Biomedical research on advanced cryopreservation has spillover effects on innovation in the food and agricultural sector. Advanced biopreservation technology has three key domains of impact in the food system: (1) improving efficiencies in storage and utilization of gametes and organoids for plant and animal breeding; (2) isochoric methods for preservation of fresh food products; and (3) in biorepositories for storage of genetic resources for agriculturally significant plants and livestock species.

We analyzed invasive group A streptococcal puerperal sepsis cases in a large health zone in Alberta, Canada between 2013 and 2022. Of the 21 cases, 85.7% were adjudicated as hospital/delivery-acquired, with 2 clusters having identical isolates found through whole genome sequencing. We implemented policy interventions across Alberta aimed at preventing future infections.

The question arises when developing and testing Unmanned Surface Vessel (USV) Manoeuvring Autonomy (MA): ‘is the performance we are seeing in our current on-water tests better than that of the last autonomy software version we deployed?’ An approach to answer this question is inspired by educators’ rubrics, in which a teacher grades a student’s work to objective criteria and then sums the individual criteria to determine the student’s overall grade. Here, individual metrics are used to evaluate a USV manoeuvring within range of another vessel. A weighted average is then applied to determine the overall score. With that objective performance value now obtained, similar manoeuvring tests can be compared between autonomy software versions to determine if the autonomy under development is progressively improving. This paper does not determine the threshold score needed to establish that a USV is safe to operate; thresholding of sufficient performance is recommended for future study.

As an industrial science, vaccinology is susceptible to changing social, economic and political frameworks. This article reconstructs the history of the birth of the Sabin strains-derived inactivated polio vaccine (sIPV) in China. The development of this nascent vaccine can be attributed first and foremost to the circulation of knowledge and technology in the global polio research network of the 1980s, before the privatization of vaccine manufacturing and the escalation of intellectual-property protections. Tracing correspondence between Jonas Salk and a Chinese scientist, Jiang Shude, and his colleagues, we chart how institutional efforts in search of a profitable product and scientists’ motives in pursuing personal careers in the post-socialist reform era led to collaboration on many levels, centered around polio vaccines. In response to recent polio history research, we also emphasize the impact of multiple temporalities of polio dramaturgy on the vaccine manufacturer, as this article demonstrates how the confluence of shifting global polio eradication agendas and contingencies in complex vaccinology undertakings ironically helped to materialize the idea of the sIPV. Finally, stories of vaccines and scientists in China add compelling subplots to the global polio history, which reveals the need to reconsider the politicization of imported technology in broader socialist contexts.

A letter dated ‘3 June 1986’ was mailed from Jonas Salk to Jiang Shude (姜述德). Jiang had been an unknown vaccinologist working at the Institute of Medical Biology (IMB) in Flower Red Cave in the Western Hills of Kunming, in south-western China. Salk had visited two years earlier to discuss the feasibility of the IMB's proposal to manufacture inactivated polio vaccine (IPV). The initial collaborative plan had come to a halt by the time Salk wrote the letter to Jiang; still, he kindly offered Jiang an opportunity to travel to Bilthoven and then Lyon to learn IPV-related technology with a generous $10,000 grant for his one-year stay in Europe.1

Automatic Identification System (AIS) provides estimated position time along with reception time and a time stamp at the receiving station; however, the exact position estimation time remains unidentified. Therefore, this study examines the extent of positional error when using current AIS reception time. As a result, a maximum positional error of 116.9 m was observed between AIS and RTK-GPS (Real-Time Kinematic GPS). Subsequent time correction reduced this error to less than 10 m, with the product of ship speed and correction time nearly matching the error pre-correction. Consequently, it was concluded that transmitting position estimation time is essential for maintaining the reliability of Position Accuracy transmitted by AIS or VHF Data Exchange System (VDES). Furthermore, VDES may possess the communication capacity to transmit and receive vessel attitude data. Therefore, to assess the required transmission frequency, the data transmission period of roll and pitch attitude data was analysed through the mutual correlation of acceleration and angular velocity. The results indicated that the correlation coefficient for each axis exceeded 0.65 at frequencies of 0.5 Hz or higher.

Anselm described god as “something than which nothing greater can be thought” [1, p. 93], and Descartes viewed him as “a supreme being” [7, p. 122]. I first capture those characterizations formally in a simple language for monadic predicate logic. Next, I construct a model class inspired by Stoic and medieval doctrines of grades of being [8, 20]. Third, I prove the models sufficient for recovering, as internal mathematics, the famous ontological argument of Anselm, and show that argument to be, on this formalization, valid. Fourth, I extend the models to incorporate a modality fit for proving that any item than which necessarily no greater can be thought is also necessarily real. Lastly, with the present approach, I blunt the sharp edges of notable objections to ontological arguments by Gaunilo and by Grant. A trigger warning: every page of this writing flouts the old saw “Existence is not a predicate” and flagrantly.

This article deals with a fiscal reform implemented in Chile during the late 1870s, when the country was suffering a severe economic and fiscal crisis, on the eve of the War of the Pacific. In 1879, the Chilean government introduced a new set of direct levies, taxing inheritance, income and wealth, despite the historic resistance of most of the economic elites to direct taxation in a highly unequal society. The process also shows that not all the economic elite avoided direct taxation. Despite other challenges faced by any developing country in extracting taxes from its population (e.g. lack of both proper information and human capital), during c.1879-1884 collection of these new direct taxes was successful, mainly on account of the improved extractive capacity built up during the preceding decades. Yet, by the mid-1890s all direct taxes (new and old) had been either derogated or transferred to local government (in some cases after being modified). Once again, Chilean central government depended entirely on indirect taxes, with export duties on nitrate being the most important. Nitrate provides a good example of an export boom shaping taxation for the worse; rather than increasing and diversifying the sources of revenue, a dominant sector of the Chilean economic elite decided to stop paying direct taxes and to make the state entirely dependent on the cycles of the international economy. However, some members of the economic elite, although defeated in their purpose, were aware of the wide range of benefits of keeping direct taxation: social justice, financial health and less vulnerability to trade cycles. Unfortunately, the balance of power favoured elite groups with enough power to hinder direct taxation.

Consider a company whose business carries the potential for investment losses and is additionally vulnerable to exogenous shocks. The unpredictability of the shocks makes it challenging for both the company and the regulator to accurately assess their impact, potentially leading to an underestimation of solvency capital when employing traditional approaches. In this paper, we utilize a stylized model to conduct an extreme value analysis of the tail risk of the company under a Fréchet-type and a Gumbel-type shock. Our main results explicitly demonstrate the different roles of investment risk and shock risk in driving large losses. Furthermore, we derive asymptotic estimates for the value at risk and expected shortfall of the total loss. Numerical studies are conducted to examine the accuracy of the obtained estimates.

This article presents a framework of ethical analysis for anticipatory evaluation of advanced biopreservation technologies and employs the framework illustratively in three domains. The framework features four clusters of general ethical considerations: (1) Producing Benefits, Minimizing Harms, Balancing Benefits, Risk, and Costs; (2) Justice, Fairness, Equity; (3) Respect for Autonomy; and (4) Transparency, Trustworthiness, and Public Trust.

My driftin’ memory goes back to the spring of ‘23.

While clozapine has risks, relative risk of fatality is overestimated. The UK pharmacovigilance programme is efficient, but comparisons with other drugs can mislead because of reporting variations. Clozapine actually lowers mortality, partly by reducing schizophrenia-related suicides, but preventable deaths still occur. Clozapine should be used earlier and more widely, but there should be better monitoring and better management of toxicity.