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Psychiatric diagnosis is based on categorical diagnostic classification, yet similarities in genetics and clinical features across disorders suggest that these classifications share commonalities in neurobiology, particularly regarding neurotransmitters. Glutamate (Glu) and gamma-aminobutyric acid (GABA), the brain's primary excitatory and inhibitory neurotransmitters, play critical roles in brain function and physiological processes.
Methods
We examined the levels of Glu, combined glutamate and glutamine (Glx), and GABA across psychiatric disorders by pooling data from 121 1H-MRS studies and further divided the sample based on Axis I disorders.
Results
Statistically significant differences in GABA levels were found in the combined psychiatric group compared with healthy controls (Hedge's g = −0.112, p = 0.008). Further analyses based on brain regions showed that brain GABA levels significantly differed across Axis I disorders and controls in the parieto-occipital cortex (Hedge's g = 0.277, p = 0.019). Furthermore, GABA levels were reduced in affective disorders in the occipital cortex (Hedge's g = −0.468, p = 0.043). Reductions in Glx levels were found in neurodevelopmental disorders (Hedge's g = −0.287, p = 0.022). Analysis focusing on brain regions suggested that Glx levels decreased in the frontal cortex (Hedge's g = −0.226, p = 0.025), and the reduction of Glu levels in patients with affective disorders in the frontal cortex is marginally significant (Hedge's g = −0.172, p = 0.052). When analyzing the anterior cingulate cortex and prefrontal cortex separately, reductions were only found in GABA levels in the former (Hedge's g = − 0.191, p = 0.009) across all disorders.
Conclusions
Altered glutamatergic and GABAergic metabolites were found across psychiatric disorders, indicating shared dysfunction. We found reduced GABA levels across psychiatric disorders and lower Glu levels in affective disorders. These results highlight the significance of GABA and Glu in psychiatric etiology and partially support rethinking current diagnostic categories.
There is a correlation mechanism between various anxiety emotions, and information anxiety, health anxiety. Consumer groups are prone to the comprehensive impact of multiple subtypes of anxiety emotions under the reception of mobile internet information. This study aims to explore the relationship between information anxiety, health anxiety, and loss anxiety among consumer groups, analyze the formation and maintenance mechanisms of health anxiety, and provide reference suggestions for preventing and alleviating health anxiety.
Subjects and Methods
This study used 280 anxious consumers as the experimental subjects and divided them into two groups. The control group of 140 people used conventional mindfulness intervention methods. In comparison, the experimental group of 140 people added logistics supply knowledge education for internet consumption based on mindfulness intervention methods. This study used SPSS 26.0 software for preliminary descriptive statistics and related data analysis.
Results
The experimental results indicate that the average values of consumers’ information anxiety, health anxiety, and loss anxiety before intervention are all higher than the average, meaning that the respondents generally have a higher level of anxiety in these three aspects. After six days of intervention, the average scores of information anxiety, health anxiety, and loss anxiety in the control group were higher than in the experimental group.
Conclusions
The study proposes that increasing logistics supply knowledge education for internet consumption based on mindfulness intervention methods can effectively alleviate consumers’ information anxiety, health anxiety, and loss anxiety emotions.
Acknowledgement
The 2024 Annual Humanities and Social Sciences Research Project of Henan Colleges and Universities (No.2024-ZDJH-304, Project Supported by Henan Provincial Department of Education).
Plasma jets are widely investigated both in the laboratory and in nature. Astrophysical objects such as black holes, active galactic nuclei and young stellar objects commonly emit plasma jets in various forms. With the availability of data from plasma jet experiments resembling astrophysical plasma jets, classification of such data would potentially aid in not only investigating the underlying physics of the experiments but also the study of astrophysical jets. In this work we use deep learning to process all of the laboratory plasma images from the Caltech Spheromak Experiment spanning two decades. We found that cosine similarity can aid in feature selection, classify images through comparison of feature vector direction and be used as a loss function for the training of AlexNet for plasma image classification. We also develop a simple vector direction comparison algorithm for binary and multi-class classification. Using our algorithm we demonstrate 93 % accurate binary classification to distinguish unstable columns from stable columns and 92 % accurate five-way classification of a small, labelled data set which includes three classes corresponding to varying levels of kink instability.
Although attentional bias modification training (ABM) and cognitive behavioural therapy (CBT) are two effective methods to decrease the symptoms of generalized anxiety disorders (GAD), to date, no randomized controlled trials have yet evaluated the effectiveness of an intervention combining internet-based cognitive behavioural therapy (ICBT) and ABM for adults with GAD.
