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Under the global dynamics of regulatory capitalism, lower-and-middle income countries have been under pressure to engage with alien models for regulating regenerative medicine. Nevertheless, Chapter 3 argues that notions of Western hegemonic power are becoming outdated as a main analytical tool for understanding global regulation: changing global reconfigurations of power and scientific institutions in the global life-sciences have created structural spaces for both enterprises and regulators to negotiate new regulation. Chapter 3 introduces the notion of regulatory capacity building to illustrate the changing global reconfigurations of power and scientific institutions in the global life-sciences through the structural spaces in which individual enterprises and regulators alike ‘broker’ regulation. The chapter argues that building regulatory capacity is not a matter of the wholesale import of internationally accepted regulation, but of the nation-state, in negotiation with local developments and interest groups, shaping regulatory boundaries at provincial, national and global levels of organisation. Case studies on regulatory development in China and in India illustrate how the adaption of ‘foreign’ regulation requires complex political efforts to forge compromises between ‘the ideal’ models used by the laboratories of the global elites and feasible standards aimed for and set ‘at home’.
The commentary raises important points like patients' actual availability of out- or in-patient services in the wake of pandemics and nationwide lockdowns. The focus is also drawn to missed opportunities to include data from hotlines and online services, a possible increase in death by suicides or changes in the factors that could add up to or protect a person from suicide.
For the past three decades, India has implemented several nutrition programmes to address malnutrition in the under-fives. To understand the programme’s impact, this study assesses the prevalence of acute malnutrition, moderate acute malnutrition (MAM) and severe acute malnutrition (SAM), using mid-upper arm circumference (MUAC) among tribal children.
Design:
The survey was conducted in two tribal blocks (Desaiganj and Bhamragad) of the Gadchiroli district in Maharashtra to identify children registered in the ‘Anganwadi’ program.
Setting:
A community-based cross-sectional survey was carried out.
Participants:
The total sample size was 1055 children (aged 0–59 months).
Results:
The overall prevalence of SAM and MAM was 1·4 % (n 15) and 9·8 % (n 103). A higher prevalence of MAM was found in males (38·5 %, n 40) and females (27·1 %, n 28) in below 6 months. Additionally, a higher prevalence of MAM was observed in females (10·7 %, n 113) compared with males (9·0 %, n 95). The prevalence of SAM was significantly (P < 0·001) higher in females (1·7 %, n 18) than in males (1·0 %, n 11). Children aged between 12 and 17 months were sixteen times more likely (OR = 16·9, P < 0·001, CI = 4·8, 59·6) to have MAM (MUAC < 12·5 cm) than children aged between 6 and 11 months. Children from the Desaiganj block were significantly less likely (OR = 0·4, P < 0·001, CI = 0·2, 0·7) to have MAM compared with children from Bhamragad. Approximately 4 % (n 42) of children were classified as critically malnourished.
Conclusion:
There is an urgent need for block-level monitoring of MAM and SAM, as well as evaluation of existing nutrition programmes, to address the disparity in the sex-specific prevalence of MAM and SAM in tribal areas.
The study was conducted on indigenous Tharparkar cow (Bos indicus) to evaluate FSH stimulation on follicular attributes, oocyte recovery and morpho-molecular developmental competence parameters concerning oocyte quality. A total of 20 OPU sessions were performed, which included 10 sessions in each FSH stimulated at the dose of 130 µg divided into four sub-doses and non-stimulated. Findings on the size of follicles having ≥6 mm showed a significantly higher, however an opposite trend was observed in the case of smaller sized follicle (<6 mm) between stimulated and non-stimulated respectively. The stimulated cows had a significantly higher number as well as the percentage of oocytes of Grade A, having a diameter ≥120 µm and BCB+VE as compared to the non-stimulated cows. The relative mRNA expression profile of GDF9, BMP15, PCNA and BCL-2 genes was higher and BAX was lower in the FSH-stimulated cow. These results indicated that FSH stimulation before OPU in Bos indicus cows has a significant impact on follicle size, oocyte yield, recovery, and their quality with respect to COC’s, diameter and BCB+VE oocytes. Further, a significant increase in the relative mRNA expression levels of GDF9, BMP15 and PCNA genes in the FSH-stimulated group suggests that FSH plays a key role in modulating the expression of these important candidate genes and thus influencing oocyte quality. The higher mRNA expression of BCL-2 genes and concomitantly lower expression of BAX gene in FSH Stimulated cows indicates the protective role of these genes and preventing programmed cell death and thus promoting cell survival, quality and embryo development.
