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This study investigates the nonlinear dynamics and control strategies for a Cessna-182 unmanned aerial vehicle (UAV). The longitudinal and lateral dynamic models were derived using aerodynamic analysis conducted in ANSYS Fluent. Various control methodologies, including PID (proportional, integral, derivative) tuning with genetic algorithm (GA), root locus (RL), MATLAB tuned (MT), Ziegler Nichols (ZN), the model reference adaptive controller (MRAC), linear quadratic regulator (LQR) and linear quadratic Gaussian (LQG), were implemented and compared through simulations. Due to the inadequacy of PID control under variable environmental and noise conditions, LQR and LQG controllers, including the full state-space model required for real-time applications, are simulated for both longitudinal and lateral motions in addition to the PID controller. Although the LQR controller has acceptable simulation results for noiseless conditions, the superiority and stable structure of the LQG controller under noise and disturbance effects are highlighted. The results, including noise Dryden turbulence effects, highlight the advantages of proposed MRAC and LQG for robust stability and precise flight performance. Experimental flight tests validate the theoretical findings, demonstrating the practical viability of the proposed control approaches. The results obtained for the Cessna-182 mini-UAV will be effective for future researchers in terms of obtaining UAV dynamics and also evaluating different control strategies of the UAV.
Associations of cerebrospinal fluid biomarkers with sleep, functionality and the MDS-UPDRS in dementia with Lewy bodies (DLB) and late-onset Alzheimer’s disease (AD) help elucidate their pathophysiological underpinnings.
Methods:
Consecutive outpatients with DLB and AD were matched by sex, cognitive scores and dementia stage, along with cognitively healthy controls matched by age and sex to investigate associations of cerebrospinal fluid amyloid-β (Aβ42,Aβ40,Aβ38), tau, phospho-tauThr181, ubiquitin, α-synuclein and neurofilament light (NfL) with sleep duration, Schwab & England scale and MDS-UPDRS, adjusted for sex, age and APOE-ϵ4 alleles.
Results:
Patients with DLB (APOE-ϵ4+:n=11, 76.64±9.0years; APOE-ϵ4-:n=16, 79.75±9.0years) were paired with patients with AD (APOE-ϵ4+:n=12, 80.17±5.7years; APOE-ϵ4-:n=15, 81.67±5.9years) and controls (APOE-ϵ4+:n=4, 82.00±6.4years; APOE-ϵ4-:n=23, 77.87±9.0years); two-thirds were women. APOE-ϵ4 carriers with dementia had more amyloidosis, higher phospho-tauThr181/Aβ42 and α-synuclein/Aβ42. In DLB, APOE-ϵ4 non-carriers had lower Schwab & England scores and higher MDS-UPDRS-I&II scores, lower tau/phospho-tauThr181 and higher ubiquitin and NfL than APOE-ϵ4 carriers. In controls, APOE-ϵ4 non-carriers had lower Aβ42 and Aβ42/Aβ38, higher phospho-tauThr181/Aβ42 and α-synuclein/Aβ42 than APOE-ϵ4 carriers. In DLB, sleep duration was associated with Aβ38 and α-synuclein and inversely associated with tau/phospho-tauThr181 and tau/ubiquitin; Schwab & England scores were associated with tau/ubiquitin and inversely associated with tau/phospho-tauThr181; MDS-UPDRS-I&II was associated with Aβ42/Aβ38; MDS-UPDRS-III was associated with tau/phospho-tauThr181; MDS-UPDRS-V ON was associated with Aβ42 and Aβ42/Aβ40, and MDS-UPDRS-V OFF was associated with Aβ42, Aβ42/Aβ40 and Aβ42/Aβ38. In AD, MDS-UPDRS-III was associated with ubiquitin.
Conclusion:
Biomarker ratios were superior to isolated biomarkers in associations with motor and non-motor experiences in DLB, though not so prominently in AD due to less motor impairment.
