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Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the most common indication for a heart transplant. Guidelines are regularly based on studies of adults and applied to the young. Children and adolescents diagnosed with DCM face different lifestyle challenges from individuals diagnosed in adulthood that include medical trauma and are influenced by maturity levels and confidence with advocacy to adults.
Using a UK patient-scientist’s perspective, we reviewed the age-specific challenges faced by the young with DCM, evaluated current guidelines and evidence, and identified areas requiring further recommendations and research. We highlight the importance of (i) the transition clinic from paediatric to adult services, (ii) repeated signposting to mental health services, (iii) standardised guidance on physical activity, (iv) caution surrounding alcohol and smoking, (v) the dangers of illegal drugs, and (vi) reproductive options and health.
Further research is needed to address the many uncertainties in these areas with respect to young age, particularly for physical activity, and such guidance would be welcomed by the young with DCM who must come to terms with being different and more limited amongst healthy peers.
Despite its contested scientific validity, polygraph interviewing is now an established yet opaque practice within criminal justice in England and Wales, with statute law covering polygraph use in the context of probation for released offenders. In this paper, we highlight non-statutory uses of the polygraph by police forces in England and Wales by presenting analysis of responses to freedom of information (FOI) requests. The boundaries around police polygraph use are undefined and potentially elastic. The policies disclosed state that polygraph interviewing is conducted with regard to the Police and Criminal Evidence Act 1984 (PACE) and the Human Rights Act 1998; yet it is denied that a polygraph examination is a criminal interview conducted under PACE. Furthermore, there is a significant risk that the common law may not satisfy the quality of law requirement insofar as it is insufficiently clear who will be subject to polygraph testing, why and in what circumstances. Therefore, we argue that the legal basis for the police’s use of the polygraph is inadequate and imprecise. Without openness and scrutiny regarding the extent of this use, it is difficult to see how the key human rights principle of foreseeability can protect citizens from the risk of arbitrariness.
There is an ongoing debate in bioethics regarding the nature of suffering. This conversation revolves around the following question: What kind of thing, exactly, is suffering? Specifically, is suffering a subjective phenomenon—intrinsically linked to personhood, personal values, feelings, and lived experience—or an objective affair, amenable to impersonal criteria and existing as an independent feature of the natural world? Notably, the implications of this determination are politically and ethically significant. This essay attempts to bring clarity to the subjective versus objective debate in suffering scholarship by examining the history of the concept of “objectivity,” and putting that history in conversation with physician Eric Cassell’s famous theory of suffering. It concludes with a novel, albeit tentative, definition of suffering: suffering is the experience of a gap between how things are and how things ought to be.
Robust research has established that preexisting physical and mental health conditions increase risk for adverse psychiatric outcomes after disasters. However, it is unclear if increased risk is independent of disaster exposure, and most studies have relied on retrospective reports of pre-disaster functioning.
Methods
In a pre-post sample of high-risk Puerto Rican adults (N = 361) who experienced Hurricanes Irma and Maria, we assessed: 1) whether indicators of pre-disaster depression and physical health conditions were associated with posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) symptoms; and 2) whether the effects of pre-disaster depression and physical health conditions on PTSD and MDD symptoms were indirect via disaster exposure or had exacerbated the effects of disaster exposure on PTSD and MDD symptoms.
Results
Pre-disaster depression and physical health problems were significantly associated with higher post-disaster MDD symptoms (B = 1.50, SE = 0.36, p < .001, and B = 0.21; SE = 0.09, P = 0.016), but not PTSD symptoms. Indirect effects of pre-disaster depression and physical health symptoms via disaster exposure were non-significant, and neither moderated the association of disaster exposure on PTSD and MDD symptoms.
Conclusions
Research is needed to understand other pathways through which pre-disaster health conditions predict post-disaster mental health.
This study explores how we can improve the government’s research and technology for disasters and safety.
Methods
This study employs the Structural Equation Model (SEM) based on 268 experts’ perspectives.
Results
R&D performance exerts a directly significant impact on R&D achievement with the coefficient of 0.429. Second, while professionality and environment of R&D do not show a direct effect on achievement, they exhibit an indirect effect on it with the coefficient of 1.124 and 0.354, respectively. Third, R&D professionality exerts a significant impact on the R&D environment (0.964), and R&D environment has a positive effect on R&D performance (0.827).
Conclusion
Governments and policymakers should develop disaster and safety policies by understanding direct and indirect effects and the relationship of factors related to R&D for improving R&D achievement.
