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Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
It is important for the research produced by industrial-organizational (I-O) psychologists to be rigorous, relevant, and useful to organizations. However, I-O psychology research is often not used in practice. In this paper, we (both practitioners and academics) argue that engaged scholarship—a particular method of inclusive, collaborative research that incorporates multiple stakeholder perspectives throughout the research process—can help reduce this academic–practice gap and advance the impact of I-O psychology. To examine the current state of the field, we reviewed empirical evidence of the current prevalence of collaborative research by examining the number of articles that contain nonacademic authors across 14 key I-O psychology journals from 2018 to 2023. We then build on these findings by describing how engaged scholarship can be integrated throughout the research process and conclude with a call to action for I-O psychologists to conduct more collaborative research. Overall, our goal is to facilitate a fruitful conversation about the value of collaborative research that incorporates multiple stakeholder perspectives throughout the research process in hopes of reducing the academic–practice gap. We also aim to inspire action in the field to maintain and enhance the impact of I-O psychology on the future world of work.
Quasi-periodic plasmoid formation at the tip of magnetic streamer structures is observed to occur in experiments on the Big Red Ball as well as in simulations of these experiments performed with the extended magnetohydrodynamics code, NIMROD. This plasmoid formation is found to occur on a characteristic time scale dependent on pressure gradients and magnetic curvature in both experiment and simulation. Single mode, or laminar, plasmoids exist when the pressure gradient is modest, but give way to turbulent plasmoid ejection when the system drive is higher, which produces plasmoids of many sizes. However, a critical pressure gradient is also observed, below which plasmoids are never formed. A simple heuristic model of this plasmoid formation process is presented and suggested to be a consequence of a dynamic loss of equilibrium in the high-$\beta$ region of the helmet streamer. This model is capable of explaining the periodicity of plasmoids observed in the experiment and simulations, and produces plasmoid periods of 90 minutes when applied to two-dimensional models of solar streamers with a height of $3R_\odot$. This is consistent with the location and frequency at which periodic plasma blobs have been observed to form by Large Angle and Spectrometric Coronograph and Sun Earth Connection Coronal and Heliospheric Investigation instruments.
Magnetic reconnection is explored on the Terrestrial Reconnection Experiment (TREX) for asymmetric inflow conditions and in a configuration where the absolute rate of reconnection is set by an external drive. Magnetic pileup enhances the upstream magnetic field of the high-density inflow, leading to an increased upstream Alfvén speed and helping to lower the normalized reconnection rate to values expected from theoretical consideration. In addition, a shock interface between the far upstream supersonic plasma inflow and the region of magnetic flux pileup is observed, important to the overall force balance of the system, thereby demonstrating the role of shock formation for configurations including a supersonically driven inflow. Despite the specialized geometry where a strong reconnection drive is applied from only one side of the reconnection layer, previous numerical and theoretical results remain robust and are shown to accurately predict the normalized rate of reconnection for the range of system sizes considered. This experimental rate of reconnection is dependent on system size, reaching values as high as 0.8 at the smallest normalized system size applied.
To assess Connecticut medical providers’ concordance (2018–2019) with the 2017 Clostridioides difficile infection (CDI) treatment update by the Infectious Disease Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). The effect of guideline concordance on CDI recurrence risk was also assessed.
Design:
Prospective, population-based study.
Setting:
New Haven County, Connecticut, from January 1, 2017, to December 31, 2019.
Patients:
CDI incident case (no positive tests in the prior 8 weeks), not limited by care setting.
Methods:
Using data from the Emerging Infections Program’s CDI surveillance, severity and concordance were defined. Presence of megacolon and/or ileus defined fulminant disease; absence defined nonsevere/severe disease. Using 2017 treatment as baseline, 2018–2019 concordance was defined as receiving the recommended first-line antibiotic (ie, vancomycin or fidaxomicin for adult patients, vancomycin or metronidazole for pediatric patients) for exactly 10 days. For all analyses, significance was P < .05.
Results:
Among 990 cases, concordance increased from 24.8% in 2018 to 37.0% in 2019. First-line antibiotic concordance increased from 61.2% in 2018 to 79.9% in 2019. Recurrence risk was significantly associated with patients aged ≥65 years and was highest for those aged 75–84 years, but this factor was not significantly associated with concordance.
Conclusions:
From 2018 through 2019, CDI treatment in New Haven County increasingly was concordant with the 2017 treatment update but remained low in 2019. Although concordance with treatment guidelines did not affect recurrence risk, close attention should be paid by medical providers to patients aged ≥65 years, specifically those aged 75–84 years because they are at an increased risk for recurrence.
