work. Twenty-six adolescents (14·1 (sd 1·5) years) with severe obesity completed a 9-month inpatient multidisciplinary intervention followed by a 4-month follow-up. Anthropometric measurements, body composition (dual X-ray absorptiometry) and resting energy expenditure (REE, indirect calorimetry) were assessed before (T0) and after 9 months of WL intervention (T1) and after a 4-month follow-up (T2). AT, at the level of REE, was defined as a significantly lower measured v. predicted (using regression models with baseline data) REE. Two pre-cited REE equations were used, using both fat mass and fat-free mass (FFM) (predicted REE using equation 1) or FFM only (predicted REE using equation 2). Measured and predicted REE significantly decreased between T0 and T1 (P < 0·001) and remained lower at T2 compared with T0 (measured REE: P = 0·017; predicted REE: P < 0·001). Predicted REE using equation 2 was significantly higher than measured REE at T1 (P = 0·012), suggesting the presence of AT. FFM at T0 was negatively correlated with ATp1T1 (Rho = –0·428; P = 0·033) and ATp2T1 (Rho = –0·485; P = 0·014). The variation of FFM between T0 and T1 was negatively correlated with AT at T1 and T2. These preliminary results suggest the existence of AT in response to WL in adolescents with obesity, independently of the degree of WL. AT was associated with subsequent body weight and fat regain, suggesting AT may represent a damper to WL attempts while increasing the adolescents’ risks for subsequent weight and adiposity rebounds.
There is a lack of knowledge available on how cats adjust their macronutrient partitioning due to the consumption of single-macronutrient meals. The objective of this study was to evaluate consumption of a single meal of ingredients that contained foods of strictly carbohydrates (CHO), fat (FAT) or protein (PRO), on energy expenditure (EE) and macronutrient metabolism in cats. Ten domestic shorthair adult cats (1·9 years; 4·12 kg) were fed 22–24 g of chicken fat (FAT), 56–62 g of whey protein solution (PRO) or 54–56 g of cornstarch solution (CHO) for a single day in a randomised complete block design. Indirect calorimetry was conducted for 24 h post-feeding. Mean average EE over 24 h was highest in cats fed PRO (44 kcal/kg BW) and FAT (43 kcal/kg BW) compared with that in cats fed CHO (42 kcal/kg BW; P < 0·01). During 0 to 4 h, cats fed FAT had greater EE (49 kcal/kg BW), suggesting that cats respond to oxidising more dietary fat over protein in the early postprandial stage. Mean 24 h respiratory quotient (RQ) was greatest for cats fed CHO (0·76) followed by PRO (0·75) and FAT (0·74; P < 0·05). During 4 to 8 h, the RQ of cats fed PRO was the greatest (0·77), suggesting that cats initially increase gluconeogenesis from amino acids for subsequent glucose oxidation. In comparison to omnivores and herbivores, obligate carnivores have unique responses to single macronutrient intake, where they apparently generate energy from carbohydrate metabolism and rely more on gluconeogenic precursors.
Due to an increased awareness of the prevalence and impact of trauma, “trauma-informed care” (TIC) was developed as an organisational framework aiming to centre the needs of survivors of trauma. TIC proposes that organisations can reduce trauma exposure by embedding specific principles (e.g., safety and trust) at every level of an organisation, improving the organisation for both service users and providers. Recent reviews of TIC implementation efforts have demonstrated its use in diverse settings; however, studies are overwhelmingly situated in high-income, predominantly English-speaking countries. Rather than reflecting a lack of TIC efforts in low- and middle-income countries (LMICs), these findings may be a result of the newness of the term TIC. To create a more inclusive evidence map, the current review captures efforts conducted in LMICs that may or may not use the label of TIC but align with the organisational approaches and key principles of TIC. A search of four databases and review of relevant references yielded 3,091 results, of which 255 met the inclusion criteria. Implementation efforts took place across 39 LMICs. The vast majority included involvement of another country, most commonly the United States. Approximately 90% of efforts were implemented within medical settings, and 69% focused on the TIC principle of cultural, historical and gender issues. The results of the current review have both theoretical and applied implications for TIC research. They query how and by whom TIC is conceptualised and defined, and how TIC aligns with other global research approaches. Results also highlight the need for organisational TIC interventions to conduct comprehensive baseline assessments of current efforts before implementing new efforts to avoid unintentional duplication. As the adoption of TIC frameworks becomes more widespread, it is imperative to increase research efforts aimed at developing a more thorough and inclusive definition of TIC.
