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In the aftermath of the Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization, several corporations signaled their support for reproductive rights by announcing expanded abortion care coverage and/or travel stipends for employees who are forced to travel out of state to receive care, including abortion care. While such moves may be celebrated and recognized as a commitment to pro-choice politics, these decisions require scrutiny and suspicion. This article details why.
Part I of this paper will discuss the corporate response to Dobbs. It will discuss the type of benefits that corporations offered, and the class of employees these benefits were offered to (for instance, “independent contractors” were mostly excluded from availing of these benefits). Part II will discuss the movement for reproductive rights, some of the harms it reinforced, and the criticisms it received from the Reproductive Justice movement. Against this backdrop, Part III will discuss the possible intentions behind corporations conferring these benefits, including those related to staff retention, microeconomic logics, and DEI efforts. It will review them against large corporations’ histories of (not) providing reproductive supports, including a living wage, paid leave, sick leave, and childcare. It will also analyze some of the evidence in the public sphere that shows the roles some of these large corporations have played in supporting antiabortion agendas and politicians. Part IV will discuss the long-term harms that this new crop of workplace policies and benefits might create. Mainly, it will discuss how the provision of abortion care without other reproductive supports reemphasizes a reproductive rights approach despite its criticisms, which were highlighted by the Reproductive Justice movement. For instance, this section will discuss the expanding role corporations are assuming in providing healthcare, and how that may lead to the exclusion of certain historically marginalized classes of workers and people. It will also discuss the impact of these policies on the deprioritization of certain types of care, which have been overlooked for decades, including gender-affirming care and fertility treatments. Part V will suggest a few steps corporations can take to mitigate the harm created by Dobbs.
Generative artificial intelligence (AI) systems, notably ChatGPT, have emerged in legal practice, facilitating the completion of tasks, ranging from electronic communications to the drafting of documents. The generative capabilities of these systems underscore the duty of lawyers to competently represent their clients by keeping abreast of technological developments that can enhance the efficiency and effectiveness of their work. At the same time, the processing of clients’ information through generative AI systems threatens to compromise their confidentiality if disclosed to third parties, including the systems’ providers. The present paper aims to determine the impact of the use of generative AI systems by lawyers on the duties of competence and confidentiality. The findings derive from the application of doctrinal and empirical research on the legal practice and its digitalisation in Luxembourg. The paper finally reflects on the integration of generative AI systems in legal practice to raise the quality of legal services for clients.
Despite recent reforms, “balance billing” – the practice of charging patients exorbitant list prices for out-of-network or uninsured care – remains a potentially devastating feature of American healthcare. Most proposed solutions have been statutory or regulatory. But the common law offers an important intervention, consistent with private law theory, through a doctrine developed by a number of state courts and recently endorsed by the Eleventh Circuit in an adjacent area of law. Under traditional tort principles, injured plaintiffs are entitled to recover the “reasonable” costs of their medical expenses, regardless of whether they were covered by insurance. Reasoning that because, in the contemporary healthcare market, neither the amount billed by healthcare providers nor the amount paid by insurers is necessarily reasonable, these courts hold that the question of reasonable damages is for the jury, on consideration of the amount billed, the amount paid, and any other relevant evidence the parties present. A similar approach could be imported into the balance billing context, leaving to juries to determine the reasonable price of services, considering all relevant evidence. This wouldn’t solve all problems related to balancing billing, and the “reasonable price” determined by juries may still be out of reach of many patients. But unlike other judicial solutions, this proposal is thoroughly consistent with common law theory, translating basic private law principles to new contexts, rather than policy reasoning. Moreover, it may even improve the public legitimacy of the industry, ensuring that providers can never collect arbitrary post-facto amounts.