The preconception, pregnancy and immediate postpartum and newborn periods are times for mothers and their offspring when they are especially vulnerable to major stressors – those that are sudden and unexpected and those that are chronic. Their adverse effects can transcend generations. Stressors can include natural disasters or political stressors such as conflict and/or migration. Considerable evidence has accumulated demonstrating the adverse effects of natural disasters on pregnancy outcomes and developmental trajectories. However, beyond tracking outcomes, the time has arrived for gathering more information related to identifying mechanisms, predicting risk and developing stress-reducing and resilience-building interventions to improve outcomes. Further, we need to learn how to encapsulate both the quantitative and qualitative information available and share it with communities and authorities to mitigate the adverse developmental effects of future disasters, conflicts and migrations. This article briefly reviews prenatal maternal stress and identifies three contemporary situations (wildfire in Fort McMurray, Alberta, Canada; hurricane Harvey in Houston, USA and transgenerational and migrant stress in Pforzheim, Germany) where current studies are being established by Canadian investigators to test an intervention. The experiences from these efforts are related along with attempts to involve communities in the studies and share the new knowledge to plan for future disasters or tragedies.
Gloss, Carr, Reichman, Abdul-Nasiru, and Oestereich (2017) present a compelling argument (or rallying call) for there being a “moral imperative for I-O psychology to overrepresent people living in the deepest forms of poverty in both science and practice” (p. 330). We agree. Our research has been dominated by a POSH perspective, and it is incumbent upon us to ensure that our science benefits those who are most affected by poverty. We believe the interest in engaging in humanitarian work psychology is growing among industrial and organizational (I-O) psychologists, yet many of us may not feel prepared to conduct such research and/or we may feel that we lack the skills to do so. Further, as Gloss et al. (2017) note, to the extent that we are unprepared to engage in research that benefits those living in poverty, in particular, we run the added risk of harming the very populations we are wanting to help. As such, the interest is there, but we may be daunted by the method. We argue that in order to heed that rallying call, without harm, we need to develop our own capabilities to engage in this important work.
Growth chamber studies using one soil investigated the effects of trifluralin (α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine) at 0.0, 0.4, and 0.8 ppmw on the root development and the mineral status of wheat (Triticum aestivum L. ‘Neepawa’) seedlings. The 0.8-ppmw trifluralin rate increased the number of seminal roots, reduced lateral root production, decreased root extension, caused root tips to swell (club-like appearance), and reduced root dry weights. However, 0.4-ppmw trifluralin caused only slight damage to the seedlings. Towards the end of the two-week growth period, damaged seedlings showed signs of recovery, which included an increased number of seminal roots, development of normal root extensions from clubbed root tips, and development of normal lateral root patterns. Trifluralin increased percent calcium and magnesium and decreased percent nitrogen, phosphorus, and potassium in wheat plants. The nutrient concentrations were more affected in 21-day-old plants than in 35-day-old plants, indicating the wheat seedlings were able to recover from trifluralin injury.
Experiments on the National Ignition Facility show that multi-dimensional effects currently dominate the implosion performance. Low mode implosion symmetry and hydrodynamic instabilities seeded by capsule mounting features appear to be two key limiting factors for implosion performance. One reason these factors have a large impact on the performance of inertial confinement fusion implosions is the high convergence required to achieve high fusion gains. To tackle these problems, a predictable implosion platform is needed meaning experiments must trade-off high gain for performance. LANL has adopted three main approaches to develop a one-dimensional (1D) implosion platform where 1D means measured yield over the 1D clean calculation. A high adiabat, low convergence platform is being developed using beryllium capsules enabling larger case-to-capsule ratios to improve symmetry. The second approach is liquid fuel layers using wetted foam targets. With liquid fuel layers, the implosion convergence can be controlled via the initial vapor pressure set by the target fielding temperature. The last method is double shell targets. For double shells, the smaller inner shell houses the DT fuel and the convergence of this cavity is relatively small compared to hot spot ignition. However, double shell targets have a different set of trade-off versus advantages. Details for each of these approaches are described.
The environmental impact resulting from the use of fossil fuel as an energy source affects the entire globe. Eventually, fossil fuels will no longer be a reasonable source of energy and alternative energy sources will be needed. Thermoelectric materials (TE) that directly convert heat into electricity are a viable option to replace the conventional fossil fuel because they are reliable, cost effective, and use no moving parts. Recently researchers discovered the existence of giant Seebeck coefficient in manganese oxide (MnO2) powders, which ignited an increased interest in MnO2-based materials. In this work we present a systematic structural and electrical characterization of amorphous and crystalline MnxOy thin films. These films were deposited at room temperature on heated silicon and sapphire substrates by DC Magnetron Sputtering. Our preliminary results show that MnxOy/silicon thin films undergo a crystalline change from Mn2O3 to Mn3O4 as annealing temperature is increased from 300°C to 500°C.
Two cases of hospital-acquired listeriosis were linked to a commercially produced, pasteurized ice cream mix. Manufacturers should implement safety measures from the Food Safety Modernization Act to minimize the risk of Listeria contamination. Dietary guidelines for persons at high risk of listeriosis may need revision to recognize the potential risk from pasteurized products.
