Though diet quality is widely recognised as linked to risk of chronic disease, health systems have been challenged to find a user-friendly, efficient way to obtain information about diet. The Penn Healthy Diet (PHD) survey was designed to fill this void. The purposes of this pilot project were to assess the patient experience with the PHD, to validate the accuracy of the PHD against related items in a diet recall and to explore scoring algorithms with relationship to the Healthy Eating Index (HEI)-2015 computed from the recall data. A convenience sample of participants in the Penn Health BioBank was surveyed with the PHD, the Automated Self-Administered 24-hour recall (ASA24) and experience questions. Kappa scores and Spearman correlations were used to compare related questions in the PHD to the ASA24. Numerical scoring, regression tree and weighted regressions were computed for scoring. Participants assessed the PHD as easy to use and were willing to repeat the survey at least annually. The three scoring algorithms were strongly associated with HEI-2015 scores using National Health and Nutrition Examination Survey 2017–2018 data from which the PHD was developed and moderately associated with the pilot replication data. The PHD is acceptable to participants and at least moderately correlated with the HEI-2015. Further validation in a larger sample will enable the selection of the strongest scoring approach.

A robust association has been reported between childhood adverse life events (ALEs) and risky substance use in adolescence. It remains unclear, however, what the impact of type and timing of these ALEs is. We investigated the association between ALEs and substance use in adolescents. ALEs were operationalized as broad (e.g., moving, parental divorce, family sickness) or physically threatening (physical and/or sexual abuse). First, we examined lifetime ALEs, followed by an investigation into their timing. The sample consisted of 909 adolescents (aged 12–18 years) from a cohort oversampled on high levels of emotional and behavioral problems. The primary caregiver indicated which ALEs each adolescent experienced across their lifetime. Adolescents self-reported on number and frequency of substances used. Poisson and ordinal regression models were used to model the associations. The associations between lifetime ALEs and a substance used were observed only for physical ALEs (incidence rate ratio 1.18 [1.03, 1.35], p = 0.02). When investigating timing, physical ALEs after the age of 12 predicted number of substances used (IRR 1.36 [1.13, 1.63], p < .001). Recent ALEs (occurring after age 12) seem to have considerable impact on substance use. Alcohol and drugs as a coping mechanism were considered a plausible explanation for the results.

The new mineral mazorite, ideally Ba3(PO4)2, a P-analogue of gurimite Ba3(VO4)2, was discovered in rankinite paralava hosted by the massive gehlenite-bearing pyrometamorphic rocks of the Hatrurim Complex in Israel. It has also recently been discovered in xenolith samples from the Bellerberg volcano in Germany. Holotype mazorite usually forms colourless plate-like crystals up to 70–100 μm in length but also occurs in small aggregates in association with other rare Ba-bearing minerals such as zadovite, celsian, hexacelsian, bennesherite, sanbornite, walstromite, fresnoite, gurimite, alforsite and barioferrite. The mineral is transparent, exhibits vitreous lustre and has a good cleavage on (001). Optically, mazorite is uniaxial (+), with ω = 1.760(3) and ɛ = 1.766(3) (λ = 589 nm). The empirical formula of the holotype mazorite calculated on 8O is (Ba2.69K0.22Na0.04Ca0.02Sr0.01)Σ2.98(P1.16V0.57S0.24Al0.04Si0.03)Σ2.04O8. Mazorite crystallises in space group R$\bar{3}$m, with unit-cell parameters a = 5.6617(5) Å, c = 21.1696(17) Å, V = 587.68(9) Å3 and Z = 3. Its crystal structure consists of BaO12, BaO10, and PO4 polyhedra, ordered along the c-axis in PO4–BaO10–BaO12–BaO10–PO4 columnar arrangement characteristic for palmierite-supergroup minerals. A tetrahedrally coordinated site is generally occupied by P5+ but can be partially substituted by V5+ and S6+. This substitution is shown in the Raman spectrum of mazorite, which reveals bands that can be assigned to the stretching and bending vibrations of (PO4)3–, (VO4)3– and (SO4)2– groups. The Raman spectra of mazorite from two localities (Hatrurim and Bellerberg) and spectra of minerals belonging to the mazorite Ba3(PO4)2 to gurimite Ba3(VO4)2 solid-solution series are presented. The gradual shift of the Raman bands, caused by cation substitutions, is well observed. The high V5+ → P5+ substitution is also observed for gurimite, for which the first X-ray structural data are also presented. Mazorite and other Ba-bearing minerals crystallised from a small portion of residual melt enriched in incompatible elements, such as Ba, V, P, U, S, Ti and Nb, at a temperature of ~1000°C.

