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Exploring novelty to unpack the black-box of motivation

Published online by Cambridge University Press:  31 January 2025

Nico Bunzeck Open the ORCID record for Nico Bunzeck [Opens in a new window]  and
Sebastian Haesler Open the ORCID record for Sebastian Haesler [Opens in a new window]
Nico Bunzeck*
Affiliation:
Department of Psychology, and Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany nico.bunzeck@uni-luebeck.de https://www.ipsy1.uni-luebeck.de/
Sebastian Haesler
Affiliation:
Neuroelectronics Research Flanders (NERF), and Department of Neuroscience, KU Leuven, Leuven, Belgium sebastian.haesler@nerf.be https://haeslerlab.com
*
*Corresponding author.
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Abstract

Murayama and Jach point out that we do not sufficiently understand the constructs and mental computations underlying higher-order motivated behaviors. Although this may be generally true, we would like to add and contribute to the discussion by outlining how interdisciplinary research on novelty-evoked exploration has advanced the study of learning and curiosity.

Information

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 48 , 2025 , e27
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Copyright
Copyright © The Author(s), 2025. Published by Cambridge University Press

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References

Aubret, A., Matignon, L., & Hassas, S. (2023). An information-theoretic perspective on intrinsic motivation in reinforcement learning: A survey. Entropy, 25(2), 327. https://doi.org/10.3390/e25020327CrossRefGoogle ScholarPubMed
Bunzeck, N., Doeller, C. F., Fuentemilla, L., Dolan, R. J., & Duzel, E. (2009). Reward motivation accelerates the onset of neural novelty signals in humans to 85 milliseconds. Current Biology, 19(15), 1294–1300.CrossRefGoogle ScholarPubMed
Bunzeck, N., Guitart-Masip, M., Dolan, R. J., & Düzel, E. (2011). Contextual novelty modulates the neural dynamics of reward anticipation. The Journal of Neuroscience, 31(36), 12816–12822. https://doi.org/10.1523/JNEUROSCI.0461-11.2011CrossRefGoogle ScholarPubMed
Bunzeck, N., Guitart-Masip, M., Dolan, R. J., & Duzel, E. (2014). Pharmacological dissociation of novelty responses in the human brain. Cerebral Cortex, 24(5), 1351–1360. https://doi.org/10.1093/cercor/bhs420CrossRefGoogle ScholarPubMed
Dahl, M. J., Mather, M., Düzel, S., Bodammer, N. C., Lindenberger, U., Kühn, S., & Werkle-Bergner, M. (2019). Rostral locus coeruleus integrity is associated with better memory performance in older adults. Nature Human Behaviour, 3(11), 1203–1214. https://doi.org/10.1038/s41562-019-0715-2CrossRefGoogle ScholarPubMed
Dahl, M. J., Kulesza, A., Werkle-Bergner, M., & Mather, M. (2023). Declining locus coeruleus–dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer's disease. Neuroscience & Biobehavioral Reviews, 153, 105358. https://doi.org/10.1016/j.neubiorev.2023.105358CrossRefGoogle ScholarPubMed
Düzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010). NOvelty-related Motivation of Anticipation and exploration by Dopamine (NOMAD): Implications for healthy aging. Neuroscience & Biobehavioral Reviews, 34(5), 660–669. https://doi.org/10.1016/j.neubiorev.2009.08.006CrossRefGoogle ScholarPubMed
Filimon, F., Nelson, J. D., Sejnowski, T. J., Sereno, M. I., & Cottrell, G. W. (2020). The ventral striatum dissociates information expectation, reward anticipation, and reward receipt. Proceedings of the National Academy of Sciences, 117(26), 15200–15208. https://doi.org/10.1073/pnas.1911778117CrossRefGoogle ScholarPubMed
Ghazizadeh, A., & Hikosaka, O. (2022). Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia. Nature Communications, 13(1), 6338. https://doi.org/10.1038/s41467-022-33514-3CrossRefGoogle ScholarPubMed
Gruber, M. J., Gelman, B. D., & Ranganath, C. (2014). States of curiosity modulate hippocampus-dependent learning via the dopaminergic circuit. Neuron, 84, 486–496. http://doi.org/10.1016/j.neuron.2014.08.060CrossRefGoogle ScholarPubMed
Guitart-Masip, M., Bunzeck, N., Stephan, K. E., Dolan, R. J., & Düzel, E. (2010). Contextual novelty changes reward representations in the Striatum. The Journal of Neuroscience, 30(5), 1721–1726. https://doi.org/10.1523/JNEUROSCI.5331-09.2010CrossRefGoogle ScholarPubMed
