Capacity development is critical to long-term conservation success, yet we lack a robust and rigorous understanding of how well its effects are being evaluated. A comprehensive summary of who is monitoring and evaluating capacity development interventions, what is being evaluated and how, would help in the development of evidence-based guidance to inform design and implementation decisions for future capacity development interventions and evaluations of their effectiveness. We built an evidence map by reviewing peer-reviewed and grey literature published since 2000, to identify case studies evaluating capacity development interventions in biodiversity conservation and natural resource management. We used inductive and deductive approaches to develop a coding strategy for studies that met our criteria, extracting data on the type of capacity development intervention, evaluation methods, data and analysis types, categories of outputs and outcomes assessed, and whether the study had a clear causal model and/or used a systems approach. We found that almost all studies assessed multiple outcome types: most frequent was change in knowledge, followed by behaviour, then attitude. Few studies evaluated conservation outcomes. Less than half included an explicit causal model linking interventions to expected outcomes. Half of the studies considered external factors that could influence the efficacy of the capacity development intervention, and few used an explicit systems approach. We used framework synthesis to situate our evidence map within the broader literature on capacity development evaluation. Our evidence map (including a visual heat map) highlights areas of low and high representation in investment in research on the evaluation of capacity development.

Number and procedures of involuntary hospital admissions vary in Europe according to the different socio-cultural contexts. The European Commission has funded the EUNOMIA study in 12 European countries in order to develop European recommendations for good clinical practice in involuntary hospital admissions. The recommendations have been developed with the direct and active involvement of national leaders and key professionals, who worked out national recommendations, subsequently summarized into a European document, through the use of specific categories. The need for standardizing the involuntary hospital admission has been highlighted by all centers. In the final recommendations, it has been stressed the need to: providing information to patients about the reasons for hospitalization and its presumable duration; protecting patients’ rights during hospitalization; encouraging the involvement of family members; improving the communication between community and hospital teams; organizing meetings, seminars and focus-groups with users; developing training courses for involved professionals on the management of aggressive behaviors, clinical aspects of major mental disorders, the legal and administrative aspects of involuntary hospital admissions, on communication skills. The results showed the huge variation of involuntary hospital admissions in Europe and the importance of developing guidelines on this procedure.

Aquarium release is a vector for introducing nonnative species that threatens the ecological integrity of aquatic systems. Following coastal invasions by released aquarium strains of Caulerpa taxifolia, aquarists began using the macroalgal genus Chaetomorpha. Use of Chaetomorpha now exceeds 50% of U.S. aquarium hobbyists we surveyed. Aquarium strains of this macroalgal genus possess broad environmental tolerances, demonstrate high nutrient uptake and growth rates, and reproduce by fragmentation. Although these characteristics make Chaetomorpha a desirable aquarium inhabitant, they may also promote invasive tendencies if the alga is introduced into a natural ecosystem. We sought to proactively mitigate this potential invasion risk by testing algal disposal techniques that serve as responsible alternatives to releasing viable individuals. We tested methods used by aquarium hobbyists—boiling, microwaving, freezing, desiccation, and exposure to freshwater. We determined the minimum durations that these techniques must be used in order to induce mortality in three aquarium purchases of Chaetomorpha. We found that boiling for at least 1 min, microwaving for at least 15 s, or freezing for at least 24 h were sufficient to induce 100% mortality in 1-cm-long fragments and clumps up to 1.5 g. Desiccation required more than 24 h when exposed to air and 6 d for samples kept in closed containers. Freshwater exposure was effective at 6 d. These results indicate that disposal of excess or unwanted Chaetomorpha via garbage (if destined for a landfill) or indoor plumbing (e.g., sinks and toilets) represent safe alternatives to release. Disposal of algal tissue, shipping water, or tank water containing small algal fragments down stormwater drains, however, could introduce this hardy species into favorable conditions that could result in detrimental biological invasions.

We present a Newtonian, one-dimensional, differential analysis for capillary breakup rheometry (CBR) to determine the surface tension to viscosity ratio $\unicode[STIX]{x1D6FC}$ . Our local differential analysis does not require specific assumptions for the axial force to preclude its measurement. Our analysis indicates that measuring gradients in filament curvature is necessary to accurately determine $\unicode[STIX]{x1D6FC}$ when axial force is not measured. CBR experiments were performed on five silicone oils ( $0.35~\text{Pa}~\text{s}<\unicode[STIX]{x1D707}<10~\text{ Pa}~\text{s}$ ), three sample volumes, and three strains to evaluate the operating range of the differential analysis and compare its performance to that of a standard integral method from literature. We investigate the role of filament asymmetry, caused mainly by gravity, on the performance of the differential method for the range of conditions studied. Experimental and analytical details for resolving gradients of curvature are also given.