Onion is sensitive to soil water stress and nitrogen limitations, causing a marked reduction in yield and bulb quality. A field trial was set in the winter seasons of 2016–17 and 2017–18 to evaluate the effects of three micro-sprinkler irrigation levels at 0.6, 0.9 and 1.2 ratios of crop evapotranspiration (ETc) and four nitrogen levels at 0, 75, 100 and 120% of the recommended nitrogen dose (RDN), including surface irrigation at 40 mm cumulative pan evaporation (CPE) with 100% RDN (SN) using an augmented strip plot design on water and N distribution in soil, their productivities, onion yield and economics. Results indicated that the root zone water content increased by 5.2% for 1.2 ETc, and 1.4% for 0.9 ETc over the cropping period, but declined by 1.5% for 0.6 ETc with micro-sprinkler irrigation compared to surface irrigation with nitrogen fertilization (SN). The largest total root zone water depletion was in 1.2 ETc (16.7%), followed by SN (15.3%) and 0.9 ETc (15.0%). The high irrigation regime produced the maximum yield and nitrogen productivity, whereas deficit irrigation displayed the greatest water productivity. However, the coupling of micro-sprinkler irrigation at 1.2 ETc and 120% RDN led to an increase of onion bulb yield (22.6%), water productivity (42.7%), plant N uptake (29.0%) and net income (30.6%) with maximum benefit-cost ratio (3.19) compared to SN. However, as this study was only based on two seasons, more field trials will be needed to confirm the optimum amount of water and nitrogen for winter onion.
Descriptions of various subsets of $\mathbb{SO}(3)$ are encountered frequently in robotics, for example, in the context of specifying the orientation workspaces of manipulators. Often, the Cartesian concept of a cuboid is extended into the domain of Euler angles, notwithstanding the fact that the physical implications of this practice are not documented. Motivated by this lacuna in the existing literature, this article focuses on studying sets of rotations described by such cuboids by mapping them to the space of Rodrigues parameters, where a physically meaningful measure of distance from the origin is available and the spherical geometry is intrinsically pertinent. It is established that the planar faces of the said cuboid transform into hyperboloids of one sheet and hence, the cuboid itself maps into a solid of complicated non-convex shape. To quantify the extents of these solids, the largest spheres contained within them are computed analytically. It is expected that this study would help in the process of design and path planning of spatial robots, especially those of parallel architecture, due to a better and quantitative understanding of their orientation workspaces.
Statistical Machine Translation (SMT) systems use various probabilistic and statistical Natural Language Processing (NLP) methods to automatically translate from one language to another language while retaining the originality of the context. This paper aims to discuss the development of bilingual SMT models for translating English into fifteen low-resource Indic languages (ILs) and vice versa. The process to build the SMT model is described and explained using a workflow diagram. Samanantar and OPUS corpus are utilized for training, and Flores200 corpus is used for fine-tuning and testing purposes. The paper also highlights various preprocessing methods used to deal with corpus noise. The Moses open-source SMT toolkit is being investigated for the system’s development. The impact of distance-based reordering and Morpho-syntactic Descriptor Bidirectional Finite-State Encoder (msd-bidirectional-fe) reordering on ILs is compared in the paper. This paper provides a comparison of SMT models with Neural Machine Translation (NMT) for ILs. All the experiments assess the translation quality using standard metrics such as BiLingual Evaluation Understudy, Rank-based Intuitive Bilingual Evaluation Score, Translation Edit Rate, and Metric for Evaluation of Translation with Explicit Ordering. From the result, it is observed that msd-bidirectional-fe reordering performs better than the distance-based reordering model for ILs. It is also noticed that even though the IL-English and English-IL systems are trained using the same corpus, the former performs better for all the evaluation metrics. The comparison between SMT and NMT shows that across various languages, SMT performs better in some cases, while NMT outperforms in others.
