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Numerous studies show that women are less likely than men to express attitudes and opinions about politics. To explore the origins of this gender gap, we use data from a series of surveys of the general public and international relations scholars in the United States between 2014 and 2023. These data show that the gender gap in political expression exists, even among knowledge elites; female IR scholars say they don’t know the answer to survey questions at higher rates than their male colleagues. We also find that differences in political knowledge explain a significant part of the gap in political expression; the highly educated female scholars we surveyed were less likely than women in the general public to say they didn’t know the answer to survey questions. At the same time, factors other than knowledge, including confidence, also matter. Our public opinion survey shows that women select extreme answers, such as “strongly agree/disagree” rather than simply “agree/disagree,” at lower rates than men. Despite high levels of education among the female scholars we surveyed, they too are more hesitant than their male counterparts to select extreme answers. These findings have important implications for civic participation as well as for the recognition of women’s expertise within the academy and society more broadly.
New South Wales (NSW) Health is committed to enhancing child health and development during the first 2000 days (conception to 5 years)(1). However, in Australia current child health behaviours indicate the need for further improvements. For example, discretionary foods (contributing high amounts of saturated fat, energy, added sodium and sugar) account for approximately 30% of total energy intakes in 2–3 years olds including the consumption of sugar sweetened beverages (SSB)(2). There remains a need to provide all parents raising children with direct and sustained support from birth to maximise health behaviours during this important life stage. Healthy Beginnings for HNEKids (HB4HNEKids) is an innovative text messaging program designed to be integrated into the usual care provided by Child and Family Health Nursing (CFHN) services. The messages were co-designed with key stakeholders to provide age-and-stage relevant preventive health information to parents/carers during the first 2000 days. HB4HNEKids has been piloted within five diverse CFHN services within the Hunter New England (HNE) local health district of NSW, reaching over 6000 families since its launch. However, the efficacy of the program on child health behaviours has not yet been explored. The aim of this study is to explore if families that received the HB4HNEKids program report reduced frequency of child discretionary food intake and a lower prevalence of SSB exposure, compared to families who did not receive the program. A cross-sectional survey of mothers 12–14 months post-partum was conducted between August 2023 and July 2024 including participants that received HB4HNEKids and a concurrent non-randomised comparison group, located in HNE. Mothers were asked to report on the frequency of child discretionary food intake per week, and whether their child had ever received SSB (including sweetened water, cordial, fruit drink, and soft-drinks). We conducted linear regression and logistic regression analyses to explore differences between the intervention and comparison participants. A total of 283 participants completed the survey, including 104 (37%) participants that had received the HB4HNEKids program. In infants aged 12–14 months, the frequency of discretionary food intake was approximately 1 serve per week and was unchanged based on if the family had received the HB4HNEKids program or not. Despite a 6-point prevalence difference in SSB exposure reported between groups (HB4HNEKids: 19.42% vs Comparison: 26.26%), this difference was not statistically significant (OR: 0.68 (95% CI: 0.37, 1.23), p = 0.2). Australian infant feeding guidelines suggest that the consumption of nutrient poor discretionary foods and sugar sweetened beverages should be avoided or limited(3). The HB4HNEKids program demonstrates some promise for improving infant feeding behaviours, however a larger effectiveness trial is required to ensure the evaluation is adequately powered.
Genetic and environmental factors, including adverse childhood experiences (ACEs), contribute to substance use disorders (SUDs). However, the interactions between these factors are poorly understood.
Methods
We examined associations between SUD polygenic scores (PGSs), ACEs, and the initiation of use and severity of alcohol (AUD), opioid use disorder (OUD), and cannabis use disorder (CanUD) in 10,275 individuals (43.5% female, 47.2% African-like ancestry [AFR], and 52.8% European-like ancestry [EUR]). ACEs and SUD severity were modeled as latent factors. We conducted logistic and linear regressions within ancestry groups to examine the associations of ACEs, PGS, and their interaction with substance use initiation and SUD severity.