Longitudinal birth cohort research provides a glimpse into the biological and social trajectories of a cohort of people, which helps us to better understand how to improve health and social outcomes. While qualitative longitudinal, ethnographic, and other qualitative research methods are increasingly used to capture complex data in trials and cohort research, they are relatively less common, and they vary greatly within and across cohorts and national contexts. The aim of this scoping review is to provide an overview of the use of qualitative and innovative methods in longitudinal preconception and birth cohort studies. Innovative methods, defined by Mannell and Davis (2019), go beyond standard surveys, interviews, and focus groups. The review summarises the literature of the integration of qualitative methods into birth cohort methodologies. Five databases were searched systematically, using MeSH and free text terms, for articles published in English before October 2022. Two-thirds of titles, abstracts, and full-text papers were screened by independent reviewers. Data extraction followed the Centre for Reviews and Dissemination guidelines and was based on features of qualitative methods from the COREQ checklist. 43 papers were included from the 13909 papers identified from the database search. The majority of the birth cohort studies used ‘traditional qualitative methods’ such as focus groups and one-to-one interviews. The studies that used ‘innovative qualitative methods’ included participatory interviews with photovoice, photographs, and using scenario and story cards, and while not a steadfast requirement of innovation, often included coproduction between the researchers and the participants. Although the literature reports challenges in conducting innovative methods within birth studies such as time and power imbalances between researcher and participant, these methods can help us better understand how to improve social and health outcomes.
Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are collectively called as Lewy body dementia (LBD). Despite the urgent clinical need, there is no reliable protein biomarker for LBD. Hence, we conducted the first comprehensive systematic review of all Differentially Abundant Proteins (DAP) in all tissues from people with LBD for advancing our understanding of LBD molecular pathology that is essential for facilitating discovery of novel diagnostic biomarkers and therapeutic targets for LBD.
Methods:
We identified eligible studies by comprehensively searching five databases and grey literature (PROSPERO protocol:CRD42020218889). We completed quality assessment and extracted relevant data. We completed narrative synthesis and appropriate meta-analyses. We analysed functional implications of all reported DAP using DAVID tools.
Results:
We screened 11,006 articles and identified 193 eligible studies. 305 DAP were reported and 16 were replicated in DLB. 37 DAP were reported and three were replicated in PDD. Our meta-analyses confirmed six DAP (TAU, SYUA, NFL, CHI3L1, GFAP, CLAT) in DLB, and three DAP (TAU, SYUA, NFL) in PDD. There was no replicated blood-based DAP in DLB or PDD. The reported DAP may contribute to LBD pathology by impacting misfolded protein clearance, dopamine neurotransmission, apoptosis, neuroinflammation, synaptic plasticity and extracellular vesicles.
Conclusion:
Our meta-analyses confirmed significantly lower CSF TAU levels in DLB and CSF SYUA levels in PDD, when compared to Alzheimer’s disease. Our findings indicate promising diagnostic biomarkers for LBD and may help prioritising molecular pathways for therapeutic target discovery. We highlight ten future research priorities based on our findings.
In 2022, an increase in invasive group A streptococcal (iGAS) infections was observed in the Netherlands. A particular increase was seen among children; therefore, we aimed to assess risk factors for iGAS infection in children aged 6 months to 5 years. A prospective case–control study was conducted between February and May 2023. We approached parents of notified iGAS cases to complete a questionnaire on exposures during 4 weeks prior to disease onset. Controls were recruited via social media and matched to cases on sex and birthyear. Conditional logistic regression was performed to estimate odds ratios (OR) of exposures. For the analysis, we included 18 cases and 103 controls. Varicella prior to onset of iGAS disease was reported in two (11%) cases and one (1%) control (OR: 12.0, 95% CI: 1.1–139.0). Exposure to group A streptococcal (GAS)-like illnesses such as impetigo, pharyngitis, and scarlet fever was reported in 8 (44%) cases and 15 (15%) controls (OR: 7.1, 95% CI: 1.8–29.0). Our findings are in line with previous studies by identifying varicella as a risk factor for iGAS among young children and highlight the association with non-invasive GAS infections in the community as a possible source of transmission.
Researchers acknowledge the need to share study results with the patients and their communities, but this is not done consistently due to a plethora of barriers, including a paucity of data to guide best practice approaches in different populations.
