A Rank Forum was convened to discuss the evidence around food insecurity (FIS), its impact on health, and interventions which could make a difference both at individual and societal level, with a focus on the UK. This paper summarises the proceedings and recommendations. Speakers highlighted the growing issue of FIS due to current economic and social pressures. It was clear that the health implications of FIS varied geographically since food insecure women in higher income regions tend to be living with overweight or obesity, in contrast to those living in low-to-middle income countries. This paradox could be due to stress and/or metabolic or behavioural responses to an unpredictable food supply. The gut microbiota may play a role given the negative effects of low fibre diets on bacterial diversity, species balance and chronic disease risk. Solutions to FIS involve individual behavioural change, targeted services and societal/policy change. Obesity-related services are currently difficult to access. Whilst poverty is the root cause of FIS, it cannot be solved simply by making healthy food cheaper due to various ingrained beliefs, attitudes and behaviours in target groups. Person-centred models, such as Capability-Opportunity-Motivation Behavioural Change Techniques and Elicit-Provide-Elicit communication techniques are recommended. Societal change or improved resilience through psychological support may be more equitable ways to address FIS and can combine fiscal or food environment policies to shift purchasing towards healthier foods. However, policy implementation can be slow to enact due to the need for strong evidence, consultation and political will. Eradicating FIS must involve co-creation of interventions and policies to ensure that all stakeholders reach a consensus on solutions.

Female genital schistosomiasis (FGS) is a chronic disease manifestation of the waterborne parasitic infection Schistosoma haematobium that affects up to 56 million women and girls, predominantly in sub-Saharan Africa. Starting from early childhood, this stigmatizing gynaecological condition is caused by the presence of Schistosoma eggs and associated toxins within the genital tract. Schistosoma haematobium typically causes debilitating urogenital symptoms, mostly as a consequence of inflammation, which includes bleeding, discharge and lower abdominal pelvic pain. Chronic complications of FGS include adverse sexual and reproductive health and rights outcomes such as infertility, ectopic pregnancy and miscarriage. FGS is associated with prevalent human immunodeficiency virus and may increase the susceptibility of women to high-risk human papillomavirus infection. Across SSA, and even in clinics outside endemic areas, the lack of awareness and available resources among both healthcare professionals and the public means FGS is underreported, misdiagnosed and inadequately treated. Several studies have highlighted research needs and priorities in FGS, including better training, accessible and accurate diagnostic tools, and treatment guidelines. On 6 September, 2024, LifeArc, the Global Schistosomiasis Alliance and partners from the BILGENSA Research Network (Genital Bilharzia in Southern Africa) convened a consultative, collaborative and translational workshop: ‘Female Genital Schistosomiasis: Translational Challenges and Opportunities’. Its ambition was to identify practical solutions that could address these research needs and drive appropriate actions towards progress in tackling FGS. Here, we present the outcomes of that workshop – a series of discrete translational actions to better galvanize the community and research funders.

There is limited evidence on heterogenous co-developmental trajectories of internalizing (INT) and externalizing (EXT) problems from childhood to adolescence and predictors of these joint trajectories. We utilized longitudinal data from Raine Study participants (n = 2393) to identify these joint trajectories from 5 to 17 years using parallel-process latent class growth analysis and analyze childhood individual and family risk factors predicting these joint trajectories using multinomial logistic regression. Five trajectory classes were identified: Low-problems (Low-INT/Low-EXT, 29%), Moderate Externalizing (Moderate-EXT/Low-INT, 26.5%), Primary Internalizing (Moderate High-INT/Low-EXT, 17.5%), Co-occurring (High-INT/High-EXT, 17%), High Co-occurring (Very High-EXT/High-INT, 10%). Children classified in Co-occurring and High Co-occurring trajectories (27% of the sample) exhibited clinically meaningful co-occurring problem behaviors and experienced more adverse childhood risk-factors than other three trajectories. Compared with Low-problems: parental marital problems, low family income, and absent father predicted Co-occurring and High Co-occurring trajectories; maternal mental health problems commonly predicted Primary Internalizing, Co-occurring, and High Co-occurring trajectories; male sex and parental tobacco-smoking uniquely predicted High Co-occurring membership; other substance smoking uniquely predicted Co-occurring membership; speech difficulty uniquely predicted Primary Internalizing membership; child’s temper-tantrums predicted all four trajectories, with increased odds ratios for High Co-occurring (OR = 8.95) and Co-occurring (OR = 6.07). Finding two co-occurring trajectories emphasizes the importance of early childhood interventions addressing comorbidity.

