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We investigate the three-dimensional (3-D) flow around and through a porous screen for various porosities at high Reynolds number $Re = {O}(10^4)$. Historically, the study of this problem has been focused on two-dimensional cases and for screens spanning completely or partially a channel. Since many recent problems have involved a porous object in a 3-D free flow, we present a 3-D model initially based on Koo & James (J. Fluid Mech., vol. 60, 1973, pp. 513–538) and Steiros & Hultmark (J. Fluid Mech., vol. 853, 2018 pp. 1–11) for screens of arbitrary shapes. In addition, we include an empirical viscous correction factor accounting for viscous effects in the vicinity of the screen. We characterize experimentally the aerodynamic drag coefficient for a porous square screen composed of fibres, immersed in a laminar air flow with various solidities and different angles of attack. We test various fibre diameters to explore the effect of the space between the pores on the drag force. Using PIV and hot wire probe measurements, we visualize the flow around and through the screen, and in particular measure the proportion of fluid that is deviated around the screen. The predictions from the model for drag coefficient, flow velocities and streamlines are in good agreement with our experimental results. In particular, we show that local viscous effects are important: at the same solidity and with the same air flow, the drag coefficient and the flow deviations strongly depend on the Reynolds number based on the fibre diameter. The model, taking into account 3-D effects and the shape of the porous screen, and including an empirical viscous correction factor that is valid for fibrous screens may have many applications including the prediction of water collection efficiency for fog harvesters.
The ultrastructure of spermiogenesis and the mature spermatozoon in Catenotaenia pusilla (Cestoda: Catenotaeniidae) is described. Spermiogenesis is characterized by the presence of a single axoneme which grows on the outside of a cytoplasmic extension at an angle of 45°. Flagellar rotation and proximodistal fusion are produced in this process. The centrioles lack striated roots and an intercentriolar body. In the mature spermatozoon four different regions are described. The anterior extremity is capped by an apical cone and presents two helical crest-like bodies of unequal length. The axoneme, of the 9 + ‘1’ pattern of the Trepaxonemata, presents a periaxonemal sheath. The cortical microtubules form a spiral pattern at an angle of about 40° to the hypothetical spermatozoon axis. The nucleus is kidney- to horseshoe-shaped in cross section. Granules and proteinaceus walls are not observed in the spermatozoon of C. pusilla.
Consumption of probiotics and/or yogurt could be a solution for restoring the balance of the gut microbiota. This study examined associations of regular intake of probiotic supplements or yogurt with the gut microbiota among a diverse population of older adults (N=1,861; 60–72 years). Faecal microbial composition was obtained from 16S rRNA gene sequencing (V1–V3 region). General linear models were used to estimate the associations of probiotic supplement or yogurt intake with microbiome measures adjusting for covariates. Compared to non-yogurt consumers (N=1,023), regular yogurt consumers (≥once/week, N=818) had greater Streptococcus (β=0.29, P=0.0003) and lower Odoribacter (β=−0.33, P<0.0001) abundance. The directions of the above associations were consistent across the five ethnic groups but stronger among Japanese Americans (Streptococcus: β=0.56, P=0.0009; Odoribacter: β=−0.62, P=0.0005). Regular intake of probiotic supplements (N=175) was not associated with microbial characteristics (i.e., alpha diversity and the abundance of 152 bacteria genera). Streptococcus is one of the predominant bacteria genera in yogurt products, which may explain the positive association between yogurt consumption and Streptococcus abundance. Our analyses suggest that changes in Odoribacter were independent of changes in Streptococcus abundance. Future studies may investigate whether these microbial genera and their sub-level species mediate potential pathways between yogurt consumption and health.
Signed in 2009, the plant protection Commission Regulation EC No 1107/2009 created a new category of active substances, the low-risk substances, with specific status defined in Article 22. The initial and specific criteria, not suitable for microorganisms and natural substances, were modified in 2018, and the first low-risk substance, allocating Part D of Regulation EC No 540/2011, was granted in the same year. Since then, thirty-three low-risk substances have been granted with this specific status through approvals and renewals, while a larger list of potential low-risk substances from already-approved active substances was published. This list is only exploited during renewals, and this process would take another five years to complete. After four years of the implementation of this status, the number of such substances is still low, but is intended to increase slowly. Two more low-risk substances are already pending in 2021, which will bring the number of low-risk substances to thirty-five, while the initial list of potential low-risk substances (only renewals) included fifty-seven substances.
