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This paper presents a new topology for a microwave active mixer using compact microstrip diplexer constituted from two dual-mode open loop resonators. The resonators are tuned to the radio frequency (RF) and local-oscillator (LO) frequencies, respectively, to effectively isolate the two input signals, while the diplexer output port is connected to the gate circuit of a commercial low cost GaAs pHEMT transistor. The drain circuit of the active device is connected to the load via an intermediate-frequency (IF)-modified Chebyshev low-pass filter to remove the unwanted RF and LO signals and reduce other spurious frequencies at the output of the mixer circuit. The circuit has been designed and constructed for an RF of 850 MHz, LO frequency of 1050 MHz, and an IF of 200 MHz. Experimental measurements show that the circuit provides a conversion gain of 18 dB at LO drive power of +2 dBm. It also operates satisfactorily over the RF range from 800 to 900 MHz with good image frequency rejection and stable operation.
This study aims to identify midwives’ post-earthquake caregiving experiences.
Methods
A phenomenological study was undertaken in May-June 2023. The participants of the study consisted of 15midwives who were included in the study with the purposeful sampling method and volunteered to provide care during the earthquake. Data were collected by an in-depth interview method using a demographic information form and a semi-structured interview form. Thematic analysis was conducted on interview transcripts.
Results
The research identified 2main themes: difficulties in managing midwifery care and the psychological impact of the earthquake on midwives. Challenges included issues with disaster organization, management, and coordination; communication gaps; insufficient medical supplies; harsh environmental conditions; inability to fulfill basic needs; lack of disaster-related knowledge and experience among midwives; and the overall survival conditions of disaster victims. The disaster caused several psychological effects on midwives, including shock, surprise, sadness, confusion, feelings of inadequacy, insomnia upon returning from the disaster area, nightmares, difficulty adapting, guilt about returning, feelings of helplessness, and experiences of loss and mourning.
Conclusions
This study detailed midwives’ experiences during disasters, difficulties, and barriers to effective care. It is crucial to record midwives’ experiences during disasters and use this information and solutions to prepare for future disasters. Disaster preparedness training for midwives should be planned to increase physical and emotional resilience.
Greenberg’s Universal 42 states that all languages have pronominal categories involving at least three persons and two numbers. However, this characterization fails to capture the properties of pronouns in Japanese, which are not bundles of person, number and gender features (so-called phi-features); rather, they contain sociolinguistic information about the interlocutors. We propose that these properties are structurally determined. Following Ritter and Wiltschko, we assume that the highest layer of structure in nominals is interactional structure. As for phi-features, we adopt the standard assumption that they are represented internal to the determiner phrase (DP). We propose that the distinctive properties of Japanese pronouns follow from the hypothesis that they spell out elements of the interactional structure and not the DP. We show that the lack of phi-features in Japanese pronouns correlates with other properties of this language’s grammar. Support for this analysis comes from languages where pronouns with phi-features can optionally be used to encode formality (e.g. German and French). We propose that in these languages, formal pronouns originate within the DP but are interpreted in the interactional structure. Finally, we suggest that this analysis may extend to imposters and vocatives in that they may also be interpreted in the interactional structure.
In homotopy type theory, few constructions have proved as troublesome as the smash product. While its definition is just as direct as in classical mathematics, one quickly realises that in order to define and reason about functions over iterations of it, one has to verify an exponentially growing number of coherences. This has led to crucial results concerning smash products remaining open. One particularly important such result is the fact that the smash product forms a (1-coherent) symmetric monoidal product on the universe of pointed types. This fact was used, without a complete proof, by, for example, Brunerie ((2016) PhD thesis, Université Nice Sophia Antipolis) to construct the cup product on integral cohomology and is, more generally, a fundamental result in traditional algebraic topology. In this paper, we salvage the situation by introducing a simple informal heuristic for reasoning about functions defined over iterated smash products. We then use the heuristic to verify, for example, the hexagon and pentagon identities, thereby obtaining a proof of symmetric monoidality. We also provide a formal statement of the heuristic in terms of an induction principle concerning the construction of homotopies of functions defined over iterated smash products. The key results presented here have been formalised in the proof assistant Cubical Agda.
As a result of increasingly intensified agricultural practices in Europe over the last century, agroecosystems have experienced severe biodiversity declines. Among the species experiencing negative population trajectories in agricultural habitats are meadow and farmland birds, which have suffered a loss in both habitat and food availability in cultivated fields. In Denmark, biotope plans (a requirement to establish small agro-environmental habitats on properties with stocking of game birds) have been implemented as a measure to mitigate biodiversity declines in the agricultural landscape and, in this paper, we investigate to what extent these initiatives fulfil the intended purpose with respect to birds in the breeding season. We demonstrate that some initiatives like hedgerows, areas of open vegetation, scrub, and lakes seemed to increase avian diversity locally, but also that other measures such as vegetation strips, grass strips, and bare soil strips had little effect given the current implementation of these initiatives. Benefitting species were mostly scrub- and woodland species that now inhabited previously open landscapes after the establishment of suitable habitats, and the initiatives failed to show clear positive effects on meadow birds and farmland birds for which they were originally intended. The most commonly registered species in our data set was (released) Pheasant Phasianus colchicus, which emphasised that the stocking of game birds can have a clear effect on avian species composition in areas where this practice is exercised. Future studies are needed to clarify how this stocking may affect local biodiversity of different taxonomic groups.