Kakade, S., & Dayan, P. (2002). Dopamine: Generalization and bonuses. Neural Networks, 15(4–6), 549–559. https://doi.org/10.1016/S0893-6080(02)00048-5CrossRefGoogle ScholarPubMed
Kang, M. J., Hsu, M., Krajbich, I. M., Loewenstein, G., McClure, S. M., Wang, J. T., & Camerer, C. F. (2009). The wick in the candle of learning: Epistemic curiosity activates reward circuitry and enhances memory. Psychological Science, 20(8), 963–973. http://doi.org/10.1111/j.1467-9280.2009.02402.xCrossRefGoogle ScholarPubMed
Kesby, J. P., Eyles, D. W., McGrath, J. J., & Scott, J. G. (2018). Dopamine, psychosis and schizophrenia: The widening gap between basic and clinical neuroscience. Translational Psychiatry, 8(1), 1–12. https://doi.org/10.1038/s41398-017-0071-9CrossRefGoogle ScholarPubMed
Krebs, R. M., Schott, B. H., & Düzel, E. (2009). Personality traits are differentially associated with patterns of reward and novelty processing in the human substantia nigra/ventral tegmental area. Biological Psychiatry, 65(2), 103–110. https://doi.org/10.1016/j.biopsych.2008.08.019CrossRefGoogle ScholarPubMed
Litman, J. A., & Mussel, P. (2013). Validity of the interest-and deprivation-type epistemic curiosity model in Germany. Journal of Individual Differences, 34(2), 59–68. https://doi.org/10.1027/1614-0001/a000100CrossRefGoogle Scholar
Modirshanechi, A., Xu, H. A., Lin, W.-H., Herzog, M. H., & Gerstner, W. (2022). The curse of optimism: A persistent distraction by novelty (p. 2022.07.05.498835). bioRxiv. https://doi.org/10.1101/2022.07.05.498835CrossRefGoogle Scholar
Modirshanechi, A., Kondrakiewicz, K., Gerstner, W., & Haesler, S. (2023). Curiosity-driven exploration: Foundations in neuroscience and computational modeling. Trends in Neurosciences, 46, 1054–1066. https://doi.org/10.1016/j.tins.2023.10.002CrossRefGoogle ScholarPubMed
Morrens, J., Aydin, Ç., Janse van Rensburg, A., Esquivelzeta Rabell, J., & Haesler, S. (2020). Cue-evoked dopamine promotes conditioned responding during learning. Neuron, 106, 142–153.e7. https://doi.org/10.1016/j.neuron.2020.01.012CrossRefGoogle ScholarPubMed
Qi, S., Schumann, G., Bustillo, J., Turner, J. A., Jiang, R., Zhi, D., … IMAGEN Consortium. (2021). Reward processing in novelty seekers: A transdiagnostic psychiatric imaging biomarker. Biological Psychiatry, 90(8), 529–539. https://doi.org/10.1016/j.biopsych.2021.01.011CrossRefGoogle ScholarPubMed
Sokolov, E. N. (1963). Higher nervous functions: The orienting reflex. Annual Review of Physiology, 25(1), 545–580. https://doi.org/10.1146/annurev.ph.25.030163.002553CrossRefGoogle ScholarPubMed
Steiger, T. K., Weiskopf, N., & Bunzeck, N. (2016). Iron level and myelin content in the ventral striatum predict memory performance in the aging brain. The Journal of Neuroscience, 36(12), 3552–3558. https://doi.org/10.1523/JNEUROSCI.3617-15.2016CrossRefGoogle ScholarPubMed
Steiger, T. K., Sobczak, A., Reineke, R., & Bunzeck, N. (2022). Novelty processing associated with neural beta oscillations improves recognition memory in young and older adults. Annals of the New York Academy of Sciences, 1511(1), 228–243. https://doi.org/10.1111/nyas.14750CrossRefGoogle ScholarPubMed
Takeuchi, T., Duszkiewicz, A. J., Sonneborn, A., Spooner, P. A., Yamasaki, M., Watanabe, M., … Morris, R. G. M. (2016). Locus coeruleus and dopaminergic consolidation of everyday memory. Nature, 537(7620), 357–362. https://doi.org/10.1038/nature19325CrossRefGoogle ScholarPubMed
Véronneau-Veilleux, F., Robaey, P., Ursino, M., & Nekka, F. (2022). A mechanistic model of ADHD as resulting from dopamine phasic/tonic imbalance during reinforcement learning. Frontiers in Computational Neuroscience, 16, 849323. https://doi.org/10.3389/fncom.2022.849323CrossRefGoogle ScholarPubMed
Wang, S.-H., Redondo, R. L., & Morris, R. G. M. (2010). Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory. Proceedings of the National Academy of Sciences, 107(45), 19537–19542. https://doi.org/10.1073/pnas.1008638107CrossRefGoogle Scholar
Wilson, F. A., & Rolls, E. T. (1990). Learning and memory is reflected in the responses of reinforcement-related neurons in the primate basal forebrain. Journal of Neuroscience, 10(4), 1254–1267. https://doi.org/10.1523/JNEUROSCI.10-04-01254.1990CrossRefGoogle ScholarPubMed
Wittmann, B. C., Daw, N. D., Seymour, B., & Dolan, R. J. (2008). Striatal activity underlies novelty-based choice in humans. Neuron, 58(6), 967–973. https://doi.org/10.1016/j.neuron.2008.04.027CrossRefGoogle ScholarPubMed