Aims:
This study aimed to investigate the effectiveness of an intervention combining ICBT and ABM for adults with GAD.
Method:
Sixty-three participants diagnosed with GAD were randomly assigned to the treatment group (ICBT with ABM; 31 participants) or the control group (ICBT with ABM placebo; 32 participants), and received 8 weeks of treatment and three evaluations. The CBT, ABM and ABM-placebo training were conducted via the internet. The evaluations were conducted at baseline, 8 weeks later, and 1 month later, respectively.
Results:
Both the treatment and control groups reported significantly reduced anxiety symptoms and attentional bias, with no clear superiority of either intervention. However, the treatment group showed a greater reduction in negative automatic thoughts than the control group after treatment and at 1-month follow-up (η2 = 0.123).
Conclusion:
The results suggest that although not differing in therapeutic efficacy, the intervention combining ICBT and ABM is superior to the intervention combining ICBT and ABM-placebo in the reduction of negative automatic thoughts. ABM may be a useful augmentation of ICBT on reducing anxiety symptoms.
This study aimed to investigate the environmental contamination of nucleic acid at 2019 novel coronavirus (2019-nCOV) vaccination site and to evaluate the effect of improvement to the vaccination process. Nucleic acid samples were collected from the surface of the objects in 2019-nCOV vaccination point A (used between 15 November 2020 and 25 December 2020) and point B (used after 27 December 2020) in a comprehensive tertiary hospital. Samples were collected from point A before improvement to the vaccination process, and from point B (B1 and B2) after improvement to the vaccination process. The real-time fluorescence polymerase chain reaction method was used for detection. The positive rate of vaccination room was 47.06% (24/51) at point A. No positive result was found in point B1 both at working hours (0/27) and after terminal disinfection (0/27). In point B2, the positive results were found in vaccine's outer packaging and staff gloves at working hours, with a positive rate of 7.41% (2/27). The positive rate was 0 (0/27) after terminal disinfection in point B2. The nucleic acid contamination in the vaccination room of 2019-nCOV vaccine nucleic acid sampling point is serious, which can be avoided through the improvement and intervention (such as personal protection, vaccination operation and disinfection methods).
We report on the observation of subcycle interferences of electron wave packets released during strong field ionization of $\text{H}_{2}$ with cycle-shaped two-color laser fields. With a reaction microscope we measure three-dimensional momentum distributions of photoelectrons correlated with either $\text{H}_{2}^{+}$ or protons within different energy ranges generated by dissociation of $\text{H}_{2}^{+}$. We refer to these different types of photoelectrons as channels. Our results show that the subcycle interference structures of electron wave packets are very sensitive to the cycle shape of the two-color laser field. We explain this behavior by the dependence of the ionization time within an optical cycle on the shape of the laser field cycle. The subcycle interference structures can be further used to obtain insight into the subcycle dynamics of molecules during strong field interaction.
With the increasing usage of Al alloys in vehicle manufacture, it is necessary to join dissimilar Al alloys with lap joint. However, hot cracking is a challenging issue due to the chemical composition and thermal tension, which greatly determines the reliability of automobile operation. Among different Al alloys, the series 5000 (Al–Mg) and 6000 (Al–Mg–Si) are widely used. To better understand the hot cracking behavior, various stack ups of AA5754 and AA6013 were laser welded to investigate the effects of process parameters on hot cracking formation. The chemical composition, microstructure, fusion ratio, and fracture morphology of the weld joint were also examined. The results showed that the order of material stacking affected weld's susceptibility to hot cracking significantly, and the critical process parameters were obtained for tested conditions which could effectively reduce hot cracking. The findings from this work provide guidance for hot cracking prevention in laser welding of dissimilar Al alloys.
Traditionally, it has been widely acknowledged that genes together with adult lifestyle factors determine the risk of developing some metabolic diseases such as insulin resistance, obesity and diabetes mellitus in later life. However, there is now substantial evidence that prenatal and early-postnatal nutrition play a critical role in determining susceptibility to these diseases in later life. Maternal nutrition has historically been a key determinant for offspring health, and gestation is the critical time window that can affect the growth and development of offspring. The Developmental Origins of Health and Disease (DOHaD) hypothesis proposes that exposures during early life play a critical role in determining the risk of developing metabolic diseases in adulthood. Currently, there are substantial epidemiological studies and experimental animal models that have demonstrated that nutritional disturbances during the critical periods of early-life development can significantly have an impact on the predisposition to developing some metabolic diseases in later life. The hypothesis that epigenetic mechanisms may link imbalanced early-life nutrition with altered disease risk has been widely accepted in recent years. Epigenetics can be defined as the study of heritable changes in gene expression that do not involve alterations in the DNA sequence. Epigenetic processes play a significant role in regulating tissue-specific gene expression, and hence alterations in these processes may induce long-term changes in gene function and metabolism that persist throughout the life course. The present review focuses on how nutrition in early life can alter the epigenome, produce different phenotypes and alter disease susceptibilities, especially for impaired glucose metabolism.
