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Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
The cooperative guidance problem of multiple inferior missiles intercepting a hypersonic target with the specific impact angle constraint in the two-dimensional plane is addressed in this paper, taking into consideration variations in a missile’s speed. The guidance law is designed with two subsystems: the direction of line-of-sight (LOS) and the direction of normal to LOS. In the direction of LOS, by applying the algebraic graph theory and the consensus theory, the guidance command is designed to make the system convergent in a finite time to satisfy the goal of cooperative interception. In the direction of normal to LOS, the impact angle is constrained to transform into the LOS angle at the time of interception. In view of the difficulty of measuring unknown target acceleration information in real scenarios, the guidance command is designed by utilising a super-twisting algorithm based on a nonsingular fast-terminal sliding mode (NFTSM) surface. Numerical simulation results manifest that the proposed guidance law performs efficiently and the guidance commands are free of chattering. In addition, the overall performance of this guidance law is assessed with Monte Carlo runs in the presence of measurement errors. The simulation results demonstrate that the robustness can be guaranteed, and that overall efficiency and accuracy in intercepting the hypersonic target are achieved.
N6-Methyladenosine (m6A) regulates oocyte-to-embryo transition and the reprogramming of somatic cells into induced pluripotent stem cells. However, the role of m6A methylation in porcine early embryonic development and its reprogramming characteristics in somatic cell nuclear transfer (SCNT) embryos are yet to be known. Here, we showed that m6A methylation was essential for normal early embryonic development and its aberrant reprogramming in SCNT embryos. We identified a persistent occurrence of m6A methylation in embryos between 1-cell to blastocyst stages and m6A levels abruptly increased during the morula-to-blastocyst transition. Cycloleucine (methylation inhibitor, 20 mM) treatment efficiently reduced m6A levels, significantly decreased the rates of 4-cell embryos and blastocysts, and disrupted normal lineage allocation. Moreover, cycloleucine treatment also led to higher levels in both apoptosis and autophagy in blastocysts. Furthermore, m6A levels in SCNT embryos at the 4-cell and 8-cell stages were significantly lower than that in parthenogenetic activation (PA) embryos, suggesting an abnormal reprogramming of m6A methylation in SCNT embryos. Correspondingly, expression levels of m6A writers (METTL3 and METTL14) and eraser (FTO) were apparently higher in SCNT 8-cell embryos compared with their PA counterparts. Taken together, these results indicated that aberrant nuclear transfer-mediated reprogramming of m6A methylation was involved in regulating porcine early embryonic development.
Supraglacial lakes and rivers dominate the storage and transport of meltwater on the southwest Greenland Ice Sheet (GrIS) surface. Despite functioning as interconnected hydrologic networks, supraglacial lakes and rivers are commonly studied as independent features, resulting in an incomplete understanding of their collective impact on meltwater storage and routing. We use Landsat 8 satellite imagery to assess the seasonal evolution of supraglacial lakes and rivers on the southwest GrIS during the 2015 melt season. Remotely sensed meltwater areas and volumes are compared with surface runoff simulations from three climate models (MERRA-2, MAR 3.6 and RACMO 2.3), and with in situ observations of proglacial discharge in the Watson River. We find: (1) at elevations >1600 m, 21% of supraglacial lakes and 28% of supraglacial rivers drain into moulins, signifying the presence of high-elevation surface-to-bed meltwater connections even during a colder-than-average melt season; (2) while supraglacial lakes dominate instantaneous surface meltwater storage, supraglacial rivers dominate total surface meltwater area and discharge; (3) the combined surface area of supraglacial lakes and rivers is strongly correlated with modeled surface runoff; and (4) of the three models examined here, MERRA-2 runoff yields the highest overall correlation with observed proglacial discharge in the Watson River.
The aim of this research was to identify variation in the yak lipin-1 gene (LPIN1) and determine whether this variation affects milk traits. PCR-single stranded conformational polymorphism (PCR-SSCP) analysis was used to detect variation in the 5′ untranslated region of LPIN1 in 500 yaks from four populations: Tianzhu white yaks, Qinghai yaks, wild × domestic-cross yaks and Gannan yaks. Four unique PCR-SSCP patterns, representing four different DNA sequence variants (named A, B, C and D), were observed. These contained six single nucleotide polymorphisms. Female Gannan yaks with BC genotype produced milk with a higher fat content (P < 0.001) and total milk solids (P < 0.001), than those with the AA, AB and BB genotypes. These results would suggest that LPIN1 is having an effect on yak milk fat synthesis.
