To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The neurodiversity movement takes a societal view of individual differences by suggesting that people should be respected and not necessarily medically treated based on personal attributes. This commentary article discusses how human differences in intellectual capacities should be considered as another form of diversity with the requirement for medical intervention needing to be considered in terms of overall social change. As a significant portion of the overall workforce could be considered as people with some form of neurological disability this article analyses how co-creation processes occur meaning neurodiverse individuals should be accepted in society regardless of their differences. This article contributes to societal discussions around managing diversity as in society the socio-demographic categories such as age and gender are well established, but newer categories such as neurodiversity are required.
The COVID-19 pandemic in 2020 significantly impacted Australia’s resources sector, particularly mining, oil, and gas industries, posing challenges for operational leaders. This study applied Adaptive Crisis Management Theory (ACMT) to understand how these leaders adapted during the crisis. Through interviews with 32 operational leaders, it was found that their roles evolved as crisis demands changed. Initially, they addressed immediate needs, then shifted focus to remote work facilitation and digital transformation, and finally emphasised recovery, trust, and resilience. These adaptations influenced leaders’ behaviours, highlighting the importance of flexibility in supporting employee wellbeing and organisational continuity during crises.
This article scrutinizes the role of transparency in the United Nations Framework Convention on Climate Change (UNFCCC). Specifically, it examines a widely heard claim that ‘transparency is the backbone of the Paris Agreement’, and the assumption that mandatory transparency (reporting and review) is essential to fill potential gaps in climate action left by voluntary, nationally determined climate targets. We subject this claim to critical scrutiny by tracing the political contestations around the desired role of transparency in the UNFCCC, with a focus on mitigation-related transparency. Our analysis shows that, despite developing countries expressing concerns during the pre-Paris negotiations, the Paris Agreement's enhanced transparency framework (ETF) is almost exclusively ‘enhanced’ (compared with earlier provisions) for developing countries, with some instances of regression for developed countries. Furthermore, the effects of such enhanced reporting are not straightforward and might de facto have an impact on countries’ autonomy to nationally determine their mitigation targets in diverse ways, even as all the detailed reporting does not facilitate comparability of effort. With implementation of the ETF due to start in 2024, our analysis provides a timely exploration of the extent to which transparency is really a backbone of the Paris Agreement, and for whom and with what implications for ambitious action from all under the international climate regime. It calls into question whether the transformative potential of transparency, much extolled within the UNFCCC process, will materialize for all countries in a similar manner or rather will have an impact on countries differentially.
Against both liberal narratives and postcolonial critiques, this article argues that sovereignty-as-responsibility – the theory of sovereignty embraced in the responsibility to protect (R2P) – is part of a problem space that emerged with decolonization, rather than the end of the Cold War. The internally displaced person (IDP), the vehicle which Francis Deng used to critique Westphalian sovereignty, had to be theorized against the rise of the postcolonial state. In recovering the questions motivating Deng, we find a stark politics driving his work on IDPs and sovereignty. Against the claim that the heart of R2P is armed coercive intervention for humanitarian purposes, Deng used sovereignty-as-responsibility to promote a profoundly political critique of the colonial legacy and the postcolonial state, which was taken up by states of the Global South in debates on the ratification of R2P. Recovering Deng's work on IDPs and sovereignty-as-responsibility highlights R2P as itself a site of contestation, and offers a case for how ideas emerge ‘from below’ in global politics.
We conducted a scoping review of peer-reviewed literature to describe the nature and extent of reporting on the involvement of stakeholders in early-stage translational research.
Methods and results:
We conducted two literature searches in six databases, screened records and full-text articles, and abstracted and analyzed data from included publications. The literature searches yielded unduplicated 2,894 records. After screening, 13 articles were included.
Findings:
Our review of the literature yielded rare reports of engagement in early-stage translational research. Half of included articles reported on engagement with patients, clinicians, and researchers while fewer that one in three reported on engagement with policymakers, industry, and insurers. One in four reported engagement in the publication’s acknowledgments but not in the main text. More than half drew unmeasured conclusions about the outcomes of engagement.
Interpretation:
Our definition of early-stage translation pointed to a specific set of peer-reviewed research; our findings indicate a reporting gap and not necessarily a gap in practice. By addressing four themes–developing a shared language, identifying frameworks and principles, creating a repository of resources, and establishing a research agenda, research leaders can develop new insights about how to engage communities in early-stage translational research.
