Almost 12% of the human population have insufficient access to food and hence are at risk from nutrient deficiencies and related conditions, such as anaemia and stunting. Ruminant meat and milk are rich in protein and micronutrients, making them a highly nutritious food source for human consumption. Conversely, ruminant production contributes to methane (CH4) emissions, a greenhouse gas (GHG) with a global warming potential (GWP) 27-30 times greater than that of carbon dioxide (CO2). Nonetheless, ruminant production plays a crucial role in the circular bioeconomy in terms of upcycling agricultural products that cannot be consumed by humans, into valuable and nutritional food, whilst delivering important ecosystem services. Taking on board the complexities of ruminant production and the need to improve both human and planetary health, there is increasing emphasis on developing innovative solutions to achieve sustainable ruminant production within the ‘One Health’ framework. Specifically, research and innovation will undoubtedly continue to focus on 1) Genetics and Breeding; 2) Animal nutrition and 3) Animal Health, to achieve food security and human health, whilst limiting environmental impact. Implementation of resultant innovations within the agri-food sector will require several enablers, including large-scale investment, multi-actor partnerships, scaling, regulatory approval and importantly social acceptability. This review outlines the grand challenges of achieving sustainable ruminant production and likely research and innovation landscape over the next 15 years and beyond, specifically outlining the pathways and enablers required to achieve sustainable ruminant production within the One Health framework.

While many children in Africa face notable psychological problems, the majority do not receive needed mental health services. The My FRIENDS Youth Program, a universal cognitive-behavioral intervention for anxiety prevention and resilience enhancement, has demonstrated effectiveness across cultures in children and adolescents. This study explores whether the program’s effectiveness extends to Zambian children. Participants were 75 children and adolescents (53% female, ages 10–15) attending low-income schools in Zambia. Four schools were randomly assigned to an intervention (n = 44) or waitlist control (n = 31). The intervention consisted of 10 weekly sessions plus two booster sessions administered in group format. Assessments were conducted at pre-intervention, immediately post-intervention and 3-month follow-up. Data were analyzed using longitudinal multilevel modeling and controlled for child and parent sociodemographic characteristics. Intervention participation did not lead to reductions in anxiety, depression or parent-child relationship conflict but was associated with reductions in parent-reported internalizing and externalizing symptoms, attention problems and increases in positive parent-child relationships. However, both the intervention and control groups exhibited lower anxiety symptoms from Post-Intervention to 3-Month Follow-Up, suggesting potentially delayed effects. Future research may need to adapt this intervention to meet the needs of children in Zambia.

The challenging tracking control issue for a space manipulator subject to parametric uncertainty and unknown disturbance is addressed in this paper. An observer-based fixed-time terminal sliding mode control methodology is put forward. Firstly, a nonlinear disturbance observer is introduced for exactly reconstructing the lumped uncertainty without requiring any prior knowledge of the lumped uncertainty. Meanwhile, the estimation time’s upper bound is not only irrelevant to the initial estimation error but can be directly predicted in advance via a specific parameter in the observer. Invoking the estimated information, a fast fixed-time tracking controller with strong robustness is designed, where a novel sliding mode surface incorporated enables faster convergence. The globally fixed-time stability of the closed-loop tracking system is rigorously demonstrated through Lyapunov stability analysis. Finally, numerical simulations and comparisons verify the validity and superiority of the suggested controller.

Scholarly and practitioner interest in authentic leadership has grown at an accelerating rate over the last decade, resulting in a proliferation of publications across diverse social science disciplines. Accompanying this interest has been criticism of authentic leadership theory and the methods used to explore it. We conducted a systematic review of 303 scholarly articles published from 2010 to 2023 to critically assess the conceptual and empirical strengths and limitations of this literature and map the nomological network of the authentic leadership construct. Results indicate that much of the extant research does not follow best practices in terms of research design and analysis. Based on the findings obtained, an agenda for advancing authentic leadership theory and research that embraces a signaling theory perspective is proposed.

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus irradiances. However, tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance. We describe several near-infrared, visible, ultraviolet and soft and hard X-ray diagnostics employed in a ∼1022 W/cm2 laser–plasma experiment. We used nearly 10 J total energy femtosecond laser pulses focused into an approximately 1.3-μm focal spot on 5–20 μm thick stainless-steel targets. We discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5 μm accuracy (i.e., around half of the short Rayleigh length) and show that several diagnostics (in particular, 3$\omega$ reflection and on-axis hard X-rays) can ensure this accuracy. We demonstrated target positioning within several micrometers from the focus, ensuring over 80% of the ideal peak laser intensity on-target. Our approach is relatively fast (it requires 10–20 laser shots) and does not rely on the coincidence of low-power and high-power focal planes.