There are numerous factors that impact human health. Sanitary and hygienic conditions in the workplace and living environments, the state of the environment, and nutrition levels play a significant role in determining environmental quality. An integral part is also the organization of effective treatment and preventive health care services for the population. The purpose of this study is to analyze the sanitary and hygienic situation in the Republic of Kazakhstan.
Methods
The methodological framework employed general theoretical methods, statistical analysis, and techniques for systematizing information.
Results
During the study, it was determined that in several cities, high levels of respiratory and skin morbidity are recorded, linked to elevated concentrations of dust, ammonia, hydrogen fluoride, and nitrogen dioxide. As a consequence of chemical contamination of drinking water sources, there is an escalation in the incidence of nephritis and hepatitis, an upsurge in the number of toxicosis cases among pregnant women, and congenital anomalies. The sanitary condition of settlements greatly impacts the development of satisfactory living conditions.
Conclusions
Therefore, this research holds significant practical relevance, and the findings can be utilized by specialists in relevant fields to analyze and address the identified problems, as safeguarding public health, development, and improvement of its protection system is currently becoming one of the paramount tasks.
This study evaluated the effect of green tea extract and metformin and its interaction on markers of oxidative stress and inflammation in overweight women with insulin resistance. After screening, 120 women were randomly allocated in 4 groups: Placebo (PC): 1g of microcrystalline cellulose/day; Green tea (GT): 1 g (558 mg polyphenols) of standardized dry extract of green tea/day and 1 g of placebo/day; Metformin (MF): 1 g of metformin/day and 1 g of placebo/day; Green Tea and Metformin (GTMF): 1 g (558 mg polyphenols) and 1 g of metformin/day. All groups were followed-up for 12 weeks with assessment of oxidative damage to lipids and proteins, specific activity of antioxidant enzymes and inflammatory cytokine serum levels. The association of green tea with metformin significantly reduced IL-6 (GTMF: –29.7((–62.6)–20.2))(p = 0.004). Green tea and metformin isolated reduced TNF-α (GT: –12.1((–18.0)–(–3.5)); MF: –24.5((–38.60)–(–4.4)) compared to placebo (PB: 13.8 (1.2–29.2))(P < 0.001). Also, isolated metformin reduced TGF-β (MF: –25.1((–64.4)–0.04)) in comparison to placebo (PB: 6.3((–1.0)–16.3))(p = 0.038). However, when combined, their effects were nullified either for TNF-α (GTMF: 6.0((–5.7)–23.9) and for TGF-β (GTMF: –1.8((–32.1)–8.5). This study showed that there is a drug-nutrient interaction between green tea and metformin that is dependent on the cytokine analyzed.
Disease-modifying therapies (DMTs) for Alzheimer’s disease (AD) are emerging following successful clinical trials of therapies targeting amyloid beta (Aβ) protofibrils or plaques. Determining patient eligibility and monitoring treatment efficacy and adverse events, such as Aβ-related imaging abnormalities, necessitates imaging with MRI and PET. The Canadian Consortium on Neurodegeneration in Aging (CCNA) Imaging Workgroup aimed to synthesize evidence and provide recommendations on implementing imaging protocols for AD DMTs in Canada.
Methods:
The workgroup employed a Delphi process to develop these recommendations. Experts from radiology, neurology, biomedical engineering, nuclear medicine, MRI and medical physics were recruited. Surveys and meetings were conducted to achieve consensus on key issues, including protocol standardization, scanner strength, monitoring protocols based on risk profiles and optimal protocol lengths. Draft recommendations were refined through multiple iterations and expert discussions.
Results:
The recommendations emphasize standardized acquisition imaging protocols across manufacturers and scanner strengths to ensure consistency and reliability of clinical treatment decisions, tailored monitoring protocols based on DMTs’ safety and efficacy profiles, consistent monitoring regardless of perceived treatment efficacy and MRI screening on 1.5T or 3T scanners with adapted protocols. An optimal protocol length of 20–30 minutes was deemed feasible; specific sequences are suggested.
Conclusion:
The guidelines aim to enhance imaging data quality and consistency, facilitating better clinical decision-making and improving patient outcomes. Further research is needed to refine these protocols and address evolving challenges with new DMTs. It is recognized that administrative, financial and logistical capacity to deliver additional MRI and positron emission tomography scans require careful planning.
