After right ventricular outflow tract obstruction reconstruction for CHD, surgical pulmonary valve replacement, or transcatheter pulmonary valve replacement may be performed if complicated by moderately severe or severe right ventricular outflow tract dysfunction. However, for patients whose anatomy is not suitable for transcatheter pulmonary valve replacement, surgical pulmonary valve replacement is the only option, but it has a higher rate of perioperative complications and longer hospitalisation for patients. In two cases of severe transcatheter pulmonary valve replacement in which percutaneous pulmonary valve implantation could not be performed directly due to the presence of a large right ventricle, a significant decrease in right ventricular function, and significant widening of the pulmonary arteries, we used a new hybridisation procedure to partially fold and reduce the diameter of the significantly widened pulmonary artery trunk without cardiopulmonary bypass by surgically opening the thorax in a median way, and then successfully implanted a percutaneous self-expanding pulmonary valve valve, with good immediate results in the postoperative period. The postoperative recovery was rapid and the recent results were excellent.

Glyphodes pyloalis Walker (Lepidoptera: Pyralidae) is a destructive monophagous pest of mulberry, Morus Linnaeus (Moraceae), trees. In order to identify mulberry cultivars resistant to G. pyloalis, 12 cultivars were examined using field and in vitro testing. Field observations indicated that cultivars AlbapC, BombyL, LaeviT, and CathaB had less than 10.0% damage, with no observed damage on the CathaB cultivar. The life table parameters showed that CathaB cultivar had the longest larval and pupal duration (23.2 days in total), the shortest adult period (5.3 days), the lowest rates of both pupation (55.0%) and adult emergence (69.7%), the highest adult mortality (61.7%), the lowest average weight of pupae (30.4 mg), and the lowest daily oviposition (5.0 eggs/female/day). The larval performance of G. pyloalis in the field revealed that CathaB had the lowest larval density. Correlation analyses confirmed that significant correlations exist between all the performance parameters of G. pyloalis for both the observed damage and larval performance. Leaf characterisation of selected cultivars indicated CathaB had significantly higher values of leaf wax, trichome density, soluble glucose, and protein contents compared to MultiQ. This study would be a valuable reference for evaluating pest-resistant cultivars and establishing a theoretical foundation for managing G. pyloalis.

This paper presents a peridynamics-based computational approach for modelling coupled fluid flow and heat transfer problems. A new thermo-hydrodynamic peridynamics model is formulated with the semi-Lagrangian scheme and non-local operators. To enhance accuracy and numerical stability, a multi-horizon scheme is developed to introduce distinct horizons for the flow field and thermal field. The multi-horizon scheme helps to capture the convective zone and complex thermal flow pattern while effectively mitigating possible oscillations in temperature. We validate the computational approach using benchmarks and numerical examples including heat conduction, natural convection in a closed cavity, and Rayleigh–Bénard convection cells. The results demonstrate that the proposed method can accurately capture typical thermal flow behaviours and complex convective patterns. This work offers a new foundation for future development of a unified peridynamics framework for robust, comprehensive multi-physics analysis of thermal fluid–solid interaction problems with complex evolving discontinuities in solids.

Asian corn borer, Ostrinia furnacalis Guenée (Lepidoptera: Crambidae), is a major pest in corn production, and its management remains a significant challenge. Current control methods, which rely heavily on synthetic chemical pesticides, are environmentally detrimental and unsustainable, necessitating the development of eco-friendly alternatives. This study investigates the potential of the entomopathogenic nematode Steinernema carpocapsae as a biological control agent for O. furnacalis pupae, focusing on its infection efficacy and the factors influencing its performance. We conducted a series of laboratory experiments to evaluate the effects of distance, pupal developmental stage, soil depth, and light conditions on nematode attraction, pupal mortality and sublethal impacts on pupal longevity and oviposition. Results demonstrated that S. carpocapsae exhibited the highest attraction to pupae at a 3 cm distance, with infection declining significantly at greater distances. Younger pupae (<12 h old), were more attractive to nematodes than older pupae, and female pupae were preferred over males. Nematode infection was highest on the head and thorax of pupae, with a significant reduction in infection observed after 24 h. Infection caused 100% mortality in pupae within 2 cm soil depth, though efficacy was reduced under light conditions. Sublethal effects included a significant reduction in the longevity of infected adults and a decrease in the number of eggs laid by infected females compared to controls. These findings underscore the potential of S. carpocapsae as an effective biocontrol agent for sustainable pest management in corn production, offering a viable alternative to chemical pesticides.

