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Although ample research links social factors and suicidality, there remains a gap in understanding how distinct processes within social communication relate to suicidality. We demonstrate how reciprocity of eye-gaze and facial expressions of happiness differ during parent-adolescent conflict based on adolescents’ future suicidal ideation (SI). Facial affect analyses were based on 103 girls (ages 11–13; M = 12.28; 75% White) and their parents. Eye-gaze analyses were conducted in subset of these dyads (N = 70). Participants completed a conflict discussion during which gaze to their partners’ eyes was assessed using mobile eye-tracking glasses and facial affect was coded using FaceReader Observer XT. Adolescents’ SI was assessed 12-months later. Actor-partner interdependence models tested whether participants’ gaze and affect predicted their own and their partners’ gaze and affect one second later and if these intra and interpersonal dynamics differed based on adolescents’ future levels of SI. Girls from dyads with less parental reciprocity of eye-gaze and happiness reported higher levels of SI 12-months later. During early adolescence, girls whose parents reciprocate their eye-contact or positive affect less during conflict may be at heightened risk for SI. If replicated, social communication could provide a promising intervention target to reduce suicidality prospectively.
This article uses the literature on subnational undemocratic regimes (SURs) and regime juxtaposition in Latin America to gain analytical leverage on the recent process of subnational democratic erosion in the United States. Based on a review of five key dimensions of federalism, we argue that the institutional landscape for the emergence and continuity of SURs is, comparatively speaking, more favorable in the US than in any of Latin America’s three federations (Argentina, Brazil, and Mexico). In addition to showing how federal structures are more detrimental for subnational democracy in the US, we assess how the two main theoretical approaches that have been developed to understand SURs in Latin America and elsewhere can be applied to the US.
Antenatal steroids (ANS) are one of the most widely prescribed medications in pregnancy, being administered to women at risk of preterm delivery. In the setting of preterm delivery at or below 35 weeks’ gestation, systematic review data show ANS reduce perinatal morbidity and mortality, primarily by promoting fetal lung maturation. However, with the expanding use of this intervention has come a growing appreciation for the potential off-target, adverse effects of ANS therapy on wider fetal development. We undertook a narrative literature review of the animal and clinical literature to assess current evidence for adverse effects of ANS exposure and fetal development. This review presents a summary of the evidence relating to the potential for wide-ranging, off-target, adverse effects of ANS therapy on fetal development and programming. We highlight an urgent need for further animal and clinical studies investigating the effects of ANS on the fetal immune, cardiovascular, renal and hepatic systems given a current sparsity of evidence. We also strongly suggest an emphasis on open disclosure, discussion and education of clinicians and patients with regard to the potential benefits and risks of ANS therapy, particularly in late preterm and term gestations where infants derive relatively few benefits from these drugs. We also propose further studies on the optimisation of ANS therapy through improved patient selection and improved dosing regimens based on a pharmacokinetic-pharmacodynamic informed understanding of ANS action on the fetal lung.
Why did Meiji Japan succeed in modernizing its state apparatus while Qing China failed? According to neorealists, states respond to threats by balancing. Successful balancing requires an efficient bureaucracy to extract enough resources from society to sustain a formidable military. Yet not all states are equal when it comes to modernizing. We argue that a state’s ability to adopt best practices depends on its past position in the international system. States suffering from a longstanding material weakness will tend to adopt new practices from abroad more quickly than states that have enjoyed a dominant position for a long time. Embeddedness decides whether or not the state perceives its model’s crisis. Therefore, we propose a theory of neorealist imitation success or failure that counts three variables: embeddedness as the independent variable, political leadership’s willingness to adopt best practices, and elite cohesion as intervening variables.