In the absence of a treaty protocol or verification regime, the Biological and Toxin Weapons Convention (BWC) instituted confidence-building measures (CBMs) as a mechanism to increase confidence in compliance by enhancing transparency and mitigating ambiguities regarding states parties’ biological activities. While a promising tool to support treaty compliance, low participation, concerns regarding the completeness and accuracy of CBM submissions, a dearth of analysis, and restricted access to many submissions have limited CBMs’ value. Through interviews with 53 international experts—38 from BWC delegations and 15 independent experts—we identified concrete opportunities to increase CBMs’ value while mitigating the burden on states parties. This study supports states parties’ efforts in the BWC Working Group on the Strengthening of the Convention, as part of a series of research on BWC assurance that aims to characterize challenges around BWC verification and increase certainty in BWC compliance.
In the aftermath of the atomic bombings of Hiroshima and Nagasaki and under the growing threat of planetary cataclysm, an array of prominent intellectuals grappled with the significance of nuclear war for the human condition and reflected upon the possibilities of escaping its peril. Following on the early interventions of Albert Camus and Jean-Paul Sartre, the collected thoughts of Karl Jaspers, Hans Morgenthau, and Günther Anders outline a philosophical current of ‘nuclear existentialism’ preoccupied with the nihilistic ‘being-towards-species-death’ entailed by the advent of the Bomb. Faced with the apparent negation of reason in bringing about the means of its own destruction through the scientific piercing of nature’s innermost workings, the nuclear existentialists end up reaffirming, however precariously, a teleological conception of history in which the apocalyptic fear of the Bomb figures as the necessary condition for the ultimate realisation of human freedom. In the light of the contemporary resurgence of nuclear anxiety, this article surveys and critically assesses the corpus of nuclear existentialism, drawing upon the distinctive existential phenomenology of Emmanuel Levinas to trace a potential alternative for thinking life and death under the Bomb.
Fostering employees’ innovative work behavior (EIB) has become one of the most important tasks of leaders. Although numerous studies have investigated the relationship between leadership and EIB, it is still unclear which specific leader behaviors promote EIB. Previous research has focused on leadership in terms of broad, non-innovation-specific leadership styles. Behavioral sub-factors have been neglected, and prioritization according to the importance of individual behaviors is still lacking. To address these issues, we identify innovation-specific leader behaviors and analyze which behaviors are best suited to increase EIB. To explain the relationship between the respective leader behaviors and EIB, we rely on the Ability–Motivation–Opportunity (AMO) framework and distinguish between ability-enhancing, motivation-enhancing, and opportunity-enhancing leadership behaviors. Our empirical analyzes are based on data from 1214 German employees. Our findings reveal that motivation- and opportunity-enhancing leadership behaviors foster EIB, with certain innovation-specific behaviors being particularly important for EIB. Building on our results, we provide guidelines for innovation-specific leadership.
The oversight of Chinese feminist traditions in transnational feminist discourse is remarkable given China’s historical importance and vast population. Despite historical suppression by Confucianism, Chinese feminisms emerged at the turn of the last century, drawing from Marxist, anarchist, and liberal movements. While scholars increasingly recognize overlooked female thinkers like Ban Zhao, contemporary discussions of China often revolve around reconciling Confucianism and feminism. This tendency underscores the perception of Chinese feminism as a derivative of Western feminism, where modern thinkers reject local culture for transnational movements. This paper contends that Chinese feminists, including Kang Youwei and He-Yin Zhen, remained deeply rooted in their traditions. While Kang incorporated foreign ideas to advocate for feminist goals and modernize society, he predominantly engaged with traditional philosophy to address its sexist elements. Similarly, He-Yin’s anarcho-feminist approach integrated Western influences to engage with traditional Chinese thought rather than rejecting it outright. By examining prevalent gender and selfhood concepts in traditional Chinese thought, this paper elucidates the notion of “correlative sexism,” and argues that women were not primarily regarded as a “second sex” as described by Simone de Beauvoir. The paper then demonstrates how Kang and He-Yin responded to this sexist discourse, offering novel perspectives on women’s liberation and societal reform.
Delirium frequently occurs among hospital in-patients, with significant attributable healthcare costs. It is associated with long-term adverse outcomes, including an eightfold increased risk of subsequent dementia. The purpose of this article is to inform clinicians of the best practices for spotting, stopping and treating delirium and provide guidance on common challenging clinical dilemmas. For spotting delirium, suggested screening tools are the 4 ‘A's Test (in general medical settings) and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Prevention is best achieved with multicomponent interventions and targeted strategies focusing on: (a) avoiding iatrogenic causes; (b) brain optimisation by ensuring smooth bodily functioning; (c) maintaining social interactions and normality. Non-pharmacological approaches are the first line for treatment; they largely mirror prevention strategies, but the focus of empirical evidence is on prevention. Although sufficient evidence is lacking for most pharmacological approaches, an antipsychotic at low doses for short durations may be of utility for highly distressing or high-risk situations, particularly in hyperactive delirium, but only as a last resort.