Objective: Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population.
Methods: We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test.
Results: No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls (X2 = 2.12, df = 2, P = 0.35 by genotype; X2 = 0.005, df = 1, P = 0.94 by allele).
Conclusions: Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.
An artificial rearing apparatus for the aquatic firefly Luciola leii Fu and Ballantyne is described, consisting of two small rearing boxes placed inside a larger outer box, a choice of diet, and a suitable substrate for oviposition. Larvae feeding on crushed prey snails (Gyraulus convexiusculus Huton and Lymnaea stagnalis (L.)) showed moderate growth, while those feeding exclusively on muscle of the snail Bellamya purificata Heude grew the best, with a pupation rate of 71%, adult emergence rate of 88.7%, larval duration of 203 days, and pupal duration of 5.1 days. Larvae feeding on fish meat (Carassius auratus L.) and pork meat did not rear well, having lower pupation rates (11% and 5.5%, respectively) and lower emergence rates (54.5% and 54.5%, respectively). Analysis of the three species of aquatic snails, isolated fish meat, and isolated pork meat revealed that the concentrations of amino acids in a protein sample of B. purificata were higher than those in samples of the other two snails, G. convexiusculus and L. stagnalis, but less than those in samples of the fish and pork meat. It is concluded that the rearing apparatus and the diet, which affects water quality, are important factors in the successful rearing of the aquatic firefly L. leii.
Light-induced metastability of amorphous/microcrystalline (micromorph) silicon tandem solar cell, in which the microcrystalline bottom cell was deposited in a single-chamber system, has been studied under a white light for more than 1000 hours. Two different light-induced metastable behaviors were observed. The first type was the conventional light-induced degradation, where the open-circuit voltage (Voc), fill factor (FF), and short-circuit current density (Jsc) were degraded, hence the efficiency was degraded as well. This phenomenon was observed mainly in the tandem cells with a bottom cell limited current mismatch. The second type was with a light-induced increase in Voc, which sometimes resulted in an increase in efficiency. The second type of light-induced metastability was observed in the tandem cells with a top cell limited current mismatch. The possible mechanisms for these phenomena are discussed.
In this article, we present a study of boron-doped hydrogenated nanocrystalline silicon (nc-Si: H) films by very high frequency-plasma enhanced chemical vapor deposition (VHF-PECVD) using high deposition pressure. Electrical, structural and optical properties of the films were investigated. Dark conductivity as high as 2.75S/cm of p-type nc-Si: H prepared at 2.5Torr pressure has been achieved at a deposition rate of 1.75Å/s for 25nm thin film. By controlling boron and phosphorus contamination, single junction nc-Si: H solar cells incorporated p-layers prepared under high pressure and low pressure, respectively, were deposited. It has been proven that nanocrystalline silicon solar cells with incorporation of p layer prepared at high pressure has resulted in enhanced open circuit voltage, short circuit current density and subsequently high conversion efficiency. Through the optimization of the bottom solar cell and application of ZnO/Al back reflector, 10.59% initial conversion efficiency of micromorph tandem solar cell (1.027cm2) with an open circuit voltage of 1.3864V, has been fabricated, where the bottom solar cell using a high pressure p layer was deposited in a single chamber.
This paper reviews our research progresses of hydrogenated amorphous silicon (a-Si:H) and microcrystalline (μc-Si:H) based thin film solar cells. It coves the three areas of high efficiency, low cost process, and large-area proto-type multi-chamber system design and solar module deposition. With an innovative VHF power profiling technique, we have effectively controlled the crystalline evolution and made uniform μc-Si:H materials along the growth direction, which was used as the intrinsic layers of pin solar cells. We attained a 9.36% efficiency with a μc-Si:H single-junction cell structure. We have successfully resolved the cross-contamination issue in a single-chamber system and demonstrated the feasibility of using single-chamber process for manufacturing. We designed and built a large-area multi-chamber VHF system, which is used for depositing a-Si:H/μc-Si:H micromorph tandem modules on 0.79-m2 glass substrates. Preliminary module efficiency has exceeded 8%.