Cryptic diversity, characterized by morphologically similar but genetically distinct species, poses significant challenges to traditional taxonomic methods. Within monogeneans parasitizing northwest African barbels, this complexity hampers species identification, limiting our understanding of diversity, distribution and evolutionary relationships. Supported by previously published genetic data, we morphologically delineate herein 9 Gyrodactylus species from Morocco. Newly described species include G. agnesei sp. nov. and G. benhoussai sp. nov. from Luciobarbus rabatensis, with the latter also found on Carasobarbus fritschii, and both G. deburonae sp. nov. and G. marruecosi sp. nov. from L. massaensis. Additionally, G. diakini sp. nov. and G. louiziae sp. nov. were identified from L. rifensis and L. yahyaouii, respectively. Pterocapoeta maroccana harboured G. pterocapoetai sp. nov., morphologically resembling G. shigoleyae sp. nov. from sympatric L. zayanensis. We also examined taxonomical discrepancies between Gyrodactylus species from L. ksibi and L. pallaryi, evaluated the status of previously described G. nyingiae and described G. qninbai sp. nov. from L. ksibi. Our findings highlight the conservative morphology in northwest African Gyrodactylus, characterized by an ancestral median ridge in the ventral bar membrane, similar to that found in species from Eurasia. Subtle phenotypic features, like bifurcations in dorsal bars and proportions of marginal hooks, serve as diagnostic traits. We further evidenced a potential host-switching event from northwest African to Iberian hosts, correlating with the region’s geological history and cyprinid dispersal events during intermittent closures of the Strait of Gibraltar. These insights illuminate the complex evolutionary processes driving gyrodactylid diversification in the West Mediterranean.
The murder of George Floyd in May 2020 sparked a wave of Black Lives Matter protests in many cities throughout the United States. Protesters’ demands ranged from constraints on police use of force to defunding and disbanding the police altogether. These have led some to worry about the possibility of a “Ferguson Effect,” where police withdraw from policing, and in particular discretionary stops and searches, with deleterious consequences for crime. Drawing on data from four cities, we evaluate whether the 2020 BLM protests impacted police behavior, and whether changes in policing negatively impacted public safety. Regression discontinuity-in-time estimates suggest that although depolicing followed the BLM protests, in some respects the quality of policing improved, and public safety was not clearly impacted. Our findings have important implications for research on policing, social movements, and structural inequality in cities.
The four Piano Sonatas by W. A. Mozart with freely composed additional accompaniment for a Second Piano by Edvard Grieg (EG 113) were first published in 1879–80 but were not heard by English concertgoers until 5 March 1890, when both Agathe Backer-Grøndahl and Anton Hartvigson opened separate recitals in London with Grieg's version of the Fantasy in C minor K475, the latter following it with the Sonata in F major K533/494. This coincidence is noteworthy not only because Grieg's additions appeared to flaunt the prevailing expectation of fidelity to classical works, but also because Mozart's solo keyboard music was rarely included in professional recitals. Focusing on Backer-Grøndahl and Hartvigson's concerts, this article considers Grieg's additions not merely as ‘arrangements’ but also as a performance practice subject to a range of interpretations by recitalists and different sections of the audience. The article begins by placing the transformation of the additions from teaching aids into concert repertoire in the context of similar supplements to classic works and concurrent attitudes to Mozart's piano music. The next section examines the mixed reception of Backer-Grøndahl and Hartvigson's recitals, situating this within contemporary debates about the role of fidelity in modern performances of historic works and its relationship with dominant conceptions of musical taste. While critics condemned the use of Grieg's additions, several disdainfully noted that they were well received by the rest of the audience. The final section attempts to account for this discrepancy by considering the widespread perception of Grieg's additions as Norwegian ‘national music’, a popular genre of exoticist parlour music that critics disparagingly associated with a mass audience of young, female players and considered inferior to ‘international’ classics. The article concludes by reflecting on how these factors might have informed Backer-Grøndahl's decision to perform Mozart's music with Grieg's additions.
To assess the association between social vulnerability index (SVI) and surgical site infections (SSIs) using National Healthcare Safety Network (NHSN) criteria.
Design:
Retrospective cohort study between August 1, 2022, and August 31, 2023.
Setting:
In total, 20 acute care hospitals in the Southeast United States.
Patients:
Totally, 23,768 total hip arthroplasty, total knee arthroplasty, abdominal hysterectomy, colon, and spinal fusion surgeries in 22,239 patients were included. Procedures with infection present at the time of surgery or incomplete geographic tracking data were excluded.
Methods:
Patient addresses as noted in the electronic health record were geocoded to determine census tract of residence and determine SVI. Demographic and clinical data were linked with SVI scores. SSIs were identified according to NHSN criteria. SVI was categorized into quartiles, and logistic regression was used to evaluate the association between SVI quartile (overall and for each SVI theme) and SSI risk. Subgroup analyses by procedure type and race were performed. Multivariable models of the association between overall SVI and SSI were adjusted for demographic and clinical factors.
