This article considers the regulatory problems of online tracking behaviour, lack of consent to data collection, and the security of data collected with or without consent. Since the mid-1990s the United States Federal Trade Commission has been using its power under the United States consumer protection regime to regulate these problems. The Australian Competition and Consumer Commission (ACCC), on the other hand, has yet to bring civil or criminal proceedings for online privacy or data security breaches, which indicates a reluctance to employ the Australian Consumer Law (‘ACL’) in this field. Recent legislative action instead points to a greater application of the specifically targeted laws under the Privacy Act 1988 (Cth) (‘Privacy Act’), and the powers of the Office of the Australian Information Commissioner (OAIC), to protect consumer privacy and data security. This article contends that while specific legislation setting out, and publicly enforcing, businesses’ legal obligations with respect to online privacy and data protection is an appropriate regulatory response, the ACL's broad, general protections and public and/or private enforcement mechanisms also have a role to play in protecting consumer privacy and data security.

We characterised the soils and vegetation in 15 sets of four quadrats on and around mounds of Macrotermes annandalei (Isoptera, Macrotermitinae) on a plain of deep dystric clay over limestone in Deciduous Dipterocarp Forest in Northern Thailand. Termites have excavated the mounds from the deep calcareous substrate. The mound soils have darker subsoils, larger contents of clays and exchangeable cations, and higher pH values than the surrounding dystric clay loams. The thickets on the mounds are visually different from the surrounding Deciduous Dipterocarp Forest. They have few dipterocarps and are floristically similar to the regionally important Mixed Deciduous Forest. The clear visual differences are confirmed by floristic similarity, cluster, and canonical correspondence analyses for each of the tree, sapling and seedling size classes. The differences between the mound clays and surrounding red clay loams and the associations between soil and forest types are confirmed by ‘t tests’ and the significant correlations of the soil base status with the main floristic axis of the canonical correspondence analyses. Soil variability due to termites and other agents of pedoturbation can significantly contribute to short-range floristic and structural diversity in some dry tropical forests.

Soil amelioration via strategic deep tillage is occasionally utilized within conservation tillage systems to alleviate soil constraints, but its impact on weed seed burial and subsequent growth within the agronomic system is poorly understood. This study assessed the effects of different strategic deep-tillage practices, including soil loosening (deep ripping), soil mixing (rotary spading), or soil inversion (moldboard plow), on weed seed burial and subsequent weed growth, compared with a no-till control. The tillage practices were applied in 2019 at Yerecoin and Darkan, WA, and data on weed seed burial and growth were collected during the following 3-yr winter crop rotation (2019 to 2021). Soil inversion buried 89% of rigid ryegrass (Lolium rigidum Gaudin) and ripgut brome (Bromus diandrus Roth) seeds to a depth of 10 to 20 cm at both sites, while soil loosening and mixing left between 31% and 91% of the seeds in the top 0 to 10 cm of soil, with broad variation between sites. Few seeds were buried beyond 20 cm despite tillage working depths exceeding 30 cm at both sites. Soil inversion reduced the density of L. rigidum to <1 plant m−2 for 3 yr after strategic tillage. Bromus diandrus density was initially reduced to 0 to 1 plant m−2 by soil inversion, but increased to 4 plants m−2 at Yerecoin in 2020 and 147 plants at Darkan in 2021. Soil loosening or mixing did not consistently decrease weed density. The field data were used to parameterize a model that predicted weed density following strategic tillage with greater accuracy for soil inversion than for loosening or mixing. The findings provide important insights into the effects of strategic deep tillage on weed management in conservational agricultural systems and demonstrate the potential of models for optimizing weed management strategies.

We compute $ku^*\left(K\!\left({\mathbb{Z}}_p,2\right)\right)$ and $ku_*\left(K\!\left({\mathbb{Z}}_p,2\right)\right)$, the connective $KU$-cohomology and connective $KU$-homology groups of the mod-$p$ Eilenberg–MacLane space $K\!\left({\mathbb{Z}}_p,2\right)$, using the Adams spectral sequence. We obtain a striking interaction between $h_0$-extensions and exotic extensions. The mod-$p$ connective $KU$-cohomology groups, computed elsewhere, are needed in order to establish higher differentials and exotic extensions in the integral groups.

Crises, defined as a period of acute stress on social systems of all kinds, are a recurrent feature of history. As such, they are best approached and understood from a comparative historical perspective. We can distinguish between those caused or precipitated by an exogenous shock and those that derive from an endogenous process that culminates in the crisis. Crises can be of short or long duration and range from local to global. The most severe are ones that lead to a civilizational collapse or radical simplification process. Historically, severe crises have been localized to specific parts of the planet, even when several occur simultaneously because of global natural phenomena, but in the modern world we have truly global crises. Evidence suggests that such a global crisis is imminent or has already commenced. This raises practical and normative pressing issues.