Applying teat dips to cows’ teats before and after milking (pre- and post-dipping) are important methods for preventing mastitis. Given the proven effectiveness of ozonated water for eliminating bacterial colonies, this study aimed to evaluate the effectiveness of ozonated water in preventing mastitis in pre- and post-dipping of dairy cows. Fifty-eight cows were selected based on negative black-bottom cup test results and the California mastitis test (CMT), and randomly allocated into two groups: the control group (CG, n = 23) where pre- and post-dipping were done with a commercial hydrogen peroxide product, and the ozone group (OG3, n = 35) where ozonated water at a concentration of 2 µg/ml was used, prepared immediately before use with an ozone generator. Samples were collected at four timepoints: M0 (pre), M1 (72 h), M2 (7 d) and M3 (14 d). Somatic cell count, CMT, pH, milk composition, and microbiological identification were analysed. The black-bottom cup test and physical evaluation of the udder were performed daily before milking. All milk composition variables were similar in both groups. SCC remained within normal ranges for both groups at all time points as per the guidelines of the Brazilian Ministry of Agriculture, Livestock and Food Supply. Microbiological cultures revealed similar pathogens across time points with the same growth dynamics. The study demonstrated that the use of ozonated water was as effective as the commercial product used in pre- and post-dipping for hygiene and prevention of mastitis in dairy cows, potentially serving as a viable alternative with lower environmental contamination, especially on organic dairy farms. Further studies comparing different concentrations and evaluations against other sanitizers are necessary.
In recent years, there has been a growing body of scholarship that distinguishes post-colonial and post-imperial migrations from other forms of migration. However, because this literature largely excludes non-European cases, it remains predominantly Eurocentric. This review article seeks to demonstrate how these studies can be further enriched by incorporating Ottoman migrations (muhacir) as a distinct form of post-imperial migration. To this end, the article evaluates four recently published works on Ottoman migration: İpek’s Migration in the Imperial Territories (Memalik-i Şahanede Muhaceret), Fratantuono’s Governing Migration in the Late Ottoman Empire, Hamed-Troyansky’s Empire of Refugees, and Oktay Özel’s Katamizes In Pursuit of the Blue (Kiske Kuşunun Peşinde Katamizeler). Through a comparative analysis of these works, the article explores the potential contributions of Ottoman post-imperial migration studies to the broader literature on post-imperial migration. In particular, it addresses issues such as the role of official historiography in shaping migration histories; debates over whether migrants were framed as returnees or repatriates; the effects of different imperial structures; and the ethnic and religious composition of both host societies and migrant populations.
Clinical researchers at U.S. academic health centers are becoming more attuned to the perspectives and values of research participants, seeking to partner with them to enhance their satisfaction and improve recruitment strategies.
Methodology:
We surveyed current or recent participants on their perspectives about the return of study results. Through a multi-site consortium of academic medical centers assessing the experiences of research participants using an online satisfaction survey, we added three questions to our institution’s version of the survey to assess the value placed on return of research results (RoR) to current or recent adult participants. Survey participants were offered anonymous participation using four different recruitment mechanisms (“sites”) hosted by our institution. Most recruitment was disease-agnostic.
Results:
A total of 506 heterogeneous respondents completed the survey. Although differences were found across recruitment sites, 73% of all participants desired and 49% expected to receive their own RoR, while 61% expected to receive the study’s aggregate results. The importance of receiving their own results was especially salient for respondents from historically underserved communities, identifying as non-white, Latino/Hispanic, primarily Spanish-speaking, older or less educated. Respondents’ sex was not a significant factor in preferences for return of results.
Conclusions:
Our results indicated our research participants’ expectations and perceived value of receiving the results from studies in which they participated, especially their individual results. This study provides direct evidence of the desires of our research participant community and suggests that institutional support for the return of study results would better serve participants’ interests and expectations in future research.
This article examines how courts in a diverse and divided society navigate tensions over a polarized religious issue. The incrementalist approach that defers difficult choices about state and religion through vague compromise has been defended in polities where achieving cohesion proves difficult. This article investigates how the court grapples with incrementalist logic underlying the regulation of interfaith marriage in Indonesia. To mitigate disagreements, the Indonesian Marriage Law has left the legality of interfaith marriage ambiguous and subject to constant negotiation and compromise. This article argues that the Indonesian Constitutional Court has failed to sustain this balance, as the court increasingly leans towards the religious aspect of marriage. Indonesian experience shows the complexities of court interventions on unclear legislative agreements and contentious issues in society. The Court adopted a rigid legal interpretation based on conservative religious views, which not only undermines rights and pluralism, but intensifies tensions and complicates future negotiations.
