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Medical autobiographies begin as pseudonymous case histories for medical doctors’ consideration of supposedly pathological conditions, and become accounts of the ways mid-twentieth-century physicians’ psychiatric practices harmed and inhibited, and did not treat or assist, gay, memoir-writing patients. Psychiatrists and psychoanalysts then recount their lives and therapeutic practices as living examples, which run contrary to conventional, prevailing professional opinions on homosexuality, and eventually negotiate their professions’ important, redefining turning points of 1969, 1973, and 1992. As a later generation narrates stories of addiction, disease, and physical abuse at family members’ hands, they can commence with the confident assumption of the health of a gay male body. They can, unlike their predecessors, see homosexuality as the least of their worries. Initially a sign of a psyche gone awry, same-sex sexuality, over the course of five generations, becomes the healthy norm, from which the most recent gay American autobiographers draw their strengths, instead of seeking supposed cures.
Focusing on the third-person formulation of many of the texts on the question tablets, and drawing on psychological and narratological research, this essay explores the mind-set of those who came to consult Zeus, asking if these texts reveal a sense of the self as fragmented in the face of crisis – which may also suggest how processes of consultation at an oracle could have provided psychological relief to pilgrims. Using analytical approaches from cognitive linguistics, this essay examines these texts for what they may reveal in terms of a cognitive blending of Viewpoints – both mortal and divine – aiding self-integration and, thus, decision making. Finally, this essay argues that awe in the face of the divine may have been a key component of the experience of consultation, with significant impacts on our brain and body.
Suicide is a serious global health problem with ~73% deaths by suicide occurring in low- or middle-income countries (LMICs), many of which are among people experiencing humanitarian emergencies. Few guidelines outline specific steps and strategies to tackle suicide risk and manage post-attempt consequences in these settings, leaving program implementers with limited information to translate guidance to practice. This article describes the implementation of the Common Elements Treatment Approach (CETA) suicide safety protocol as part of a randomized controlled trial in northern Thailand for displaced adults from Myanmar with chronic physical health conditions. The CETA safety protocol has been used in many trials and programs to screen for and manage suicide risk, including in a prior CETA effectiveness trial with Myanmar adults. In this article, we describe how this safety protocol was adapted for the study setting, and utilized to effectively screen, assess suicidal thoughts and behaviors, develop and manage action plans for study participants with active suicidal ideation. We present three illustrative case descriptions of individuals with whom we implemented the safety protocol to highlight how suicide risk intersects with physical illness, psychosocial stressors and structural vulnerability. Reflections on feasibility, acceptability and adaptations – such as language translation, culturally grounded referral pathways and training for nonspecialist providers – are shared to inform future implementation. Our findings support the implementation of suicide safety protocols within humanitarian programming and offer practical insights for global health practitioners and policymakers working in similarly complex settings.
The relationship between media portrayal of psychedelic drugs, scientific research and drug policy is an area of debate.
Aims
To apply artificial intelligence technology to measure trends in media sentiment towards the therapeutic potential of psychedelic drugs.
Method
Up to 300 of the most relevant articles from Google News searches for the term ‘psychedelics’ were sampled for each year from 2000 to 2025. A large language model, ChatGPT, evaluated subject matter and sentiment.
Results
In total, 88.3% of screened URLs (3308 of 3747) were included in the analysis. The proportion of articles focusing on the therapeutic potential of psychedelics increased from 13.3% (26 of 198) from 2000 to 2009 to 85.3% (1254 of 1470) from 2020 to 2025. The average sentiment score from 2000 to 2025 for articles from all publications (N = 2168) was 78.5 ± 9.3 (mean ± s.d.) (possible range: 1–100). 1.3% (29 of 2168) of articles carried negative sentiment (<50) whereas 4.8% (103 of 2168) had extremely positive sentiment (≥90). Average sentiment reached a peak in 2020 (80.8 ± 7.0), and a statistically significant trough in sentiment was observed in 2024 relative to 2020–2023 (2020–2023, 79.2; 2024, 74.3, P < 0.00001, Mann–Whitney U-test). The proportion of negative-neutral articles (≤65) increased annually from a trough of 3.6% (8 of 267) in 2020 to a peak of 20.9% (43 of 253) in 2024. Artificial intelligence sentiment scores were correlated and concordant with average human rater scores (r = 0.88, concordance correlation coefficient 0.84).