Land use change has significantly altered most ecosystem functioning, such as nutrition provisioning, water flows and pollination services. So far, the impact of land use change on the dietary diversity of predatory insects has remained largely unexplored. In this study, we explored the prey composition of reared yellow-legged hornets Vespa velutina Lepeletier (Hymenoptera: Vespidae) in landscapes with a gradient of surrounding green lands, using metabarcoding of feces eliminated by larvae. The hornets primarily fed upon insects, with dipterans, coleopterans, lepidopterans, hemipterans, hymenopterans, and orthopterans being the dominant prey groups. The percentage of green lands had a significantly positive effect on prey richness at a spatial scale of 1500 m, but no effect on Shannnon index of the prey community. Meanwhile, the green lands had significantly positive effects on richness of coleopteran prey and lepidopteran prey, but no significant effect on richness of dipteran prey, hemipteran prey, hymenopteran prey, or orthopteran prey. In terms of beta diversity, the percentage of green lands explained the dissimilarity of prey communities among landscapes, whereas local factors, such as the distance to green lands and the distance to buildings, did not explain the dissimilarity. Our study indicated that the green lands in the landscape positively affected the dietary diversity of reared yellow-legged hornets, but this effect varied among different taxonomic groups of prey.

This paper provides an overview of the current status of ultrafast and ultra-intense lasers with peak powers exceeding 100 TW and examines the research activities in high-energy-density physics within China. Currently, 10 high-intensity lasers with powers over 100 TW are operational, and about 10 additional lasers are being constructed at various institutes and universities. These facilities operate either independently or are combined with one another, thereby offering substantial support for both Chinese and international research and development efforts in high-energy-density physics.

Broadband frequency-tripling pulses with high energy are attractive for scientific research, such as inertial confinement fusion, but are difficult to scale up. Third-harmonic generation via nonlinear frequency conversion, however, remains a trade-off between bandwidth and conversion efficiency. Based on gradient deuterium deuterated potassium dihydrogen phosphate (KDxH2-xPO4, DKDP) crystal, here we report the generation of frequency-tripling pulses by rapid adiabatic passage with a low-coherence laser driver facility. The efficiency dependence on the phase-matching angle in a Type-II configuration is studied. We attained an output at 352 nm with a bandwidth of 4.4 THz and an efficiency of 36%. These results, to the best of our knowledge, represent the first experimental demonstration of gradient deuterium DKDP crystal in obtaining frequency-tripling pulses. Our research paves a new way for developing high-efficiency, large-bandwidth frequency-tripling technology.

This paper presents a numerical study on the flow around two tandem circular cylinders beneath a free surface at a Reynolds number of $180$. The free-surface effects on the wake dynamics and hydrodynamic forces are investigated through a parametric study, covering a parameter space of gap ratios from $0.20$ to $2.00$, spacing ratios from $1.50$ to $4.00$ and Froude numbers from $0.2$ to $0.8$. A jet-like flow accompanied by a shear layer of positive vorticity separating from the free surface is formed in the wake at small gap ratios, which significantly alters the wake pattern through its dynamic behaviours. At shallow submergence depths, the three-dimensional wake transitions from mode B to mode A as the distance between the cylinders increases. As submergence depth increases, the wavy deformation of the primary vortex cores disappears in the wake, and the flow transitions to a two-dimensional state. Higher Froude numbers can extend the effect of the free surface to deeper submergence depths. The critical spacing ratio tends to be larger at higher Froude numbers. Furthermore, the free-surface deformation is examined. The free-surface profile typically comprises a hydraulic jump immediately ahead of the upstream cylinder, trapped waves in the vicinity of the two tandem cylinders and well-defined travelling waves on the downstream side. The frequencies of the waves cluster around the vortex shedding frequency, indicating a close association between the generation of waves and the vortex shedding process.

The development of thermal boundary layers and plume near a section-triangular roof under different isothermal heating conditions has been the focus of numerous numerical studies. However, flow transition in this type of flow has never been observed experimentally. Here, phase-shifting interferometry and thermistor measurements are employed to experimentally observe and quantify the flow transitions in a buoyancy-driven flow over an isothermal section-triangular roof. Visualisation of temperature contours is conducted across a wide range of Rayleigh numbers from laminar at 103 to chaotic state at 4 × 106. Power spectral density of the temperature measurements reveals the type of bifurcations developing as the Rayleigh number is increased. This flow transition is characterised as a complex bifurcation route with the presence of two fundamental frequencies, a low and a high frequency. We found that the thermal stratification in the environment plays a significant role in the flow transition. The spatial development of flow is also quantitatively and qualitatively described. In addition to clarifying flow transition in experiments, the work demonstrates the implementation of phase-shifting interferometry and punctual temperature measurements for characterisation of near-field flow over a heated surface.