A pair of bouncing geometric Brownian motions (GBMs) is studied. The bouncing GBMs behave like GBMs except that, when they meet, they bounce off away from each other. The object of interest is the position process, which is defined as the position of the latest meeting point at each time. We study the distributions of the time and position of their meeting points, and show that the suitably scaled logarithmic position process converges weakly to a standard Brownian motion as the bounce size δ→0. We also establish the convergence of the bouncing GBMs to mutually reflected GBMs as δ→0. Finally, applying our model to limit order books, we derive a simple and effective prediction formula for trading prices.
Pilophyllia Ge and Yu, 1974 represents a major group of distinctive amplexoid corals in the Silurian, whose taxonomic relationships, species composition, and evolutionary trends remain contentious. A critical revision of type material and new specimens of several species (and subspecies) assigned to Pilophyllia, including the type species P. involuta Ge and Yu, 1974, provides solutions to some of these problems. Pilophyllia is revised to include only those forms characterized by a distinct peripheral stereozone and amplexoid major septa with club-shaped rhabdacanths set in thick lamellar stereomes. Other species, previously referred to Pilophyllia but having generally short septa with wedge-shaped rhabdacanths, are transferred herein to the new genus Neopilophyllia Wang. Both genera, together with other Silurian amplexoid rugosan genera such as Amplexoides, are referred to the new family Amplexoididae Wang, which is thought to be evolutionarily unrelated to the much younger (Devonian to early Carboniferous) amplexoid rugosan family Amplexidae Chapman, 1893. The first appearance of Neopilophyllia n. gen. in the middle Telychian, much later than that of Pilophyllia in the late Rhuddanian, probably marks a significant stage during the evolution of Silurian amplexoid corals.
Previous studies using Fourier transformation (FT) methods to analyze subglacial roughness have shown promise for distinguishing between different types of subglacial landscape from raw subglacial elevation data. We derive a two-parameter FT roughness index {ξ, η}, where • is based on the FT of elevation (as previously considered in isolation), and η is based on both the FT of elevation and the FT of bed-slope profile. In this way, we take account of both vertical and horizontal irregularities in subglacial surfaces. We demonstrate the statistical veracity of using {ξ, η} to consider roughness in terms of obstacle amplitudes and spacing, and consider the use of {ξ, η} in studies of ice dynamics and subglacial geomorphological interpretation. We show that {ξ, η} can be linked to basal sliding rates on the metre scale, and can be used to differentiate further than single-parameter roughness indices between different classes of subglacial landscape, in particular between erosional and depositional settings.
Here, we present initial results from the ALFABURST radio transient survey, which is currently running in a commensal mode with the ALFA receiver at the Arecibo telescope. We observed for a total of 1400 hours and have detected single pulses from known pulsars but did not detect any FRBs. The non-detection of FRBs is consistent with the current FRB sky rates.
The effects of non-flooded plastic film mulching cultivation (PM) and polymer-coated urea (PCU) on rice yield, soil properties, and weed diversity were investigated in experimental plots of rice monoculture in Lanxi, China. The combination of PM and PCU increased rice yield. Compared with traditional flooded cultivation, under PM, soil pH remained higher, but decreased soil organic matter, total nitrogen, available phosphorus, and exchangeable potassium in the 0- to 10-cm soil layer. Soil fertility influenced winter weed communities, with hairy bittercress, Asian mazus, and shortawn foxtail being the most abundant species. Multivariate analysis indicated that changes in the winter weed species diversity were primarily due to exchangeable potassium. PCU had no significant influence on weed diversity, while plots without nitrogen fertilizer had higher spring-germinating weed density.
The thermal expansion behavior of polymer carbon nanotube (CNT) nanocomposites was investigated, and a micromechanical model was proposed to explain the highly nonlinear dependence of the coefficient of thermal expansion of the nanocomposite with CNT content for the CNT/polyimide nanocomposite. The microscopic analysis of CNT/polyimide matrix showed homogeneous dispersion of bundles composed of CNTs. Therefore, the proposed model to predict the thermal expansion behavior of the nanocomposite considered a random, homogeneous distribution of CNT bundles with a hierarchical arrangement of helical CNTs within the polymeric matrix. The CNT bundle morphology influenced the thermal expansion response of the nanocomposite through (i) bundle volume fraction and (ii) degree of helicity, affecting thermo-mechanical properties of the bundle. The effective, homogenized, properties of CNT bundles were determined by the elasticity based solution of the layered cylinder model. Bundle effective properties were used in the micromechanical model implementing the homogenized strain rule of the mixture expression to predict the thermal expansion behavior of nanocomposite in a wide range of CNT volume contents. The proposed micromechanical analytical model was found to correlate closely with the experimental results for polyimide/CNT nanocomposite films as measured using a digital image correlation method.