Host–parasite coevolution resulted in parasites optimizing their life cycle to obtain the most benefit from the host’s behaviour. In passerines, for instance, some parasite groups have found means to match their egg shedding rhythms with the hours of the day when hosts are most active. In other bird groups, such as shorebirds, whose active times are not determined by day–night cycles but by other external factors such as tidal or lunar cycles, it is not yet known whether their endoparasites exhibit any predictable pattern in their egg shedding rhythms. Here we used a simple wild-caught (captive) system, to provide a first approximation of the parasite egg shedding patterns in wintering Rufous-chested dotterels (Zonibyx modestus). We collected faeces every 2 hours over 10 days until completing a 24-hour cycle, which was coupled with continuous video recordings to determine their feeding and drinking habits. Contrary to our expectation, we showed that parasite egg shedding followed a cyclic pattern, characterized by 2 peaks: one at midnight and another in the afternoon. Importantly, this shedding pattern was not related to the birds’ feeding or drinking habits. We discuss possible environmental and physiological cues that parasites might use to trigger egg production, including the potential influence of tidal cycles on our results.
Onion seed productivity, quality, and profitability in Ethiopia are constrained by declining soil fertility and inadequate fertilizer management, particularly due to a historical reliance only on blanket nitrogen-phosphorus-based recommendations for bulb production. Therefore, the study examined the impacts of NPSB fertilizer, vermicompost, and their integrated application on soil fertility, onion seed yield, and quality in Yaya-Gulele, Oromia, Ethiopia. Treatments comprised a factorial combination of four NPSB rates (0, 75, 150, 225 kg/ha) and four vermicompost rates (0, 1.25, 2.5, 3.75 t/ha), arranged in a randomized complete block design with three replications. Seed quality was evaluated under laboratory conditions using a completely randomized design with four replications. The integrated application of NPSB and vermicompost improved key soil chemical properties, prolonged vegetative growth, and enhanced seed yield and quality parameters of onions compared to sole applications and the control. The highest-performing integrated treatment increased seed yield by up to threefold relative to the control. The integration of 150 kg/ha NPSB with 3.75 t/ha vermicompost was identified as the most agronomically and economically optimal treatment, producing the highest seed yield and net returns. This first report from North Shewa shows that the synergistic integration of NPSB and vermicompost significantly increases onion seed productivity and quality by improving soil fertility. This approach offers a practical and sustainable nutrient management strategy for onion seed production systems in Ethiopia.
This study aimed to explore whether health effects of dietary nitrate depend on its source, by investigating associations between plant and animal-sourced dietary nitrate groups with markers of inflammation and CVD risk factors. Among 100 non-smoking adults (mean age 49 (sd 13) years, 31 % male), dietary nitrate intake was assessed using FFQ (n 100) and 3-d food diary (n 89), combined with nitrate food composition databases. Nitrate intake was classified into plant, naturally occurring animal and additive-permitted meat-sourced groups. Associations between source-dependent nitrate intakes and lipoprotein-associated phospholipase A2 (Lp-PLA2), C-reactive protein (CRP), fasting plasma lipids, anthropometry and blood pressure were examined using multivariable linear regression, adjusted for socio-demographic, lifestyle and dietary confounders. Each 1 sd (∼57 mg/d) increment in plant-sourced nitrate intake was associated with a 0·191 sd lower LDL-cholesterol (β = −0·191, 95 % CI (–0·369, −0·004), P = 0·045; equivalent to −0·21 mmol/l) in primary models, though this association was attenuated in sensitivity analyses. Naturally occurring animal-sourced nitrate intake was not associated with any outcomes. A 1 sd (0·08 mg/d) increment in additive-permitted meat-sourced nitrate intake was associated with a 0·208 sd lower HDL-cholesterol (β = −0·208, (–0·362, −0·054), P = 0·009; equivalent to −0·10 mmol/l) and a 0·192 sd higher waist circumference (β = 0·192, (0·005, 0·380), P = 0·042; equivalent to +1·29 cm) but not with LDL-cholesterol, TAG, blood pressure, Lp-PLA2 or CRP. These preliminary findings suggest potential differential associations between nitrate source and cardiometabolic markers that warrant confirmation in larger studies.