Findings from observational studies have suggested a possible association between dietary inflammatory index (DII) and risk of gestational diabetes mellitus (GDM) and preeclampsia (PE). However, the results of these studies were inconclusive. A systematic review and meta-analysis was carried out to illuminate this association. Systematic literature search was conducted in PubMed, Web of Science, Cochrane Library, EMBASE, Scopus and other databases from inception until January 2023. The qualities of included studies were assessed using the Newcastle–Ottawa scale. Nine studies (seven cohort, two case–control) were included in the meta-analysis, including 11 423 participants from five different countries. The meta-analysis indicated that a 1-unit increase in the DII score, representing pro-inflammatory diet, was associated with 13 % higher risk of GDM (OR = 1·13; 95 % CI 1·02, 1·25, I2 = 68·4 %, P = 0·004) and 24 % higher risk of PE (OR = 1·24; 95 % CI 1·14, 1·35, I2 = 52·0 %, P = 0·125). Subgroup analysis found that this association was evident among studies with Chinese populations (OR = 1·16; 95 % CI 1·06, 1·28) and studies with mid pregnancy (OR = 1·20; 95 % CI 1·07, 1·34). The findings indicate that pro-inflammatory diet can increase the risk of GDM and PE. Considering some limitations in this study, more studies are needed to verify this association.

Given the threat presented by parasites and pathogens, insects employ various defences to protect themselves against infection, including chemical secretions. The red flour beetle Tribolium castaneum releases a secretion containing the benzoquinones methyl-1,4-benzoquinone (MBQ) and ethyl-1,4-benzoquinone (EBQ) into the environment. These compounds have known antimicrobial effects; however, their role in defence against macroparasites is not known. Entomopathogenic nematodes, such as Steinernema carpocapsae, present a serious threat to insects, with successful infection leading to death. Thus, quinone-containing secretions may also aid in host defence. We tested how exposure to the individual components of this quinone secretion, as well as a mix at naturally-occurring proportions, affected the survival and thrashing behaviour of S. carpocapsae, as well as their virulence to a model host (Galleria mellonella). Exposure to high concentrations of MBQ and EBQ, as well as the quinone mix, significantly increased nematode death but did not consistently reduce thrashing, which would otherwise be expected given their toxicity. Rather, quinones may act as a host cue to S. carpocapsae by triggering increased activity. We found that exposure to quinones for 24 or 72 hours did not reduce nematode virulence, and surviving nematodes remained infective after non-lethal exposure. Our results indicate that quinone secretions likely serve as a defence against multiple infection threats by reducing S. carpocapsae survival, but further research is required to contextualize their roles by testing against other nematodes, as well as other helminths using insects as hosts.

We introduce a formula for translating any upper bound on the percolation threshold of a lattice $G$ into a lower bound on the exponential growth rate of lattice animals $a(G)$ and vice versa. We exploit this in both directions. We obtain the rigorous lower bound ${\dot{p}_c}({\mathbb{Z}}^3)\gt 0.2522$ for 3-dimensional site percolation. We also improve on the best known asymptotic bounds on $a({\mathbb{Z}}^d)$ as $d\to \infty$. Our formula remains valid if instead of lattice animals we enumerate certain subspecies called interfaces. Enumerating interfaces leads to functional duality formulas that are tightly connected to percolation and are not valid for lattice animals, as well as to strict inequalities for the percolation threshold.

