Interruption of the aortic arch is a rare congenital cardiac malformation with rare cases described in adulthood. Survival in adulthood relies on developing collateral networks to maintain distal flow. CHD occurs in almost 50% of Turner syndrome and is the most frequent cause of early mortality. Also, they have an increased risk factor for thoracic aortic dilatation, and elective surgery should be considered according to body surface area. Surgical correction is the preferred treatment for the interrupted aortic arch and aortic root dilatation. We present the case of a 46-year-old patient with Turner syndrome with a diagnosis of interrupted aortic arch and aortic root aneurysm who underwent the Bentall procedure and interposition of a Dacron graft in the descending aorta. Post-procedural recovery was uneventful with a good haemodynamic response.

The shift to telework and hybrid arrangements has prompted organizations to reevaluate leadership competencies specific to remote environments. Therefore, we developed the Leadership Competencies for Telework (LCT) scale, designed for telework settings and addressing new challenges such as telework-life balance and virtual distance. The validation process included two studies: (1) Two content validity panels with 27 experts, and (2) validation of the 67-item scale through a survey of 543 Spanish teleworkers. Confirmatory factor analysis supported a five-factor structure: Digital Communication, Digital Trust-Building, Remote Goal Management, Remote Relationships Development, and Telework-Life Balance Support. The scale demonstrated high reliability (α < 0.90 for all factors) and validity, correlating with key outcomes such as job satisfaction, professional isolation, telework-life conflict, and organizational citizenship behaviors. The LCT scale provides organizations with a validated tool for assessing and developing effective telework leadership. Future research could validate the scale through longitudinal studies, exploring its predictive power over time.

We present a dataset of 1,119 radiocarbon dates and their contexts for Oaxaca, Mexico, a best effort to include all published dates, plus hundreds of unpublished samples. We illustrate its potential and limitations with five examples: (1) dated stratigraphy in stream cutbanks show how aggradation, downcutting, and stability responded to global climate and human activities; (2) 14C samples from Late/Terminal Formative contexts allow interregional comparisons of temple and palace construction, use, and abandonment; (3) new 14C dates provide better understanding of events during the Late Classic/Epiclassic, a problematic time in the ceramic chronology; (4) individual Classic/Postclassic residential contexts had long durations—several hundred years; and (5) model constraints from other data permit refinement at times of calibration curve deviation, as during AD 1400–1600. We recommend further chronological refinement with best-practice standards, new samples, existing collections, and statistical modeling.

We present a number of measures and techniques to characterise and effectively construct quasi-isodynamic stellarators within the near-axis framework, without the need to resort to the computation of global equilibria. These include measures of the reliability of the model (including aspect-ratio limits and the appearance of ripple wells), quantification of omnigeneity through $\epsilon _{\mathrm{eff}}$, measure and construction of MHD-stabilised fields, and the sensitivity of the field to the pressure gradient. The paper presents, discusses and gives examples of all of these, for which expansions to second order are crucial. This opens the door to the exploration of how key underlying choices of the field design govern the interaction of desired properties (‘trade-offs’) and provides a practical toolkit to perform efficient optimisation directly within the space of near-axis quasi-isodynamic configurations.

The intensity of the turbulence in tokamaks and stellarators depends on its ability to excite and sustain zonal flows. Insight into this physics may be gained by studying the ‘residual’, i.e. the late-time linear response of the system to an initial perturbation. We investigate this zonal-flow residual in the limit of a small magnetic mirror ratio, where we find that the typical quadratic approximation to RH (Rosenbluth & Hinton, 1998 Phys. Rev. Lett. vol. 80, issue 4, pp. 724–727) breaks down. Barely passing particles are in this limit central in determining the resulting level of the residual, which we estimate analytically. The role played by the population with large orbit width provides valuable physical insight into the response of the residual beyond this limit. Applying this result to tokamak, quasi-symmetric and quasi-isodynamic equilibria, using a near-axis approximation, we identify the effect to be more relevant (although small) in the core of quasi-axisymmetric fields, where the residual is smallest. The analysis in the paper also clarifies the relationship between the residual and the geodesic acoustic mode, whose typical theoretical set-ups are similar.

The shear Alfvén wave (SAW) continuum plays a critical role in the stability of energetic particle-driven Alfvén eigenmodes. We develop a theoretical framework to analyze the SAW continuum in three-dimensional (3-D) quasisymmetric magnetic fields, focusing on its implications for stellarator design. By employing a near-axis model and degenerate perturbation theory, the continuum equation is solved, highlighting unique features in 3-D configurations, such as the interactions between spectral gaps. Numerical examples validate the theory, demonstrating the impact of flux-surface shaping and quasisymmetric field properties on continuum structure. The results provide insights into optimizing stellarator configurations to minimize resonance-driven losses of energetic particles. This work establishes a basis for incorporating Alfvénic stability considerations into the stellarator design process, demonstrated through optimization of a quasihelical configuration to avoid high-frequency spectral gaps.