This paper presents the development and psychometric analyses of the Mentee Competency Self-Assessment (MCSA), a tool designed to evaluate mentee skills in research mentoring relationships and assess the Mentoring Up curriculum. By assessing mentee competencies across diverse settings, the study aims to enhance understanding of mentoring dynamics and highlight the importance of considering both mentor and mentee perspectives in assessing mentorship effectiveness.
Methods:
The 26-item MCSA instrument was developed based on the validated Mentoring Competency Assessment (MCA) to evaluate the Mentoring Up curriculum. Data was obtained from 401 mentees who attended Mentoring Up workshops between 2015 and 2022. Principal component analysis (PCA) was performed with varimax rotation to examine the internal structure of the MCSA. A team of mentoring experts independently reviewed and reached consensus on component alignment. Confirmatory factor analysis (CFA) and internal consistency were performed to assess construct validity and reliability.
Results:
Factor and reliability analyses support an eight-component structure of a 22-item MCSA. All parameter estimates were significant, and the components demonstrated acceptable to high internal consistency (Cronbach’s alpha = 0.58–0.90).
Conclusions:
The final 22-item scale (MCSA-22) aligns with eight competencies and is now suited for measuring mentee mentorship skills. Given the modest sample size and other study limitations, replication of this proposed modification of the MCSA is an important next step. Additional recommendations for future scale development are offered.
To investigate the association between dietary advanced glycation end products (dAGE) and sarcopenia in USA adults. A total of 7590 participants aged 20–59 years were included in this study using data from the National Health and Nutrition Examination Survey 2011–2018. Dietary AGE intake was assessed by ultra-performance liquid chromatography-tandem MS-based AGE database combined with 24-h dietary recall. Sarcopenia was assessed by appendicular lean BMI (ALMI). Linear regression was used to examine the association between dAGE and ALMI. Logistic regression was adopted to examine the association between total and food-derived AGE with the prevalence of sarcopenia. The mediating role of bone mineral density (BMD) and serum 25 (OH) D3 on the association between dAGE and ALMI was also explored. The prevalence of sarcopenia was 7·26 %. Compared with the low intake tertile (T1), the OR for sarcopenia among participants in the high tertile (T3) of dAGE, (1-carboxyethyl) lysine and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine intake was 1·66 (95 % CI: 1·05, 2·64; Ptrend = 0·031), 1·56 (95 % CI: 1·01, 2·40; P trend = 0·042) and 1·60 (95 % CI: 1·03, 2·48; Ptrend = 0·033), respectively. Meat and baked foods derived AGE showed significant associations with the prevalence of sarcopenia. Mediation analysis demonstrated that 14·75% and 12·95 % of the association between dAGE and ALMI were mediated by the BMD and serum 25 (OH) D3, respectively. In the USA adult population, dietary AGE were positively associated with sarcopenia, particularly in meat and baked foods, with BMD and serum 25 (OH) D3 partially mediating this association.
Reproducibility, consistency, and transparency are essential to responsible and ethical scientific inquiry, though practices supporting these qualities are often neglected. However, in many cases data are confidential or otherwise unable to be shared publicly. This tutorial describes a method utilizing generative adversarial networks (GANs) to create synthetic data that are sufficiently similar to the original dataset in such cases where the source data cannot be shared or where the source data are too sparse as to internally validate results.
Methods:
Utilizing an exemplar study that aimed to create a clinical prediction model employing a novel echocardiographic measurement to differentiate between acute coronary syndrome and Takotsubo syndrome, we demonstrate the procedure of fitting a GAN and evaluating the resulting synthetic dataset against the results from the source dataset using conventional analytic methodologies. Further, we include relevant R code and output from this process to aid in implementation.
Results:
The procedure we detail yielded a synthetic dataset that was largely similar to the source data used in univariate descriptive statistics, significance testing comparing variables across datasets, data visualizations, and yielded largely comparable secondary model fit and accuracy metrics.
Conclusions:
We demonstrated that through the implementation of a well-tuned GAN, synthetic data can be generated as a sufficiently faithful simulacrum of the source data for the purposes of internal validation, transparency of method, and reproducibility of analytic results.