Current fault diagnosis (FD) methods for heating, ventilation, and air conditioning (HVAC) systems do not accommodate for system reconfigurations throughout the systems’ lifetime. However, system reconfiguration can change the causal relationship between faults and symptoms, which leads to a drop in FD accuracy. In this paper, we present Fault-Symptom Brick (FSBrick), an extension to the Brick metadata schema intended to represent information necessary to propagate system configuration changes onto FD algorithms, and ultimately revise FSRs. We motivate the need to represent FSRs by illustrating their changes when the system reconfigures. Then, we survey FD methods’ representation needs and compare them against existing information modeling efforts within and outside of the HVAC sector. We introduce the FSBrick architecture and discuss which extensions are added to represent FSRs. To evaluate the coverage of FSBrick, we implement FSBrick on (i) the motivational case study scenario, (ii) Building Automation Systems’ representation of FSRs from 3 HVACs, and (iii) FSRs from 12 FD method papers, and find that FSBrick can represent 88.2% of fault behaviors, 92.8% of fault severities, 67.9% of symptoms, and 100% of grouped symptoms, FSRs, and probabilities associated with FSRs. The analyses show that both Brick and FSBrick should be expanded further to cover HVAC component information and mathematical and logical statements to formulate FSRs in real life. As there is currently no generic and extensible information model to represent FSRs in commercial buildings, FSBrick paves the way to future extensions that would aid the automated revision of FSRs upon system reconfiguration.
Short-term exposure to antipsychotics has proven to be beneficial. However, naturalistic studies are lacking regarding the long-term use of antipsychotics. This study aimed to investigate changes in use of antipsychotics over 20 years after a first-episode schizophrenia.
Methods
This study is part of the Danish OPUS trial (1998–2000), including 496 participants with first-episode schizophrenia. Participants were reassessed four times over 20 years. The main outcomes were days on medication, redeemed prescriptions of clozapine, psychiatric hospitalizations, and employment.
Results
At the 20-year follow-up, an attrition of 71% was detected. In total, 143 out of 496 participated, with 36% (n = 51) in remission-of-psychotic-symptoms-off-medication. The lowest number of days on medication (mean [s.d.], 339 [538] days) was observed in this group over 20 years. Register data on redeemed antipsychotics were available for all trial participants (n = 416). Individuals in treatment with antipsychotics (n = 120) at the 20-year follow-up had spent significantly more days in treatment (5405 [1857] v. 1434 [1819] mean days, p = 0.00) and more had ever redeemed a prescription of clozapine (25% v. 7.8%, p = 0.00) than individuals who had discontinued antipsychotics (n = 296). Further, discontinuers had significantly higher employment at the 20-year follow-up (28.4% v. 12.5%, p = 0.00).
Conclusion
In a cohort of individuals with first-episode schizophrenia, 36% were in remission-of-psychotic-symptoms-off-medication. However, high attrition was detected, potentially affecting study results by inflating results from individuals with favorable outcomes. From register data, free from attrition, approximately 30% were in treatment with antipsychotics, and 70% had discontinued antipsychotics. Individuals in treatment had the least favorable outcomes, implying greater illness severity.
The extended $3/2$ short rate model is a mean reverting model of the short rate which, for suitably chosen parameters, permits a sensible term structure of bond yields and closed-form valuation formulae of zero-coupon bonds and options. This article supplies proofs of the formulae for the expected present values of future cash flows under the real-world probability measure, known as actuarial valuation. Finally, we give formulae for asymptotic levels of bond yields and formulae for bond option prices for the extended $3/2$ model, under particular conditions on its parameters.
A retrospective naturalistic evaluation was undertaken to identify if pre- and post-disaster factors may predict the likelihood of those considered “at risk” of post-traumatic stress disorder (PTSD) entering a post-disaster clinical treatment program.
Methods
The intake data of 881 people referred to the program following the Queensland (Australia) natural disasters of 2010-11 was evaluated. Those referred scored >2 on the Primary Care PTSD scale. Assessment included the disaster exposure experience, demographic and clinical information, and measures of coping and resilience. Descriptive analyses and a Classification Tree Analysis (CTA) were undertaken to ascertain which factors may predict treatment participation.
Results
The treatment group (TG) in comparison to the non-treatment group (NTG) were more likely to perceive their life was threatened (85.1% vs 8.1%), less able to cope (67% vs 25.8%) and less resilient (4.2% vs 87.5%). The CTA using all the assessment variables found the Connor-Davidson (2-item scale) (P < 0.001), degree of property damage (P < 0.001), financial losses (P < 0.001), perception their life was threatened (P < 0.001) and insurance claims (P < 0.003) distinguished the TG from the NTG.
Conclusions
The study identified factors that distinguished the TG from the NTG and predicted the likelihood of participation in a post-disaster mental health treatment.
