To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Chapter 3 describes how quantum entanglement leads to probabilities based on a symmetry, but—in contrast to subjective equal likelihood based solely on ignorance—it is an objective symmetry of known quantum states. Entanglement-assisted invariance (or envariance for short) relies on quantum correlations: One can know the quantum state of the whole and use this to quantify the resulting ignorance of the states of parts. Thus, quantum probability is, in effect, an objective consequence of the Heisenberg-like indeterminacy between global and local observables. This derivation of Born’s rule is based on the consistent subset of quantum postulates. It justifies statistical interpretation of reduced density matrices, an indispensable tool of decoherence theory. Hence, it gives one the mandate to explore—in Part II of this book—the fundamental implications of decoherence and its consequences using reduced density matrices and other customary tools.
There are two widely known interpretations of quantum theory: Bohr’s Copenhagen interpretation and Everett’s interpretation. The focus of Chapter 9 is to assess, within the context they provide, the interpretation-independent advances discussed in this book. We want to see whether the advances that include decoherence and quantum Darwinism fit these two established and widely known points of view. In fact, it is surprising that (with minor but significant adjustments) decoherence and quantum Darwinism fit very naturally, addressing questions that were recognized as open and important. We then discuss the existential interpretation. It can be seen as a continuation of the Copenhagen interpretation, with the Universe consisting of quantum and classical realms, but with classicality that is emergent, rather than preordained. It is also compatible with Everett’s interpretation, since quantum states and evolutions are all that is needed. However, unlike the Many Worlds interpretation (which regards the quantum state of the Universe as objectively existing, akin to a classical point in phase space or a classical electromagnetic field), the existential interpretation recognizes that quantum states combine information and existence—they are epiontic. The mix of existence and information they represent fits the relative states reading of Everett’s approach.
We consider the flow of a volume $\mathcal {V} = q t^\alpha$ of viscous fluid injected into a gap $H$ between two horizontal plates ($q$ and $\alpha$ are positive constants, $t$ is time). When the viscosity of the displaced fluid is negligible, the injected fluid forms a slug in contact with both plates connected (at a moving grounding line) to a gravity current (GC) with a downward-inclined interface. Hutchinson et al. (J. Fluid Mech., 598, 2023, pp. A4–1–13) considered a constant source ($\alpha = 1$) of Newtonian fluid at the center of an axisymmetric gap; the flow, governed by the parameter $J$ (the height ratio of the unconfined GC to $H$), admits a similarity solution. Here, the self-similar flow theory is (a) extended to rectangular geometry and power-law fluids, and (b) simplified. Similarity appears when $\alpha = n/(n+1)$ (two-dimensional) and $\alpha = 2n/(n+1)$ (axisymmetric), with propagation $\sim t^\beta$, where $\beta /\alpha = 1$ and $1/2$, respectively, and $n-1$ is the power of the shear in the viscosity law ($n=1$ for Newtonian fluid). The flow is governed by a single parameter $J$, representing the above-mentioned ratio. For small $J$, the GC is mostly unconfined; for large $J$, almost all the injected fluid is in contact with both boundaries of the gap. For given geometry and $n$, we solve one ordinary differential equation (ODE) for the reduced thickness over the reduced length $0\lt y \leqslant 1$, with a singular-regular condition at $y=1$. The details of the confined GC, functions of $J$, follow by simple formulae.
The Cloudy photoionization codes have been employed to study a spherically distributed cloud, around an arbitrary planetary nebula, with core temperature 105 K. The ionization factor ${\chi (H)}$ is close to unity, in the inner face of the dusty plasma (DP) cloud, which follows a monotonic declining trend, afterwards. For hydrogen density ${n_H} = 10\;\textrm{c}{\textrm{m}^{ - 3}}$, an exponentially falling trend of temperature could be noticed. A grain charging$\setminus$discharging process is also witnessed, which is very common in a DP environment. For ${n_H} = 10\;\textrm{c}{\textrm{m}^{ - 3}}$, photoionization of grains is more common due to higher photon density; compared with ${n_H} > 10\;\textrm{c}{\textrm{m}^{ - 3}}$, where the grain–electron acquiring probability is maximum, because of significant electron density. Owing to the electrostatic interactions between the charged grain and the electrons, an unusual trend in temperature has been observed.