Global discussions around the risks, benefits and governance of solar radiation modification (SRM) in the climate change response portfolio are accelerating, but the topic remains nascent in Latin America and the Caribbean (LAC). In 2023, a US start-up (Make Sunsets) performed a small-scale, non-research deployment of SRM in Baja California, Mexico, without prior permission or community engagement. Their actions prompted Mexico to announce its intention to ban SRM experimentation, underscoring the need for governance to prevent irresponsible practices that could discredit legitimate research. We perform an empirical and ethical analysis of the landscape of academic discussions and media coverage on SRM in the LAC region, focusing on the Make Sunset case. Our analysis leads us to three conclusions: first, a lack of regulations in LAC that fosters mistrust, fuels perceptions of neo-colonialism and restricts potentially valuable and responsible research; second, we argue that the theatrical Make Sunsets case is not ethically justified in light of the diversity of risks associated with it; third, we offer foundational, participatory recommendations to promote effective, transparent and sustainable governance of SRM, including LAC in global conversations.

Antimicrobial resistance (AMR) poses a significant global health threat, projected to cause 10 million deaths annually by 2050. Addressing AMR requires a coordinated, multidisciplinary approach encompassing infectious disease (ID) clinicians, pharmacists, microbiologists, infection preventionists, and policymakers. The inaugural AMR Summit, hosted by bioMérieux in collaboration with Tampa General Hospital and the University of South Florida Morsani College of Medicine in November 2024, convened experts from various fields to explore innovative strategies for combating AMR. Key topics discussed included the role of multidisciplinary teams in antimicrobial stewardship programs, advancements in rapid diagnostic tests and antimicrobial susceptibility testing, the application of implementation science in AMR, and the integration of next-generation sequencing in ID diagnostics. The summit underscored the importance of diagnostic innovation, interdisciplinary collaboration, policy, advocacy, and public engagement in advancing efforts against AMR.

Background: Schizencephaly is a congenital brain malformation involving a cleft in the cerebral hemisphere lined with abnormal gray matter with an estimated incidence of 1.5 per 100,000 live births. Methods: This study aims to characterize the radiological, etiological, and clinical features of schizencephaly, identifying factors predictive of patient outcomes. A retrospective cohort of 94 individuals, both adult and pediatric, was analyzed across four tertiary care centers. A neuroradiologist systematically reviewed imaging, while charts were reviewed for clinical features. Results: Several perinatal risk factors were identified, including young maternal age and prenatal infections. However, genetic testing yielded only one pathogenic COL4A1 mutation. MRI findings showed frequent additional malformations, including those in the pituitary, corpus callosum, and fornix. Clinical characteristics included neurodevelopmental delay (71.6%), seizures (50.0%), and motor impairments (53.3%). Outcomes were heterogeneous, with bilateral and open-lip clefts associated with more severe developmental delays, while seizure rates were comparable across subtypes. Conclusions: The complexity of schizencephaly is highlighted in the largest cohort reported with high rates of seizures, neurodevelopmental delays, and motor impairments, but outcomes varied widely based on imaging features, underscoring the importance of individualized management. The low yield of genetic findings emphasizes prenatal environmental risk factors as etiological contributors.

Background: In generalized myasthenia gravis (gMG), there remains an unmet need for treatments providing meaningful symptom control. Methods: Mean changes in MG-ADL were compared between nipocalimab + standard-of-care (SoC) and placebo+SoC. The proportion of patients achieving: Minimal Symptom Expression (MSE), MG-ADL score 0/1, time with MSE, sustained within person meaningful change (WPMC) starting from Week 4, and time spent with WPMC were compared. Results: Nipocalimab+SoC demonstrated significant improvement in MG-ADL compared to placebo+SOC, LS-mean-change[SE] -4.7[0.329] vs -3.25[0.335]; Difference in means[SE]=-1.45 [0.470], p=0.002. The mean difference favoured nipocalimab+SoC, and was significant as early as week 1: LS-mean-change[SE]: -2.72[2.979] vs -1.77[2.426]; Difference in means[SE] -0.82[0.410], p=0.046. Nipocalimab+SoC patients were three times more likely to achieve MSE at any point during the study vs placebo; Odds Ratio[95% CI]: 3.0[1.3, 6.8]; 31.2% vs. 13.2%. For the 25 patients reaching MSE, the time sustaining MSE [percent time with MSE] was 101.5 days, (60.4%, nipocalimab+SOC) vs 55 days, (32.7%, placebo+SOC). Similarly, the proportion of patients with sustained WPMC favored nipocalimab+SOC, 55.8% vs 26.3%, placebo+SOC, p<0.001. The median percent time spent with WPMC was 84.5%, nipocalimab+SOC vs 39.9%, placebo+SOC, p=0.007. Conclusions: Based on MG-ADL data from Phase 3, nipocalimab an FcRn blocker, demonstrated rapid, substantial, and sustained symptom control.