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The resonance constraint holds that something can benefit someone only if it bears a connection to her favoring attitudes. It is widely taken as a decisive reason to reject objective views of well-being since they do not guarantee such a connection. I aim to show that this is a mistake and that felt-quality hedonism about well-being can in fact meet the constraint. First, I argue that the typical way of putting the constraint is misguided in its demandingness. I then introduce alternatives and argue that the most plausible among them are compatible with felt-quality hedonism. I proceed to show that the same considerations which animate traditional resonance concerns motivate another kind of resonance which the hedonist is well-positioned to accommodate. One upshot is that the constraint does not provide us with a reason to favor subjective views of well-being, as they are traditionally formulated, over objective ones.
The virtues of the scapular tip free flap for reconstruction of complex midface oncologic defects have been claimed by many. To obtain optimal functional and aesthetic results, precise positioning of the free flap used for reconstruction is paramount.
Methods
Four cases illustrate our approach to midface reconstruction with angular branch-based scapular tip flaps. A standard surgical navigation device was used both to plan bone cuts for the oncologic resection and to optimise the positioning of the flap.
Results
Case 1 illustrates the usefulness of navigation for reconstruction of total palato-septectomy defects, using a horizontally positioned flap. Optimal neo-palate height, alignment of the anterior nasal spine and nasal projection were obtained. For cases 2–4, vertical inset of the flap yielded optimal midface projection and orbital floor position.
Conclusion
Surgical navigation systems are useful adjuncts for midface reconstruction.
Posttraumatic stress disorder (PTSD) has been associated with advanced epigenetic age cross-sectionally, but the association between these variables over time is unclear. This study conducted meta-analyses to test whether new-onset PTSD diagnosis and changes in PTSD symptom severity over time were associated with changes in two metrics of epigenetic aging over two time points.
Methods
We conducted meta-analyses of the association between change in PTSD diagnosis and symptom severity and change in epigenetic age acceleration/deceleration (age-adjusted DNA methylation age residuals as per the Horvath and GrimAge metrics) using data from 7 military and civilian cohorts participating in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (total N = 1,367).
Results
Meta-analysis revealed that the interaction between Time 1 (T1) Horvath age residuals and new-onset PTSD over time was significantly associated with Horvath age residuals at T2 (meta β = 0.16, meta p = 0.02, p-adj = 0.03). The interaction between T1 Horvath age residuals and changes in PTSD symptom severity over time was significantly related to Horvath age residuals at T2 (meta β = 0.24, meta p = 0.05). No associations were observed for GrimAge residuals.
Conclusions
Results indicated that individuals who developed new-onset PTSD or showed increased PTSD symptom severity over time evidenced greater epigenetic age acceleration at follow-up than would be expected based on baseline age acceleration. This suggests that PTSD may accelerate biological aging over time and highlights the need for intervention studies to determine if PTSD treatment has a beneficial effect on the aging methylome.
Exposure to adversity during the perinatal period has been associated with cognitive difficulties in children. Given the role of the nucleus accumbens (NAcc) in attention and impulsivity, we examined whether NAcc volume at age six mediates the relations between pre- and postnatal adversity and subsequent attention problems in offspring. 306 pregnant women were recruited as part of the Growing Up in Singapore Towards Healthy Outcomes Study. Psychosocial stress was assessed during pregnancy and across the first 5 years postpartum. At six years of age, children underwent structural MRI and, at age seven years, mothers reported on their children’s attention problems. Separate factor analyses conducted on measures of pre- and postnatal adversity each yielded two latent factors: maternal mental health and socioeconomic status. Both pre- and postnatal maternal mental health predicted children’s attention difficulties. Further, NAcc volume mediated the relation between prenatal, but not postnatal, maternal mental health and children’s attention problems. These findings suggest that the NAcc is particularly vulnerable to prenatal maternal mental health challenges and contributes to offspring attention problems. Characterizing the temporal sensitivity of neurobiological structures to adversity will help to elucidate mechanisms linking environmental exposures and behavior, facilitating the development of neuroscience-informed interventions for childhood difficulties.
Given a set of items (predictors) suppose one wishes to predict another set of items (predictands) in asimultaneous way. Such a situation may occur when the predictands are different measurable aspects of the same phenomenon. Alternatively one might wish to predict the success of an event (say a successfully performed task) which has many correlated or uncorrelated failure modes (say a set of possible mental or physical disabilities each of them by itself precluding the achievement of the said task.) In such a case a unidimensional prediction is of value only if prediction is simultaneous for all possible failure modes. A linear summarization of the predictors is suggested, which is unique and has “maximum” predictability value for all predictands simultaneously. Other summarizations or scores are found that give “maximum” explanation of residual measures on the predictands and that are uncorrelated. The set of those simultaneous linear predictions is compared to the set of the individual multiple regression predictions as used, for instance, in the same context by Horst [4] for each predictand given the original predictors. We suggest that this technique can be applied in particular to the summarization of a subset of items when the whole set of items constitutes the set of predictands.