Results
All three SUD PGS were associated with ACEs in EUR individuals, indicating a gene–environment correlation. Among EUR individuals, only the CanUD PGS was associated with initiating use, whereas ACEs were associated with initiating use of all three substances in both ancestry groups. Additionally, a negative gene-by-environment interaction was identified for opioid initiation in EUR individuals. ACEs were associated with all three SUD severity latent factors in EUR individuals and with AUD and CanUD severity in AFR individuals. PGS were associated with AUD severity in both ancestry groups and with CanUD severity in AFR individuals. Gene-by-environment interactions were identified for AUD and CanUD severity among EUR individuals.
Conclusions
Findings highlight the roles of ACEs and polygenic risk in substance use initiation and SUD severity. Gene-by-environment interactions implicate ACEs as moderators of genetic susceptibility, reinforcing the importance of considering both genetic and environmental influences on SUD risk.
This study explored the effects of different human milk oligosaccharides (HMOs), solely and in combination, on gut microbiota composition and metabolic activity (organic acid production), using anaerobic in vitro batch culture fermenters. The aim was to compare prebiotic effects of HMOs (2’FL, 3’FL, 3’SL, 6’SL, LNT, LNnT, and 1:1 ratio mixes of 2’FL/3’SL and 3’SL/LNT) in faecal samples from irritable bowel syndrome (IBS) donors and healthy controls, and to determine the best-performing HMO in IBS. Fluorescent in situ hybridisation coupled with flow cytometry was utilised to study microbiota changes in major colonic genera, and organic acid production was assessed by gas chromatography. IBS donors had different starting microbial profiles compared to healthy controls and lower levels of organic acids. In response to HMOs, there were alterations in both the control and IBS faecal microbiomes. In IBS donor fermenters, Bifidobacterium, Faecalibacterium, total bacterial numbers, and organic acid production significantly increased post-HMO intervention. When comparing the effect of HMO interventions on the microbiota and organic acid production, a mix of 3’SL/LNT HMOs may be the most promising intervention for IBS patients.
A general one-way analysis of variance components with unequal replication numbers is used to provide unbiased estimates of the true and error score variance of classical test theory. The inadequacy of the ANOVA theory is noted and the foundations for a Bayesian approach are detailed. The choice of prior distribution is discussed and a justification for the Tiao-Tan prior is found in the particular context of the “n-split” technique. The posterior distributions of reliability, error score variance, observed score variance and true score variance are presented with some extensions of the original work of Tiao and Tan. Special attention is given to simple approximations that are available in important cases and also to the problems that arise when the ANOVA estimate of true score variance is negative. Bayesian methods derived by Box and Tiao and by Lindley are studied numerically in relation to the problem of estimating true score. Each is found to be useful and the advantages and disadvantages of each are discussed and related to the classical test-theoretic methods. Finally, some general relationships between Bayesian inference and classical test theory are discussed.
In many applications, it is desirable to estimate binomial proportions in m groups where it is anticipated that these proportions are similar but not identical. Following a general approach due to Lindley, a Bayesian Model II aposteriori modal estimate is derived that estimates the inverse sine transform of each proportion by a weighted average of the inverse sine transform of the observed proportion in the individual group and the average of the estimated values. Comparison with a classical method due to Jackson spotlights some desirable features of Model II analyses. The simplicity of the present formulation makes it possible to study the behavior of the Bayesian Model II approach more closely than in more complex formulations. Also, it is possible to estimate the amount of gain afforded by the Model II analyses.
An explicit solution is given to the problem of assigning relative lengths to the subtests of a test so as to maximize the correlation of the unit weight composite with a specified criterion when the total testing time is fixed. This solution is valid and unique whenever it specifies nonnegative times for all variables. A step-down procedure is suggested for cases in which some of the testing times are zero. This procedure does not necessarily provide an optimal allocation. However in examples studied it is found to provide near optimum results. Algorithms are also developed for the determination of the least total testing time required to attain specified multiple and composite correlations. A numerical example is given illustrating the use of the unit weight procedure in combination with the regression weight algorithm.