Water is often referred to as our most precious resource, and for a good reason – drinking water and wastewater services sustain core functions of the critical infrastructure, communities, and human life itself. Our water systems are threatened by aging infrastructure, floods, drought, storms, earthquakes, sea level rise, population growth, cyber-security breaches, and pollution, often in combination. Marginalized communities inevitably feel the worst impacts, and our response continues to be hampered by fragmented and antiquated governance and management practices. This paper focuses on the resilience of water sector (drinking water, wastewater, and stormwater [DWS]) to three major hazards (Sea-Level Rise, Earthquake, and Cyberattack). The purpose of this paper is to provide information useful for creating and maintaining resilient water system services. The term resilience describes the ability to adapt to changing conditions and to withstand and recover from disruptions. The resilience of DWS systems is of utmost importance to modern societies that are highly dependent on continued access to these water sector services. This review covers the terminology on water sector resilience and the assessment of a broad landscape of threats mapped with the proposed framework. A more detailed discussion on two areas of resilience is given: Physical Resilience, which is currently a major factor influencing disruptions and failures in DWS systems, and Digital Resilience, which is a rapidly increasing concern for modern infrastructure systems. The resilience of DWS systems should be considered holistically, inclusive of social, digital, and physical systems. The framework integrates various perspectives on water system threats by showcasing interactions between the parts of the DWS systems and their environment. While the challenges of change, shock and stresses are inevitable, embracing a social–ecological–technical system-of-systems and whole-life approach will allow us to better understand and operationalize resilience.

OBJECTIVES/GOALS: Supported by the State of Alabama, the Alabama Genomic Health Initiative (AGHI) is aimed at preventing and treating common conditions with a genetic basis. This joint UAB Medicine-HudsonAlpha Institute for Biotechnology effort provides genomic testing, interpretation, and counseling free of charge to residents in each of Alabama’s 67 counties. METHODS/STUDY POPULATION: Launched in 2017, as a state-wide population cohort, AGHI (1.0) enrolled 6,331 Alabamians and returned individual risk of disease(s) related to the ACMG SF v2.0 medically actionable genes. In 2021, the cohort was expanded to include a primary care cohort. AGHI (2.0) has enrolled 750 primary care patients, returning individual risk of disease(s) related to the ACMG SF v3.1 gene list and pre-emptive pharmacogenetics (PGx) to guide medication therapy. Genotyping is done on the Illumina Global Diversity Array with Sanger sequencing to confirm likely pathogenic / pathogenic variants in medically actionable genes and CYP2D6 copy number variants using Taqman assays, resulting in a CLIA-grade report. Disease risk results are returned by genetic counselors and Pharmacogenetics results are returned by Pharmacists. RESULTS/ANTICIPATED RESULTS: We have engaged a statewide community (>7000 participants), returning 94 disease risk genetic reports and 500 PGx reports. Disease risk reports include increased predisposition to cancers (n=38), cardiac diseases (n=33), metabolic (n=12), other (n=11). 100% of participants harbor an actionable PGx variant, 70% are on medication with PGx guidance, 48% harbor PGx variants and are taking medications affected. In 10% of participants, pharmacists sent an active alert to the provider to consider/ recommend alternative medication. Most commonly impacted medications included antidepressants, NSAIDS, proton-pump inhibitors and tramadol. To enable the EMR integration of genomic information, we have developed an automated transfer of reports into the EMR with Genetics Reports and PGx reports viewable in Cerner. DISCUSSION/SIGNIFICANCE: We share our experience on pre-emptive implementation of genetic risk and pharmacogenetic actionability at a population and clinic level. Both patients and providers are actively engaged, providing feedback to refine the return of results. Real time alerts with guidance at the time of prescription are needed to ensure future actionability and value.

The Brú na Bóinne World Heritage Site, Ireland is best known for its megalithic monuments, in particular the great developed passage tombs of Knowth, Dowth, and Newgrange, and its abundance of megalithic art. However, our understanding of the wider Brú na Bóinne landscape has changed beyond all recognition in the last decade owing to the application of modern, non-invasive survey technologies – in particular LiDAR and large-scale geophysical survey – and most recently as a result of the hot, dry summer of 2018 which revealed a series of remarkable cropmarks between Newgrange and the River Boyne. Despite a lack of excavation it can be argued, based on their morphological characteristics, that many of the structures revealed belong within the corpus of late Neolithic ritual/ceremonial structures, including earthen henges, square-in-circle monuments, palisaded enclosures, and pit/post-alignments. These display both extraordinary diversity, yet also commonality of design and architecture, both as a group and with the passage tombs that preceded them. This paper provides an up-to-date survey of the late Neolithic and presumed late Neolithic landscape of Brú na Bóinne. It provides new evidence and new insights from ongoing survey campaigns, suggesting parallels within the British Neolithic but also insular development within some monument classes.

Priorities in Medical Research (PMR) was published in 1988 by a select committee of the House of Lords. The report ushered in an era of NHS research and development (R & D) that lasted from 2001 to 2006. The inquiry's origins lay in concerns about academic medicine in the United Kingdom, yet PMR gave relatively little attention to this subject. Instead the report focused critically on the disconnect between the Department of Health and the NHS in R & D. This, the committee argued, had led to the neglect of research into health services and public health. To sidestep the report's unwelcome proposal for a National Health Research Agency, the department eventually grafted R & D management onto structures created as part of wider NHS reforms. The Medical Research Council successfully pursued a strategy of keeping the committee's attention away from sensitive aspects of its own programme. The final focus of PMR was shaped by an alignment between committee members with an industrial view of research and champions of health services research. The actions of the various actors involved are interpreted using elite models of the state, and the applicability of these models is critically examined.