Critiques of police brutality and dire warnings about public safety are a seemingly inescapable topic of controversy today, saturating headlines and political campaigns all over the world. In 2020, the murder of George Floyd in Minneapolis prompted huge protests across the United States, with activists denouncing yet another episode of excessive police violence against a Black man. As Covid-19 lockdowns kept people tethered to their homes, protests echoed globally, affirming solidarity in the value of Black lives and critiques of police violence. In Europe, marchers filled the streets everywhere from the United Kingdom to Poland, and, notably for this essay, in France. France, of course, did not need an American example to reckon with police misconduct. Since at least the 1970s, French activists have been calling attention to the way that police violence is directed disproportionately at economically marginalised banlieues and socially marginalised immigrant populations. In 2018, French citizens witnessed the brutal policing of the gilets jaunes, a populist movement that criticised economic inequality and President Macron's neoliberal policies. With horror, they read stories of protestors battered by police batons, grenades, and tear gas, losing hands and eyes in the fray. More recently, in June 2023, the police murder of Nahel Merzouk in Nanterre, following a routine traffic stop, reopened old wounds. ‘Who, exactly, do the police serve?’, protestors asked. Certainly not Nahel.
The reprocessing of personal protective equipment that is only intended for single use has been brought into focus by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, especially regarding respiratory masks.1–4
Turbulent flows in three dimensions are characterized by the transport of energy from large to small scales through the energy cascade. Since the small scales are the result of the nonlinear dynamics across the scales, they are often thought of as universal and independent of the large scales. However, as famously remarked by Landau, sufficiently slow variations of the large scales should nonetheless be expected to impact small-scale statistics. Such variations, often termed large-scale intermittency, are pervasive in experiments and even in simulations, while differing from flow to flow. Here, we evaluate the impact of temporal large-scale fluctuations on velocity, vorticity and acceleration statistics by introducing controlled sinusoidal variations of the energy injection rate into direct numerical simulations of turbulence. We find that slow variations can have a strong impact on flow statistics, raising the flatness of the considered quantities. We discern three contributions to the increased flatness, which we model by superpositions of statistically stationary flows. Overall, our work demonstrates how large-scale intermittency needs to be taken into account in order to ensure comparability of statistical results in turbulence.
Cardiac surgery-associated acute kidney injury (CS-AKI) and fluid overload (FO) are common among neonates who undergo cardiopulmonary bypass, and increase mortality risk. Current diagnostic criteria may delay diagnosis. Thus, there is a need to identify urine biomarkers that permit earlier and more accurate diagnosis.
Methods:
This single-centre ancillary prospective cohort study describes age- and disease-specific ranges of 14 urine biomarkers at perioperative time points and explores associations with CS-AKI and FO. Neonates (≤28 days) undergoing cardiac surgery were included. Preterm neonates or those who had pre-operative acute kidney injury were excluded. Urine biomarkers were measured pre-operatively, at 0 to < 8 hours after surgery, and at 8 to 24 hours after surgery. Exploratory outcomes included CS-AKI, defined by the modified Kidney Disease Improving Global Outcomes criteria, and>10% FO, both measured at 48 hours after surgery.
Results:
Overall, α-glutathione S-transferase, β-2 microglobulin, albumin, cystatin C, neutrophil gelatinase-associated lipocalin, osteopontin, uromodulin, clusterin, and vascular endothelial growth factor concentrations peaked in the early post-operative period; over the sampling period, kidney injury molecule-1 increased and trefoil factor-3 decreased. In the early post-operative period, β-2 microglobulin and α-glutathione S-transferase were higher in neonates who developed CS-AKI; and clusterin, cystatin C, neutrophil gelatinase-associated lipocalin, osteopontin, and α-glutathione S-transferase were higher in neonates who developed FO.
Conclusion:
In a small, single-centre cohort, age- and disease-specific urine biomarker concentrations are described. These data identify typical trends and will inform future studies.
Les élections municipales de 2021 à la Ville de Québec ont été marquées par une forte compétition entre cinq candidats et une saillance des enjeux concernant la construction d'un tramway et d'un troisième lien autoroutier entre Québec et sa Rive-Sud. Ainsi, cette élection représente un contexte idéal pour étudier le comportement électoral au niveau local et plus spécifiquement le vote sur enjeu qui a été très peu étudié dans le contexte municipal. Nous soutenons que ces deux enjeux ont acquis une valeur symbolique et ont été exploités comme enjeu de brèche par le candidat à la mairie Jean-François Gosselin. À l'aide d'une analyse multivariée, nous testons la relation entre l'appui aux deux projets de transport et l'intention de vote. Nos résultats montrent que les attitudes des électeurs envers ces deux enjeux sont fortement corrélées avec leur choix de vote et suggèrent une continuité entre le comportement électoral municipal, provincial et fédéral, du moins lorsqu'il est question de vote sur les enjeux.
