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In this study, we investigate the sedimentation of spheroidal particles in an initially quiescent fluid by means of particle-resolved direct numerical simulations. Settling particles with three different shapes – oblate spheroid, sphere and prolate spheroid – but fixed Galileo number $Ga=80$ and density ratio $\gamma =2$ at volume fraction $\phi =1\%$ are considered. Oblate and prolate particles are found to form column-like clusters as a consequence of the wake-induced hydrodynamic interactions in the suspension. This effect, together with the change of particle orientation, enhances the mean settling velocity of the dispersed phase. In contrast, spherical particles do not exhibit clustering, and settle with hindered velocity in the suspension. Furthermore, we focus on the pseudo-turbulence induced by the settling particles. We report a non-Gaussian distribution of the fluid velocity and a robust $-3$ power law of the energy spectra. By scrutinizing the scale-by-scale budget, we find that the anisotropy of the particle-induced pseudo-turbulence is manifested not only by the uneven allocation of turbulence kinetic energy among the different velocity components, but also by the anisotropic distribution of energy in spectral space. The fluid–particle interactions inject energy into the vertical velocity component, thus sustaining the turbulence, while pressure redistributes the kinetic energy among the different velocity components. The clustering of oblate/prolate particles significantly increases the energy input at large scales, forcing elongated flow structures. Moreover, the redistribution and nonlinear transfer of the energy are also intensified in the presence of particle clustering, which reduces the anisotropy of the particle-induced pseudo-turbulence.
This study employs volume-of-fluid-based computational fluid dynamics modelling to investigate the coupled effects of surface wettability and inflow vapour velocity on R134a ($p/p_{cri}=0.25$) condensation heat transfer in horizontal tubes. The results demonstrate that both the condensation heat transfer coefficient (HTC) and Nusselt number consistently increase with rising vapour velocity, indicating enhanced convective heat transfer at higher flow rates. Within this overall trend, the influence of surface wettability varies significantly across different velocity regimes. At moderate inlet velocities (10 m s−1), surface wettability demonstrates maximum impact, with the HTC enhancement exceeding 19.1% between peak and minimum values, optimising at contact angles of 120$^\circ$–140$^\circ$. As velocity increases to 20 m s−1, while surface wettability effects persist with $\gt$11.7 % enhancement, convective heat transfer becomes increasingly dominant, showing $\gt$38.8 % improvement in the maximum HTC compared with the 10 m s−1 case. At higher velocities (40 m s−1), the influence of surface wettability diminishes substantially, with the HTC variation reducing to $\gt$1.04 %. At extreme velocities (80 m s−1), surface tension effects become negligible compared with vapour shear forces, resulting in minimal (0.53 %) variation across different contact angles. The equivalent Reynolds number peaks at 20 m s−1, indicating optimal conditions for condensate formation and flow characteristics. These findings provide crucial insights for condensation system design, suggesting that while increasing velocity generally enhances heat transfer performance, surface wettability modifications are most effective at moderate velocities, while high-velocity applications should prioritise flow dynamics and system geometry optimisation.
Loneliness, while a common human experience, is something to which people often respond quite differently. Here, I examine how an individual’s social position, as well as his socialization into a particular cultural milieu, can shape his response to the fact of his loneliness (as well as the features of human existence that loneliness makes salient). Specifically, I argue that in cases where the individual experiencing loneliness has been socialized to disvalue the features of existence that loneliness makes salient (e.g., our dependence on and vulnerability to others) and/or to feel entitled to the social goods that they are, or perceive themselves to be, lacking (e.g., recognition or intimate connection), loneliness may catalyze the vicious, extremist attitude of ressentiment. This analysis allows us to see how loneliness may play a role in catalyzing vicious, extremist attitudes—though I contend that loneliness never warrants such attitudes.
While we now have a relatively good understanding of low-Reynolds-number hydrodynamics, and elegant techniques to dissect it, one cannot truly say the same for yield-stress fluids. For these materials, the nonlinearity associated with the yield stress complicates analysis and prevents the use of many of the techniques used for slow viscous flow. Simultaneously, the presence of a yield stress introduces a range of new features into the problem beyond those of traditional Stokes flow. Accordingly, in this essay, we discuss the impact of a yield stress in the relatively simple setting of two-dimensional, steady, inertialess flow. The main goals are to establish intuition for the dramatically different features that can be introduced to the flow by the yield stress, and to outline the various tools available to the modeller to construct and interpret these flows.
The safety of the utilization of methicillin-susceptible Staphylococcus aureus (MSSA)-targeted therapy for the treatment of MSSA bloodstream infections in the setting of neutropenia is not well studied. This single-center, retrospective cohort study of 40 patients found no significant difference in clinical outcomes between broad-spectrum anti-Pseudomonal and MSSA-targeted beta-lactam therapy.
To understand the pathogenetic mechanisms shared among schizophrenia (SCZ), bipolar disorder (BP), and major depression (MDD), we investigated the pleiotropic mechanisms using large-scale genome-wide and brain transcriptomic data.
Methods
We analyzed SCZ, BP, and MDD genome-wide association datasets available from the Psychiatric Genomics Consortium using the PLEIO framework and characterized the pleiotropic loci identified using pathway and tissue enrichment analyses. Pleiotropic and disorder-specific loci were also assessed.