Binding sites are key components of biomolecular structures, such as proteins and RNAs, serving as hubs for interactions with other molecules. Identification of the binding sites in macromolecules is essential for structure-based molecular and drug design. However, experimental methods for binding site identification are resource-intensive and time-consuming. In contrast, computational methods enable large-scale binding site identification, structure flexibility analysis, as well as assessment of intermolecular interactions within the binding sites. In this review, we describe recent advances in binding site identification using machine learning methods; we classify the approaches based on the encoding of the macromolecule information about its sequence, structure, template knowledge, geometry, and energetic characteristics. Importantly, we categorize the methods based on the type of the interacting molecule, namely, small molecules, peptides, and ions. Finally, we describe perspectives, limitations, and challenges of the state-of-the-art methods with an emphasis on deep learning-based approaches. These computational approaches aim to advance drug discovery by expanding the druggable genome through the identification of novel binding sites in pharmacological targets and facilitating structure-based hit identification and lead optimization.
The present study aims to provide an understanding of the influence of an afterbody on the flow-induced vibration (FIV) of cylinders. This is achieved through experimental and numerical investigations into the FIV response of a reverse-D-cross-section cylinder of aspect ratio $AR=5$. By carefully monitoring the point of flow separation to show it always occurs at the sharp top and bottom edges and never further upstream, it is demonstrated that vortex-induced vibration (VIV) can occur without an afterbody. However, for other aspect ratios, an afterbody does play a crucial role in determining the type of fluid forces responsible for sustaining VIV from low to moderate Reynolds numbers in the range $100$–$4700$. For a cylinder without an afterbody, it is found that the viscous force originating from the presence of strong compact vortices forming close to the leeward side of the cylinder is responsible for sustaining strong transverse vibration. In contrast, for a cylinder with an afterbody, the dominant force component depends on the size of the afterbody. In cylinders with a small afterbody, such as a reverse-D semi-circular cylinder, the viscous force dominates, while in cylinders with a larger afterbody such as a circular cylinder, the pressure force dominates.
Two-dimensional particle-in-cell (PIC) simulations explore the collisionless tearing instability developing in a Harris equilibrium configuration in a pair (electron–positron) plasma, with no guide field, for a range of parameters from non-relativistic to relativistic temperatures and drift velocities. Growth rates match the predictions of Zelenyi & Krasnosel'skikh (Astron. Zh., vol. 56, 1979, pp. 819–832) modified for relativistic drifts by Hoshino (Astrophys. J., vol. 900, issue 1, 2020, p. 66) as long as the assumption holds that the thickness $a$ of the current sheet is larger than the Larmor radius $\rho _L$, with the fastest growing mode at $ka \approx 1/\sqrt {3}$. Aside from confirming these predictions, we explore the transitions from thick to thin current sheets and from classical to relativistic temperatures. We show that for thinner current sheets ($a< \rho _L$), the growth rate matches the prediction for the case $a=\rho _L$. We also explore the nonlinear evolution of the modes. While the wavenumber with the fastest growth rate initially matches the prediction of Zelenyi & Krasnosel'skikh (1979), these modes saturate moving the dominant mode to lower wavenumbers (especially for thick current sheets with low growth rates). Furthermore, at a late, nonlinear stage, the growth rate (initially following the growth rate prediction proportional to $(\rho _L/a)^{3/2} < 1$) increases faster than exponentially, reaching a maximum growth rate equivalent to the linear growth rate prediction at $\rho _L/a = 1$, before eventually saturating.
The intrinsic uncertainty of fluid properties, including the equation-of-state, viscosity and thermal conductivity, on boundary layer stability has scarcely been addressed. When a fluid is operating in the vicinity of the Widom line (defined as the maximum of isobaric specific heat) in supercritical state, its properties exhibit highly non-ideal behavior, which is an ongoing research field leading to refined and more accurate fluid property databases. Upon crossing the Widom line, new mechanisms of flow instability emerge, feasibly leading to changes in dominating modes that yield turbulence. The present work investigates the sensitivity of three-dimensional boundary layer modal instability to these intrinsic uncertainties in fluid properties. The uncertainty, regardless of its source and the fluid regimes, gives rise to distortions of all profiles that constitute the inputs of the stability operator. The effect of these distortions on flow stability is measured by sensitivity coefficients, which are formulated with the adjoint operator and validated against linear modal stability analysis. The results are presented for carbon dioxide at a representative supercritical pressure of approximately 80 bar. The sensitivity to different inputs of the stability operator across various thermodynamic regimes shows an immense range of sensitivity amplitude. A balancing relationship between the density gradient and its perturbation leads to a quadratic effect across the Widom line, provoking significant sensitivity to distortions of the second derivative of the pressure with respect to the density, $\partial ^2 p/\partial \rho ^2$. From an application-oriented point of view, one important question is whether the correct baseflow profiles can be meaningfully analysed by the simplified ideal-fluid model. The integrated modal disturbance growth – the N factor calculated with different partly idealised models – indicates that the answer depends strongly on the thermodynamic regime investigated.