Conclusions
Although most 21st-century media coverage of psychedelic drugs has been positively framed, negative and neutral coverage has increased in frequency since 2020. Researchers, clinicians, regulators and policy-makers should be mindful of the complex relationship between media portrayals of psychedelics and the results of scientific research.
Metacognition and mentalising are central change mechanisms in psychotherapy, with transdiagnostic relevance. The how, why and when of metacognition creates a roadmap for psychotherapy, enhancing awareness, understanding and options for changing maladaptive behaviours that maintain psychiatric disorders. This offers a framework for psychotherapy, fostering deeper self-understanding and improved interpersonal interactions.
Childhood trauma is a well-established risk factor for the onset and persistence of psychotic symptoms. Consequently, trauma-focused interventions (TFIs) are increasingly incorporated into psychosis treatment, though their effectiveness in reducing hallucinations and delusions remains unclear. This systematic review and meta-analysis evaluated the effects of TFIs on psychosis-related outcomes in individuals with psychotic disorders or subclinical symptoms. Thirty-six studies (N = 1,384) were included, with 18 (N = 806) contributing to meta-analyses. Study quality and risk of bias were assessed using AXIS, Cochrane RoB2, and GRADE. Pre–post analyses showed small reductions in hallucinations (g = −0.37; adjusted g = −0.28; K = 15) and medium reductions in delusions (g = −0.55; K = 14), with younger participants benefiting more. In controlled trials, TFIs did not significantly reduce hallucinations at the end of treatment or follow-up (g = −0.12 and −0.01; both K = 7), whereas delusions showed significant reductions at both time points (g = −0.44 and g = −0.48; both K = 7). No significant effect on negative symptoms was observed at the end of trial (g = −0.02; K = 6), though a small improvement appeared at follow-up (g = −0.26; K = 6). TFIs produced small but significant reductions in PTSD symptoms at both time points (K = 6). No consistent effects were found for secondary outcomes: depression (K = 7), anxiety (K = 5), or quality of life (K = 3), though functioning improved at follow-up (K = 6). TFIs appear particularly effective in reducing delusions, but show limited benefit for hallucinations and other secondary outcomes. Further work is needed to design and test symptom-specific psychological interventions for distinct psychotic experiences.
High-functioning depression (HFD) describes individuals experiencing persistent depressive symptoms, such as low mood and emotional exhaustion, while maintaining outward success. Owing to preserved functionality, the underlying distress is often unnoticed, misattributed or suppressed. HFD challenges existing psychiatric frameworks, delays diagnosis and increases the risk of progression to major depressive disorder and suicidality. Current screening tools may lack sensitivity, and stigma can lead to disengagement from therapy. Expanded diagnostic awareness, improved clinician training and culturally attuned care are essential for recognising and validating internal suffering in this overlooked population.
This brief article outlines a training programme, implemented during day-to-day practice, to teach psychodynamic skills to resident doctors in a variety of specialties and at all levels of training. By identifying and exploring the interpersonal dynamics between individual patients and staff, psychiatry residents learn skills such as psychodynamic assessment and formulation, intervention planning and risk reduction.
In England, psychological therapies provided in primary care are recommended as first-line treatment for people living with mild-to-moderate dementia experiencing depression or anxiety. It is known that people living with dementia experience more barriers to accessing therapy than people without dementia, but such inequalities in terms of rates of access to primary care services are yet to be characterised.
Methods
In this retrospective, observational study of linked electronic healthcare records, the national database of the National Health Service (NHS) Talking Therapies for anxiety and depression programme was used to compare pathways to accessing therapy between 6623 people living with dementia and 4 825 489 without dementia between 2012 and 2019. Outcomes included access to an assessment, to therapy and reasons for discharge. Primary analyses used a propensity-score matched cohort to compare outcomes. Exact matching was used for the NHS service entity.