Methods:
This study was nested within a large multi-center randomized controlled trial of antimalaria treatment. Data on dissemination preferences were collected at the third-month follow-up visit using a short questionnaire. Data were analyzed using descriptive statistics and subsequently fed into an iterative process with key stakeholders, to develop suitable strategies for result dissemination.
Results:
A total of 960 patients were enrolled in the trial, of whom 84.0% participated in the nested survey. A total of 601 (74.6%) participants indicated interest in receiving trial results. There was significant heterogeneity by study country, with 33.3% (58/174) of patients indicating being interested in Cambodia, 100% (334/334) in Ethiopia, 97.7% (209/214) in Pakistan, but none (0/85) in Indonesia. The preferred method of dissemination varied by site, with community meetings, favored in Ethiopia (79.0%, 264/334) and individualized communication such as a letter (27.6%, 16/58) or phone calls (37.9%, 22/58) in Cambodia. Dissemination strategies were designed with key stakeholders and based on patient preferences but required adaptation to accommodate local logistical challenges.
Conclusion:
The varying preferences observed across different sites underscore that a one-size-fits-all approach is inadequate. Strategies can be tailored to patient preference but require adaptation to accommodate logistical challenges.
In this paper, I begin a philosophical theorisation of the phenomenon of toxic positivity (TP) within the framework of social epistemology. TP is the phenomenon of people being positive and optimistic to a degree that is unreasonable in a given situation, and as such makes others feel as if their own (less than positive) feelings are invalid or in some way wrong. I begin by providing an example of TP. I then identify four features of TP: appropriate emotion, unreasonableness, dismissal, and potential harm. Following this, I discuss the possible epistemic effects of TP and argue that it can affect knowledge in three ways: doubting belief, losing belief, and undermining self-trust. Finally, I argue that TP can in some cases be a form of gaslighting and can undermine epistemic agency, both of which are epistemic injustices.
In this paper, I argue against a widely held view about interpersonal moral relations inspired by Benjamin Cardozo’s landmark judgment in Palsgraf v Long Island Railroad Company, which I call the Relational Fault Requirement. The requirement holds that in order for A to commit a directed wrong against B, A must be at fault in relation to B. I present two ways of understanding wrongs that violate this requirement: (1) that one is wronged if one is harmed by a wrongful action, and (2) that one is wronged if one is harmed by a wrongful action and the outcome one suffers is sufficiently similar to the grounds on which the action is wrong. Accepting either of these ideas requires rejecting the Relational Fault Requirement and encourages us to rethink the core elements of directed wrongdoing.
The fast-growing clinical research outsourcing over the course of the past decade has attracted the active involvement of private equity buyers to the “business” of Clinical Research Organizations (CROs). The fragmentation of pharmaceutical services through CROs offers an opportunity to lower the financial risk of drug development in a highly critical industry. Justified by the operational efficiency that integrating assets and services to decrease costs even further may represent, private equity has recently demonstrated an appetite for vertical integrations to expand the geographic, patient, and service reach of clinical research sites. Since private equity managers have the incentive to maximize financial returns, gaining greater access and control of patient identification, enrollment and retention, and quality protocols may pose significant equity-based risks to biopharmaceutical stakeholders, fundamentally, drug end users.
The proliferation of CROs and their plans to gain further operational control of clinical trials pose the potential tradeoff between drug development efficiency and equitable development and access to drugs and research knowledge. This reasonable concern is most present in the efficiency-based scholarship debate on shareholder and stakeholder governance of recent years. The discussion centers on whether new corporate leaders and investors might be paying too much attention to shareholder value while not enough to stakeholder value. A balance, the debate seems to suggest, is critical to generating long-term shareholder wealth, shifting the long-standing “shareholder value” corporate governance model toward an equity-based, “deliver value” type, commitment.
By observing the lay of the land of CROs in the United States and using as a theoretical framework the increasingly influential stakeholderism approach to corporate governance, this essay offers a critical view of the use of stakeholder factors in stewardship decisions made by CROs’ corporate leaders and private equity investors. Ultimately, it aims to identify key areas of organizational and governance concerns in medical research and the shortcomings they represent to equitable access to medical innovation.