Results:
Patients in the top SVI quartiles had significantly higher odds of developing SSIs after adjusting for other clinical and demographic factors. Increased risk was found for socioeconomic status and household characteristics themes, but not for the racial/ethnic minority theme. Association between SVI and SSI risk varied by type of surgery.
Conclusions:
Living in an area with a higher SVI is associated with increased SSI risk. Targeted interventions are needed to mitigate these disparities and improve outcomes.
We rely heavily on cut-off points of brief measures of psychological distress in research and clinical practice to identify those at risk of mental health conditions; however, few studies have compared the performance of different scales.
Aim
To determine the extent to which the child- and parent-report Strength and Difficulty Questionnaire (SDQ), Revised Children’s Anxiety and Depression Scale (RCADS), short Mood and Feeling Questionnaire (sMFQ) and child-report KIDSCREEN correlated and identified the same respondents above cut-off points and at risk of mental health conditions.
Method
A cross-sectional survey was conducted among 231 children aged 11–16 years and 289 parents who completed all the above measures administered via a mobile app, MyJournE, including the SDQ, RCADS and sMFQ.
Results
The psychopathology measures identified similar proportions of young people as above the cut-off point and at risk of depression (child report 14.7% RCADS, 19.9% sMFQ, parent report 8.7% RCADS, 12.1% sMFQ), anxiety (child report 24.7% RCADS, 26.0% SDQ-Emotional subscale, parent report 20.1% RCADS, 26% SDQ-Emotional subscale) and child-report internalising problems (26.8% RCADS, 29.9% SDQ). Despite strong correlations between measures (child report 0.77–0.84 and parent report 0.70–0.80 between the SDQ, sMFQ and RCADS) and expected directions of correlation with KIDSCREEN and SDQ subscales, kappa values indicate moderate to substantial agreement between measures. Measures did not consistently identify the same children; half (n = 36, 46%) of those on child report and a third (n = 30, 37%) on parent report, scoring above the cut-off point for the SDQ-Emotional subscale, RCADS total or sMFQ, scored above the cut-off point on all of them. Only half (n = 46, 54%) of the children scored above the cut-off point on child report by the SDQ-Internalising and RCADS total scales.
Conclusion
This study highlights the risk of using a screening test to ‘rule out’ potential psychopathology. Screening tests should not be used diagnostically and are best used together with broad assessment.
The global incidences of leishmaniasis are increasing due to changing environmental conditions and growing poverty. Leishmaniasis, caused by the Leishmania parasite, presents itself in six different clinical forms, the cutaneous and the visceral diseases being the most prevalent. While the cutaneous form causes disfigurement, the visceral form could be fatal if not treated. With no available vaccines combined with serious side effects of current medications and emerging drug resistance, it is crucial to discover new drugs whether as novel compounds or as repurposed existing pharmaceuticals. In the realm of drug development, mitochondria are recognized as important pharmacological targets due to their critical role in energy control, which, when disrupted, leads to irreversible cell damage. Certain plant-based compounds able to target the parasite mitochondrion, have been studied for their potential anti-leishmanial effects.
Search results
These compounds have shown promising effects in eliminating the Leishmania parasite. Artemisinin and chloroquine, two anti-malarial drugs that target mitochondria, exert strong anti-leishmanial effectiveness in both in vitro cultures and in vivo animal models. Quinolones, coumarins and quercetin are other compounds with leishmanicidal properties, which disrupt mitochondrial activity to effectively eliminate parasites in animal models of the disease and could be considered as potential drugs.
Conclusions
Therefore, plant-based compounds hold promise as potential candidates for anti-leishmanial drug development.
