We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Antarctica's ice shelves modulate the grounded ice flow, and weakening of ice shelves due to climate forcing will decrease their ‘buttressing’ effect, causing a response in the grounded ice. While the processes governing ice-shelf weakening are complex, uncertainties in the response of the grounded ice sheet are also difficult to assess. The Antarctic BUttressing Model Intercomparison Project (ABUMIP) compares ice-sheet model responses to decrease in buttressing by investigating the ‘end-member’ scenario of total and sustained loss of ice shelves. Although unrealistic, this scenario enables gauging the sensitivity of an ensemble of 15 ice-sheet models to a total loss of buttressing, hence exhibiting the full potential of marine ice-sheet instability. All models predict that this scenario leads to multi-metre (1–12 m) sea-level rise over 500 years from present day. West Antarctic ice sheet collapse alone leads to a 1.91–5.08 m sea-level rise due to the marine ice-sheet instability. Mass loss rates are a strong function of the sliding/friction law, with plastic laws cause a further destabilization of the Aurora and Wilkes Subglacial Basins, East Antarctica. Improvements to marine ice-sheet models have greatly reduced variability between modelled ice-sheet responses to extreme ice-shelf loss, e.g. compared to the SeaRISE assessments.
To investigate whether measurement of plasma levels can predict tolerance to oxcarbazepine (OXC).
Methods
We reviewed medical records to identify all inpatients consecutively treated by OXC at the University Department of Psychiatry in Bordeaux. Adverse effects were rated before treatment onset, at day 3, then every week and at discharge or at discontinuation. Residual hydroxy-OXC concentrations were measured on blood samples at the same periods.
Results
OXC was prescribed to 20 patients with bipolar (n = 18) or schizoaffective bipolar-type disorder (n = 2). Reported side effects were transient and occurred mostly at the beginning of the treatment. Three patients stopped OXC because of severe cutaneous side effects. Residual hydroxy-OXC plasma levels were similar in patients with or without occurrence of side effects at all times of assessment.
Conclusion
Our data suggest that the occurrence of severe side-effects is relatively high with OXC. Measurement of plasma OXC levels does not appear to be of interest in clinical practice since plasma concentrations are not predictive of the occurrence of side effects.
Prenatal exposure to persistent organic pollutants (POPs) has been associated with the development of metabolic syndrome-related diseases in offspring. According to epidemiological studies, father’s transmission of environmental effects in addition to mother’s can influence offspring health. Moreover, maternal prenatal dietary folic acid (FA) may beneficially impact offspring health. The objective is to investigate whether prenatal FA supplementation can overcome the deleterious effects of prenatal exposure to POPs on lipid homeostasis and inflammation in three generations of male rat descendants through the paternal lineage. Female Sprague-Dawley rats (F0) were exposed to a POPs mixture (or corn oil) +/− FA supplementation for 9 weeks before and during gestation. F1 and F2 males were mated with untreated females. Plasma and hepatic lipids were measured in F1, F2, and F3 males after 12-h fast. Gene expression of inflammatory cytokines was determined by qPCR in epididymal adipose tissue. In F1 males, prenatal POPs exposure increased plasma lipids at 14 weeks old and hepatic lipids at 28 weeks old and prenatal FA supplementation decreased plasma total cholesterol at 14 weeks old. Prenatal POPs exposure decreased plasma triglycerides at 14 weeks old in F2 males. No change was observed in inflammatory markers. Our results show an impact of the paternal lineage on lipid homeostasis in rats up to the F2 male generation. FA supplementation of the F0 diet, regardless of POPs exposure, lowered plasma cholesterol in F1 males but failed to attenuate the deleterious effects of prenatal POPs exposure on plasma and hepatic lipids in F1 males.