X-ray frequency combs (XFCs) are of great interest in many scientific research areas. In this study, we investigate the generation of high-power tunable XFCs at the Shanghai soft X-ray Free-Electron Laser facility (SXFEL). To achieve this, a chirped frequency-beating laser is employed as the seed laser for echo-enabled harmonic generation of free-electron lasers. This approach enables the formation of an initial bunching of combs and ultimately facilitates the generation of XFCs under optimized conditions. We provide an optical design for the chirped frequency-beating seed laser system and outline a method to optimize and set the key parameters that meets the critical requirements for generating continuously tunable XFCs. Three-dimensional simulations using realistic parameters of the SXFEL demonstrate that it is possible to produce XFCs with peak power reaching 1.5 GW, central photon energy at the carbon K edge (~284 eV) and tunable repetition frequencies ranging from 7 to 12 THz. Our proposal opens up new possibilities for resonant inelastic X-ray scattering experiments at X-ray free-electron laser facilities.

Milk fat is a high-value component of the U.S. dairy market. It is the major energy component of milk and is responsible for many organoleptic and technological characteristics of milk and dairy products. In addition, milk fat is unquestionably distinctive among all dietary fats that humans consume, as it is not only comprised of several hundred different fatty acids (FAs) but also contains a wide and unique array of bioactive lipids. Milk fat is dispersed in milk primarily in the form of fat globules. These cytoplasmic lipid droplets originate from mammary epithelial cells (MECs) and are secreted into the alveolar lumen surrounded by a membrane. Many advances in our knowledge of specific enzymes involved in milk lipid synthesis, the selectivity of the triacylglyceride (TAG) synthesis enzymes for specific FAs, the molecular mechanisms behind the uptake of long-chain FAs into the cells and the milk lipid secretion process have led to an improved understanding of the biology of milk fat synthesis. However, research to provide deeper insights into the mechanism of lipid synthesis in MECs is warranted and might lead to novel strategies to alter milk fat content and quality to benefit the dairy industry and meet dietary recommendations and consumer demands for foods that positively impact health. In this review, we aimed to provide a general overview of our current knowledge of the molecular aspects of milk lipid synthesis in MECs, from the uptake of blood-derived precursors to the intracellular formation of TAG-rich fat droplets secreted into milk as milk fat globules. We also highlight some current gaps in the knowledge that warrant further exploration. Given the importance of dairy food in the human diet, a better understanding of these processes could help develop novel strategies to alter milk fat composition in ways that benefit both human health and dairy producers.

Tree-ring cellulose is a commonly used material for radiocarbon analysis. Extracting cellulose is labor-consuming and several devices that enable batchwise extraction have been developed. However, these devices bear the risk of sample contamination. The present study describes a new device which improves upon two aspects of currently available devices. First, to prevent cross-sample-contamination, we redesigned the drainage module to enable independent removal of chemical waste from each individual sample funnel. Second, we added covers to the sample funnels to reduce the risk of external contamination. Cellulose purity (i.e., holocellulose) was confirmed by Fourier Transform Infrared (FTIR) Spectroscopy. Furthermore, accuracy of the radiocarbon analysis was confirmed by results of 14C-blank samples and samples of known age. In conclusion, while maintaining labor-saving, our modified device significantly reduces the risk of sample contamination during extraction of tree-ring cellulose.

The transition route and bifurcations of the buoyant flows developing on a heated horizontal circular surface are elaborated using direct numerical simulations and direct stability analysis. A series of bifurcations, as a function of Rayleigh numbers ($Ra$) ranging from $10^6$ to $6.0\times 10^7$, are found on the route to chaos of the flows at $Pr=7$. When $Ra<1.0\times 10^3$, the buoyant flows above the heated horizontal surface are dominated by conduction, because of which the distinct thermal boundary layer and plume are not present. At $Ra=1.1\times 10^6$, a Hopf bifurcation occurs, resulting in the flow transition from a steady state to a periodic puffing state. As $Ra$ increases further, the flow enters a periodic rotating state at $Ra=1.9\times 10^6$, which is a unique state that was rarely discussed in the literature. These critical transitions, leaving from a steady state and subsequently entering a series of periodic states (puffing, rotating, flapping and period-doubling) and finally leading to chaos, are diagnosed using two-dimensional Fourier transforms. Moreover, direct stability analysis is conducted by introducing random numerical perturbations into the boundary condition of the surface heating. We find that when the state of a flow is in the vicinity of critical values (e.g. $Ra=2.0\times 10^6$), the flow is conditionally unstable to perturbations, and it can bifurcate from the rotating state to the flapping state in advance. However, for relatively stable flow states, such as at $Ra=1.5\times 10^6$, the flow remains in its periodic puffing state even though it is being perturbed.