Results
The prevalence of dementia in the study cohort was lower than the prevalence of dementia in a representative population, based on an estimation of prevalence in people with mild-to-moderate age over 35 (0.23% in our study vs 3.82% in previous research). Compared to people without dementia, people living with dementia were less likely to access an assessment (odds ratio [OR] = 0.60; 95% confidence interval [CI]: 0.55–0.65), to subsequently receive therapy (OR = 0.67; 95% CI: 0.61–0.73) and more likely to be discharged because services were deemed not suitable before having an assessment (relative rate ratio [RRR] = 4.90; 95% CI: 4.20–5.72) and starting therapy (RRR = 2.74; 95% CI: 2.24–3.35). Female gender, social deprivation, Asian ethnicity and less common dementia subtypes (such as frontotemporal dementia) were also associated with poorer access rates and a higher likelihood of services being deemed not suitable. Involvement of care partners in the referral process was associated with better access rates.
Conclusions
Pathways to accessing primary care psychological therapy services must be made more accessible for people living with dementia. Better access could be achieved by increasing referrer awareness and training for staff within services to promote access for people living with dementia (especially for groups under-represented in services), better understanding how to involve care partners in the process, as well as when specialist support might be more suited in secondary care. More granularity in the medical coding of rarer dementia diagnoses in electronic health records would also allow for better statistically powered research for these groups.
The present chapter describes the twofold interest of the life story investigation in people experiencing mental disorders. First, life narratives provide substantial insights into mental conditions from a first-person perspective. They represent valuable testimonies of patients’ disrupted life trajectories and allow us to understand the subjective experience of mental illness. Second, analyzing the coherence and characteristics of patients’ life stories also enhances our understanding of psychopathology. We present and discuss the alterations of narrative identity possibly caused by mental disorders, either hindering the development of or disrupting the acquired abilities necessary to craft a coherent and meaningful life story. Reversely, low aptitudes in narrating one’s entire life, selecting relevant life experiences, and assembling them into a coherent story might also play a role in both the initiation and maintenance of mental disorders. Building upon these twofold interests, this chapter will open therapeutic perspectives. The importance of working with narrative material when investigating patients’ memories in psychotherapy and how to do so will be discussed.
This study evaluated whether brief teaching sessions on transference-focused psychotherapy (TFP) could improve psychiatric trainees’ attitudes and clinical confidence in managing patients with personality disorders. A mixed-methods design was used, combining pre- and post-training validated questionnaires with a focus group discussion. Two 4-h workshops covered TFP theory and techniques, and case discussions.
Results
Twenty-six participants completed paired questionnaires. Statistically significant improvements were observed in overall attitudes (Attitudes to Personality Disorder Questionnaire total score, P = 0.022) and enthusiasm towards patients with personality disorders (P = 0.003). Clinical confidence (Clinical Confidence with Personality Disorder Questionnaire) improved markedly (P < 0.001). Qualitative analysis identified high acceptability, valuing TFP concepts and enhanced emotional awareness, although participants desired more practical components.
Clinical implications
Even brief TFP training can positively influence trainees’ attitudes and confidence in treating personality disorders. Incorporating TFP-informed training into psychiatric education may reduce clinician frustration and improve therapeutic engagement with this complex patient group.
Little has been written regarding the experience of training in medicine with a diagnosis of a personality disorder. The stigma of personality disorders, evidenced even within psychiatry, potentially marginalises affected students and resident doctors. This article provides a first-hand account of the lead author’s (E.M.) lived experience of being a medical student with a diagnosis of emotionally unstable personality disorder (EUPD). Challenges that have been faced include a lack of understanding, limited literature about medical students and doctors with personality disorders, and derogatory attitudes. Despite this, the positive aspects of the diagnosis are recognised, through enhanced resilience and heightened emotional sensitivity, which can benefit patients.
Accommodation of treatment preferences is known to improve treatment outcomes and increase patient satisfaction, and is further advised in several national guidelines.
Aims
The aim of this study was to systematically review studies that elicited treatment preferences and related determinants among adults with depressive or anxiety disorder for out-patient mental healthcare.
