People with lived experience of incarceration have higher rates of morbidity and mortality compared to people without history of incarceration. Research conducted unethically in prisons and jails led to increased scrutiny of research to ensure the needs of those studied are protected. One consequence of increased restrictions on research with criminal-legal involved populations is reluctance to engage in research evaluations of healthcare for people who are incarcerated and people who have lived experience of incarceration. Ethical research can be done in partnership with people with lived experience of incarceration and other key stakeholders and should be encouraged. In this article, we describe how stakeholder engagement can be accomplished in this setting, and further, how such engagement leads to impactful research that can be disseminated and implemented across disciplines and communities. The goal is to build trust across the spectrum of people who work, live in, or are impacted by the criminal-legal system, with the purpose of moving toward health equity.

Coefficients of thermal linear expansion were determined for sea ice using a Michelson interferometer. Over a temperature range of −4 °to −15 °C, the coefficients varied from 45 ×10−6 to 54×10−6 °C−1 for ice with a salinity of 2 ppt, and from 33 ×10−6 to 53 ×10−6 °C−1 for ice with a salinity of 4 ppt. Initially, warming the sea ice resulted in coefficients that were the same as those for fresh-water ice, within the limits of experimental error. Subsequent sea-ice cooling resulted in coefficients that were initially lower than those for fresh-water ice, but that asymptotically approached the coefficient values for fresh-water ice at colder temperatures. On the second warming and cooling cycle, the coefficients of thermal linear expansion exhibited hysteresis and a decrease in magnitudes. We have also shown that Pettersson’s (1883) and Malmgren’s (1927) measurements of the thermal volume expansion of sea ice were the result of phase transitions that caused brine expulsion, when air-free sea ice was cooled, and internal porosity increases, when sea ice was warmed.

Our results indicate that Petterson’s (1883) and Malmgren’s (1927) measurements of the thermal volume expansion of sea ice are in error. Consequently, theoretical descriptions based on their results are incorrect (Anderson, 1960; Zubov and Savelyev (given in Doronin and Kheisin (1977)); Doronin and Kheisin, 1977). Our results for the initial sea-ice warming cycle do agree with Cox’s (1983) analysis.

The estimation of genetic effects from twin studies usually relies upon the equal environment assumption — that monozygous (MZ) and dizygous (DZ) twin pairs experience equal similarity of their environments from prenatal experiences through adulthood. However, the sharing of a chorion may make a subset of identical twins more similar, or in some cases, more different, than twins that do not share a chorion. Recent studies suggest monochorionic MZ twins resemble one another more than dichorionic MZ twins in cognitive abilities, personality, and risk for psychiatric disorder. To the extent that prenatal environment affects these characteristics, the traditional twin method will yield biased estimates of genetic and environmental influences. We develop models for quantifying this bias and estimating the influence of chorion type on estimates of heritability.

As part of an ongoing study on young adult psychological and social development, data were obtained through parental reports on the present residences and educational and occupational attainments of 718 present or former residents of Hawaii (average age 31 years). These subjects, as well as their parents, had been tested between 1972 and 1976 on measures of cognitive abilities and personality. The extent of emigration to the mainland in this middle to upper-middle class sample was over 40%. On average, former Hawaii residents now living on the US mainland were of higher intelligence and educational background than their counterparts still living in Hawaii. Differences were also found for number of children, crossethnic marriages, and occupational attainment (males only). In addition, parents of US mainland residents scored significantly higher on measures of cognitive abilities and education than parents of current Hawaii residents.

This study reports on the relative influences of parental attainment and cognitive ability and subjects’ own cognitive ability, personality, and social attitudes on the educational and occupational attainments and incomes of 183 Generation 3 subjects of Caucasian ancestry and 186 of Japanese ancestry originally tested in 1972–76 in the Hawaii Family Study of Cognition (HFSC) and re-tested in 1987–88. In contrast to earlier reports of sex differences in the influence of Generation 2 attainment and on Generation 3 attainment when these offspring were younger, family background had a trivial influence and own cognitive ability had a substantial influence on educational attainment for both racial/ethnic groups and both sexes. For income, however, own cognitive ability was only a significant predictor for male subjects. Within-family correlational analyses also supported this sex difference in influences on attainment.

Glutamate release from photoreceptor terminals is controlled by voltage-dependent calcium channels (VDCCs). In humans, mutations in the Cacna1f gene, encoding the α1F subunit of VDCCs, underlie the incomplete form of X-linked congenital stationary night blindness (CSNB2). These mutations impair synaptic transmission from rod and cone photoreceptors to bipolar cells. Here, we report anatomical and functional characterizations of the retina in the nob2 (no b-wave 2) mouse, a naturally occurring mutant caused by a null mutation in Cacna1f. Not surprisingly, the b-waves of both the light- and dark-adapted electroretinogram are abnormal in nob2 mice. The outer plexiform layer (OPL) is disorganized, with extension of ectopic neurites through the outer nuclear layer that originate from rod bipolar and horizontal cells, but not from hyperpolarizing bipolar cells. These ectopic neurites continue to express mGluR6, which is frequently associated with profiles that label with the presynaptic marker Ribeye, indicating potential points of ectopic synapse formation. However, the morphology of the presynaptic Ribeye-positive profiles is abnormal. While cone pedicles are present their morphology also appears compromised. Characterizations of visual responses in retinal ganglion cells in vivo, under photopic conditions, demonstrate that ON-center cells have a reduced dynamic range, although their basic center-surround organization is retained; no alteration in the responses of OFF-center cells was evident. These results indicate that nob2 mice are a valuable model in which to explore the pathophysiological mechanisms associated with Cacna1f mutations causing CSNB2, and the subsequent effects on visual information processing. Further, the nob2 mouse represents a model system in which to define the signals that guide synapse formation and/or maintenance in the OPL.

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Data from 949 families of Caucasian and 400 families of Japanese ancestry who took part in the Hawaii Family Study of Cognition were used to ascertain the associations of parental cognitive ability, parental education and paternal occupation with offspring cognitive ability. In particular, analyses were focused on testing the possible moderating effects of parental socioeconomic status on the familial transmission of cognitive abilities. Parental cognitive ability was substantially associated and parental education and paternal occupation only trivially associated with offspring performance. In contrast to the findings of Turkheimer et al. (2003), there was no evidence in these data that familiality for cognitive abilities was lower in the lower as opposed to upper levels of socioeconomic status. These results were consistent across measures, ethnicity and sex of offspring.

The wonder-rabbi of Kuzmir provided a troubled person with advice that was consonant with the Judaic tradition and also with behavioural therapy that led this person to overcoming his problems.