Air pollution in households is a prime contributor to health issues in developing countries, as in the case of India. According to the latest National Family Health Survey Report 2022, more than half of India’s rural population and 41 per cent overall still depend on solid or unclean fuel combustions, which may reflect in future health hazards. Thus, it is crucial to understand the issue empirically. To that end, the study traces the transitional pattern of unclean cooking fuel users towards clean fuel over the last 30 years using responses from all five National Family Health Survey rounds. Further, the study uses an adjusted probit model to analyse the determinants that lead to the choice of cooking fuel in a household and a logistic model to examine the association between the choice made and the respiratory health of children under five. The empirical results show that the number of households using unclean fuel has declined over the years, with a slightly higher decline in the last five years. Moreover, it also shows that poverty status and place of residence significantly influence cooking fuel choice. Additionally, children residing in households that use clean fuels are less likely to suffer respiratory infections. In conclusion, the present study provides strong evidence to ameliorate the existing policies in a way that exhorts clean energy use. The authors propose pro-poor, pro-rural policies to expedite the clean energy transition, benefitting the most vulnerable households.
This article was written before Andrea Robin Skinner, daughter of Alice Munro, wrote an essay in the Toronto Star on July 7, 2024, describing her mother's silence in the face of her abuse at the hands of Munro's husband/Skinner's stepfather, Gerald Fremlin. I wish to honour Skinner's story and her courage in coming forward, as well as her wish that “… this story, my story, to become part of the stories people tell about my mother.” I, like so many others, will continue to grapple with Munro's writing and her reflections on intimate human relationships — as well as her literary legacy — following these revelations.
To explore the association of cardiovascular-kidney-metabolic (CKM) health with the risk of depression and anxiety and to investigate the joint association of CKM health and social connection with depression and anxiety.
Methods
This prospective cohort study included 344 956 participants from the UK Biobank. CKM syndrome was identified as a medical condition with the presence of metabolic risk factors, cardiovascular disease, and chronic kidney disease, and was classified into five stages (stage 0–4) in this study. Loneliness and social isolation status were determined by self-reported questionnaires. Cox proportional hazards models were applied for analyses.
Results
Compared with participants in stage 0, the HRs for depression were 1.17 (95% CI 1.10–1.25), 1.40 (95% CI 1.33–1.48), and 2.14 (95% CI 1.98–2.31) for participants in stage 1, 2–3, and 4, respectively. Similarly, participants in stage 2–3 (HR = 1.20, 95% CI 1.14–1.26) and stage 4 (HR = 1.63, 95% CI 1.51–1.75) had greater risks of incident anxiety. We found additive interactions between loneliness and CKM health on the risk of depression and anxiety. Participants simultaneously reported being lonely and in stage 4 had the greatest risk of depression (HR = 4.44, 95% CI 3.89–5.07) and anxiety (HR = 2.58, 95% CI 2.21–3.01) compared with those without loneliness and in stage 0. We also observed an additive interaction between social isolation and CKM health on the risk of depression.
Conclusions
Our findings suggest the importance of comprehensive interventions to improve CKM health and social connection to reduce the disease burden of depression and anxiety.
The Pension Benefit Guaranty Corporation (PBGC) becomes the trustee for private defined benefit plans that have defaulted. The PBGC pays retirement benefits as provided by the plan and that are consistent with federal guidelines concerning the type and amounts of distributions. In response to a Freedom of Information Request, the PBGC provided us with relevant information on all individuals who received retirement benefits from the PBGC in the last 10 years, over 250,000 retirees. Individuals requesting payouts from PBGC managed plans have the option of selecting either a single-life annuity or a joint-and-survivor (J&S) annuity. We examine the PBGC distributions chosen over the last decade and how they vary by age at retirement, sex, months of service, and other relevant variables. Key findings indicate that men are much more likely to choose a joint and survivor annuity compared to female claimants, and the difference increases with age. Conditional on selecting a J&S annuity, men are more likely to select a 100 percent survivor's annuity, while women tend to choose a 50 percent survivor's benefit.
Mental disorders and physical-health conditions frequently co-occur, impacting treatment outcomes. While most prior research has focused on single pairs of mental disorders and physical-health conditions, this study explores broader associations between multiple mental disorders and physical-health conditions.
Methods
Using the Norwegian primary-care register, this population-based cohort study encompassed all 2 203 553 patients born in Norway from January 1945 through December 1984, who were full-time residents from January 2006 until December 2019 (14 years; 363 million person-months). Associations between seven mental disorders (sleep disturbance, anxiety, depression, acute stress reaction, substance-use disorders, phobia/compulsive disorder, psychosis) and 16 physical-health conditions were examined, diagnosed according to the International Classification of Primary Care.