Radiocarbon (14C) results on cremated bone are frequently published in high-ranking journals, but 14C laboratories employ different pretreatment methods as they have divergent perceptions of what sources of contaminants might be present. We found pretreatment protocols to vary significantly between three laboratories (Brussels [RICH], Kiel [KIA], and Groningen [CIO]), which all have a long history of dating cremated bone. We present a case study of 6 sets of replicate dates, to compare laboratory pretreatment protocols, and a further 16 sets of inter-laboratory replicate measurements, which compare specific steps of the conversion and measuring process. The 14C results showed dates to be reproducible between the laboratories and consistent with the expected archaeological chronology. We found that differences in pretreatment, conversion to CO2 and accelerator mass spectrometry (AMS) measurement to have no measurable influence on the majority of obtained results, suggesting that any possible diagenesis was probably restricted to the most soluble ≤5% of each sample, as this proportion of the sample mass was removed under all laboratory protocols.
Delirium is very frequent in older patients presenting to the emergency department (ED), but is often undetected. The purpose of this study was to evaluate the performance of the French version of the 4 A’s Test (4AT-F) for the detection of delirium and cognitive impairment in older patients.
Methods
The study was conducted in four Canadian ED. Participants (n= 320) were independent or semi-independent patients (able to perform ≥5 activities of daily living) aged 65 and older and had an 8-hour exposure to the ED environment. The Telephone Interview for Cognitive Status (TICS-m), the Confusion Assessment Method (CAM) as well as the 4AT-F were administered to patients at the initial interview. The CAM and 4AT-F were then administered twice a day during the patients’ ED or hospital stay. The 4AT-F’s sensitivity and specificity were compared to those of the CAM (for delirium), and to that of the TICS (for cognitive impairment).
Results
Our results suggest that the 4AT-F has a sensitivity of 84% (95% CI: [76, 93]) and a specificity of 74% (95% CI: [70, 78]) for delirium, as well as a sensitivity of 49% (95% CI: [34, 64]) and a specificity of 87% (95% CI: [82, 92]) for cognitive impairment.
Conclusion
The 4AT-F is a fast and reliable screening tool for delirium and cognitive impairment in ED. Due to its quick administration time, it allows a systematic screening of patients at risk of delirium, without significantly increasing the workload of the ED staff.
Ice flow numerical models are essential for predicting the evolution of ice sheets in a warming climate. Recent research emphasizes the need for higher-order and even full-Stokes flow models, instead of the traditional shallow-ice approximation, whose assumptions are not valid in certain critical areas. These higher-order models are, however, computationally intensive and difficult to use at the continental scale. Here we present a new technique, the Tiling method, to couple ice flow models of varying orders of complexity. The goal of the method is to limit the spatial extent of where higherorder models are applied to reduce the computational cost, while maintaining the model precision. We apply this method on synthetic geometries to demonstrate its practical use. We first use a geometry for which all models yield the same results to check the consistency of the method. Then we apply our method to a geometry for which a full-Stokes model is required in the vicinity of the ice front. Our results show that the hybrid models present significant improvements over mono-model approaches and reduce computational times.
Ten ice-sheet models are used to study sensitivity of the Greenland and Antarctic ice sheets to prescribed changes of surface mass balance, sub-ice-shelf melting and basal sliding. Results exhibit a large range in projected contributions to sea-level change. In most cases, the ice volume above flotation lost is linearly dependent on the strength of the forcing. Combinations of forcings can be closely approximated by linearly summing the contributions from single forcing experiments, suggesting that nonlinear feedbacks are modest. Our models indicate that Greenland is more sensitive than Antarctica to likely atmospheric changes in temperature and precipitation, while Antarctica is more sensitive to increased ice-shelf basal melting. An experiment approximating the Intergovernmental Panel on Climate Change’s RCP8.5 scenario produces additional first-century contributions to sea level of 22.3 and 8.1 cm from Greenland and Antarctica, respectively, with a range among models of 62 and 14 cm, respectively. By 200 years, projections increase to 53.2 and 26.7 cm, respectively, with ranges of 79 and 43 cm. Linear interpolation of the sensitivity results closely approximates these projections, revealing the relative contributions of the individual forcings on the combined volume change and suggesting that total ice-sheet response to complicated forcings over 200 years can be linearized.