Two-dimensional (2D) leaky-wave antennas (LWAs) are commonly designed to radiate pencil beams at broadside and/or scanned conical beams. Recently, the possibility to radiate narrow null patterns at broadside has also been preliminarily explored. In this work, we first review the design rules to obtain a pencil beam from an infinite 2D LWA and then show how they change for having a beam with a narrow null at broadside. The effects of antenna truncation are also accounted for in both cases, and numerical results show how the optimum conditions are in turn affected. Finally, full-wave validations of practical structures excited with either horizontal or vertical dipoles validate the analysis.
We present the Sydney Radio Star Catalogue, a new catalogue of stars detected at megahertz to gigahertz radio frequencies. It consists of 839 unique stars with 3 405 radio detections, more than doubling the previously known number of radio stars. We have included stars from large area searches for radio stars found using circular polarisation searches, cross-matching, variability searches, and proper motion searches as well as presenting hundreds of newly detected stars from our search of Australian SKA Pathfinder observations. The focus of this first version of the catalogue is on objects detected in surveys using SKA precursor and pathfinder instruments; however, we will expand this scope in future versions. The 839 objects in the Sydney Radio Star Catalogue are distributed across the whole sky and range from ultracool dwarfs to Wolf-Rayet stars. We demonstrate that the radio luminosities of cool dwarfs are lower than the radio luminosities of more evolved sub-giant and giant stars. We use X-ray detections of 530 radio stars by the eROSITA soft X-ray instrument onboard the Spectrum Roentgen Gamma spacecraft to show that almost all of the radio stars in the catalogue are over-luminous in the radio, indicating that the majority of stars at these radio frequencies are coherent radio emitters. The Sydney Radio Star Catalogue can be found in Vizier or at https://radiostars.org.
Diagnostic criteria for major depressive disorder allow for heterogeneous symptom profiles but genetic analysis of major depressive symptoms has the potential to identify clinical and etiological subtypes. There are several challenges to integrating symptom data from genetically informative cohorts, such as sample size differences between clinical and community cohorts and various patterns of missing data.
Methods
We conducted genome-wide association studies of major depressive symptoms in three cohorts that were enriched for participants with a diagnosis of depression (Psychiatric Genomics Consortium, Australian Genetics of Depression Study, Generation Scotland) and three community cohorts who were not recruited on the basis of diagnosis (Avon Longitudinal Study of Parents and Children, Estonian Biobank, and UK Biobank). We fit a series of confirmatory factor models with factors that accounted for how symptom data was sampled and then compared alternative models with different symptom factors.
Results
The best fitting model had a distinct factor for Appetite/Weight symptoms and an additional measurement factor that accounted for the skip-structure in community cohorts (use of Depression and Anhedonia as gating symptoms).
Conclusion
The results show the importance of assessing the directionality of symptoms (such as hypersomnia versus insomnia) and of accounting for study and measurement design when meta-analyzing genetic association data.
Metabolic and bariatric surgery (MBS) is safe and efficacious for adolescents with severe obesity. Pairing MBS with behavioral lifestyle interventions may be effective for optimizing treatment outcomes. However, no standardized program exists. Adolescent perspectives are critical to understanding how to design interventions to enhance engagement, sustain motivation, and meet informational needs for pre- and post-MBS self-management behaviors. The aim of this study was to develop an MBS lifestyle support intervention built on evidence-based content with input from adolescents and their families.
Methods:
A mixed-methods design identified adolescent preferences for MBS lifestyle support. Data were collected from a racially and ethnically diverse sample of adolescents (N = 17, 76% females, 24% males 41.2% non-Hispanic Black, 41.2% Hispanic/Latino, 11.8% non-Hispanic White, 5.8% Other) and their mothers (N = 13, 38.4% Hispanic) recruited from an MBS clinic. Quantitative surveys and qualitative interviews assessed preferred types of pre-post MBS content, modality, frequency, and delivery platforms to inform the design of the intervention. Mixed methods data were triangulated to provide a comprehensive understanding of adolescent/parent preferences.