Explaining fast magnetic reconnection in electrically conducting plasmas has been a theoretical challenge in plasma physics since its first description by Eugene N. Parker. In recent years, the observed reconnection rate has been shown by numerical simulations to be explained by the plasmoid instability that appears in highly conductive plasmas. In this work, by studying numerically the Orszag–Tang vortex, we show that the plasmoid instability is very sensitive to the numerical resolution used. It is shown that well-resolved runs display no plasmoid instability even at Lundquist numbers as large as $5\times 10^5$ achieved at resolutions of $32\,768^2$ grid points. On the contrary, in simulations that are under-resolved below a threshold, the plasmoid instability manifests itself with the formation of larger plasmoids the larger the under-resolving is. The present results thus emphasize the importance of performing convergence tests in numerical simulations and suggest that further investigations on the nonlinear evolution of the plasmoid instability are required.
We investigate viscous dissipation in linear flows driven by small-amplitude longitudinal librations in rotating fluid spheres focusing on the rapid rotation regime applicable to planets. Viscous coupling can resonate with inertial modes in the bulk of the fluid when the frequency of the forcing is within the range $(0,2\Omega _0)$, where $\Omega _0$ is the mean angular velocity of the sphere. We solve the linearised equations of motion with a semi-spectral numerical method and with an asymptotic expansion exploiting the small Ekman number, $E$, which quantifies the strength of viscous forces relative to the Coriolis force. Our results confirm that the dominant contribution to the dissipation occurs in the Ekman boundary layer with leading-order scaling $E^{1/2}$. When the forcing frequency coincides with that of an inertial mode, dissipation is reduced by as much as 9 % compared with boundary layer theory alone. The percentage-wise reduction is independent of $E$ and the frequency width of the reduction envelope scales as $E^{1/2}$. At non-resonant frequencies conic shear layers develop in the bulk interior and, together with the Ekman layer bulge at critical latitude, slightly enhance dissipation. We confirm critical latitude bulge and shear layer contributions to the overall dissipation scale as $E^{4/5}$ and $E^{6/5}$ respectively, becoming negligible compared with dissipation in the main boundary layer as $E\rightarrow 0$. The frequencies at which the dissipation enhancement from critical latitude effects is maximised are displaced from the inviscid limit periodic orbit frequencies by a factor that scales with $E^{0.23}$.
We review some of the processes leading to dispersion and mixing in porous media, exploring the differences between the travel time distribution of fluid particles within a pore throat and between pore throats of different size within the porous layer. A recent paper of Liu et al. (2024) has combined a model of these travel time distributions with a continuous time random walk to quantify the dispersion as a function of the Peclet number. We describe some further problems relating to dispersive mixing of tracer which may be amenable to this approach, including dispersion caused by macroscopic lenses of different permeability, dispersion of tracer which partitions between the fluid and matrix and the effects of buoyancy on mixing.
In this paper, the reflection of shock waves with downstream expansion fan interference in two-dimensional, inviscid flow is investigated, including steady Mach reflection (MR) and the unsteady transition process from regular reflection (RR) to MR. A threshold for the configuration based on non-dimensional wedge length is proposed. The analytical model for the steady MR and RR$\rightarrow$MR transition process is established based on the classical shock and expansion wave relations, whose prediction agrees well with results obtained through inviscid numerical simulation. It is found that the expansion fan interference significantly influences the steady flow patterns, especially the height of the Mach stem and the shape of the slip line. The interaction accelerates the formation of the sonic throat, stabilizing the flow structure rapidly, and results in generally small Mach stem heights. The exposure of the triple point to the expansion fan eliminates the inflection point on the slip line, whose slope increases smoothly. The interaction further affects the time evolution of the Mach stem during the multiple-interaction stage of the RR$\rightarrow$MR transition process. It appears that the modifications come from the curvature of the incident shock brought by the wave interference. During the multiple-interaction stage, the triple point moves upstream along the curved incident shock, where the incident shock angle changes according to the curvature, resulting in the variation of the evolution velocity.