A previous article was concerned with simultaneous linear prediction. There one was given a set of predictor tests or items and one predicted a set of predictands (also tests or items, or perhaps criteria.) We proposed a simultaneous prediction which was a certain weighted sum of the predictors. In the present article the constraint that the prediction be a weighted sum is relaxed. We seek a general function of the predictors which will maximize the quantity chosen for measuring prediction efficiency. This quantity is the same as the one used in linear prediction and we justify this approach by showing it is the appropriate one when there is only one predictand. In order to solve the problem we restrict consideration to a vector of predictors having only a finite number of possible values, i.e., it possesses discrete probability distribution weights. This can be applied in the case of dichotomous items for instance. It may also be used in continuous distributions as an approximation, by first dividing the original range of values into a finite number of intervals. Then one attributes to the interval the weight corresponding to the probability mass it underlies in the original distribution.
Screen time in infancy is linked to changes in social-emotional development but the pathway underlying this association remains unknown. We aim to provide mechanistic insights into this association using brain network topology and to examine the potential role of parent–child reading in mitigating the effects of screen time.
Methods
We examined the association of screen time on brain network topology using linear regression analysis and tested if the network topology mediated the association between screen time and later socio-emotional competence. Lastly, we tested if parent–child reading time was a moderator of the link between screen time and brain network topology.
Results
Infant screen time was significantly associated with the emotion processing-cognitive control network integration (p = 0.005). This network integration also significantly mediated the association between screen time and both measures of socio-emotional competence (BRIEF-2 Emotion Regulation Index, p = 0.04; SEARS total score, p = 0.04). Parent–child reading time significantly moderated the association between screen time and emotion processing-cognitive control network integration (β = −0.640, p = 0.005).
Conclusion
Our study identified emotion processing-cognitive control network integration as a plausible biological pathway linking screen time in infancy and later socio-emotional competence. We also provided novel evidence for the role of parent–child reading in moderating the association between screen time and topological brain restructuring in early childhood.
Performance validity (PVTs) and symptom validity tests (SVTs) are necessary components of neuropsychological testing to identify suboptimal performances and response bias that may impact diagnosis and treatment. The current study examined the clinical and functional characteristics of veterans who failed PVTs and the relationship between PVT and SVT failures.
Method:
Five hundred and sixteen post-9/11 veterans participated in clinical interviews, neuropsychological testing, and several validity measures.
Results:
Veterans who failed 2+ PVTs performed significantly worse than veterans who failed one PVT in verbal memory (Cohen’s d = .60–.69), processing speed (Cohen’s d = .68), working memory (Cohen’s d = .98), and visual memory (Cohen’s d = .88–1.10). Individuals with 2+ PVT failures had greater posttraumatic stress (PTS; β = 0.16; p = .0002), and worse self-reported depression (β = 0.17; p = .0001), anxiety (β = 0.15; p = .0007), sleep (β = 0.10; p = .0233), and functional outcomes (β = 0.15; p = .0009) compared to veterans who passed PVTs. 7.8% veterans failed the SVT (Validity-10; ≥19 cutoff); Multiple PVT failures were significantly associated with Validity-10 failure at the ≥19 and ≥23 cutoffs (p’s < .0012). The Validity-10 had moderate correspondence in predicting 2+ PVTs failures (AUC = 0.83; 95% CI = 0.76, 0.91).
Conclusion:
PVT failures are associated with psychiatric factors, but not traumatic brain injury (TBI). PVT failures predict SVT failure and vice versa. Standard care should include SVTs and PVTs in all clinical assessments, not just neuropsychological assessments, particularly in clinically complex populations.
The seedcorn maggot, Delia platura (Meigen) (Diptera: Anthomyiidae), is reported as a polyphagous pest species found in numerous crops, including onion, corn, crucifers, and soy. Two morphologically identical genetic lines of D. platura (H- and N-lines) with distinct distribution ranges were recently discovered. Although many biological traits have been described for D. platura, no study to date has been conducted on the life history strategies and reproductive behaviours of its two lines. Using laboratory-reared colonies, this project investigates the effect of group composition (sex ratio and density) on the mating success and preoviposition period of the two D. platura lines. We found a substantial increase in mating success with increasing proportion of males within mating groups for both lines, whereas we found group density had negligible effects. However, the H-line had a lower average mating probability across treatments compared to the N-line. The preoviposition period decreased as the ratio of males to female increased at low density only for the N-line, and the opposite trend was observed at high density for both lines. These results suggest differences between the mating systems of these two lines, thereby highlighting the need for further research into the factors that influence their respective mating systems.