The Global Diet Quality Score (GDQS), the Global Dietary Recommendations score (GDR), Nova ultra-processed foods score and Minimum Diet Diversity for Women were listed by the UN as promising food-based metrics to track dietary quality. The aim was to evaluate those diet metrics performances for monitoring diet-related type 2 diabetes risk and insulin resistance in comparison with the Alternative Healthy Eating Index (AHEI). The study included 12 254 participants (56 % women; 35–74 years) of the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil) with available dietary, biochemical, socio-demographic and lifestyle data. Diet quality scores were derived from a validated FFQ covering the previous 12 months. Incident diabetes and changes in insulin resistance (HOMA-IR) over time were evaluated, and mediation by BMI was assessed. After an average 8·2 years follow-up period (17 % attrition; n 10 191), with 1-standard deviation increase in GDQS, GDR and AHEI, a 5 %, 6 % and 7 % decrease in incident diabetes was observed with BMI mediation effect of 39·6 %, 74·8 % and 59·4 %, respectively (P < 0·001 for all the analysis). HOMA-IR increase rate over time was higher in the lower quintile of GDQS (P = 0·002) and GDR (P < 0·001), compared with the upper quintile. As AHEI, GDR and GDQS had similar performances in monitoring diet-related type 2 diabetes risk, food-based metrics, such as the GDR and the GDQS, can be advantageous in lower resources settings and in nations where there is no food composition data availability.
This article offers a counter-reading of the Ghaznavid panegyric that resists reducing its idiom of praise to an effect of political legitimation, as dominant accounts of the genre have done. By highlighting how two panegyrics, one by ʿUnṣurī and the other by Farrukhī, subvert the aesthetic-didactic expectations surrounding praise born from Islamicate rhetorical and poetic theory, it contends that Persian panegyric poetry does not transparently deploy praise. To this end, the article first proposes four structures of praise that render praise both legible and susceptible to ironizing: evidentiary agreement, intradistich agreement, interdistich agreement, and metapoetic balance. A subsequent analysis of ʿUnṣurī and Farrukhī’s panegyrics reveals how ostensibly laudatory claims can ironize these structures to produce effects of delegitimation, rather than legitimation, while maintaining a posture of praise.
At ANSTO, we have developed an automated dissolved inorganic carbon (DIC) processing line, known as A-DIC, designed to sequentially process 10 water samples for radiocarbon analysis without any operator intervention. The A-DIC works at ambient pressure using helium (He) gas as a carrier. It includes a water pump capable of drawing adjustable sample volumes between 22-180 mL into a 250 mL reaction vessel. Upon the addition of 5 mL of phosphoric acid to the vessel, the sample is sparged with helium (He) gas at a rate of 45 mL/min for 16 min. The desorbed CO2 from the sample is then carried along with He through a series of traps: water vapor traps at –75 °C, a sulphur (SOx) trap containing silver wires at 650 °C, and two CO2 traps at –196 °C. The A-DIC is automated via a Python script executed on a PC connected via USB. It demonstrates consistent performance and CO2 trapping efficiency across batches of up to 10 samples. For contamination study, the CO2 gas collected is transferred to graphitization units to be converted into graphite for AMS analysis.
Child hunger is a significant global health concern prioritised by multiple global public health organisations. In 2006, the US Committee on National Statistics (CNSTAT) highlighted the need for clarity and consistency in the operationalisation and measurement of child hunger. This review examines whether these recommendations have been implemented in child nutrition programming over the past two decades. In addition, we explore how child hunger is currently conceptualised and measured across different contexts.
Design:
We conducted a pre-registered rapid review of studies that define or measure ‘child hunger’. Six electronic databases (Web of Science, MEDLINE, Embase, PsycINFO, Social Science Database and ERIC) and websites of twenty public health organisations were searched for reports that mentioned the term ‘child hunger’ or ‘child’ near ‘hunger’ published after 2006.
Setting:
There were no restrictions on study settings.
Participants:
Studies focusing on children under the age of 18 years were included.
Results:
Sixty-seven articles measured child hunger and were therefore eligible for inclusion. Of these, only twenty-three provided a definition of child hunger. Definitions commonly described child hunger as a consequence of or as a subcategory of household ‘food insecurity’. Most scales used in the included studies examined the quantity or amount of food intake by children, while few measures also assessed the quality of food consumed. The physiological dimension of hunger was not measured by any of the questionnaires.
Conclusions:
The findings underscore the need for more comprehensive and standardised approaches that account for the multidimensional nature of child hunger.