We find the optimally time-dependent (OTD) orthogonal modes about a time-varying flow generated by a strong gust vortex impacting a NACA 0012 airfoil. This OTD analysis reveals the amplification characteristics of perturbations about the unsteady base flow and their amplified spatiotemporal structures that evolve over time. We consider four time-varying laminar base flows in which a vortex with a strength corresponding to the gust ratio $G$ of $\{-1,-0.5,0.5,1\}$ impinges on the leading edge of the airfoil at an angle of attack of $12^\circ$. In these cases, the impingement of the strong gust vortex causes massive separation and the generation of large-scale vortices around the airfoil within two convective time units. As these flow structures develop around the airfoil on a short time scale, the airfoil experiences large transient vortical lift variations in the positive and negative directions that are approximately five to ten times larger than the baseline lift. The highly unsteady nature of these vortex–airfoil interactions necessitates an advanced analytical technique capable of capturing the transient perturbation dynamics. For each of the considered gust ratios, the OTD analysis identifies the most amplified region to perturbations, the location of which changes as the wake evolves differently. For interactions between a moderate positive vortex gust ($G=0.5$) and the airfoil, the area where perturbations are amplified transitions from the leading-edge vortex (LEV) sheet to the forming LEV. Later, this most amplified structure becomes supported in the airfoil wake directly behind the trailing edge. In contrast, a strong vortex gust ($G=\pm 1$) encountered by the airfoil shows the most amplified OTD mode to appear around the core of the shed vortices. This study provides an analysis technique and fundamental insights into the broader family of unsteady aerodynamic problems.
We derive leading-order governing equations and boundary conditions for a sheet of viscous fluid retracting freely under surface tension. We show that small thickness perturbations about a flat base state can lead to regions of compression, where one or both of the principal tensions in the sheet becomes negative, and thus drive transient buckling of the sheet centre-surface. The general theory is applied to the simple model problem of a retracting viscous disc with small axisymmetric thickness variations. Transient growth in the centre-surface is found to be possible generically, with the dominant mode selected depending on the imposed initial thickness and centre-surface perturbations. An asymptotic reduction of the boundary conditions at the edge of the disc, valid in the limit of large normalised thickness perturbations, reduces the centre-surface evolution equation to an ordinary differentional equation (ODE) eigenvalue problem. Analysis of this eigenvalue problem leads to insights such as how the degree of transient buckling depends on the imposed thickness perturbation and which thickness perturbation gives rise to the largest transient buckling.
Electro-osmotic flow (EOF) in nanochannels exhibits a puzzling non-monotonic dependence on salt concentration, which contrasts with observations in microchannels and remains not fully understood. In this work, we address this phenomenon through a theoretical investigation of EOF in $\mathrm{pH}$-regulated channels. New analytical approximations for electrostatic potential, EOF profile and electro-osmotic mobility beyond the Debye–Hückel limit are derived through asymptotic analysis. Our findings reveal that the surface electrostatic potential is independent of the channel size only when the half-channel size exceeds the Gouy–Chapman length. In contrast, surface ionization and net charge distribution play more crucial roles in EOF at the nanoscale, as they govern both the magnitude and the spatial distribution of the Coulomb driving force. As salt concentration increases, EOF velocity initially rises due to enhanced surface ionization, followed by a decline attributed to increased wall shear stress. This work provides key insights for EOF applications in nanofluidics and biomedical devices, and deepens the understanding of electrokinetic phenomena influenced by $\mathrm{pH}$-regulation effects.
The flow-induced oscillation of a transversely clamped buckled flexible filament in a uniform flow was explored using the penalty immersed boundary method. Both inverted and conventional configurations were analysed. The effects of bending rigidity, filament length and Reynolds number were examined. As these parameters were varied, four distinct modes were identified: conventional transverse oscillation mode, deflected oscillation mode, inverted transverse oscillation mode and structurally steady mode. The filament exhibited a 2S wake pattern under the conventional transverse oscillation mode and the small-amplitude inverted transverse oscillation mode, a P wake pattern under the deflected oscillation mode and a 2S + 2P wake pattern for the large-amplitude inverted transverse oscillation mode. Irrespective of their initial conditions, all of the filaments converged to the conventional transverse oscillation mode under low bending rigidity. Multistability was observed in the transversely clamped buckled flexible filament under moderate bending rigidity. The deflection in the oscillation mode increased with increasing filament length. The inverted buckled filament was sensitive to the Reynolds number, unlike the conventional buckled filament. The transverse oscillation mode demonstrated superior energy-harvesting performance.
Quantum field theory predicts a nonlinear response of the vacuum to strong electromagnetic fields of macroscopic extent. This fundamental tenet has remained experimentally challenging and is yet to be tested in the laboratory. A particularly distinct signature of the resulting optical activity of the quantum vacuum is vacuum birefringence. This offers an excellent opportunity for a precision test of nonlinear quantum electrodynamics in an uncharted parameter regime. Recently, the operation of the high-intensity Relativistic Laser at the X-ray Free Electron Laser provided by the Helmholtz International Beamline for Extreme Fields has been inaugurated at the High Energy Density scientific instrument of the European X-ray Free Electron Laser. We make the case that this worldwide unique combination of an X-ray free-electron laser and an ultra-intense near-infrared laser together with recent advances in high-precision X-ray polarimetry, refinements of prospective discovery scenarios and progress in their accurate theoretical modelling have set the stage for performing an actual discovery experiment of quantum vacuum nonlinearity.