The evolutionary relationship between domesticated Oryza species and their wild relatives in North East India is not well understood. To improve the understanding of the evolutionary relationship, this study investigates the genetic diversity of 68 indigenous rice landraces from North East India, ten O. rufipogon genotypes, and nine O. nivara genotypes using chloroplast variable repeat markers which, due to non-recombination and uniparental inheritance, enable better phylogenetic inference. Reference genotypes IR64 (indica) and Nipponbare (japonica) were included to characterize various phylogenetic clusters. Using distance-based hierarchical clustering, model-based structuring and principal component analysis, selected landraces from the three North Eastern Indian states of Assam, Manipur and Arunachal Pradesh were grouped into two phylogenetically different clusters that represented the IR64 and Nipponbare groupings. Interestingly, despite the fact that a cluster analysis combining North East landraces and wild relatives likewise produced two separate clusters (cluster I: Nipponbare, cluster II: IR64), the majority of the wild relatives were only clustered in the IR64 cluster. This suggests that the two distinct evolutionary histories of the rice landraces in North East India are distinguished by their genetic affinity for wild relatives and their variation in the indica and japonica pools. These results highlight chloroplast divergence influencing the genetic diversity of North East landraces with wild relatives. Further, these findings will enable in-depth studies on the functional significance of chloroplast diversity on trait adaptation in rice landraces.
We identify a set of essential recent advances in climate change research with high policy relevance, across natural and social sciences: (1) looming inevitability and implications of overshooting the 1.5°C warming limit, (2) urgent need for a rapid and managed fossil fuel phase-out, (3) challenges for scaling carbon dioxide removal, (4) uncertainties regarding the future contribution of natural carbon sinks, (5) intertwinedness of the crises of biodiversity loss and climate change, (6) compound events, (7) mountain glacier loss, (8) human immobility in the face of climate risks, (9) adaptation justice, and (10) just transitions in food systems.
Technical summary
The Intergovernmental Panel on Climate Change Assessment Reports provides the scientific foundation for international climate negotiations and constitutes an unmatched resource for researchers. However, the assessment cycles take multiple years. As a contribution to cross- and interdisciplinary understanding of climate change across diverse research communities, we have streamlined an annual process to identify and synthesize significant research advances. We collected input from experts on various fields using an online questionnaire and prioritized a set of 10 key research insights with high policy relevance. This year, we focus on: (1) the looming overshoot of the 1.5°C warming limit, (2) the urgency of fossil fuel phase-out, (3) challenges to scale-up carbon dioxide removal, (4) uncertainties regarding future natural carbon sinks, (5) the need for joint governance of biodiversity loss and climate change, (6) advances in understanding compound events, (7) accelerated mountain glacier loss, (8) human immobility amidst climate risks, (9) adaptation justice, and (10) just transitions in food systems. We present a succinct account of these insights, reflect on their policy implications, and offer an integrated set of policy-relevant messages. This science synthesis and science communication effort is also the basis for a policy report contributing to elevate climate science every year in time for the United Nations Climate Change Conference.
Social media summary
We highlight recent and policy-relevant advances in climate change research – with input from more than 200 experts.
We study the gravity-induced collisions of charged spheres of dielectric materials dispersed in a gaseous medium. When the gap thickness between the surfaces of two spheres is shorter than the mean free path of the surrounding fluid medium, continuum assumptions for the hydrodynamics interactions are no longer valid, and the non-continuum lubrication interactions result in surface-to-surface contact in finite time. Two like-charged dielectric spheres attract each other at close separations for a wide range of size and charge ratio values. We use trajectory analysis to calculate the collision rate and, thus, explore the role of electrostatic interactions in the collision dynamics of a pair of like-charged dielectric spheres. We present the modifications of pair trajectories due to electrostatic forces and show how collision efficiencies vary with the non-dimensional parameter capturing the relative strength of the electrostatic force to gravity as well as the charge ratio and size ratio.
14CO2 activity in air samples collected at Kakrapar Gujarat Site, India, was measured, and site-specific dilution factor for 14CO2 has been evaluated. 14CO2 activity in air samples was monitored for 72 different sampling events at onsite stack of Nuclear Power Plant (NPP) and at ESL meteorology laboratory (at 1.6 km from NPP stack). 14CO2 activity in air at stack of NPP and at ESL meteorology laboratory was observed to 0.10–0.18 TBq (GWe.year)–1, with mean value 0.12 TBq (GWe.year)–1 and ≤0.04–0.13 Bq m–3, with mean value 0.08 Bq m–3 respectively. The results were correlated with meteorological parameters. Site specific dilution factor for 14CO2 in air was evaluated at 1.6 km and was found to be in the range of 4.6E-05 to 21E-05 s m–3. Inter angle (degree) between plume direction and fixed sampling location and rainfall (mm) are found to be the important influencing parameters for dilution factor of 14CO2 in air.
