Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37–3.17), and convulsions (aOR 2.83, 95% CI 1.12–7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR 2.2, 95% CI 1.3–3.6) and wasted (OR 2.5, 95% CI 1.3–4.6). Among MSD cases, tEPEC was associated with mortality (aOR 2.85, 95% CI 1.47–5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised and implemented.

Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.

Well-developed surface channels on Taylor Glacier, McMurdo Dry Valleys, Antarctica, begin as medial moraines incised as shallow, narrow surface depressions, and retain this geometry for tens of km. Over a distance of 1100 m, the channel geometry dramatically changes, reaching depths >20m and widths >100 m. After rapidly enlarging, the channels appear to evolve toward a new equilibrium geometry. Compared to the glacier surface, the air temperature in the channels is warmer by ∼1.7˚C, wind speed is reduced by ∼2.4ms–1 and net shortwave radiation is greater by ∼14Wm–2. The microclimate in the channel shifts the energy balance towards enhanced melt. Field evidence and energy-balance modeling indicate ablation in the deep channels is ∼4.5 times greater than the local horizontal glacier surface and that melt accounts for ∼99% of the summer ablation, compared to ∼75% on the adjacent horizontal glacier surface. Melt in these channels supplies 65% of the unaccounted water discharge into the neighboring lake. In large part, the channels generate the water they carry, rather than merely route water generated elsewhere.

Field experiments were conducted to study the effects of various tillage and mulching practices on fruit maturity and weed suppression in pumpkins. Conventional tillage (CT), disking, no tillage with rye removed (RR), no tillage with standing rye (SR), and strip tillage (ST) were evaluated with and without ethalfluralin plus halosulfuron (1.5 plus 0.036 kg ai/ha, respectively) applied preemergence. In 2001, when heavy rain after herbicide application caused significant crop injury, the herbicides delayed maturity and significantly reduced yields of mature pumpkins within each herbicide treatment, total yields did not differ with tillage. In 2002, weed populations were significantly greater than those in 2001, and in 2002, regardless of herbicides, yields of mature fruit were greater in tillage treatments with higher rye residues (SR, ST). Although weed populations were less in one year than the other, herbicides provided effective control in both seasons, and RR, ST, and SR effectively suppressed weeds compared with CT. Averaged over treatments, greater yield losses were attributable to weed competition (42%) in 2002 than to herbicide injury (32%) in 2001.

Dense populations of glyphosate-resistant (GR) Italian ryegrass are problematic for spring burndown herbicide programs and crop establishment in the midsouthern United States. Two field studies were conducted to evaluate fall-applied residual herbicides for control of GR Italian ryegrass and to identify the most effective application timing for these herbicides. Fall applications of clomazone at 0.84 and 1.12 kg ai ha−1, pyroxasulfone at 0.16 kg ai ha−1, and S-metolachlor at 1.79 kg ai ha−1 controlled GR Italian ryegrass ≥ 93% 180 d after application. Control from incorporated applications of pendimethalin at 1.59 kg ai ha−1 and trifluralin at 1.68 kg ai ha−1 and surface applications of S-metolachlor at 1.42 kg ha−1 provided control similar to the best treatments. Glyphosate-resistant Italian ryegrass control following clomazone, pyroxasulfone, S-metolachlor, or trifluralin applied in mid September, October, or November exceeded that from fall tillage by 19 to 56% at 90 and 140 d after the last treatment. Pyroxasulfone and S-metolachlor controlled more GR Italian ryegrass following October or November applications compared with those in September at both 90 and 140 d after the last application timing. However, the benefit of delaying clomazone application from October to November was not realized until the last evaluation (140 d after the last treatment). Clomazone, pyroxasulfone, and S-metolachlor offer growers the best opportunity for residual control of GR Italian ryegrass, and control is optimized when these herbicides are applied in November.

General linguistics, like any other academic subject, is always moving. But in recent years there have been more signs of fundamental change than for some time before, at least as far as may be gathered from published literature, necessarily the main source of information on contemporary trends on the part of most of one’s colleagues the world over. The earlier undercurrents and movements in linguistic thinking and discussion can only be known by those in personal contact with their prime movers.

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.