High rate deposition of hydrogenated microcrystalline silicon (μc-Si:H) films and solar cells were prepared by very high frequency plasma enhanced chemical vapor deposition (VHF-PECVD) process in a high power and high pressure regime. The experiment results demonstrate that in high-rate deposited μc-Si:H films, the structural evolution is much more dramatic than that in low-rate deposited μc-Si:H films. A novel VHF power profiling technique, which was designed by dynamically decreasing the VHF power step by step during the deposition of μc-Si:H intrinsic layers, has been developed to control the structural evolution along the growth direction. Another advantage of this VHF power profiling technique is the reduced ion bombardments on growth surface because of decreasing the VHF power. Using this method, a significant improvement in the solar cell performance has been achieved. A high conversion efficiency of 9.36% (Voc=542mV, Jsc=25.4mA/cm2, FF=68%) was obtained for a single junction μc-Si:H p-i-n solar cell with i-layer deposited at deposition rate over 10 �/s.
The clogging of the Submerged Entry Nozzle (SEN) duringbillet continuous casting of mid-carbon steel is studied.Clogging materials and inclusions in steel samples taken atladles, tundish and billets are investigated. The total oxygen onthe whole section of the billet is measured. Steel cleanliness atunsteady casting states, including cast start, ladle change, SENchange, cast end, and the special unsteady pouring periodinduced by SEN clogging, are studied. Fluid flow and inclusionmotion and entrapment to SEN surface are also simulated.
A wide bandgap microcrystalline silicon film for the window layer of microcrystalline silicon thin film solar cells was obtained with very high frequency (VHF) glow discharge technology. The material was deposited on corning 7059 substrate at about 170 When H2/SiH4 was more than 100, Raman spectra showed that this material was highly crystallized, and no peak correlation with amorphous silicon was observed. This material showed strong n type before any intentional doping. We considered that the unintentional doping of oxygen and unpurified gases. The doping performance of this material was investigated by introducing B2H6 into the reacting gas. As increasing the rate of B2H6/SiH4 from zero to 0.5%, the conductivity changed from 10-1S.cm-1 (n type) to 10-8 S.cm-1 dramatically and than backed to 10-1 S.cm-1 (p type), which indicated that this material had excellent doping ability. Raman spectra also showed that the microstructure of these materials did not change obviously in this doping range. We gained the p-uc-Si:H film with thickness less than 30nm, and the conductivity was more than 10-2 S.cm-1, and crystalline volume fraction no less than 40%, the Egopt could be wider than 2.10eV. Using this p window layer in microcrystalline silicon solar cells with no ZnO rear reflection, the conversion efficiency was 8.30% (Voc=0.531V, Jsc=24.66mA/cm2, FF=63.41% ).
The influence of the density of gap states and the band gap width of the intrinsic a-Si:H active layer on the characteristics of a-Si PIN/OLED coupling pair was analyzed by a-Si:H PIN/OLED CAD simulation model. The CAD simulation model was carried out based on a-Si PIN Hack & Shur model and OLED TCL transport model. At the same band gap width, for the intrinsic a-Si:H active layer with the higher density of gap states, the reverse current of a-Si PIN trended to be saturated at the higher reverse bias voltage. As a result, I-V curve of a-Si PIN/OLED around the turn point Vt became smoother with the increase of the density of gap states. At the same state density, the light induced current of a-Si PIN increased against the band gap width, assuming the input light had the same spectrum as AM1.5 solar light. Thus the luminance emitted from OLED increased with the decrease of the band gap width because OLED belongs to the light-emitting device controlled by current. The simulation results also showed that the influence of the state density intensified with the increase of the band gap of a-Si:H.
High rate deposition of high quality and stable hydrogenated amorphous silicon (a-Si:H) films were performed near the threshold of amorphous to microcrystalline phase transition using a very high frequency plasma enhanced chemical vapor deposition (VHF-PECVD) method. The effect of hydrogen dilution on optic-electronic and structural properties of these films was investigated by Fourier-transform infrared (FTIR) spectroscopy, Raman scattering and constant photocurrent method (CPM). Experiment showed that although the phase transition was much influenced by hydrogen dilution, it also strongly depended on substrate temperature, working pressure and plasma power. With optimized condition high quality and high stable a-Si:H films, which exhibit σph/σd of 4.4×106 and deposition rate of 28.8Å/s, have been obtained.
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