Federal grant funding to support infrastructure development of translational biomedical research centers is a form of public health intervention. Establishing rigorous methods for measuring center success and outcomes is essential to justify continued funding.
Methods:
Bibliometric data compiled from a 5-year funding cycle of neurodegeneration and translational neuroscience research center were analyzed using the package bibliometrix for open-source software R and the NIH-developed research tool iCite.
Results:
The research team and their collaborators (n = 485) produced 157 grant-citing publications from 2015–2020. The science was produced by small research teams clustered around three main communities of topics: Alzheimer’s Disease, brain imaging, and neuropsychological testing in the elderly. Using the relative citation ratio, the publications produced by the research team were found to be influential when compared to other R01-funded publications.
Conclusion:
Recent developments in bibliometric analysis expand beyond traditional measurement capabilities to better understand the characteristics, outcomes, and influences of research teams. These findings can be used to inform researchers and institutions about research team composition, productivity, and success. Measures of research influence may be used to justify return on investment to funders.
As past usual diet quality may affect gut microbiome (GM) composition, we examined the association of the Healthy Eating Index (HEI)-2015 assessed 21 and 9 years before stool collection with measures of fecal microbial composition in a subset of the Multiethnic Cohort. A total of 5936 participants completed a validated quantitative FFQ (QFFQ) at cohort entry (Q1, 1993–1996), 5280 at follow-up (Q3, 2003–2008) and 1685 also at a second follow-up (Adiposity Phenotype Study (APS), 2013–2016). All participants provided a stool sample in 2013–2016. Fecal microbial composition was obtained from 16S rRNA gene sequencing (V1–V3 regions). HEI-2015 scores were computed based on each QFFQ. Using linear regression adjusted for relevant covariates, we calculated associations of HEI-2015 scores with gut microbial diversity and 152 individual genera. The mean HEI-2015 scores increased from Q1 (67 (sd 10)) to Q3 (71 (sd 11)) and APS (72 (sd 10)). Alpha diversity assessed by the Shannon Index was significantly higher with increasing tertiles of HEI-2015. Of the 152 bacterial genera tested, seven (Anaerostipes, Coprococcus_2, Eubacterium eligens, Lachnospira, Lachnospiraceae_ND3007, Ruminococcaceae_UCG-013 and Ruminococcus_1) were positively and five (Collinsella, Parabacteroides, Ruminiclostridium_5, Ruminococcus gnavus and Tyzzerella) were inversely associated with HEI-2015 assessed in Q1, Q3 and APS. The estimates of change per unit of the HEI-2015 score associated with the abundance of these twelve genera were consistent across the three questionnaires. The quality of past diet, assessed as far as ∼20 years before stool collection, is equally predictive of GM composition as concurrently assessed diet, indicative of the long-term consistency of this relation.
The specific status of active substance candidates for substitution (CfS) is detailed by Article 24 of plant protection Commission Regulation EC No 1107/2009 (PPP Regulation). The criteria of candidates for substitution are now clearly defined: low acceptable daily intake/acute reference dose/acceptable operator exposure level or two persistent, bio-accumulative or toxic criteria, or by nature of the critical effects: non-active isomers, carcinogen 1A/1B, toxic for reproduction 1A/1B or endocrine disruption properties, with these later properties now being well characterised. The total number of active substances CfS has been in constant evolution since 2011, with the first batch of candidates for substitution being published in 2015 and updated since then. After a slow decrease, growth is again observed, with another list of active substances being granted this status. CfS are substances targeted by the PPP Regulation that are supposed to be cancelled or non-renewed at the active substance level or substituted at the market authorisation level. CfS are also supposed to be replaced by substances with better toxicological profiles. However, after five years of implementation of the status, their number, which is intended to decrease, remains high, at sixty residual CfS. We exhibit here their evolution.