Results:
Adolescents prioritized eating well, managing stress, and maintaining motivation as desired support strategies. Parents identified parental support groups and nutrition guidance as priorities. Peer support and social media platforms were identified as key approaches for boosting motivation and engagement.
Conclusions:
The patient voice is an important first step in understanding how, and whether behavioral lifestyle programs combined with MBS for weight management can be optimized. Adolescent preferences may enhance program fit and identify health behavior supports needed to sustain behavior change.
This paper presents an artificial neural network (ANN)-based nonlinear model predictive visual servoing method for mobile robots. The ANN model is developed for state predictions to mitigate the unknown dynamics and parameter uncertainty issues of the physics-based (PB) model. To enhance both the model generalization and accuracy for control, a two-stage ANN training process is proposed. In a pretraining stage, highly diversified data accommodating broad operating ranges is generated by a PB kinematics model and used to train an ANN model first. In the second stage, the test data collected from the actual system, which is limited in both the diversity and the volume, are employed to further finetune the ANN weights. Path-following experiments are conducted to compare the effects of various ANN models on nonlinear model predictive control and visual servoing performance. The results confirm that the pretraining stage is necessary for improving model generalization. Without pretraining (i.e., model trained only with the test data), the robot fails to follow the entire track. Weight finetuning with the captured data further improves the tracking accuracy by 0.07–0.15 cm on average.
Autistic people have a high likelihood of developing mental health difficulties but a low chance of receiving effective mental healthcare. Therefore, there is a need to identify and examine strategies to improve mental healthcare for autistic people.
Aims
To identify strategies that have been implemented to improve access, experiences of care and mental health outcomes for autistic adults, and to examine evidence on their acceptability, feasibility and effectiveness.
Method
A co-produced systematic review was conducted. MEDLINE, PsycINFO, CINHAL, medRxiv and PsyArXiv were searched. We included all study designs reporting acceptability or feasibility outcomes and empirical quantitative study designs reporting effectiveness outcomes. Data were synthesised using a narrative approach.
Results
A total of 30 articles were identified. These included 16 studies of adapted mental health interventions, eight studies of service improvements and six studies of bespoke mental health interventions developed for autistic people. There was no conclusive evidence on effectiveness. However, most bespoke and adapted approaches appeared to be feasible and acceptable. Identified adaptations appeared to be acceptable and feasible, including increasing knowledge and detection of autism, providing environmental adjustments and communication accommodations, accommodating individual differences and modifying the structure and content of interventions.
Conclusion
Many identified strategies are feasible and acceptable, and can be readily implemented in services with the potential to make mental healthcare more suitable for autistic people, but important research gaps remain. Future research should address these and investigate a co-produced package of service improvement measures.
Geotechnical drilling for a tunnel between Port Moody and Burnaby, BC, Canada, uncovered a buried fjord. Its sedimentary fill has a thickness of at least 130 m and extends more than 37 m below present mean sea level. Recovered sediments record cyclical growth and decay of successive Cordilleran ice sheets. The oldest sediments comprise 58 m of almost stoneless silt conformably overlying ice-proximal sediments and till, which in turn overlie bedrock. These sediments may predate Marine Isotope Stage (MIS) 4. Glacial sediments assigned to MIS 4 overlie this basal succession and, in turn, are overlain by MIS 3 interstadial sediments and sediments from two MIS 2 glacial advances. Indicators of relative sea-level elevations that bracket glacial deposits of MIS 4 and 2 indicate the cyclic existence of moat-like isostatic depressions in the front of expanding ice sheets. Compared with present sea level, these depressions were at least 160 m during the onsets of MIS 4 and MIS 2. Assuming a maximum eustatic drawdown of 120 m during MIS 2, isostatic depression may have exceeded 200 m during retreat of glacial ice from the Evergreen tunnel area. This is consistent with region-specific low mantle viscosity and rapid Cordilleran Ice Sheet buildup and wasting.