The report of a detection of an absorption profile centred at 78 MHz in the continuum radio background spectrum by the EDGES experiment and its interpretation as the redshifted 21 cm signal of cosmological origin has become one of the most debated results of observational cosmology in recent times. The cosmological 21 cm has long been proposed to be a powerful probe for observing the early Universe and tracing its evolution over cosmic time. Even though the science case is well established, measurement challenges posed on the technical ground are not fully understood to the level of claiming a successful detection. EDGES’s detection has naturally motivated a number of experimental attempts worldwide to corroborate the findings. In this paper, we present a precision cross-correlation spectrometer HYPEREION purpose-designed for a precision radio background measurement between 50–120 MHz to detect the absorption profile reported by the EDGES experiment. HYPEREION implements a pre-correlation signal processing technique that self-calibrates any spurious additive contamination from within the system and delivers a differential measurement of the sky spectrum and a reference thermal load internal to the system. This ensures an unambiguous ‘zero-point’ of absolute calibration of the purported absorption profile. We present the system design, measurement equations of the ideal system, systematic effects in the real system, and finally, an assessment of the real system output for the detection of the absorption profile at 78 MHz in the continuum radio background spectrum.
In Southeast Greenland, summer melt and high winter snowfall rates give rise to firn aquifers: vast stores of meltwater buried beneath the ice-sheet surface. Previous detailed studies of a single Greenland firn aquifer site suggest that the water drains into crevasses, but this is not known at a regional scale. We develop and use a tool in Ghub, an online gateway of shared datasets, tools and supercomputing resources for glaciology, to identify crevasses from elevation data collected by NASA's Airborne Topographic Mapper across 29000 km2 of Southeast Greenland. We find crevasses within 3 km of the previously mapped downglacier boundary of the firn aquifer at 20 of 25 flightline crossings. Our data suggest that crevasses widen until they reach the downglacier boundary of the firn aquifer, implying that crevasses collect firn-aquifer water, but we did not find this trend with statistical significance. The median crevasse width, 27 meters, implies an aspect ratio consistent with the crevasses reaching the bed. Our results support the idea that most water in Southeast Greenland firn aquifers drains through crevasses. Less common fates are discharge at the ice-sheet surface (3 of 25 sites) and refreezing at the aquifer bottom (1 of 25 sites).
We study the collisions in a gaseous medium of a dilute bidisperse suspension of non-Brownian spherical particles sedimenting along the flow axis of a simple shear flow. Continuum lubrication forces prevent particles from coming into contact in a finite time, thus collisions can occur only due to attractive interactions such as the van der Waals force. However, in a low-pressure medium, the lubrication forces are weaker than their continuum counterparts and allow particle pairs to collide, even without any attractive forces. The Knudsen number, defined as the ratio of the mean free path of the medium to the mean radius of the interacting spheres, captures the significance of non-continuum interactions. We use uniformly valid hydrodynamic mobility functions, reflecting non-continuum lubrication at small separations and full continuum hydrodynamic interactions at moderate to larger separations. Due to the nature of the pair trajectory topology, the collision efficiency vanishes at a critical Knudsen number when simple shear flow alone drives the dynamics. Thus we perform collision calculations where particles experience the combined effects of van der Waals attraction and non-continuum hydrodynamics; van der Waals interactions enable collisions below the critical Knudsen number. Next, we calculate the collision efficiency for coupled differential sedimentation and simple shear driven motion in the presence of van der Waals interaction and non-continuum hydrodynamics. Finally, we explore the role of small particle inertia on relative trajectories and collision efficiencies in a non-continuum gas subject to a simple shear flow, ignoring the van der Waals force and gravity.
Long-term physiological dysfunction in coronary/systemic vasculature may persist in individuals with Kawasaki disease even in the absence of coronary artery abnormalities. We perform a systematic review and meta-analyses of studies assessing long-term vascular function in Kawasaki disease.
Methods:
PubMed, Embase, and Web of Science databases were searched for relevant literature published till May 2021. Patients with Kawasaki disease were included as cases and healthy age/sex-matched individuals as controls. Newcastle Ottawa Scale was used to assess the study quality. Outcome measures were differences in markers of vascular function 1 year after diagnosis of Kawasaki disease. Data were analysed using Review Manager software. Comprehensive meta-analysis software was used for meta-regression. To assess the certainty of evidence, GRADE Profiler software was utilised.