Dicarbonyl compounds are highly reactive precursors of advanced glycation end products (AGE), produced endogenously, present in certain foods and formed during food processing. AGE contribute to the development of adverse metabolic outcomes, but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO) and 3-deoxyglucosone (3-DG), and body weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263 095 European Prospective Investigation into Cancer and Nutrition–Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home in Relation to Anthropometry participants with two body weight assessments (median follow-up time = 5·4 years). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0·089 kg (per 1-sd increase, 95 % CI 0·072, 0·107). 3-DG was inversely associated with body-weight change (–0·076 kg, −0·094, −0·058). No significant association was observed for GO (0·018 kg, −0·002, 0·037). In stratified analyses, GO was associated with body-weight gain among women and older participants (above median of 52·4 years). MGO was associated with higher body-weight gain among older participants. 3-DG was inversely associated with body-weight gain among younger and normal-weight participants. MGO was associated with a higher risk of becoming overweight/obese, while inverse associations were observed for 3-DG. No associations were observed for GO with overweight/obesity. Dietary dicarbonyls are inconsistently associated with body weight change among European adults. Further research is needed to clarify the role of these food components in overweight and obesity, their underlying mechanisms and potential public health implications.

This paper investigates the issue of tracking control for a free-floating space manipulator with prescribed performance constraints, considering the inertia uncertainties, internal disturbances and input saturation. An inherently continuous adaptive controller is proposed by incorporating non-singular fixed-time sliding mode control, prescribed performance control (PPC), and auxiliary compensation. First, a modified non-singular fast fixed-time terminal sliding surface is constructed, which has a shorten convergence time than the conventional fixed-time sliding surface. Unlike the existing complicated PPCs, a simple structure controller is developed to satisfy prescribed performance constraints through a unique tangent-type PPC technique. The input saturation is then compensated adaptively by an auxiliary mechanism. The Lyapunov theory thoroughly validates the stability and fixed-time convergence of the closed-loop tracking system. With the suggested control scheme, the system states can converge quickly to a small neighbourhood around the origin within a preassigned time, while the position tracking error can be confined within a prescribed performance bounds even in the presence of input saturation. Compared to the existing tracking methods, the suggested control approach has the advantages of faster transient convergence, higher steady-state tracking precision, and stronger robustness. Simulation comparisons demonstrate the effectiveness and superiority of the proposed controller.

A continuous-wave (CW) single-longitudinal-mode (SLM) Raman laser at 1240 nm with power of up to 20.6 W was demonstrated in a free-running diamond Raman oscillator without any axial-mode selection elements. The SLM operation was achieved due to the spatial-hole-burning free nature of Raman gain and was maintained at the highest available pump power by suppressing the parasitic stimulated Brillouin scattering (SBS). A folded-cavity design was employed for reducing the perturbing effect of resonances at the pump frequency. At a pump power of 69 W, the maximum Stokes output reached 20.6 W, corresponding to a 30% optical-to-optical conversion efficiency from 1064 to 1240 nm. The result shows that parasitic SBS is the main physical process disturbing the SLM operation of Raman oscillator at higher power. In addition, for the first time, the spectral linewidth of a CW SLM diamond Raman laser was resolved using the long-delayed self-heterodyne interferometric method, which is 105 kHz at 20 W.

A high-load counter-rotating compressor is optimised based on the method of coupling aerodynamic optimisation technology and computational fluid dynamics, and the flow structures in the passage are analysed and evaluated by vorticity dynamics diagnosis. The results show that the aerodynamic performance of optimised compressor are obviously improved at both design point and off-design point. By comparing the distribution characteristics of vorticity dynamics parameters on the blade surface before and after the optimisation, it is found that BVF (boundary vorticity flux) and circumferential vorticity can effectively capture high flow loss regions such as shock waves and secondary flow in the passage. In addition, the BEF (Boundary enstrophy flux) diagnosis method based on the theory of boundary enstrophy flux is developed, which expands the application scenario of the boundary vorticity dynamics diagnosis method. The change of vorticity dynamics parameters shows blade geometric parameters’ influence on the passage’s viscous flow field, which provides a theoretical basis for the aerodynamic optimisation design.