This research challenges the conventional wisdom that value-driven protests in China are exceedingly rare and face harsh state repression. Drawing on a hand-coded, multi-source dataset of over 3,100 protests in three Chinese megacities from 2014 to 2016, we identify 67 protests that reveal a hitherto unknown underbelly of everyday, value-driven contention. Qualitatively, we identify three main forms of contentious performances. Quantitatively, we show how value-driven protesters combine non-disruptive tactics with ambitious targets and virtually never extract concessions. Surprisingly, we find that such protests are less often policed and repressed than other protests. They are also never met with violence from non-state actors. We provide three interpretations for the counter-intuitive finding on repression. This study shows that the Chinese state coexists with a non-negligible amount of explicitly regime-critical contention. It adopts a containment strategy, tolerating a certain extent of value-driven performances when the risk of spill-over into wider society is limited.
Rectifying the imbalance of theorisation of education expansion focusing on its benefits, this study examines the relationship between education expansion and income inequality by turning our attention to its risky aspects. We investigate how expanding education might not effectively mitigate income inequality, because it brings about costly and risky competition for the positional value of education. We consider welfare regimes as relevant institutional factors associated with educational positionality based on the similarities between two environmental conditions that make education positional and two underlying dimensions of welfare regimes (de-stratification and commodification). We analysed higher education cases in twenty-four to twenty-five developed countries from 2000 to 2020. Our results show that higher education expansion initially reduced income inequality, but the reducing effect was attenuated, and eventually, it increased income inequality when higher education was positional, corresponding to the countries with a liberal regime and two East Asian countries such as Japan and Korea.
Saccharin is a widely used sugar substitute, but little is known about the long-term health effects of saccharin intake. Our study aimed to examine the association between saccharin intake and mortality in diabetic and pre-diabetic population and overweight population from NHANES 1988–1994. Cox proportional hazard models were used to evaluate the association between saccharin intake and CVD, cancer and all-cause mortality. After multivariable adjustment, increased absolute saccharin intake was associated with the risk of all-cause mortality (hazard ratio (HR): 1·41, 95 % CI: 1·05, 1·90), CVD mortality (HR: 1·93, 95 % CI: 1·15, 3·25) and cancer mortality (HR: 2·26, 95 % CI: 1·10, 4·45) in diabetic and pre-diabetic population. Among overweight population, higher absolute saccharin intake was associated with the risk of cancer mortality (HR: 7·369, 95 % CI: 2·122, 25·592). Replacing absolute saccharin intake with total sugar significantly reduced all-cause mortality by 12·5 % and CVD mortality by 49·7 % in an equivalent substitution analysis in the diabetic and pre-diabetic population. Aspartame substitution reduced all-cause mortality by 29·2 % and cancer mortality by 30·2 %. Notably, the relative daily intake of saccharin also had similar effects as the absolute intake on all-cause, cardiovascular and cancer mortality in all analyses. This was despite the fact that the relative daily intake in our study was below the Food and Drug Administration limit of 15 mg/kg. In conclusion, our study showed a considerable risk of increased saccharin intake on the all-cause, CVD mortality and cancer mortality.
The spatio-temporal scales, as well as a comprehensive self-sustained mechanism of the reattachment unsteadiness in shock wave/boundary layer interaction, are investigated in this study. Direct numerical simulations reveal that the reattachment unsteadiness of a Mach 7.7 laminar inflow causes over $26\,\%$ variation in wall friction and up to $20\,\%$ fluctuation in heat flux at the reattachment of the separation bubble. A statistical approach, based on the local reattachment upstream movement, is proposed to identify the spanwise and temporal scales of reattachment unsteadiness. It is found that two different types, i.e. self-induced and random processes, dominate different regions of reattachment. A self-sustained mechanism is proposed to comprehend the reattachment unsteadiness in the self-induced region. The intrinsic instability of the separation bubble transports vorticity downstream, resulting in an inhomogeneous reattachment line, which gives rise to baroclinic production of quasi-streamwise vortices. The pairing of these vortices initiates high-speed streaks and shifts the reattachment line upstream. Ultimately, viscosity dissipates the vortices, triggering instability and a new cycle of reattachment unsteadiness. The temporal scale and maximum vorticity are estimated with the self-sustained mechanism via order-of-magnitude analysis of the enstrophy. The advection speed of friction, derived from the assumption of coherent structures advecting with a Blasius-type boundary layer, aligns with the numerical findings.