We report two patients with dyskinesia responding to antidepressants. The first is a 70-year-old man with depression, Parkinsonism and neuroleptic-induced tardive dyskinesia who presented with hysterical mutism. After recovery from the mutism, he was started on desipramine for depression. One week later the dyskinesia improved markedly. The second patient is a 61-year-old man with Parkinson's disease, dementia, depression and L-dopa-induced oro-lingual-facial dyskinesias. He was taking levodopa, trihexyphenydil and bromocriptine. The depression was treated first with desipramine and later with trazodone. The dyskinesia improved significantly on both drugs. The response of the dyskinesias to antidepressant medication may be due to the fact that antidepressants decrease beta-adrenoreceptor sensitivity and density which in turn may result in a diminished release of dopamine since beta-adrenoceptors mediate the noradrenaline-stimulated release of dopamine.

Polymer drag reduction, diffusion and degradation in a high-Reynolds-number turbulent boundary layer (TBL) flow were investigated. The TBL developed on a flat plate at free-stream speeds up to 20ms−1. Measurements were acquired up to 10.7m downstream of the leading edge, yielding downstream-distance-based Reynolds numbers up to 220 million. The test model surface was hydraulically smooth or fully rough. Flow diagnostics included local skin friction, near-wall polymer concentration, boundary layer sampling and rheological analysis of polymer solution samples. Skin-friction data revealed that the presence of surface roughness can produce a local increase in drag reduction near the injection location (compared with the flow over a smooth surface) because of enhanced mixing. However, the roughness ultimately led to a significant decrease in drag reduction with increasing speed and downstream distance. At the highest speed tested (20ms−1) no drag reduction was discernible at the first measurement location (0.56m downstream of injection), even at the highest polymer injection flux (10 times the flux of fluid in the near-wall region). Increased polymer degradation rates and polymer mixing were shown to be the contributing factors to the loss of drag reduction. Rheological analysis of liquid drawn from the TBL revealed that flow-induced polymer degradation by chain scission was often substantial. The inferred polymer molecular weight was successfully scaled with the local wall shear rate and residence time in the TBL. This scaling revealed an exponential decay that asymptotes to a finite (steady-state) molecular weight. The importance of the residence time to the scaling indicates that while individual polymer chains are stretched and ruptured on a relatively short time scale (~10−3s), because of the low percentage of individual chains stretched at any instant in time, a relatively long time period (~0.1s) is required to observe changes in the mean molecular weight. This scaling also indicates that most previous TBL studies would have observed minimal influence from degradation due to insufficient residence times.

Defining the causal relationship between a microbe and encephalitis is complex. Over 100 different infectious agents may cause encephalitis, often as one of the rarer manifestations of infection. The gold-standard techniques to detect causative infectious agents in encephalitis in life depend on the study of brain biopsy material; however, in most cases this is not possible. We present the UK perspective on aetiological case definitions for acute encephalitis and extend them to include immune-mediated causes. Expert opinion was primarily used and was supplemented by literature-based methods. Wide usage of these definitions will facilitate comparison between studies and result in a better understanding of the causes of this devastating condition. They provide a framework for regular review and updating as the knowledge base increases both clinically and through improvements in diagnostic methods. The importance of new and emerging pathogens as causes of encephalitis can be assessed against the principles laid out here.

A set of controlled high-Reynolds-number experiments has been conducted at the William B. Morgan Large Cavitation Channel (LCC) in Memphis, Tennessee to investigate the friction drag reduction achieved by injecting aqueous poly(ethylene oxide) (PEO) solutions at three different mean molecular weights into the near-zero-pressure-gradient turbulent boundary layer that forms on a smooth flat test surface having a length of nearly 11m. The test model spanned the 3.05m width of the LCC test section and had an overall length of 12.9m. Skin-friction drag was measured with six floating-plate force balances at downstream-distance-based Reynolds numbers as high as 220 million and free stream speeds up to 20ms−1. For a given polymer type, the level of drag reduction was measured for a range of free stream speeds, polymer injection rates and concentrations of the injected solution. Polymer concentration fields in the near-wall region (0 < y+ < ~103) were examined at three locations downstream of the injector using near-wall planar laser-induced-fluorescence imaging. The development and extent of drag reduction and polymer mixing are compared to previously reported results using the traditional K-factor scaling. Unlike smaller scale and lower speed experiments, speed dependence is observed in the K-scaled results for the higher molecular weight polymers and it is postulated that this dependence is caused by molecular aggregation and/or flow-induced polymer degradation (chain scission). The evolution of near-wall polymer concentration is divided into three regimes: (i) the development region near the injector where drag reduction increases with downstream distance and the polymer is highly inhomogeneous forming filaments near the wall, (ii) the transitional mixing region where drag reduction starts to decrease as the polymer mixes across the boundary layer and where filaments are less pronounced and (iii) the final region where the polymer mixing and dilution is set by the rate of boundary layer growth. Unlike pipe-flow friction-drag reduction, the asymptotic maximum drag reduction (MDR) either was not reached or did not persist in these experiments. Instead, the nearest approach to MDR was transitory and occurred between the development and transitional regions. The length of the development region was observed to increase monotonically with increasing polymer molecular weight, injection rate, concentration and decreasing free stream speed. And finally, the near-wall polymer concentration is correlated to the measured drag reduction for the three polymer molecular weights in the form of a proposed empirical drag-reduction curve.