The water surface response to subcritical turbulent flow over a backward-facing step (BFS) is studied via high-resolution large-eddy simulation (LES). The LES method is validated first using data of previously reported experiments. The LES-predicted water surface is decomposed into different types of gravity waves as well as turbulence-driven forced waves. Analysis of the LES data reveals the interplay between low-frequency large-scale turbulence structures, which are the result of flow separation from the step and reattachment behind the step, and the dynamics of the water surface. The water surface deformation is mainly the result of freely propagating gravity waves and forced waves, owing to turbulence in the form of rollers and/or hairpin vortices. Gravity waves with zero group velocity define the characteristic spatial and temporal scales of the surface deformations at higher frequencies, while large eddies determine their low-frequency modulation. These deformations are mainly confined in lateral bands that propagate downstream following the advection of the near-surface streamwise vortices (rollers) that are shed from the step. Steeper surface waves are observed in regions of negative perturbation velocity gradient and down-welling, downstream of the larger rollers, and are associated with thin isolated regions of high vorticity near the surface. The investigation of such a complex flow has shown that the decomposition of the water surface fluctuations into its different physical components may be used to identify the dynamics of the underlying flow structure.

Provision of high-quality care and ensuring retention of children on antiretroviral therapy (ART) are essential to reduce human immunodeficiency virus (HIV)-associated morbidity and mortality. Virological non-suppression (≥1000 viral copies/ml) is an indication of suboptimal HIV care and support. This retrospective cohort study included ART-naïve children who initiated first-line ART between July 2015 and August 2017 in Johannesburg and rural Mopani district. Of 2739 children started on ART, 29.5% (807/2739) were lost to care at the point of analysis in August 2018. Among retained children, overall virological non-suppression was 30.2% (469/1554). Virological non-suppression was associated with higher loss to care 30.3% (229/755) compared with suppressed children (9.7%, 136/1399, P < 0.001). Receiving treatment in Mopani was associated with virological non-suppression in children under 5 years (adjusted odds ratio (aOR) 1.7 (95% confidence interval (CI) 1.1–2.4), 5–9 years (aOR 1.8 (1.1–3.0)) and 10–14 years (aOR 1.9 (1.2–2.8)). Virological non-suppression was associated with lower CD4 count in children 5–9 years (aOR 2.1 (1.1–4.1)) and 10–14 years (aOR 2.1 (1.2–3.8)). Additional factors included a shorter time on ART (<5 years aOR 1.8–3.7 (1.3–8.2)), and male gender (5–9 years, aOR1.5 (1.01–2.3)), and receiving cotrimoxazole prophylaxis (10–14 years aOR 2.0 (1.2–3.6)). In conclusion, virological non-suppression is a factor of subsequent programme loss in both regions, and factors affecting the quality of care need to be addressed to achieve the third UNAIDS 90 in paediatric HIV.

White matter development during adolescents is crucial for a mature integration of neural networks in the brain. Autism spectrum condition (ASC), characterized by social and communication difficulties and rigid behaviour may interact with white matter development observed during adolescence. Changes in white matter development may link autistic symptoms to its genetic underpinnings and explain a 10-fold increase in susceptibility to ASC among siblings of individuals with ASC.

We used diffusion tensor imaging to study an association between age and white matter integrity measures, fractional anisotropy (FA) and mean diffusivity (MD), in adolescents with ASC, their siblings and age-matched healthy controls. Diffusion-weighted data were acquired with 64-direction protocol with 3mm slices and TR of 6600ms and tract-based spatial statistics analysis was performed.

The control subjects showed robust signs of increase in white matter integrity correlated with age. In contrast, individuals with ASC showed significantly lower negative correlation between MD and age in a broad area centred in the right superior longitudinal fasciculus (rSLF). When the three eigenvalues constituting a tensor ellipsoid were considered separately, siblings of individuals with ASC showed a diminished negative correlation between the second eigenvalue and age also centred in the rSLF.

Adolescents with ASC and their siblings experience alterations in white matter development in comparison to age-matched healthy controls, which are similar in direction yet different in scale for the two affected groups. The alterations are observed in the area associated with flexibility of behaviour and may explain both symptoms of ASC and increased susceptibility to ASC.