Predictions of marine ice-sheet behaviour require models able to simulate grounding-line migration. We present results of an intercomparison experiment for plan-view marine ice-sheet models. Verification is effected by comparison with approximate analytical solutions for flux across the grounding line using simplified geometrical configurations (no lateral variations, no buttressing effects from lateral drag). Perturbation experiments specifying spatial variation in basal sliding parameters permitted the evolution of curved grounding lines, generating buttressing effects. The experiments showed regions of compression and extensional flow across the grounding line, thereby invalidating the boundary layer theory. Steady-state grounding-line positions were found to be dependent on the level of physical model approximation. Resolving grounding lines requires inclusion of membrane stresses, a sufficiently small grid size (<500 m), or subgrid interpolation of the grounding line. The latter still requires nominal grid sizes of <5 km. For larger grid spacings, appropriate parameterizations for ice flux may be imposed at the grounding line, but the short-time transient behaviour is then incorrect and different from models that do not incorporate grounding-line parameterizations. The numerical error associated with predicting grounding-line motion can be reduced significantly below the errors associated with parameter ignorance and uncertainties in future scenarios.
The mechanical properties of glacier beds play a fundamental role in regulating the sensitivity of glaciers to environmental forcing across a wide range of timescales. Glaciers are commonly underlain by deformable till whose mechanical properties and influence on ice flow are not well understood but are critical for reliable projections of future glacier states. Using synoptic-scale observations of glacier motion in different seasons to constrain numerical ice flow models, we study the mechanics of the bed beneath Hofsjökull, a land-terminating ice cap in central Iceland. Our results indicate that the bed deforms plastically and weakens following incipient summertime surface melt. Combining the inferred basal shear traction fields with a Coulomb-plastic bed model, we estimate the spatially distributed effective basal water pressure and show that changes in basal water pressure and glacier accelerations are non-local and non-linear. These results motivate an idealized physical model relating mean basal water pressure and basal slip rate wherein the sensitivity of glacier flow to changes in basal water pressure is inversely related to the ice surface slope.
Hydrodynamic journal bearings supporting high mass rotating machinery are subjected tolow rotational speeds during start-up or idling phases. These working conditions need ahydrostatic pressure contribution to ensure a correct load capacity when the hydrodynamicpressure is not established yet. This is possible by means of hydrostatic lift pockets.These pockets avoid mechanical damages via sufficient film thickness from start-up tohydrodynamic working conditions. In a first part, it is showed how an existing isothermal3D hydrodynamic numerical modelling of tilting pad bearing has been adapted to take intoaccount the lift pocket impact on static bearing performance. This approach is only validfor low rotational speeds, when inertia step pressure effects (rises or drops) at thefilm-pocket edge can be neglected compared to the total bearing pressure pattern. Then,numerical simulations have been performed, from 1 to 200 rpm with pockets and from 75 to200 rpm without pockets. The results have been compared and discussed in terms of pressurefields and bearing static performance such minimum film thickness, friction torque orrotor center position. Therefore, the interest of such lift pockets has been highlighted.Finally, calculations with and without pockets have been carried out in case of a strongbearing misalignment. As a result, the benefits of the lift pockets in this configurationare also significant in terms of static performance.
In this paper we deal with the preemptive asymmetric stacker crane problem in a heuristic way. We first present some theoretical results which allow us to turn this problem into a specific tree design problem. We next derive from this new representation an integer linear programming model together with simple and efficient greedy and local search heuristics. We conclude by presenting experimental results which aim at both testing the efficiency of our heuristic and evaluating the impact of the preemption hypothesis.
In this paper, we investigate the computation of the moments of the compound Poisson sums with discounted claims when introducing dependence between the interclaim time and the subsequent claim size. The dependence structure between the two random variables is defined by a Farlie-Gumbel-Morgenstern copula. Assuming that the claim distribution has finite moments, we give expressions for the first and the second moments and then we obtain a general formula for any mth order moment. The results are illustrated with applications to premium calculation and approximations based on moment matching methods.