Established studies show that after the fall of the capital-based elites during the end of the Tang dynasty, the Northern Song literati became active in serving the central government. However, after the century-long Interregnum (878–978), during which literati from the South remained beyond the rule of the Central Plains dynasties, how did they establish a cooperative relationship with the emerging Song court? Taking Puyang in Fujian as an example, this article analyzes the writings of Puyang literati to illustrate how their narratives shaped political relationships between the center and periphery. It demonstrates how literati responded variously to specific political contexts, sometimes showcasing their own local identity and at other times extolling the rule of the Central Plains. The case of Puyang reveals that the challenging political environment of the Interregnum actually stimulated and accelerated cooperation between the Central Plains and the local literati through civil service examinations.
To evaluate the perception of disaster preparedness and response self-efficacy of nurses living and working in the region affected by the earthquakes in Turkey on February 6, 2023.
Methods
This cross-sectional, relationship-seeking research was conducted between March 10 and May 10, 2024 with 344 nurses in a hospital in the province of Kahramanmaraş, which was the epicentre of the February 2023 earthquake. A Personal Information Form, the Perception of Nurses of Disaster Preparedness Scale (PNDPS), and the Disaster Response Self-Efficacy Scale (DRSES) were used in data collection. Pathway analysis and confirmatory factor analyis were used in the evaluation of the data.
Results
Age, gender, educational level, disaster training, and having lost someone close in a disaster were determined to have a significant effect on the perception of disaster preparedness, and response self-efficacy (P < 0.05). The perception of the stage of preparation was determined to be 0.136-fold greater in those with a disaster preparation plan (P < 0.05). Perception of the post-disaster stage was determined to be 0.130-fold greaater in those with a disaster preparation plan (P < 0.05).
Conclusions
This study demonstrated that nurses working in the earthquake region had high levels of disaster preparedness perception and response self-efficacy.
This article focuses on the early history of Northwestern European opinion polling (1940s–1950s), specifically the cases of the Netherlands and Sweden. The evolution of opinion polling and its influence on post-war politics and society should be understood in light of processes of international transfer and entanglement. The Dutch-Swedish comparison brings into focus the ways in which the national experiences of the Second World War influenced how opinion pollsters discursively linked the practice to ideas about democracy. Furthermore, the article highlights entanglements across the boundaries of science, as commercial survey methods were picked up by social scientists, and across national borders, as opinion pollsters across Western Europe were in frequent contact with each other.
The interaction between planar incident shocks and cylindrical boundary layers is prevalent in missiles equipped with inverted inlets, which typically leads to substantial three-dimensional flow separation and the formation of vortical flow. This study utilizes wind-tunnel experiments and theoretical analysis to elucidate the shock structure, surface topology and pressure distributions induced by a planar shock with finite width impinging on a cylinder wall at Mach 2.0. In the central region, a refraction phenomenon occurs as the transmitted shock bends within the boundary layer, generating a series of compression waves that coalesce into a shock, forming a ‘shock triangle’ structure. As the incident shock propagates backward along both sides, it gradually evolves into a Mach stem, where the transmitted shock refracts the expansion wave. The incident shock interacts with the boundary layer, resulting in the formation of a highly swept separation region that yields a pair of counter-rotating horseshoe-like vortices above the separation lines. These vortices facilitate the accumulation of low-energy fluid on both sides. Although the interaction of the symmetry plane aligns with free-interaction-theory, the separation shock angle away from the centre significantly deviates from the predicted value owing to the accumulation of low-energy fluids. The primary separation line and pressure distribution jointly exhibit an elliptical similarity on the cylindrical surface. Furthermore, the potential unsteady behaviour is assessed, and the Strouhal number of the low-frequency oscillation is found to be 0.0094, which is insufficient to trigger significant alterations in the flow field structure.
At the entrance to this impressive exhibition stands Umberto Boccioni's dramatic bronze sculpture, Forms of Continuity in Space (1913), a Futurist piece filled with power, movement and innovation. It is a fitting introduction to what follows.