Results
Of 112 mental-disorder/physical-health condition pairs, 96% of associations yielded positive and significant ORs, averaging 1.41 and ranging from 1.05 (99.99% CI 1.00–1.09) to 2.38 (99.99% CI 2.30–2.46). Across 14 years, every mental disorder was associated with multiple different physical-health conditions. Across 363 million person-months, having any mental disorder was associated with increased subsequent risk of all physical-health conditions (HRs:1.40 [99.99% CI 1.35–1.45] to 2.85 [99.99% CI 2.81–2.89]) and vice versa (HRs:1.56 [99.99% CI 1.54–1.59] to 3.56 [99.99% CI 3.54–3.58]). Associations were observed in both sexes, across age groups, and among patients with and without university education.
Conclusions
The breadth of associations between virtually every mental disorder and physical-health condition among patients treated in primary care underscores a need for integrated mental and physical healthcare policy and practice. This remarkable breadth also calls for research into etiological factors and underlying mechanisms that can explain it.
The Zones of Regulation (The Zones) is an 18-lesson curriculum that is aimed at helping students develop an awareness of emotions and skills for regulation. Although used by schools globally, no peer-reviewed evidence currently exists to support the use of The Zones. The purpose of this study was to examine the experiences of teachers implementing The Zones curriculum with autistic students. Feedback was gathered from 26 teachers throughout their implementation of The Zones. In this study, we employed a qualitative methodology to analyse the feedback from teachers. Descriptive statistics were used to report on acceptability, appropriateness, and feasibility. Our findings revealed that teachers described high levels of acceptability, appropriateness, and feasibility when reflecting on the delivery of The Zones. However, teachers reported that The Zones was not suitable for all students and classrooms. For students for whom The Zones was deemed appropriate, teachers modified the lessons and required peer support to deliver these modifications. With modifications, the teachers observed growth in areas such as students’ comprehension of others’ emotions and improved language around emotions. This study highlights the importance of further research to refine and tailor interventions like The Zones to better meet the diverse needs of autistic students in educational settings.
Experimental studies on the sloshing of fluid layers are usually performed in rectangular tanks with fixed boundaries. In contrast, the present study uses a 4.76-m-long circular channel, a geometry with open periodic boundaries. Surface waves are excited by means of a submerged hill that, together with the tank, performs a harmonic oscillation. Laboratory measurements are made using 18 ultrasonic probes, evenly distributed over the channel to track the wave propagation. It is shown that a two-dimensional long-wave numerical model derived via the Kármán–Pohlhausen approach reproduces the experimental data as long as the forcing is monochromatic. The sloshing experiments imply a highly complex surface wave field. Different wave types such as solitary waves, undular bores and antisolitary waves are observed. For order one $\delta _{hill} = h_{hill}/h_0$, where $h_0$ is the mean water level and $h_{hill}$ the obstacle's height, the resonant reflections of solitary waves by the submerged obstacle give rise to an amplitude spectrum for which the main resonance peaks can be explained by linear theory. For smaller $\delta _{hill}$, wave transmissions lead to major differences with respect to the more common cases of sloshing with closed ducts having fully reflective ends for which wave transmission through the end walls is not possible. This ultimately results in more complex resonance diagrams and a pattern formation that changes rather abruptly with the frequency. The experiments are of interest not only for engineering applications but also for tidal flows over bottom topography.
Genetic vulnerability to mental disorders has been associated with coronavirus disease-19 (COVID-19) outcomes. We explored whether polygenic risk scores (PRSs) for several mental disorders predicted poorer clinical and psychological COVID-19 outcomes in people with pre-existing depression.
Methods
Data from three assessments of the Australian Genetics of Depression Study (N = 4405; 52.2 years ± 14.9; 76.2% females) were analyzed. Outcomes included COVID-19 clinical outcomes (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infection and long COVID, noting the low incidence of COVID-19 cases in Australia at that time) and COVID-19 psychological outcomes (COVID-related stress and COVID-19 burnout). Predictors included PRS for depression, bipolar disorder, schizophrenia, and anxiety. The associations between these PRSs and the outcomes were assessed with adjusted linear/logistic/multinomial regressions. Mediation (N = 4338) and moderation (N = 3326) analyses were performed to explore the potential influence of anxiety symptoms and resilience on the identified associations between the PRSs and COVID-19 psychological outcomes.
Results
None of the selected PRS predicted SARS-CoV-2 infection or long COVID. In contrast, the depression PRS predicted higher levels of COVID-19 burnout. Anxiety symptoms fully mediated the association between the depression PRS and COVID-19 burnout. Resilience did not moderate this association.
Conclusions
A higher genetic risk for depression predicted higher COVID-19 burnout and this association was fully mediated by anxiety symptoms. Interventions targeting anxiety symptoms may be effective in mitigating the psychological effects of a pandemic among people with depression.