Incidentally, we prove that the rate of the exponential decay of the cluster size distribution of Bernoulli percolation is a continuous function of $p\in (0,1)$.

Several relational program logics have been introduced for integrating reasoning about relational properties of programs and measurement of quantitative difference between computational effects. Toward a general framework for such logics, in this paper, we formalize the concept of quantitative difference between computational effects as divergences on monads, then develop a relational program logic called approximate computational relational logic (acRL for short). It supports generic computational effects and divergences on them. The semantics of the acRL is given by graded strong relational liftings constructed from divergences on monads. We derive two instantiations of the acRL: (1) for the verification of various kinds of differential privacy of higher-order functional probabilistic programs and (2) the other for measuring difference of distributions of cost between higher-order functional probabilistic programs with a cost counting operator.

Spontaneous pulmonary artery thrombosis in neonates is rare and can be life-threatening. Clinical presentation may mimic pulmonary hypertension or CHD. Further, not all children present with identifiable risk factors. We report the case of two infants with pulmonary artery thromboses who underwent rapid diagnosis and therapy, one with percutaneous intervention and the other with anticoagulation. We also conducted a literature review to highlight the importance of early identification and referral to a centre capable of performing appropriate medical and interventional therapies.

In this paper, I revisit a debate between Ludwig Feuerbach and Karl Barth, known as the ‘Barth–Feuerbach confrontation’. I begin by framing the contours of this dispute as it was initiated by Barth and carried forward by his interpreters, who have sought in vain to make Barth's and Feuerbach's positions commensurable. Having narrated the history of this ongoing scholarly discussion and clarified why it remains intractable, I turn to Dietrich Bonhoeffer, whose this-worldly conception of theology, I argue, provides resources for ‘mediating’ the insights of Feuerbach and Barth. By attending to Bonhoeffer's earliest engagements with Barth on the question of divine revelation, and by exploring his striking proximity to Feuerbach on the issue of this-worldliness, we can see how Bonhoeffer helps overcome not only the dichotomies that plague the Barth–Feuerbach confrontation but also those that pervade modern attempts to safeguard this-worldliness by dispensing with divine transcendence.

This essay examines the relationship between Jean-Luc Marion's argument of ‘conceptual idolatry’ and John Duns Scotus’ doctrine of the univocity of being. I argue that Scotus does fall under Marion's criticisms, which radically undermine the use of ‘being’ in theology, but that univocity, in its barest Scotist form, also seems impossible to avoid. After arguing that attempts to move past this ontological conundrum fail, I conclude the relationship stands at an impasse. While this conclusion is critical, I make it for the sake of a constructive argument: post-metaphysical theology should reckon with the inevitability of being, appreciating this impasse between the apparent hegemony of being and the priority of God's self-revelation. Making the impasse clear at least points the way towards a renewed theological consideration of being.

This article explores the ways in which the thirteen ‘biographical superscriptions’ which are found throughout the Psalter contribute to the blending of the Davidic voice which they invoke and the corporate voice of the community which receives them. It suggests that by receiving these thirteen Psalms, the canonical community enters an intensive identification with David and participates in the Davidic life and experience. Once this is established, the discussion turns to examine these insights in a Christian theological context in conversation with Augustine's totus Christus principle. It is suggested that the hermeneutical situation created by the biographical superscriptions provides a way for the totus Christus principle to be re-invoked in contemporary interpretation.

This case report discusses a 25-year-old male who was referred to community mental health services from primary care with symptoms of anxiety and depression related to climate change, which the referring clinician believed were of delusional intensity. This case report gives the history of his interaction with the service. A literature review is performed noting the dearth of case reports in this area and a subsequent discussion charts the emerging literature on mental health issues related to climate change. Finally the paper makes some broad recommendations for mental health practitioners on how to approach these issues.