Ice patches have implications for landscape and ecosystem dynamics in polar deserts, however, the understanding of the driving factors that control their spatio-temporal variability is limited. This study aims to assess the seasonal and long-term evolution of ice patches on Ward Hunt Island (WHI; 83°N, Canadian High Arctic) based on field measurements of surface mass and energy balance. Results show that mass gains of the ice patch systems occur mostly through drifting snow, making them highly linked to the topography as well as the frequency and magnitude of wind events. Summer ablation is primarily driven by net radiation, but the short-term variability in melt rate is driven by sensible heat fluxes. The highest ablation rates occur during the passage of warm fronts that combine strong winds and mild temperatures. Conversely, foggy days reduce fluxes of solar radiation and sensible heat to the snow/ice surface, thereby suppressing ablation. Ice patches are less climate-sensitive than other cryospheric elements due to a feedback between snow accumulation and topography, however, summer ablation is strongly influenced by micrometeorology. Model projections of these factors suggest that conditions will become critical for preserving ice patches at WHI and along the northern coast of Ellesmere Island as early as in the next decades.
Mail-delivered get-out-the-vote (GOTV) field experiments have been found to increase voter turnout in some but not all contexts. We hypothesize that mail-delivered GOTV interventions are more successful in low-salience elections and test this in a systematic way for the first time. Relying on a systematic literature review and a meta-regression framework, we find that primary elections have a strong and significant positive impact on the success of mail-delivered GOTV interventions, whereas other commonly used measures of election salience, such as voter turnout, margin of victory, and a dummy for local elections, do not. These results highlight the possibility of fostering voter turnout using GOTV mail messages, especially in primary elections.
Optimizing research on the developmental origins of health and disease (DOHaD) involves implementing initiatives maximizing the use of the available cohort study data; achieving sufficient statistical power to support subgroup analysis; and using participant data presenting adequate follow-up and exposure heterogeneity. It also involves being able to undertake comparison, cross-validation, or replication across data sets. To answer these requirements, cohort study data need to be findable, accessible, interoperable, and reusable (FAIR), and more particularly, it often needs to be harmonized. Harmonization is required to achieve or improve comparability of the putatively equivalent measures collected by different studies on different individuals. Although the characteristics of the research initiatives generating and using harmonized data vary extensively, all are confronted by similar issues. Having to collate, understand, process, host, and co-analyze data from individual cohort studies is particularly challenging. The scientific success and timely management of projects can be facilitated by an ensemble of factors. The current document provides an overview of the ‘life course’ of research projects requiring harmonization of existing data and highlights key elements to be considered from the inception to the end of the project.
This study documented the provision of services and issues experienced by community organizations supporting older adults and caregivers in the province of Quebec during the coronavirus disease (COVID-19) pandemic, as well as promising strategies to adapt the provision of services in this context. A cross-sectional electronic survey using open- and closed-ended questions was conducted in July 2020. Almost three-quarters of the 307 respondents (71.4%) reported having maintained services at least partially throughout the lockdown, and the majority (85.3%) adapted their services. Among key challenges, participants reported difficulties identifying and supporting older adults at greater risk of vulnerability (54.8%), managing health risks for service users (60.2%), and recruiting volunteers (59.5%). Promising strategies included strategies to reach out to older adults and understand their needs (e.g., systematic phone calls) in addition to direct interventions supporting them (e.g., activities promoting social ties); implementing prevention and protection measures; accessing and using technologies; human resources management (e.g., recruiting new volunteers); finding financial support for their organization; developing intersectoral partnerships (e.g., multisectoral crisis cell); and promoting a positive view of older adults. The integration of multiple perspectives from different stakeholders may help identify strategies potentially transferable to other crises in order to meet older adults’ needs.
In polar deserts, depth hoar (hereinafter: DH) growth is not systematic unlike on tundra and this is critical for snowpack properties. Here, we address the spatio-temporal variability of the DH layer in the polar desert at two sites in the Canadian High Arctic: Ward Hunt Island (83° N) and Resolute Bay (75° N). Our data show that, over humid areas, DH represented a larger fraction of the snowpack and was characterized by lower density and coarser crystals than over dry gravelly areas. Increased soil moisture extends the zero-curtain period during freeze-up, leading to stronger temperature gradients in the snowpack and greater kinetic metamorphism. Our results also demonstrate that the large inter-annual variability in DH is primarily driven by wind conditions in the fall since this key variable controls the initial snow density and snow onset date. These strong controls exerted by soil moisture and meteorological conditions on DH growth in polar deserts highlight the possibility of major changes in polar snowpacks physical properties in response to the rapid climate and environmental changes currently affecting these regions.
