This study aimed to investigate gastrointestinal tolerability, treatment persistence and iron status markers in patients with iron deficiency anaemia (IDA) who received oral iron replacement therapy (IRT) with v. without concomitant Lactobacillus plantarum 299v (L. plantarum 299v) probiotic supplementation. A total of 295 patents with newly diagnosed IDA were randomly assigned to receive either IRT alone (n 157, IRT-only group) or IRT plus L. plantarum 299v (n 138, IRT-Pro group) in this prospective randomised non-placebo-controlled study (ClinicalTrials.gov Identifier: NCT06521879). Gastrointestinal intolerance symptoms (at baseline, within the first 30 d of IRT and at any time during 3-month IRT), serum Hb levels (at baseline and 3rd month of IRT) and iron status markers (at baseline and 3rd month of IRT) were recorded. IRT-Pro group, when compared with IRT-only group, experienced significantly lower rates of gastrointestinal intolerance over the course of IRT (13·0 % v. 46·5 %, P < 0·001) and treatment discontinuation within the first 30 d (3·6 % v. 15·9 %, P < 0·001). At 3rd month of therapy, IRT-Pro v. IRT-only group had significantly higher serum levels for iron (76·0 (51·0–96·0) v. 60·0(43·0–70·0) µg/dl, P < 0·001) and transferrin saturation (20·1 (12·5–28·5) v. 14·5 (10·5–19·0) %, P < 0·001) and higher change from baseline Hb (0·9 (0·3–1·3) v. 0·4 (–0·1–1·1) g/dl, P < 0·001) levels. Use of L. plantarum 299v probiotic supplementation during the first 30 d of IRT in IDA patients significantly reduces the gastrointestinal burden of IRT (particularly abdominal pain and bloating), the likelihood of intolerance development (by ∼3 times) and treatment discontinuation (by∼5 times), as accompanied by improved serum Hb levels and serum iron markers.

Metabolic dysfunction is an established phenomenon in people with severe mental illness (SMI), and it has a higher prevalence than in the general population. It is associated with increased morbidity and mortality, and effective recognition and management are essential to enable good psychiatric care. Despite widespread awareness of this disparity for several decades, health outcomes continue to worsen, highlighting the need for more effective preventive and treatment measures. This article outlines the risk factors that contribute to metabolic dysfunction in this population, including genetic, environmental and pharmacological factors, and considers underlying metabolic pathophysiological processes as part of SMI itself. To aid discussions with patients, recognition and interpretation of metabolic risk factors are outlined, together with mitigating strategies. Novel areas of uncertainty are discussed, including the use of a ketogenic diet. This article advocates use of the term ‘metabolic psychiatry’, to increase awareness of the significant overlap between psychiatric illness and metabolic dysfunction.

In this brief discussion of McKaughan and Howard-Snyder’s “How Does Trust Relate to Faith?” I call into question the authors’ finding that faith is necessarily resilient while trust is not. To do this, I demonstrate how the constraints of McKaughan and Howard-Snyder’s inquiry screen out a particular kind of trust, two-place trust, which does manifest resilience. Turning then to two-place trust, I offer two positive reasons—proportionality and the value of relationships—to think that trust may be essentially resilient after all. If this is correct, it takes us a step closer to understanding how trust relates to faith.

In my examination of Sophocles’ Antigone, I use Beauvoir’s existential philosophy as a lens and hermeneutic model and apply her language and terms—immanence, transcendence, and ambiguity—to the original ancient text to understand the gendered metaphors of the play and to reveal an area of oversight in her superficial treatment of the tragedy. Taking this theoretical approach, I use “feminist” or “existentialist” Beauvoir (The ethics of ambiguity, The second sex) against herself, that is, her interpretation of the Antigone in “Moral idealism and political realism,” to show how existentialist freedom is achieved in the tragedy. In my reading, I cast Antigone as a figure of ambiguity, situated in an oppressive context, and I argue that she creates her own project and strives towards freedom, in the Beauvoirian sense. I also extend the subjectivity of ambiguity to Ismene and illustrate the course of her own existential freedom to portray the reversibility of the transcendence/immanence polarity in these two figures and, ultimately, to suggest that the sisters are intertwined. Inscribing my reading in a tradition of feminist interpretations surrounding the Antigone, I advance a new reading that finds in the play a feminist political theory of existentialism, inclusive of the sororal pair.