Seven kaolins from Georgia (southeastern U.S.A.), ranging from high to low commercial grade, were characterized by X-ray powder diffraction and chemical techniques to establish that the variation in quality was caused by impurities. The Ca and Cs cation-exchange capacities (CEC) varied from 2.67 to 8.17 and from 3.29 to 8.77 meq/100g, respectively. Selective dissolution and correlation analyses strongly indicated that expandable 2:1 minerals, particularly smectite (1.2-5.9%), were responsible for most of the observed variations in Ca CEC (r = 0.85*). The external surface CEC of kaolinite ranged from 0 to 1 meq/ 100 g. The positive significant correlation (r = 0.90**) between the Ca CEC and the K-mica content (03.9%) suggested that Ca CEC may be related to the degree of mica weathering through an expandable mineral stage.
The Cs-retention capacity (0.19–1.14 meq/100 g) was closely related to Cs-measured vermiculite content (r = 0.80*), and this content plus specific surface (R = 0.93**) or mica content (R = 0.86*). The Cs retention appeared to be primarily related to the presence of interlayer wedges at mica/vermiculite XY interfaces.
The influence of geomorphological site characteristics on soil clay mineral stability of montmorillonite-containing horizons of a southern Wisconsin soil catena was interpreted in terms of the solute activity function values of pSi(OH)4, pH-1/2pMg2+ and pH-1/3pAl3+ in suspensions of the separated clay fractions. Montmorillonite stability and/or formation vs that of kaolinite for the soil clays was evaluated by a plot of the solute activity functions on a three dimensional diagram derived for montmorillonite, kaolinite, and gibbsite at constant temperature (25°C) and constant pressure (one atm.). Although all the soil clays contained both montmorillonite and kaolinite, the position of the soil clay solute activity functions in the stability diagram clearly reflected the influence of the geomorphological—geochemical site conditions in which each soil horizon was developed, with corresponding differences in the SiO2/Al2O3 molar ratio of the reactive fraction. Montmorillonite stability positions of the solute activity functions were induced by soils (clays with reactive fractions with SiO2/Al2O3 molar ratios = 3–4) from calcareous or poorly drained horizons, while kaolinite stability positions of the functions were induced by soils (clays with reactive fractions of SiO2/Al2O3 molar ratios = 2) from acid, freely drained horizons.
A steady state reaction of apparent equilibrium of K mica + Ca2+ ⇄ Ca vermiculite + K+ was indicated by prolonged dissolution extractions from Blount soil clay (from northern Indiana) abundant in dioctahedral mica and vermiculite, with log Keq = 2.92 for the reaction when extrapolated to infinite time. From this and published free energies of formation of mica and kaolinite, a mineral phase stability diagram depicting the phase joins of Ca vermiculite, muscovite, and kaolinite was constructed with the solute activity functions pH-pK+, 2pH-pCa2+, and pSi(OH)4. These solute functions for 14-day reactions of calcareous (and dolomitic), poorly drained Harps soil (from central Iowa) fell near the calcite-dolomite-CO2-H2O phase join, suggesting equilibrium. These functions for Harps soil and the control minerals muscovite, biotite, and (or) vermiculite plus calcite were plotted on the mica-vermiculite stability diagram for various CO2 partial pressures. The points fell on the vermiculite-stable side of the mica-vermiculite plane at CO2 partial pressures of 0.15 and 0.20 atm (similar to soil air that would exist under frozen soil during winter and early spring; 2pH-pCa2+ ≃ 10.3). They fell on the muscovite-stable side of the muscovite-vermiculite plane at CO2 partial pressures of 0.0001 and 0.001 atm (similar to soil air under natural summer conditions; 2pH-pCa2+, 13.6 and 12.6, respectively) and therefore K+ (and 137Cs+ in rainfall) would be expected to be fixed.