A major obstacle in understanding and treating posttraumatic stress disorder (PTSD) is its clinical and neurobiological heterogeneity. To address this barrier, the field has become increasingly interested in identifying subtypes of PTSD based on dysfunction in neural networks alongside cognitive impairments that may underlie the development and maintenance of symptoms. The current study aimed to determine if subtypes of PTSD, based on normative-based cognitive dysfunction across multiple domains, have unique neural network signatures.
Methods
In a sample of 271 veterans (90% male) that completed both neuropsychological testing and resting-state fMRI, two complementary, whole-brain functional connectivity analyses explored the link between brain functioning, PTSD symptoms, and cognition.
Results
At the network level, PTSD symptom severity was associated with reduced negative coupling between the limbic network (LN) and frontal-parietal control network (FPCN), driven specifically by the dorsolateral prefrontal cortex and amygdala Hubs of Dysfunction. Further, this relationship was uniquely moderated by executive function (EF). Specifically, those with PTSD and impaired EF had the strongest marker of LN-FPCN dysregulation, while those with above-average EF did not exhibit PTSD-related dysregulation of these networks.
Conclusion
These results suggest that poor executive functioning, alongside LN-FPCN dysregulation, may represent a neurocognitive subtype of PTSD.
Recent studies suggest that close-range blast exposure (CBE), regardless of acute concussive symptoms, may have negative long-term effects on brain health and cognition; however, these effects are highly variable across individuals. One potential genetic risk factor that may impact recovery and explain the heterogeneity of blast injury’s long-term cognitive outcomes is the inheritance of an apolipoprotein (APOE) ε4 allele, a well-known genetic risk factor for Alzheimer’s disease. We hypothesized that APOE ε4 carrier status would moderate the impact of CBE on long-term cognitive outcomes.
Methods:
To test this hypothesis, we examined 488 post-9/11 veterans who completed assessments of neuropsychological functioning, psychiatric diagnoses, history of blast exposure, military and non-military mild traumatic brain injuries (mTBIs), and available APOE genotypes. We separately examined the effects of CBE on attention, memory, and executive functioning in individuals with and without the APOE ε4 allele.
Results:
As predicted, we observed a differential impact of CBE status on cognition as a function of APOE ε4 status, in which CBE ε4 carriers displayed significantly worse neuropsychological performance, specifically in the domain of memory. These results persisted after adjusting for clinical, demographic, and genetic factors and were not observed when examining other neurotrauma variables (i.e., lifetime or military mTBI, distant blast exposure), though these variables displayed similar trends.
Conclusions:
These results suggest APOE ε4 carriers are more vulnerable to the impact of CBE on cognition and highlight the importance of considering genetic risk when studying cognitive effects of neurotrauma.
The Developmental Origins of Health and Disease (DOHaD) framework aims to understand how environmental exposures in early life shape lifecycle health. Our understanding and the ability to prevent poor health outcomes and enrich for resiliency remain limited, in part, because exposure–outcome relationships are complex and poorly defined. We, therefore, aimed to determine the major DOHaD risk and resilience factors. A systematic approach with a 3-level screening process was used to conduct our Rapid Evidence Review following the established guidelines. Scientific databases using DOHaD-related keywords were searched to capture articles between January 1, 2009 and April 19, 2019. A final total of 56 systematic reviews/meta-analyses were obtained. Studies were categorized into domains based on primary exposures and outcomes investigated. Primary summary statistics and extracted data from the studies are presented in Graphical Overview for Evidence Reviews diagrams. There was substantial heterogeneity within and between studies. While global trends showed an increase in DOHaD publications over the last decade, the majority of data reported were from high-income countries. Articles were categorized under six exposure domains: Early Life Nutrition, Maternal/Paternal Health, Maternal/Paternal Psychological Exposure, Toxicants/Environment, Social Determinants, and Others. Studies examining social determinants of health and paternal influences were underrepresented. Only 23% of the articles explored resiliency factors. We synthesized major evidence on relationships between early life exposures and developmental and health outcomes, identifying risk and resiliency factors that influence later life health. Our findings provide insight into important trends and gaps in knowledge within many exposures and outcome domains.
First, I discuss cross-cultural evidence showing that a good deal of enculturation takes place outside of thinking through other minds. Second, I review evidence challenging the claim that humans seek to minimize entropy. Finally, I argue that optimality claims should be avoided, and that descriptive Bayesianism offers a more promising avenue for the development of a Bayesian theory of culture.