The need for collaborative and transparent sharing of COVID-19 clinical trial and large-scale observational study data to accelerate scientific discovery and inform clinical practice is critical. Responsible data-sharing requires addressing challenges associated with data privacy and confidentiality, data linkage, data quality, variable harmonization, data formats, and comprehensive metadata documentation to produce a high-quality, contextually rich, findable, accessible, interoperable, and reusable (FAIR) dataset. This communication explores the experiences and lessons learned from sharing National Heart Lung and Blood Institute (NHLBI) COVID-19 clinical trial (including adaptive platform trials) and cohort study datasets through the NHLBI BioData Catalyst® (BDC) ecosystem, focusing on the challenges and successes of harmonizing these datasets for broader research use. Our findings highlight the importance of establishing standardized data formats, adopting common data elements and creating and maintaining robust data governance structures that address common challenges (i.e., data privacy and data-sharing limitations resulting from informed consent). These efforts resulted in a set of comprehensive and interoperable datasets from 5 clinical trials and 13 cohort studies that will enable downstream reuse in analyses and collaborations. The principles and strategies outlined, derived through experience with consortia data, can lay the groundwork for advancing collaborative and efficient data sharing.
Current prevalence of disability in Bangladesh stands at 7.14%. Due to various misconceptions, stigma, and lack of policies, they are more vulnerable to violence and abuse from perpetrators. However, there is a paucity of research on the prevalence of emotional, physical, and sexual violence in the country. To address this knowledge gap, the current study aims to estimate the prevalence and explore the experiences of emotional abuse, physical, and sexual violence of persons with disabilities with their coping strategies. This study adopted a mixed-method sequential design comprising qualitative and quantitative components. A total of 5000 persons with disabilities were interviewed during the survey, and mini-ethnographic case studies were conducted with 51 purposively selected persons with disabilities from all eight administrative divisions of Bangladesh. Descriptive and bivariate statistical analysis was performed for quantitative data. Qualitative data were analysed through thematic analysis. The study concludes that the lifetime prevalence of emotional, physical, and sexual abuse is 68.9%, 26.6%, and 11.5%, respectively. Male participants were more prone to experience sexual abuse than females for both lifetimes (male: 12.7% & female: 10.3%) and within the last 12 months before the survey (male: 6.6% & female: 5.1%). Neighbours and close family members were found to be perpetrators of emotional and physical violence, whereas immediate family members were the perpetrators of sexual violence. Even though participants shared several coping mechanisms, equal to or less than 0.5% sought help from a counsellor to cope with the trauma. Results from the study correspond to the earlier studies with implications for future research and urgent policy reform. Although women are more vulnerable to experiencing different forms of violence, men with disabilities are no different. However, this remains unseen and unheard. To reduce the prevalence of violence against this marginalised group, a coordinated and collaborative approach is required targeting nationwide sensitisation, easy access to help-seeking centres, and adequate policy implementation.
Russia’s 2014 seizure of parts of Ukraine, notably the Crimean Peninsula, set in motion a flurry of legal activity. Ukraine’s “lawfare” strategy, which aims to fight Russia via international legal means, included explicit encouragement of Ukrainian investors to file disputes under the Ukraine-Russia Bilateral Investment Treaty. We consider the resulting Investor-State Dispute Settlement (ISDS) arbitrations, the first instances of ISDS in which state parties to the treaty are actively engaged in armed conflict. Although Ukrainian actors have consistently won at ISDS arbitrations, Ukraine moved to formally withdraw from the treaty a year after the full-scale Russian invasion of 2022. Developments before and since the invasion point to the diverging interests between commercial actors and their home states, the weakness of ISDS as a tool during wartime, and a reconsideration of treaty-based commitments to international investor protections. We highlight the implications of these events for several literatures in international relations.
Within this paper, glocalization is presented to explain the heterogeneity of the Uruk Expansion/Phenomenon, a process which saw extensive interactions and cultural integration across Mesopotamia during the fourth millennium bce, characterized by the spread of southern Mesopotamian material culture and cultural practices. Through close examination of archaeological data from the Adhaim-Sirwan Drainage Basin, southern Iraqi Kurdistan, a region which is emerging as a focus of intense culture-contact during the Uruk Phenomenon, I contend that a glocalized perspective of this phenomenon better illuminates its regional nuances and complexities, as well as the interactions between local and Uruk communities within the Adhaim-Sirwan. By employing a glocalizing framework, this paper demonstrates that cultural interactions led to varied adaptations of the Uruk Phenomenon and illustrates the dynamic interplay between global influences and local responses. Ultimately, this paper advocates for a nuanced understanding of the Uruk Phenomenon, highlighting its regional variability and the importance of local agency in shaping cultural outcomes, thereby framing it as a distinctly glocalized process rather than an expression of globalization.