The 2pH-pMg2+ values determined for Harps soil at the various CO2 partial pressures plotted either in the Mg montmorillonite stability field or on the Mg-montmorillonite-kaolinite phase join, in concordance with the abundance of montmorillonite and some kaolinite in the medium and fine clay fractions. The solute values for the nearby Clarion soil (upland, noncalcareous) plotted on the montmorillonite-kaolinite join, or with higher CO2 partial pressure, in the kaolinite stability area. The Gibbs free energy of formation (△Gf0) for a dioctahedral Ca vermiculite of −1303.7 kcal per 010 was determined from the Keq. The solute functions for the Blount soil showed kaolinite to be the thermodynamically stable phase with respect to dioctahedral mica and (or) vermiculite. The 14-day solute values for the Harps and upland Clarion soils were also on the kaolinite stability side of the kaolinite-vermiculite join. The kinetics of kaolinite formation in the upper midwestern U.S.A. are apparently slow on a scale of ~ 104 years.
Three kinds of opal-cristobalite, differentiated by the sharpness of the 4·1 Å XRD peak, were isolated from the Helms (Texas) bentonite by selective chemical dissolution followed by specific gravity separation. The δ18O value (oxygen isotope abundance) for these cristobalite isolates ranged from approximately 26–30‰ (parts per thousand), increasing with increased breadth of the 4·1 Å XRD peak. Opal-cristobalite isolated from the Monterey diatomite had a δ18O value of 34‰. These δ18O values are in the range for Cretaceous cherts (approximately 32‰) and are unlike the values of 9–11‰ obtained for low-cristobalite (XRD peaks at 4·05, 3·13, 2·4, and 2·49) formed hydrothermally or isolated from the vesicles of obsidian. The morphology pseudomorphic after diatoms, observed with the scanning electron microscope, was more apparent in the opal-cristobalite from the Monterey diatomite of Miocene age (approximately 10 million yr old) than in the spongy textured opal-cristobalite from the Helms bentonite, reflecting the 40 million yr available for crystallization since Upper Eocene.
The oxygen isotope abundance of Helms montmorillonite (δ18O = 26‰) indicates that it was formed in sea water while the δ18O values of the associated opal-cristobalite indicate that this SiO2 polymorph probably formed at approximately 25°C in meteoric water. Although both cristobalite and mont-montmorillonite in the bentonite were authigenic, the crystallization of the SiO2 phase apparently required a considerably longer period and occurred mainly after tectonic uplift.
In contrast to the results for cristobalite, quartz from the Helms and Upton (Wyoming) bentonites had δ18O values of 15 and 21‰ respectively. Such intermediate values, similar to those of aerosolic dusts of the Northern Hemisphere, loess, and many fluvial sediments and shales of the North Central United States (U.S.A.), preclude either a completely authigenic or a completely igneous origin for the quartz. These values probably result from a mixing of quartz from high and low temperature sources, detritally added to the ash or bentonite bed.
From 2 to 28% opal-cristobalite was isolated from the 2–20 µm fraction of rhyolitic and andesitic tuffaceous pyroclastics from the Island of Honshu, Japan, where it had been formed in hydrothermal springs at temperatures of ∼25–170°C as calculated from the oxygen isotopic ratios (18O/16O). Three of the isolates gave X-ray powder diffractograms with strong peaks at 4.07 Å. Two of these also had very weak peaks at 4.32 Å indicative of the presence of traces of tridymite. The fourth isolate had a strong 4.11 Å cristobalite peak and a very weak 4.32 Å peak. The morphology, determined by the scanning electron microscope, varied with the formation temperature indicated by the oxygen isotopic ratio (δ18O), from spheroidal and spongy for the opal-cristobalite formed at ∼25°C (δ18O = 26.0‰) in contrast to angular irregular plates and prisms for that formed at ∼115°C (11.9‰), ∼135°C (7.9 ‰) and ∼170°C (6.8 ‰). The differences in δ18O values are attributed to variation in hydrothermal temperature, but some variability in oxygen isotopic composition of the water is possible. The field-measured temperatures related roughly with the calculated fractionation temperatures except in one site, while the contrast in cristobalite morphology related well to calculated low and high fractionation temperatures. Low-cristobalite of hydrothermal origin in New Zealand (δ18O = 9‰) had characteristic rounded grains with some evidence of platiness. Co-existing quartz grains (δ18O = 10‰) showed more subhedral and irregular prismatic morphology.