Veins of intimately associated fibrous and granular saponitic clay occur in a basalt quarry at Orrock, Fife, Scotland. Preliminary X-ray diffraction studies suggested that both fibrous and granular forms consisted of pure saponite but chemical and thermal studies showed the presence of subsidiary amounts of interstratified chlorite. The fibrous clay, which is strongly oriented around the a axis but with a uniform distribution of the b and c poles, consists mainly of highly-crystalline laths with minor amounts of turbostratically-ordered particles. The granular clay consists of turbostratically-ordered particles only. The swelling behaviour of both types of clay in water and in ethylene glycol is similar to that of pure saponite. With glycerol, only the granular clay swells completely but the fibrous clay behaves similarly if first subjected to grinding or chemical pre-treatment. These observations are accounted for on the basis that the fibrous clay has better order than the granular form, thus enabling the interlamellar constituents to participate more fully in layer-to-layer bonding.

The pearceite-polybasite group of minerals, general formula [M6T2S7][Ag9CuS4] with M = Ag, Cu; and T = As, Sb, show a crystal structure which can be described as the succession, along the c axis, of two pseudo-layer modules: a [M6T2S7]2–A module layer and a [Ag9CuS4]2+B module layer. Copper is present in one structural position of the B module layer and replaces Ag in the only fully occupied M position of the A module layer. When the Cu content is >4.00 a.p.f.u., the structural position of the A module layer becomes Cu-dominant and, consequently, the mineral deserves its own name. In this paper we report the crystal-chemical characterization of two Cu-rich members exhibiting the 111 unitcell type (corresponding to the Tac polytype). One sample (space group (P )m1, a 7.3218(8), c 11.8877(13) Å, V 551.90(10) Å3, Z = 1) having As >Sb and with the structural position of the A module layer dominated by Cu, has been named cupropearceite and the other sample (space group (P3̄)m1, a 7.3277(3), c 11.7752(6) Å, V 547.56(8) Å3, Z = 1) having Sb >As has been named cupropolybasite.

Both the new minerals and mineral names have been approved by the IMA-CNMNC.

With respect to wind tunnel aerodynamic load measurement, an internal strain gauge balance (often referred to as a sting balance) is essentially a compact load cell designed to fit within a cavity of the aerodynamic body and form a link between the model and a fixed ground point via a sting support system. The structure of an internal strain gauge balance is designed to incorporate a series of planar surfaces such that the deflection of each surface is predominantly induced by a unique aerodynamic load. Strain gauges, mounted on groups of surfaces in a Wheatstone bridge arrangement produce output signals proportional to the applied aerodynamic loads. A strain gauge balance is calibrated by applying known loads, measuring the bridge outputs and then formulating an equation which relates the two variables together. Although calibration techniques are well established, reservations have been recently expressed concerning the ability of the associated calibration equation to satisfactorily model the response of the balance when subjected to a six component aerodynamic loading. This generally accepted calibration equation (referred to here as the traditional equation) results in a quadratic approximation to the behaviour of the output signals with applied loads, whereas a more appropriate variation would be cubic. Other limitations of the traditional calibration equation are that the behaviour of the balance to two simultaneously applied loads is based upon limited combinations of the two applied loads, and that the acquisition of the required loads from the strain gauge signals is frequently based upon an approximate matrix inversion method. The proposed calibration equation, described within this paper, models the behaviour of the sting balance to the third order, takes account of all possible combinations of two simultaneously applied loads, and avoids the use of an approximate matrix inversion when deriving the desired aerodynamic loading from the signal outputs. It is also shown that the proposed method may be used to determine the interaction of all possible combinations of up to three simultaneously applied loads.

Reliability and safety criteria have, in one form or another, made a significant contribution to engineering design since the earliest times. They gained added significance in Victorian times as the scale of civil and mechanical engineering projects increased. Codes of practice came into use, based both on practical experience and theoretical knowledge. Redundancy and diversity, though not given those names, were introduced as a means of achieving improved reliability and safety. Reliability and safety technology in the modern sense only developed, however, when predictive techniques, based on statistical information, were introduced. This technology has now taken its place in a wide range of engineering activities and is adopting an increasingly international role. It makes use of numerical reliability and safety goals and pays attention to problems associated with human reliability and ergonomics. This paper reviews the particularly important contribution made by civil aviation to the development of present day reliability and safety technology.