Results:
Of 2280 citations, 49 case-control studies (comprising 2714 cases and 2118 controls) were included for data synthesis. Decreased flow-mediated dilatation [3.83, 95%CI 0.94–6.72] and increased pulse-wave velocity [39.34 cm/sec, 95%CI 20.86–57.83], arterial stiffness [0.35, 95%CI 0.11–0.59], and common carotid artery intima-media thickness were noted in patients with Kawasaki disease. No significant difference was observed for nitroglycerine-mediated dilatation and endothelial peripheral artery tonometry (endo-PAT). Significant inter-study heterogeneity was observed for flow-mediated dilatation, arterial stiffness, carotid artery intima-media thickness, and endo-PAT. The GRADE evidence was of ‘very low quality’ for all outcome measures except ‘moderate quality’ for pulse-wave velocity.
Conclusions:
Evidence suggests the presence of long-term endothelial dysfunction in patients with Kawasaki disease even in the absence of coronary artery abnormalities. Avoidance of development of other cardiovascular risk factors seems prudent in patients with Kawasaki disease.
A new genus, Mystocestus, is proposed to accommodate a new species, Mystocestus anindoi n. g., n. sp. from Mystus vittatus (Bloch) (type host) in West Bengal and Mystus cavasius (Hamilton) (Siluriformes: Bagridae) in Maharashtra, India. The new genus is most similar to Lucknowia Gupta, 1961 in the shape of the body, which is elongate, slightly tapering towards the anterior end, and scolex, which is digitiform, but differs in the shape of the ovary, which is H-shaped (vs. inverted A-shaped in Lucknowia), the absence of a seminal receptacle (present in Lucknowia) and exclusively cortical vitelline follicles (vs. some follicles in the medulla in the latter genus). Molecular data support the erection of the new genus and place it close to Bovienia Fuhrmann, 1931, species of which can be easily distinguished by exclusively lateral vitelline follicles (lateral and median in the new genus), the presence of a seminal receptacle (absent in Mystocestus) and scolex shape (digitiform, with blunt or slightly concave anterior edge in the new genus vs. small, unspecialized or spatulate in Bovienia). The convoluted taxonomy of tapeworms placed in Mystoides Mathur, 1992 is critically reviewed to clean up taxonomic chaos in Indo-Malayan caryophyllideans. Mystoides was erected in an unpublished PhD thesis and thus its generic name becomes unavailable and also, its type species is conspecific with Lucknowia fossilisi Gupta, 1961 from the stinging catfish, Heteropneustes fossilis (Bloch). Other species of this genus are also conspecific with L. fossilisi. In addition, specific names of most of these taxa are unavailable because they were described in unpublished theses or conference abstracts. Based on recent revisions of Indo-Malayan caryophyllideans, the following nine genera with 15 species are considered valid (numbers of species of individual genera are provided in parentheses): Bovienia (3), Djombangia (1), Lucknowia (2), Lytocestus (2), Mystocestus (1), Pseudocaryophyllaeus (2) (all family Lytocestidae); Adenoscolex (1), Lobulovarium (2), Paracaryophyllaeus (1) (all family Caryophyllaeidae).
The $\rho $-Einstein soliton is a self-similar solution of the Ricci–Bourguignon flow, which includes or relates to some famous geometric solitons, for example, the Ricci soliton and the Yamabe soliton, and so on. This paper deals with the study of $\rho $-Einstein solitons on Sasakian manifolds. First, we prove that if a Sasakian manifold M admits a nontrivial$\rho $-Einstein soliton $(M,g,V,\lambda )$, then M is $\mathcal {D}$-homothetically fixed null $\eta $-Einstein and the soliton vector field V is Jacobi field along trajectories of the Reeb vector field $\xi $, nonstrict infinitesimal contact transformation and leaves $\varphi $ invariant. Next, we find two sufficient conditions for a compact $\rho $-Einstein almost soliton to be trivial (Einstein) under the assumption that the soliton vector field is an infinitesimal contact transformation or is parallel to the Reeb vector field $\xi $.
Wick polynomials and Wick products are studied in the context of noncommutative probability theory. It is shown that free, Boolean, and conditionally free Wick polynomials can be defined and related through the action of the group of characters over a particular Hopf algebra. These results generalize our previous developments of a Hopf-algebraic approach to cumulants and Wick products in classical probability theory.