Several studies have been carried out in order to describe the impact ofwater-contaminated lubricants on lubrication performance. One approach considers thewater-contaminated oil as a homogeneous lubricant with physical characteristics varyingwith water concentration. The presented work is being achieved in order to experimentallyvalidate this theory. First investigations showed that the variation of contaminatedlubricant viscosity has the most significant effect on lubricating performance.Consequently, the lubricant viscosity is the only parameter taken into account in thisstudy. Thus, based on the rheological measurements, water-in-oil emulsion viscosity hasbeen modelled according to water concentration and temperature. Water concentration wasconsidered relatively to total mass of oil: the mass concentration varied then from 0 to7% and temperature from 10 to 80 °C. Viscosity modelling was then used to perform thenumerical simulations of a hydrodynamic thrust bearing supplied with water contaminatedoil. Finally, the experimental validation will be done by measuring various bearingcharacteristics like the film/pad temperature, the film thickness and the friction torqueon a tilting pad thrust bearing test rig.
Investigar si la medida de las concentraciones en plasma puede predecir la tolerancia a oxcarbacepina (OXC).
Métodos
Revisamos las historias médicas para identificar a todos los pacientes ingresados consecutivamente y tratados con OXC en el Departamento de Psiquiatría de la Universidad de Burdeos. Los efectos adversos se puntuaron antes del inicio del tratamiento, el día 3 y, después, cada semana y en el momento del alta o de la suspensión del tratamiento. Se midieron las concentraciones residuales de hidroxi-OXC en muestras de sangre recogidas en los mismos períodos.
Resultados
Se prescribió OXC a 20 pacientes con trastorno bipolar («= 18) o bipolar esquizoafectivo (n=2). Los efectos secundarios encontrados fueron transitorios y ocurrieron sobre todo al principio del tratamiento. Tres pacientes suspendieron la OXC debido a efectos secundarios cutáneos graves. Las concentraciones residuales de hidroxi-OXC en plasma eran similares en pacientes con o sin efectos secundarios en cualquier momento de la evaluación.
Conclusión
Nuestros datos sugieren que la aparición de efectos secundarios graves es relativamente alta con OXC. La medida de las concentraciones de OXC en plasma no parece tener interés en la práctica clínica ya que estas concentraciones en plasma no predicen la aparición de efectos secundarios.
Here we demonstrate the synthesis of a new type of layered poly(3,4-ethylenedioxy- thiophene) (PEDOT)/MoS2 nanocomposite via flocculation of delaminated MoS2 with subsequent in situ oxidative polymerization of 3,4-ethylenedioxythiophene. The resulting nanocomposite was characterized by Fourier transform infrared spectroscopy, powder x-ray diffraction, x-ray photoelectron spectroscopy, thermal analysis, transmission electron microscopy, and four-probe electrical conductivity measurements with respect to temperature. X-ray diffraction results indicated that the exfoliated MoS2 and PEDOT are restacked to produce a novel nanoscale composite material containing alternate nanoribbons of PEDOT in between MoS2 with a basal distance of ∼1.38 nm. The nanocomposite, which could be used as a cathode material for small power rechargeable lithium batteries, has also been demonstrated by the electrochemical insertion of lithium into the PEDOT/MoS2 nanocomposite, where a significant enhancement in the discharge capacity is observed, compared to that of respective pristine molybdenum disulfide.
Hydrostatic bearings working at high rotational speeds are usually designed as hybrid bearings. They benefit of a load carrying capacity at low or zero speed and of a reduced torque at high working regimes. Therefore they are provided with pockets or recesses fed via hydraulic restrictors. Modeling the flow in these pockets and its coupling with thin film in the bearing is not a straightforward task. Comparisons with experimental data have shown that the capacity of correctly predicting the bearing characteristics (mainly the dynamic coefficients) is influenced by the accurate modeling of the pressure pattern in the pockets. The present work presents typical recess pressure patterns and shows the way they can influence on the bearing characteristics.
Recommend this
Email your librarian or administrator to recommend adding this to your organisation's collection.