En France, 6,9 millions d’adultes sont obèses et le recours à la chirurgie bariatrique est en augmentation. L’évaluation psychiatrique est obligatoire [1] et il peut exister, nous semble-t-il, un biais de « non divulgation » [3] de symptômes dans le but d’obtenir « l’accord du psychiatre ». L’objectif principal de cette étude est de savoir s’il est utile de proposer des tests psychométriques en consultation psychiatrique préopératoire de chirurgie bariatrique en aide à la détection de comorbidités psychiatriques, et permettre ainsi l’amélioration de la prise en charge.
Methods
Étude monocentrique, anonyme, non interventionnelle visant à améliorer la prise en charge des patients candidats à la chirurgie bariatrique. Réalisée entre mars et octobre 2012. Inclusions des patients en deux temps : un premier temps avec un entretien clinique ouvert, un deuxième temps avec un entretien clinique structuré (MINI 5.0.0.).
Résultats
Vingt-huit patients inclus. La moyenne d’âge est de 37,2 ans, l’IMC moyen est de 43,2 kg/m2. Parmi les patients, 60,7 % présentaient au moins un trouble actuel ou passé au MINI contre 32,1 % en entretien clinique ouvert. Le MINI n’est pas significativement plus sensible que l’entretien clinique structuré pour la détection de l’ensemble des comorbidités psychiatriques (p = 0,2), par contre il est significativement plus sensible pour la détection des troubles anxieux (p = 0,02).
Conclusion
Prévalence d’au moins un trouble actuel ou passé proche des taux de la littérature scientifique [2] pour le MINI. Pour aider à la détection des comorbidités psychiatriques, en diminuant ce biais de « non divulgation », nous proposons un nouvel auto-questionnaire.
Brominated flame retardants (BFR) are primarily used as flame retardant additives in insulating materials. These lipophilic compounds can bioaccumulate in animal tissues, leading to human exposure via food ingestion. Although their concentration in food is not yet regulated, several of these products are recognised as persistent organic pollutants; they are thought to act as endocrine disruptors. The present study aimed to characterise the occurrence of two families of BFRs (hexabromocyclododecane (HBCDD) and polybrominated diphenyl ethers (PBDE)) in hen eggs and broiler or pig meat in relation to their rearing environments. Epidemiological studies were carried out on 60 hen egg farms (34 without an open-air range, 26 free-range), 57 broiler farms (27 without an open-air range, 30 free-range) and 42 pig farms without an open-air range in France from 2013 to 2015. For each farm, composite samples from either 12 eggs, five broiler pectoral muscles or three pig tenderloins were obtained. Eight PBDE congeners and three HBCDD stereoisomers were quantified in product fat using gas chromatography–high-resolution mass spectrometry, or high-performance liquid chromatography–tandem mass spectrometry, respectively. The frequencies of PBDE detection were 28% for eggs (median concentration 0.278 ng/g fat), 72% for broiler muscle (0.392 ng/g fat) and 49% for pig muscle (0.403 ng/g fat). At least one HBCDD stereoisomer was detected in 17% of eggs (0.526 ng/g fat), 46% of broiler muscle (0.799 ng/g fat) and 36% of pig muscle (0.616 ng/g fat). Results were similar in concentration to those obtained in French surveillance surveys from 2012 to 2016. Nevertheless, the contamination of free-range eggs and broilers was found to be more frequent than that of conventional ones, suggesting that access to an open-air range could be an additional source of exposure to BFRs for animals. However, the concentration of BFRs in all products remained generally very low. No direct relationship could be established between the occurrence of BFRs in eggs and meat and the characteristics of farm buildings (age, building materials). The potential presence of BFRs in insulating materials is not likely to constitute a significant source of animal exposure as long as the animals do not have direct access to these materials.
In the Miller Field, diagenetic quartz abundance, isotopic compositions and salinities of quartz-cementing fluids display a distinct pattern which is related to the structural depth of the reservoir sandstones. Quartz cement volumes increase from the crest of the field (average 6.0±1.5%) towards the flanks of the field (average 13.2±2.1%) and directly reduce reservoir porosity. By integrating petrographic observations with results of fluid inclusion measurements and O isotope analyses of diagenetic quartz, the pattern of quartz cementation is seen to be related to the reservoir filling history. Oil filled the crest of the reservoir first and prevented extensive quartz cementation. At greater depth in the reservoir oil zone, quartz overgrowths continued to precipitate until inhibited by the developing oil column. Oxygen isotope compositions of diagenetic quartz imply that quartz cement continued to precipitate in the water zone of the reservoir up to the present day.