This cross-sectional study investigated how care home size influences COVID-19 transmission dynamics, focusing on outbreaks in England during the second wave of COVID-19 (Wave 2; December 2020 to March 2021) and the Omicron wave (December 2021 to February 2022). Using data from the UK Health Security Agency and the Care Quality Commission, positive SARS-CoV-2 test results were matched to care home registration and occupancy data, examining outbreak trajectories in homes of varying sizes and resident age groups. The study included over 90,000 positive cases across the two waves. Small care homes (SCHs, with 10 or fewer beds), predominantly housing younger adults, showed significantly higher early positivity rates: 42% of residents were positive at outbreak detection, rising to 61% by day 7. In contrast, larger homes had early positivity rates of only 3–6%. These findings suggest that SCHs, often designed for communal living, facilitate rapid within-home transmission similar to household settings. The study concludes that outbreak control strategies in SCHs should differ from those in larger care homes, emphasizing proportionate, individualized approaches that consider resident vulnerability and minimize disruption to social support systems. These results have broader implications for managing future infectious disease outbreaks and support the development of tailored guidance based on care home size and resident demographics.
Recent studies show an association between lower socioeconomic status and worse outcomes in single ventricle patients after stage 1 palliation. We sought to investigate the association between socioeconomic status, using the social deprivation index, after the second and third stage palliations. We hypothesised that higher social deprivation index scores (higher deprivation) are associated with worse short and medium-term outcomes following Glenn and Fontan palliations.
Methods:
We performed a retrospective single-centre review on patients who underwent Glenn or Fontan palliation from 2007 to 2024. Social deprivation index was calculated using the last known address. Outcomes were collected at 1 year after Glenn and 1 and 5 years after Fontan.
Results:
There were 292 patients included. Higher social deprivation index scores were associated with higher weight (ρ = 0.19, p-value = 0.01) and fewer number of attended cardiology appointments at 1 year after Fontan (ρ = −0.20, p-value = 0.01) and higher weight (ρ = 0.36, p-value < 0.01) and weight percentile (ρ = 0.22, p-value = 0.02) at 5 years after Fontan. After adjusting for race and preferred language, weight at 1 year after Fontan (p-value = 0.007) and weight and weight percentile at five years after Fontan (p-value < 0.0001 and p-value = 0.04, respectively), remained significant. There was no association between social deprivation index score and number of hospitalisations, transplant, or mortality.
Conclusion:
Higher social deprivation index scores were associated with higher weight and weight percentile and fewer number of attended cardiology appointments after Fontan palliation. Longer-term follow-up and multi-centre collaboration across diverse regions will be critical to understanding clinical impact.
Vegetables are a key aspect of a healthy diet, but they are under-consumed throughout West Africa, where there is a lack of evidence on food environments. This study aimed to understand the physical availability of vegetables around schools in urban areas of Benin and Mali, as well as describe other aspects of the food environment.
Design:
The study used neighbourhood surveys of food outlets around schools in marginalised areas in five cities of Benin and Mali.
Setting:
Food outlets within a 1 km radius of the main public primary schools.
Participants:
Owners/managers/vendors of food outlets.
Results:
Vegetables are in general highly available around schools in representative urban areas of both Mali and Benin, with more outlets and more outlet diversity in general in the Benin contexts but a greater proportion of outlets selling vegetables in the Mali contexts. There is nuance, however, in which vegetables are sold (global or traditional vegetables) and what they are sold alongside that provides healthier or unhealthier options for consumers. Quality, convenience, source, cost and promotion were variable across sites.