Results
Our pleiotropy-informed genome-wide analysis identified 553 variants that included 192 loci not reaching genome-wide significance in input datasets. These were enriched for five molecular pathways: cadherin signaling (p = 2.18 × 10−8), Alzheimer’s disease-amyloid secretase (p = 4 × 10−4), oxytocin receptor-mediated signaling (p = 1.47 × 10−3), metabotropic glutamate receptor group III (p = 5.82 × 10−4) and Wnt signaling (p = 1.61 × 10−11). Pleiotropic loci demonstrated the strongest enrichment in the brain cortex (p = 5.8 × 10−28), frontal cortex (p = 3 × 10−31), and cerebellar hemisphere (p = 9.8 × 10−28). SCZ-BP-MDD pleiotropic variants were also enriched for neurodevelopmental brain transcriptomic profiles related to the second-trimester post-conception (week 21, p = 7.35 × 10−5; week 17, p = 6.36 × 10−4) and first year of life (p = 3.25 × 10−5).
Conclusions
Genetic mechanisms shared among SCZ, BP, and MDD appear to be related to early neuronal development. Because the genetic architecture of psychopathology transcends diagnostic boundaries, pleiotropy-focused analyses can lead to increased gene discovery and novel insights into relevant pathogenic mechanisms.
Previous research has characterized those resisting slavery as quite atypical of the enslaved population: most of them being young, male, and engaged in particular occupations. In this article, we study transgressive behavior among an enslaved population quantitatively. We employ a unique census from the Caribbean island of St. Croix in 1846, which allows us to study not only the characteristics of those that transgressed the masters’ order in some way, but also to compare them with those of the entire enslaved population on the island. We find that the individuals in our dataset who transgressed the oppressive institution were, in many respects, quite typical of the entire enslaved population under study. Opposition to the oppressive system could be found among all groups of enslaved persons in the studied society. Nonetheless, we find that specific characteristics, such as marital status and gender, were more likely to be associated with transgression on St. Croix.
Faith-based organizations that are rooted in India’s diverse faiths give shape to their roles in an operational space shaped by the Hindu nationalist government. This paper, based on interviews with 34 FBOs, compares how FBOs rooted in five different faith traditions perceive that operational space, and how they relate to the state based on their perceptions of these conditions. One key finding is that there are important similarities in these FBOs’ perceptions and ways of responding. Another key finding is that ways of understanding and responses vary in ways that can be explained at least partly by the differentiated position of diverse faith communities in Indian society itself and the specific challenges faced by members of each faith tradition. That is, the specific context of marginalization or promotion of a religious community by the state positions FBOs to advance their objectives through collaboration, confrontation, or by keeping distant from state agencies.
A structurally transforming multi-mode product can realize a changing set of functions across its modes, replacing multiple related products while offering increased cost, space, and time efficiency. However, there is a lack of connected methods that address the additional design complexities due to the product’s physical transformations and the resulting structural component-sharing between modes. A framework, grounded in standard design practice and built upon existing methods, is proposed to help navigate the two most impacted design stages: 1. Problem Definition and 2. Conceptual Design. The Problem Definition stage in this new framework involves identifying the external factor that determines the product’s modes and defining the functional requirements for the modes and transformation methods. The Conceptual Design stage involves iteratively linking conceptualized forms of each mode to adjacent modes through conceptualized transformation methods. The framework is demonstrated in a case study involving the design of a structurally transforming multi-mode piece of children’s furniture that transforms between a cradle, floor seat and a multipurpose toddler step stool. The proposed framework is a promising step toward systematically, cohesively, and comprehensively addressing design challenges during the development of a wide variety of structurally transforming multi-mode products, therefore facilitating better, more effective product design.
This article defines and defends three Rawlsian rationales for a cultural turn in education for democratic citizenship within digitized societies. Due to the importance of political culture for realizing deliberative democracy, it is misguided to hold that a primary or exclusive focus of such education should be on learning how to use digital tools for engaging in politics. Pace this technique- or skills-oriented focus, this article argues that the educational responses to the wide-ranging cultural developments of the digital political public sphere should not be a matter of “training” but of “cultivation.” Accordingly, democratic education for digital citizenship should pay attention to nurturing citizens’ political virtues so that, when they are dealing with fundamental political questions, they are willing to comply with the requirements of public reason and a corresponding duty of civility.
The aim of this work is to prove a new sure upper bound in a setting that can be thought of as a simplified function field analogue. This result is comparable to a recent result of the author concerning an almost sure upper bound of random multiplicative functions. Having a simpler quantity allows us to make the proof more accessible.
Anthropogenic actions are likely to harm dung beetle populations directly through habitat loss and indirectly through the cascading effects of large mammal depletions. Despite the reliance of dung beetles on mammal dung, there are only a handful of studies that have directly assessed the impact of habitat degradation and associated mammalian loss on dung beetle populations in Africa. We evaluated whether patterns in dung beetle species abundance, richness, and body size can be associated with mammalian herbivore abundance and species richness, habitat structure, and the distance between sample sites. Additionally, we ascertained how the presence of elephants (Loxodonta africana) may affect a dung beetle assemblage by determining which species could be used as bioindicators of elephant presence. We found herbivore and overall mammal abundance explained 17% of dung beetle assemblage structure, 2% of dung beetle abundance, 10% of dung beetle species richness and, 15% of the variation in dung beetle body size. Habitat structure explained 27% of dung beetle assemblage structure, 11% of dung beetle abundance, and 14% of the variation in dung beetle body size. Spatial distance between trapping locations explained 13% of the dung beetle assemblage structure, 4% of species richness, 3% of abundance, and but had no effect on dung beetle body size. We also identified four dung beetle species that may be used in future management plans as bioindicators of elephant density Afromontane Forest in East Africa. This information may become especially important for future monitoring as it is predicted that the areas in which elephants occur in Afromontane Forest are set to decline due to deforestation, and the expansion and intensification of agriculture.