Evidence suggests that egg intake may be implicated in the aetiology of sex hormone-related cancers. However, dose–response relationships between egg intake and such cancers are unclear. Thus, we conducted a dose–response meta-analysis to summarise the dose–response relationships between egg consumption and the risk of breast, prostate and gynaecological cancers. A literature search was performed using PubMed and Embase up to April 2015 to identify relevant prospective observational studies. Summary relative risk (RR) and 95 % CI were estimated using a random-effects model. For breast cancer, the linear dose–response meta-analysis found a non-significantly increased risk (RR for an increase of 5 eggs consumed/week: 1·05, 95 % CI 0·99, 1·11, n 16 023 cases). Evidence for non-linearity was not statistically significant (Pnon-linearity= 0·50, n 15 415 cases) but consuming ≥ 5 eggs/week was significantly associated with an increased risk of breast cancer compared with no egg consumption, with the summary RR being 1·04 (95 % CI 1·01, 1·07) for consuming 5 eggs/week and 1·09 (95 % CI 1·03, 1·15) for consuming about 9 eggs/week. For other cancers investigated, the summary RR for an increase of 5 eggs consumed/week was 1·09 (95 % CI 0·96, 1·24, n 2636 cases) for ovarian cancer; 1·47 (95 % CI 1·01, 2·14, n 609 cases) for fatal prostate cancer, with evidence of small-study effects (PEgger= 0·04). No evidence was found for an association with the risk of total prostate cancer. While our conclusion was tempered by the potential for publication bias and confounding, high egg intake may be associated with a modestly elevated risk of breast cancer, and a positive association between egg intake and ovarian and fatal prostate cancers cannot be ruled out.
To fulfill the transport applications, either for traction or on-board auxiliaries systems, a power generator based on fuel cell needs significant power. For this purpose, long fuel cell stacks, either mono- or multi-stack systems, are already implemented as technological solutions. Long stacks though may be affected by spatial discrepancies (fluidics, temperature) causing possible failures. The latter often occur on localized stack sections. A corrective action has to be taken to quickly restore the fuel cell’s state of health. As an alternative to fluidic action, segmented electric action is explored in this paper. First, an “All or Nothing” solution achieved with electrical by-pass circuits is analyzed: it proved simple to implement but restrictive to exploit. Consequently, a “gradual” action is proposed by using the power electronics converter associated to the fuel cell. Hence, the present work investigates the approach consisting in individually driving the electric power delivered by each segment of a long polymer electrolyte membrane fuel cell stack. Each segment is controlled independently according to its state of health. To achieve this objective, the article provides an extended multi-criteria analysis of several power converter topologies. The converter topology has to be in agreement with transportation specifications: simple, compact, having a high efficiency and should be adapted to manage fuel cell degraded modes. Among several studied topologies, resonant isolated boost stands out as a candidate topology. The related multi-port architecture and algorithm structure are analyzed by numerical simulations, taking into account degraded modes and technology considerations.
This paper focuses on the hysteresis effect of the polarization characteristics of a polymer electrolyte membrane fuel cell (PEMFC), mainly due to the compressor-air supply system dynamics. Indeed in PEMFC/ultracapacitor hybrid vehicles, fuel cells can be used to supply the low frequencies of the power demand only. First, the different parts of a FC system are described and modeled in order to analyze the transient stack performance decrease and to identify its main influential factors for automotive applications. Then, apart from humidity and temperature variations, each phenomenon is dynamically described, leading to a complete mathematical model based on macroscopic component parameters. Thus, an analytical model based on this set of equations enables us to draw the static voltage versus current FC characteristics. Furthermore, the hysteresis effect on the V-I curve, which still occurs during low dynamic responses, is shown while temperature and humidity are kept constant. Finally, dynamic responses of the Ballard PEMFC Nexa 1200 W generator are analyzed, and detailed experimentation and simulation are carried out for a large magnitude sinusoidal waveform at different frequencies.