Major advances have been made over the past 30 years in the development of an integrated computational materials design (ICMD) technology. The hierarchical structure of its methods, tools, and supporting fundamental materials databases is reviewed here, with an emphasis on successful applications of CALPHAD (calculation of phase diagrams)-based tools as an example of ICMD, expressing mechanistic understanding in quantitative form to support science-based materials engineering. Opportunities are identified for rapid expansion of CALPHAD databases, as well as a major restructuring of materials education.
The Wisconsin Plasma Astrophysics Laboratory (WiPAL) is a flexible user facility designed to study a range of astrophysically relevant plasma processes as well as novel geometries that mimic astrophysical systems. A multi-cusp magnetic bucket constructed from strong samarium cobalt permanent magnets now confines a $10~\text{m}^{3}$, fully ionized, magnetic-field-free plasma in a spherical geometry. Plasma parameters of $T_{e}\approx 5$ to $20~\text{eV}$ and $n_{e}\approx 10^{11}$ to $5\times 10^{12}~\text{cm}^{-3}$ provide an ideal testbed for a range of astrophysical experiments, including self-exciting dynamos, collisionless magnetic reconnection, jet stability, stellar winds and more. This article describes the capabilities of WiPAL, along with several experiments, in both operating and planning stages, that illustrate the range of possibilities for future users.
To assess nasal morbidity resulting from nasoseptal flap use in the repair of skull base defects in endoscopic anterior skull base surgery.
Methods:
Thirty-six patients awaiting endoscopic anterior skull base surgery were prospectively recruited. A nasoseptal flap was used for reconstruction in all cases. Patients were assessed pre-operatively and 90 days post-operatively via the Sino-Nasal Outcome Test 20 questionnaire and visual analogue scales for nasal obstruction, pain, secretions and smell; endoscopic examination findings and mucociliary clearance times were also recorded.
Results:
Sino-Nasal Outcome Test 20 questionnaire data and visual analogue scale scores for pain, smell and secretions showed no significant differences between pre- and post-operative outcomes, with visual analogue scale scores for nasal obstruction actually showing a significant improvement (p = 0.0007). A significant deterioration for both flap and non-flap sides was demonstrated post-operatively on endoscopic examination (p = 0.002 and p = 0.02 respectively).
Conclusion:
Whilst elevation of a nasoseptal flap in endoscopic surgery of the anterior skull base engendered significant clinical deterioration on examination post-operatively, quality of life outcomes showed that no such deterioration was subjectively experienced by the patient. In fact, there was significant nasal airway improvement following nasoseptal flap reconstruction.
We investigate the shock-induced turbulent mixing between a light and a heavy gas, where a Richtmyer–Meshkov instability (RMI) is initiated by a shock wave with Mach number $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}\mathit{Ma}= 1.5$. The prescribed initial conditions define a deterministic multimode interface perturbation between the gases, which can be imposed exactly for different simulation codes and resolutions to allow for quantitative comparison. Well-resolved large-eddy simulations are performed using two different and independently developed numerical methods with the objective of assessing turbulence structures, prediction uncertainties and convergence behaviour. The two numerical methods differ fundamentally with respect to the employed subgrid-scale regularisation, each representing state-of-the-art approaches to RMI. Unlike previous studies, the focus of the present investigation is to quantify the uncertainties introduced by the numerical method, as there is strong evidence that subgrid-scale regularisation and truncation errors may have a significant effect on the linear and nonlinear stages of the RMI evolution. Fourier diagnostics reveal that the larger energy-containing scales converge rapidly with increasing mesh resolution and thus are in excellent agreement for the two numerical methods. Spectra of gradient-dependent quantities, such as enstrophy and scalar dissipation rate, show stronger dependences on the small-scale flow field structures as a consequence of truncation error effects, which for one numerical method are dominantly dissipative and for the other dominantly dispersive. Additionally, the study reveals details of various stages of RMI, as the flow transitions from large-scale nonlinear entrainment to fully developed turbulent mixing. The growth rates of the mixing zone widths as obtained by the two numerical methods are ${\sim } t^{7/12}$ before re-shock and ${\sim } (t-t_0)^{2/7}$ long after re-shock. The decay rate of turbulence kinetic energy is consistently ${\sim } (t-t_0)^{-10/7}$ at late times, where the molecular mixing fraction approaches an asymptotic limit $\varTheta \approx 0.85$. The anisotropy measure $\langle a \rangle _{xyz}$ approaches an asymptotic limit of ${\approx }0.04$, implying that no full recovery of isotropy within the mixing zone is obtained, even after re-shock. Spectra of density, turbulence kinetic energy, scalar dissipation rate and enstrophy are presented and show excellent agreement for the resolved scales. The probability density function of the heavy-gas mass fraction and vorticity reveal that the light–heavy gas composition within the mixing zone is accurately predicted, whereas it is more difficult to capture the long-term behaviour of the vorticity.