In the late 1920s and the 1930s a fully developed discourse emerged in China that linked either travel as a general concept (mostly with a primary focus on its leisure form) or tourism more specifically to the interests of society and the nation. This article analyses its development as it evolved in the first half of the twentieth century. For this purpose, it first probes into the discourse that surrounded, from the 1920s onwards, the constitution and the activity of the Travel Department of the Shanghai Commercial and Savings Bank and of the China Travel Service, in line with which the travel service that one and the other provided was considered to involve dimensions of service to the nation and to society. The article proceeds by looking into two separate but ultimately linked lines of discourse that came to full bloom during the Nanjing decade and after: one that linked travel to the building of society, and another that linked it to the strengthening of the nation.
This article investigates indigenous light as an element in the conceptualization of photography as a ‘Greek’ art from the mid-nineteenth to the first decades of the twentieth century. Key moments linking photography, writing through light, with the light of Greece will be discussed: from the mid-nineteenth-century debate about the alleged ‘Greek’ origins of photography to the thematization of light and gazing at the Greek landscape in the writings of Periklis Yannopoulos and, eventually, to interwar photographic projects bringing together contemporary scenery with antique material relics.
Health care today is the most regulated industry in America. Statutes and regulations govern everything from licensing and insurance to privacy and emergency care. In pursuit of the iron triangle of improved access, better quality, and lower cost, health law scholars have long focused on “public law,” or law that involves governmental action, including action by administrative agencies at both the state and federal levels.
Radiomics refers to converting medical images into high-quality quantitative data. This review examines applications of radiomics in vestibular schwannomas and future considerations for translation into clinical practice.
Methods
The review was pre-registered on Prospero (ID: CRD42024579319). A comprehensive systematic review-informed search of the Ovid Medline, Embase and Global Health online databases was undertaken using the keywords ‘acoustic neuroma’ or ‘vestibular schwannoma’ or ‘cerebellopontine angle tumour’ or ‘cerebellopontine tumour’ or ‘head and neck cancer’ were combined with ‘radiomic’ or ‘signature’ or ‘machine learning’ or ‘artificial intelligence’.
Results
The studies (n = 6) were categorised into two groups: radiomics for pre-operative decision-making (n = 1) and radiomics for treatment outcomes (n = 5). Radiomic features were significantly associated with clinical outcomes. Radiomics-based predictive models were superior to expert vision.
Conclusion
Radiomics has potential for improving multiple aspects of vestibular schwannoma care, but lack of studies inhibited firm conclusions. Prospective studies are required to progress this field.
This research explores the extent of private law and the influence of private entities in healthcare in Europe. The three-part analysis reveals a complex interplay between different health system structures, laws, and influences. First, it highlights four distinctions between Europe and the United States (US) concerning universal health care, the role of government, private insurance, and the legal framework for disputes. Second, it considers the role of private law in resolving disputes in Europe. Ultimately, this research calls for further research to close those gaps in the literature concerning the number and scope of health disputes governed under contract law and the laws that health lobbies have influenced. Third, it emphasizes the influence of private healthcare lobbies in Europe and provides a case study of their influence on the United Kingdom’s (UK) health landscape.
Fiduciaries abound in health care. Employers pretend they can act in the best interests of employees when maintaining health plans – even though they pay (directly or indirectly) for claims against those plans. Physicians pretend they can act in the best interests of patients – even when hospitals and group practices pressure them to see more patients and spend less time with them, and even though physicians and their employers are incentivized to order expensive tests and procedures. But what if, instead of ignoring these conflicts of interest, the American healthcare system abandoned the fiduciary fallacy?
Building on recent scholarship showing that targeted legislation, regulation, and self-policing – rather than broad fiduciary duties – better manage these conflicts, I use game theory to analyze different scenarios relating to the financing and provision of health care involving two actors – a provider and a payor. For this analysis, I assume that the actors are rational and behave in their own self-interest until constrained by external rules and social and professional norms. My goal is to advance this scholarship by arguing that broad fiduciary duties are inadequate to address conflicts in our healthcare system, while also proposing paths forward.