Objectives: In this study, we compared the performance of a rapid polymerase chain reaction (PCR) method in detecting carbapenemase-producing organisms (CPOs) and its impact on infection prevention and control (IPC) measures compared with a culture PCR method. Methods: All patients requiring CPO screening were included. Rectal swabs were collected with double rayon swabs (Copan 139C). They were simultaneously analyzed for the presence of CPOs using rapid PCR assay (Xpert Carba-R assay, Cepheid, Sunnyvale, CA) and a culture–PCR method (ChromID CARBA-SMART, bioMerieux, Marcy-l’Etoile, France). For CARBA-SMART, only colored colonies (ie, Enterobacterales) were evaluated for CPOs according to the prevailing institutional protocol. We tracked time to CPO detection. Using CPO positivity from either the rapid PCR or the culture PCR method as the gold standard, we calculated the sensitivity and specificity of both tests. We calculated the number of epidemiologically linked contacts generated when the first test results were known. We prospectively followed the ward census to identify the putative additional number of contacts generated by the later known result. Contacts were patients who shared the same ward (with overlapping time) as the CPO patients. Results: Between April 2019 and June 2020, culture PCR method detected CPOs in 316 (1.3%) of 24,514 samples (blaOXA48, N = 211; blaNDM, N = 51; blaIMI, N = 21; blaIMP, N = 10; blaKPC, N = 9; mixed genotypes, N = 14). The rapid PCR test detected CPOs in 605(2.5%) of 24,514 samples (blaOXA48, N = 266; blaNDM, N = 161; blaIMP, N = 99; blaVIM, N = 29; blaKPC, N = 15; mixed genotypes, N = 35). The sensitivity of direct PCR and culture PCR methods were 94.2% (95% CI, 92.1%–95.8%) and 43.5% (95% CI, 39.6%–47.4%), respectively. Both tests had 100% specificity. The median times to detection for the rapid PCR and culture PCR methods were 3–4 hours and 4 days, respectively. Compared with rapid PCR, the culture PCR method generated additional 7,415 contacts when it also tested positive for CPOs and an additional 23,135 contacts when it tested negative for CPOs. Conclusions: In our study, the rapid PCR test was more sensitive, identified CPO faster, and generated fewer epidemiologically linked contacts than the culture PCR method.

It is important to understand the impact of individual differences in decision making from childhood to adulthood. This cohort-based study extends our knowledge by comparing decision making of children across the age range of 8 to 17 years and their parents. Based on prior research and theory focusing on different types of framing effects, we uncover several key differences across ages, including levels of risk taking and sensitivity to expected value differences between risky and riskless choices. Furthermore, we find that measures such as Numeracy and Surgency help explain both age-related and individual differences on our tasks, especially for decisions involving risk. We discuss the role of diverse task measures in understanding how individual difference factors affect different aspects of decision making, including the ability and effort to process numerical information and the ability to suppress affective reactions to stimulus labels.

Understanding cross-cultural differences in attitudes to animal welfare issues is important in maintaining good international relations, including economic and trade relations. This study aimed to investigate the attitudes of stakeholders towards improving the welfare of animals during slaughter and transport in four key SE and E Asian countries: China, Thailand, Vietnam and Malaysia. Logistic regression analysis of the associations between demographic factors and attitudes identified nationality as the most significant factor influencing attitude. Motivating factors for improving welfare were ranked according to their importance: religion, knowledge levels, monetary gain, availability of tools and resources, community issues, approval of supervisor and peers. Strong beliefs in the influence of animal welfare laws, the power of the workplace and the importance of personal knowledge were shared by all countries. In addition, religion and peer consideration were significantly associated with attitudes in Malaysia and Thailand, respectively. The findings of this research will assist in the development of international animal welfare initiatives.

The cooperative guidance problem of multiple inferior missiles intercepting a hypersonic target with the specific impact angle constraint in the two-dimensional plane is addressed in this paper, taking into consideration variations in a missile’s speed. The guidance law is designed with two subsystems: the direction of line-of-sight (LOS) and the direction of normal to LOS. In the direction of LOS, by applying the algebraic graph theory and the consensus theory, the guidance command is designed to make the system convergent in a finite time to satisfy the goal of cooperative interception. In the direction of normal to LOS, the impact angle is constrained to transform into the LOS angle at the time of interception. In view of the difficulty of measuring unknown target acceleration information in real scenarios, the guidance command is designed by utilising a super-twisting algorithm based on a nonsingular fast-terminal sliding mode (NFTSM) surface. Numerical simulation results manifest that the proposed guidance law performs efficiently and the guidance commands are free of chattering. In addition, the overall performance of this guidance law is assessed with Monte Carlo runs in the presence of measurement errors. The simulation results demonstrate that the robustness can be guaranteed, and that overall efficiency and accuracy in intercepting the hypersonic target are achieved.

The commercial Computational Fluid Dynamics (CFD) software STAR-CCM+ was used to simulate the flow and breakup characteristics of a Liquid Jet Injected into the gaseous Crossflow (LJIC) under real engine operating conditions. The reasonable calculation domain geometry and flow boundary conditions were obtained based on a civil aviation engine performance model similar to the Leap-1B engine which was developed using the GasTurb software and the preliminary design results of its low-emission combustor. The Volume of Fluid (VOF) model was applied to simulate the breakup feature of the near field of LJIC. The numerical method was validated and calibrated through comparison with the public test data at atmospheric conditions. The results showed that the numerical method can capture most of the jet breakup structure and predict the jet trajectory with an error not exceeding ±5%. The verified numerical method was applied to simulate the breakup of LJIC at the real engine operating condition. The breakup mode of LJIC was shown to be surface shear breakup at elevated condition. The trajectory of the liquid jet showed good agreement with Ragucci’s empirical correlation.