The recent resurgence of exclusionary nationalism across the advanced capitalist world has caused historical scholarship on neoliberalism to reorient itself. Previous accounts of neoliberalism proved inadequate to theorize the hegemonic crisis that neoliberalism has been thrust into, prematurely rushing to declare neoliberalism dead. The task is to offer an interpretation of resurgent nationalism that can account for points of tension with hegemonic neoliberalism without underestimating the ways it lives on in the present. This essay critically reviews three books that offer distinct interpretations of neoliberalism’s enduring hegemonic crisis. If Melinda Cooper and Tehila Sasson’s respective works provide new critical perspectives on the history and present of neoliberal ideas, Jennifer Burns’s study offers an insider’s perspective on the pressures that neoliberalism is under from the nationalist right.
The topic of impersonalization has received a lot of attention in the literature, but the focus has mostly been on a limited number of strategies, such as the use of personal and indefinite pronouns and passive constructions. Impersonal strategies have thus far been examined using: (i) grammars, (ii) corpora, and (iii) language-based questionnaires. These methods suffer from several shortcomings if one wants to study the range of impersonal strategies. The present article aims to argue for a new way of investigating impersonal strategies that complements the other approaches, by reporting on the results of a visual questionnaire. More precisely, it discusses a visual questionnaire completed by speakers of Dutch and Afrikaans to determine whether this method is a satisfactory way of studying impersonal strategies and to also examine and compare the impersonal strategies of the two languages.*
The cosmic 21 cm signal serves as a crucial probe for studying the evolutionary history of the Universe. However, detecting the 21 cm signal poses significant challenges due to its extremely faint nature. To mitigate the interference from the Earth’s radio frequency interference (RFI), the ground and the ionospheric effects, the Discovering the Sky at the Longest Wavelength (DSL) project will deploy a constellation of satellites in lunar orbit, with its high-frequency daughter satellite tasked with detecting the global 21 cm signal from cosmic dawn and reionization era (CD/EoR). We intend to employ the vari-zeroth-order polynomial (VZOP) for foreground fitting and subtracting. We have studied the effect of thermal noise, thermal radiation from the Moon, the lunar reflection, anisotropic frequency-dependent beam, inaccurate antenna beam pattern, and RFI contamination. We discovered that the RFI contamination can significantly affect the fitting process and thus prevent us from detecting the signal. Therefore, experimenting on the far side of the moon is crucial. We also discovered that using VZOP together with DSL, after 1080 orbits around the Moon, which takes about 103 days, we can successfully detect the CD/EoR 21 cm signal.
Identity-protective reasoning – motivated reasoning driven by defending a social identity – is often dismissed as a paradigm of epistemic vice and a key driver of democratic dysfunction. Against this view, I argue that identity-protective reasoning can play a positive epistemic role, both individually and collectively. Collectively, it facilitates an effective division of cognitive labor by enabling groups to test divergent beliefs, serving as an epistemic insurance policy against the possibility that the total evidence is misleading. Individually, it can correct for the distortions that arise from taking ideologically skewed evidence at face value. This is particularly significant for members of marginalized groups, who frequently encounter evidence that diminishes the value of their identities, beliefs, and practices. For them, identity-protective reasoning can counter dominant ideological ignorance and foster resistant standpoint development. While identity-protective reasoning is not without risks, its application from marginalized and counter-hegemonic positions carries epistemic benefits crucial in democracies threatened by elite capture. Against dominant views in contemporary political epistemology and psychology, identity-protective reasoning should be reconceived as a resource to be harnessed and not a problem to be eradicated.
The crystal structure of sparsentan has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Sparsentan crystallizes in space group P-1 (#2) with a = 11.4214(8), b = 12.0045(9), c = 14.1245(12) Å, α = 97.6230(22), β = 112.4353(16), γ = 110.2502(11)°, V = 1599.20(6) Å3, and Z = 2 at 298 K. The crystal structure consists of an isotropic packing of dimers of sparsentan molecules, linked by N–H···O=S hydrogen bonds. Several intra- and intermolecular C–H···O and C–H···N hydrogen bonds also link the molecules. The powder pattern has been submitted to the International Centre for Diffraction Data for inclusion in the Powder Diffraction File™ (PDF®).