Internalizing and externalizing problems tend to co-occur beginning in early childhood. However, the dynamic interplay of symptom-level internalizing and externalizing problems that may drive their co-occurrence is poorly understood. Within the frameworks of the Network Approaches to Psychopathology and the Developmental Cascade Perspective, this study used a panel network approach to examine how symptoms of internalizing and externalizing problems are related in early childhood both concurrently and longitudinally and whether the pattern may differ in American (N = 1,202) and Chinese (N = 180) preschoolers. Internalizing and externalizing problems were rated by mothers in two waves. Results from cross-sectional networks showed that the bridge symptoms underlying the co-occurrence of internalizing and externalizing problems were largely consistent in American and Chinese preschoolers (e.g., withdrawal, aggressive behavior, anxiety and depressive moods). Results from cross-lagged panel networks further showed that the co-occurrence was manifested by unidirectional relations from internalizing to subsequent externalizing symptoms in both American and Chinese preschoolers. The findings contribute needed cross-cultural evidence to better understand the co-occurrence of internalizing and externalizing problems and highlight the temporal heterogeneity of the symptom networks of internalizing and externalizing problems in early childhood.

The analysis delves into the complex legal intricacies surrounding the establishment of South Slavic state entities post-World War I, as international law of the time didn't fully encompass modern legal instruments defining international relations subjects. Nonetheless, legal arguments affirm the statehood of the State of SCS, formed within the former Austro-Hungarian Empire through legitimate representative bodies, despite lacking formal international recognition. The Croatian state transitioned governance under the National Council of SCS without abolishing its institutions. The analysis of the “December 1st Act” highlights procedural violations during the forming of the Kingdom of SCS, indicating a deviation from authorized scope, though it did not render the new state's government illegitimate. The negotiating process favored Serbian authorities, evident in the “Vidovdan” Constitution, yet it doesn't suffice to claim the State of SCS was annexed by the Kingdom of Serbia. Legally, there's little ambiguity, but disputes in international legal rulings and interpretations uncover internal political tensions and external pragmatic influences.

Dominant historiography in Singapore celebrates Sinnathamby Rajaratnam as one of the city-state’s founding national fathers, and the intellectual superintendent of state-sponsored multiculturalism in what has been characterized as an ‘illiberal democracy’. Little attention, however, has been paid to the extensive periods of Rajaratnam’s life in which he was not in governance with the People’s Action Party, and thus had considerable intellectual autonomy. This article examines the first of these periods—his sojourn in London from 1935 to 1947—marked by connections with overlapping communities of anti-colonial intellectuals drawn from Africa, the Caribbean, and East and South Asia. Close reading of Rajaratnam’s London lifeworld, his published fiction and journalism, and the many annotations he made in the books he read reveals a very different intellectual history than the one that we think we know, and allows us to better understand his lifelong uneasiness with capitalism and racial governmentality. Re-reading Rajaratnam as an autonomous intellectual disembeds his early intellectual life from the story of the developmental state, enabling a focus on the role of affect and form in his writing. The process also offers new insights into Singapore today, where the legacies of state-sponsored multiculturalism are increasingly challenged, and where citizens, residents, and migrants seek new forms of solidarity in and across difference.

As practised by Nicholas Cook, Philip Tagg, and Nicolai Graakjær, the analysis of advertising music has largely concentrated on how advertising works to communicate meaning. Within media and communications studies, such a focus is seen as a distraction — albeit a fascinating one. For Sut Jhally, for example, advertising has pernicious social and ecological effects and advertising scholars’ goal should be to understand ‘what work advertising does’ in order to mitigate them. This examination of a Ford automobile advert featuring Nina Simone’s ‘I Wish I Knew …’ (1967) shows how music analysis might contribute to this pressing project.

With which sources can we write environmental histories of mining and oil drilling in Africa? Paradoxically, the pollution and environmental disruption caused by extractive industries are at once omnipresent and difficult to trace. In documentary evidence, multinational companies are hesitant to disclose the full extent of their polluting activities. In order to understand how people living around sites of extraction make sense of polluted rivers or suffocating smoke, we argue that archives need to be pluralized. State and company archives can fruitfully be paired with newspaper collections, oral history interviews, cultural production (songs, poems and literary works) and photography. Using examples from Johannesburg, Mazowe, the Central African Copperbelt and the Niger Delta, we map sources and methodologies that might be employed to grasp people’s lived experiences of environmental change in localities of resource extraction.