Conclusion:
The detailed findings in this study on outlet types, vegetable characteristics and the characteristics of vending are a significant contribution to understanding physical food environments in urban neighbourhoods that can inform policy responses in West Africa and beyond.
MRI-guided focused ultrasound (MRgFUS) thalamotomy has expanded the surgical treatment envelope for patients with essential tremor who fail on first-line pharmacological therapies. Understanding differences in access to MRgFUS thalamotomy, a procedure publicly funded in Ontario, is a first step to ensuring equitable opportunity for treatment across the province. In this brief communication, we explore the frequency of referrals directed to our tremor program between 2018 and 2023. We highlight differences in referral rates by jurisdiction and medical specialty, and explore associations with socio-economic factors. Our findings inform public policy and identify geographical areas for targeted outreach to enhance equitable access.
The threshold values of visceral fat area (VFA) proposed by existing studies for predicting metabolic syndrome (MetS) are contentious, necessitating further empirical evidence. We conducted a cross-sectional study to assess VFA using bioelectrical impedance analysis technology among middle-aged and elderly individuals in the Sichuan area of China. First, we compared the predictive ability of VFA, waist circumference (WC) and body mass index (BMI) among participants with MetS (excluding WC). In males, the area under the receiver operating characteristic curve (AUC) was 0·680 for VFA, 0·670 for WC and 0·665 for BMI, with corresponding optimal cut-off values of 77·45 cm2, 83·50 cm and 24·19 kg/m2. In females, the AUC values and optimal cut-offs were 0·628 (103·55 cm2) for VFA, 0·671 (77·50 cm) for WC and 0·643 (24·32 kg/m2) for BMI. Additionally, for MetS defined with WC included, the AUC of VFA for prediction was higher in males (0·785) than in females (0·717), with optimal cut-offs of 85·15 cm2 (males) and 109·55 cm2 (females). Further age-stratified analysis revealed sex-specific VFA cut-offs: in males, 80·95 cm2 (45–59 years), 85·15 cm2 (60–74 years) and 77·50 cm2 (≥ 75 years); in females, 109·65 cm2 (45–59 years), 112·15 cm2 (60–74 years) and 103·05 cm2 (≥ 75 years). In conclusion, VFA is an effective predictor of MetS, with its optimal cut-off value varying by age and being higher in females than in males.
International migrant workers (IMWs) may face insecure work and housing, limited access to healthcare and increased risk of psychological problems. Two scalable, evidence-based interventions to support individuals experiencing psychological distress are Doing What Matters in Times of Stress (DWM) and Problem Management Plus (PM+). This study aimed to explore IMWs’ problems, daily functioning and help-seeking behaviour, to inform cultural adaptation of the DWM/PM+ stepped-care intervention in the Netherlands. Following the Design, Implementation, Monitoring, and Evaluation (DIME) model, we conducted various qualitative interviews and a focus group discussion with IMWs (n = 30) and professionals (n = 18). Data were analysed thematically, and findings informed adaptations. Participants described problems related to work, housing, administration, finances, healthcare access and the COVID-19 pandemic. Daily routines focused on practical needs. Help-seeking was hindered by stigma, fear of job loss, low trust and reliance on informal or cross-border healthcare. Based on these results, the intervention was adapted to the needs of Polish IMWs in the Netherlands, regarding content and examples, which were tailored to their context; the intervention was offered remotely and collaboration with employers was avoided. These findings highlight the structural vulnerabilities of IMWs and demonstrate how qualitative insights can guide the cultural adaptation of a psychological intervention.
Delivering safe, high-quality care needs a competent and capable workforce, particularly as clinical practices change with scientific and technical advances. Structured learning opportunities are a central approach to building and maintaining competencies, but ineffective training wastes the scarce resources and staff time. This Element provides a review of education and training design, implementation, and evaluation methods used in healthcare improvement. Drawing from the general learning sciences and healthcare education and training literatures, the authors describe five pillars of effective training. For each pillar, they provide actionable guidance based on the best available evidence. Three examples of quality and safety programmes are given to illustrate the positive impact of well-designed training, and the challenges of good training design in healthcare improvement. This title is also available as open access on Cambridge Core.