This cross-sectional and longitudinal study sought to refine the measurement of foreign language learning boredom (FLLB) and examine its links with overall/skill-specific second and foreign language (L2) achievement (curriculum-based course exam scores) and proficiency (Cambridge English test scores). In Substudy 1, we developed and validated an 11-item Foreign Language Learning Boredom Scale–Short Form among secondary and tertiary English as a foreign language (EFL) learners in China (n1 = 2,223, n2 = 504, n3 = 934, n4 = 1,109). The scale showed sound psychometric properties (i.e., construct/criterion/convergent/discriminant/predictive validity, reliability, and measurement invariance across time and groups). In Substudy 2, structural equation modeling results show that FLLB had a consistent modest negative effect on overall and skill-specific (vocabulary and grammar, listening, reading, and writing) L2 achievement and proficiency (n4 = 1,109). Substudy 3 was a 12-month three-semester longitudinal investigation (n4 = 1,109). Cross-lagged panel modeling results show that L2 achievement predicted subsequent FLLB negatively, while FLLB did not predict subsequent L2 achievement.

Visual simultaneous localisation and mapping (vSLAM) has shown considerable promise in positioning and navigating across a variety of indoor and outdoor settings, significantly enhancing the mobility of robots employed in industrial and everyday services. Nonetheless, the prevalent reliance of vSLAM technology on the assumption of static environments has led to suboptimal performance in practical implementations, particularly in unstructured and dynamically noisy environments such as substations. Despite advancements in mitigating the influence of dynamic objects through the integration of geometric and semantic information, existing approaches have struggled to strike an equilibrium between performance and real-time responsiveness. This study introduces a lightweight, multi-modal semantic framework predicated on vSLAM, designed to enable intelligent robots to adeptly navigate the dynamic environments characteristic of substations. The framework notably enhances vSLAM performance by mitigating the impact of dynamic objects through a synergistic combination of object detection and instance segmentation techniques. Initially, an enhanced lightweight instance segmentation network is deployed to ensure both the real-time responsiveness and accuracy of the algorithm. Subsequently, the algorithm’s performance is further refined by amalgamating the outcomes of detection and segmentation processes. With a commitment to maximising performance, the framework also ensures the algorithm’s real-time capability. Assessments conducted on public datasets and through empirical experiments have demonstrated that the proposed method markedly improves both the accuracy and real-time performance of vSLAM in dynamic environments.

Genes involved in melanin production directly impact insect pigmentation and can affect diverse physiology and behaviours. The role these genes have on sex behaviour, however, is unclear. In the present study, the crucial melanin pigment gene black was functionally characterised in an urban pest, the German cockroach, Blattella germanica. RNAi knockdown of B. germanica black (Bgblack) had no effect on survival, but did result in black pigmentation of the thoraxes, abdomens, heads, wings, legs, antennae, and cerci due to cuticular accumulation of melanin. Sex-specific variation in the pigmentation pattern was apparent, with females exhibiting darker coloration on the abdomen and thorax than males. Bgblack knockdown also resulted in wing deformation and negatively impacted the contact sex pheromone-based courtship behaviour of males. This study provides evidence for black function in multiple aspects of B. germanica biology and opens new avenues of exploration for novel pest control strategies.

Oxidative stress is a risk factor for mammary health, resulting in decreased milk yield and milk quality. Application of exogenous bioactive compounds has been a research focus of antioxidation of animals in the mammary gland. Quercetin is a flavonoid extracted from vegetables, fruits and tea and has been shown to have a variety of biological activities, but the effect of quercetin on redox imbalance in mammary epithelial cells is unclear. In this study, cells of HC11, a mouse mammary epithelial cell line, were treated with quercetin, and the effects and molecular mechanisms of quercetin protection on hydrogen peroxide-induced oxidative stress were studied. Results showed that 20 μΜ quercetin attenuated hydrogen peroxide-induced lactate dehydrogenase release and reactive oxygen species (ROS) accumulation and alleviated the reduction of cell viability and antioxidant capacity. Quercetin significantly restored the activation of mitogen-activated protein kinase (MAPK) and nuclear factor E2-related factor 2 (Nrf2) pathways induced by hydrogen peroxide. Importantly, the inhibitors of p38 MAPK and extracellular regulated protein pathways affected the activation of Nrf2 pathway. All inhibitors of MAPK and Nrf2 pathways reduced the protective effects of quercetin on cell proliferation, the activity of catalase and the expression of glutamate-cysteine ligase modifier subunit. Meanwhile, the effects of quercetin on the production of ROS and expression of glutamate/cystine reverse transporter light chain were mainly dependent on Nrf2 pathway. In summary, the protective effect of quercetin in mammary epithelial cells was mediated via MAPK and Nrf2 pathways.