PEM fuel cell performance and lifetime strongly depend on the polymer membrane and MEA hydration. As the internal moisture is very sensitive to the operating conditions (temperature, stoichiometry, load current, water management…), keeping the optimal working point is complex and requires real-time monitoring. This article focuses on PEM fuel cell stack health diagnosis and more precisely on stack fault detection monitoring. This paper intends to define new, simple and effective methods to get relevant information on usual faults or malfunctions occurring in the fuel cell stack. For this purpose, the authors present a fault detection method using simple and non-intrusive on-line technique based on the space signature of the cell voltages. The authors have the objective to minimize the number of embedded sensors and instrumentation in order to get a precise, reliable and economic solution in a mass market application. A very low number of sensors are indeed needed for this monitoring and the associated algorithm can be implemented on-line. This technique is validated on a 20-cell PEMFC stack. It demonstrates that the developed method is particularly efficient in flooding case. As a matter of fact, it uses directly the stack as a sensor which enables to get a quick feedback on its state of health.
The modeling and design of eddy currents sensors for non-destructive testing applications, generally, requires numerical methods. Among these methods, the finite element method is one of the most used. Indeed, it presents a great capability to treat a large variety of configurations. However, in the study of eddy current testing problems, the existence of structures that have a geometrical dimension smaller than the others (thin air gaps, coatings...) will lead to difficulties related to the meshing process. The introduction of particular elements such as shell elements allows to simplify the modeling of these problems. In this paper, the shell elements are used in two different 2D axisymmetric formulations, the electric formulation a* and the magnetic formulation t-ϕ in order to simulate the behaviour of the electromagnetic fields. The results obtained with the two formulations are compared with analytical solutions.
This paper deals with an original approach of the Switched Reluctance Machine (SRM) control for the purpose of reducing stator vibrations. Two combined approaches are studied in the aim of reducing the vibratory acceleration generated and thus the acoustic noise. The first one is based on a sinusoidal control of the magnetic phase current and the second one, on an optimal control of piezoelectric actuators (PZT) stuck on the SRM stator. The sinusoidal control of the magnetic phase current introduces properties on the vibratory acceleration distribution that are used to design an original actuator controller. Principles and viability of these combined vibration damping methods are deduced from theories and experiments.
Much work has been done in the past on the chemical composition of South African soils. The study of the physical properties of soils has, however, been somewhat neglected.
Transvaal soils differ from those of European countries in several important respects. In the first place, a large proportion of the soil is derived in situ from igneous rocks, and secondly, the country has never been glaciated in recent geological times. These two factors bear directly on the physical properties of the soils. Soil formation takes place chiefly by the chemical decomposition of rocks and only to a limited extent by mechanical disintegration. As a consequence we find in our soils very fine material, resulting from the chemical decomposition of easily weathered minerals, and rather coarse material which represents those rock constituents which are only subject in a limited degree to decomposition. In comparison with European soils particles of intermediate size do not play any dominant part in the mechanical make-up of Transvaal soils. Soils of alluvial origin are, of course, excepted. These latter occupy only a small area, but they are of considerable importance in the present stage of development of the country. Another factor which differentiates Transvaal soils from European ones is the presence in many of the former of finely divided hydrated ferric oxide. This feature will be discussed later.
Keen and Coutts(8) and Coutts(1) have suggested that the percentage of water in a soil at the sticky point is related to the colloidal content of the soil, as measured by “loss on ignition,” in the following manner:
S = mI + c,
i.e. by a rectilinear equation, and point out that the figure obtained for c approximates to the theoretical percentage of water held in the interstitial spaces of an ideal soil.
A one-dimensional Lagrangian code is used to model the interaction of laser light with plasma. The equation of state used is a realistic, piecewise analytic fit, which allows simulations starting from normal density and temperature conditions. The atomic physics required in the code (ionization, radiation rate, and opacities) is interpolated from tables generated using a non-LTE hydrogenic atom model. Radiation transport is treated approximately using a new, numerically efficient recursive algorithm. Results from numerical simulations are compared with recent X-ray measurements from Al, Ti, and Fe plasmas. The code is also used to investigate the X-ray conversion efficiency and the effect of radiation transport on the mass ablation rate and ablation pressure.