Method
The systematic review was registered in PROSPERO (CRD42024546311). Studies were retrieved from Web of Science, PubMed, CINAHL and PsycINFO. We included studies of all types that assessed treatment preferences of adults with depressive or anxiety disorder for out-patient care. Extracted data on preferences and determinants were summarised and categorised. Preferences were categorised into treatment approaches, psychotherapy delivery and setting, and psychotherapy parameters. Study quality was assessed with the Mixed-Methods Appraisal Tool.
Results
Nineteen studies were included in the review. Preferences examined related to treatment approaches (n = 13), psychotherapy delivery and setting (n = 10), and psychotherapy parameters (n = 7). High heterogeneity in statistical methods and preference types restricted the derivation of robust conclusions, but tendencies toward a preference for psychotherapy (compared with medication), and particularly individual and face-to-face therapy, were observed. Regarding determinants, results were highly diverse and many findings were derived from single studies.
Conclusions
Our review synthesised evidence on treatment preferences and related determinants in out-patient mental healthcare. Results showed considerable heterogeneity regarding preference types, determinants and statistical methods. We highly recommend to develop and use standardised instruments to assess treatment preferences. Care providers should consider preference variance among patients, and provide individualised care.
Howard CH Khoe, National Psychiatry Residency Programme, Singapore,Cheryl WL Chang, National University Hospital, Singapore,Cyrus SH Ho, National University Hospital, Singapore
Chapter 5 covers the topic of grief and prolonged grief disorder. Through a case vignette with topical MCQs for consolidation of learning, readers are brought through the diagnosis and treatment of a patient with normal grief and prolonged grief disorder. We also explore how to differentiate it from major depressive disorder. Topics covered include the symptoms, psychopathology, treatment including psychological therapies.
Howard CH Khoe, National Psychiatry Residency Programme, Singapore,Cheryl WL Chang, National University Hospital, Singapore,Cyrus SH Ho, National University Hospital, Singapore
Chapter 31 covers the topic of borderline personality disorder. Through a case vignette with topical MCQs for consolidation of learning, readers go through the management of a patient with borderline personality disorder from from first presentation to subsequent complications of the condition and its treatment. Topics covered include symptoms and diagnosis of borderline personality disorder, risk factors, co-morbidities, non-pharmacological management involving different psychotherapies and pharmacolgical management.
Howard CH Khoe, National Psychiatry Residency Programme, Singapore,Cheryl WL Chang, National University Hospital, Singapore,Cyrus SH Ho, National University Hospital, Singapore
Chapter 10 covers the topic of separation anxiety disorder and selective mutism. Through a case vignette with topical MCQs for consolidation of learning, readers are brought through the diagnosis and treatment of a patient with separation anxiety disorder and selective mutism. We delineate the investigations to rule out organic causes and explore treatment options and its side effects. Topics covered include the symptoms, investigations, differential diagnoses, treatment of separation anxiety disorder and selective mutism including pharmacological and psychological therapies.
Howard CH Khoe, National Psychiatry Residency Programme, Singapore,Cheryl WL Chang, National University Hospital, Singapore,Cyrus SH Ho, National University Hospital, Singapore
Chapter 4 covers the topic of persistent depressive disorder or dysthymia, and premenstrual dysphoric disorder. Through a case vignette with topical MCQs for consolidation of learning, readers are brought through the diagnosis of a patient with dysthymia. We also explore the presentation and treatment of premenstural dysphoric disorder and how to differentiate it from premenstural syndrome. Topics covered include the symptoms, psychopathology, treatment including psychological therapies, pharmacological treatment including antidepressants.
Howard CH Khoe, National Psychiatry Residency Programme, Singapore,Cheryl WL Chang, National University Hospital, Singapore,Cyrus SH Ho, National University Hospital, Singapore
Chapter 3 covers the topic of major depressive disorder. Through a case vignette with topical MCQs for consolidation of learning, readers are brought through the management of a patient with major depressive disorder from first presentation to subsequent complications of the conditions and its treatment. Things covered include the symptoms, psychopathology, co–morbid conditions, psychological therapies, the evidence-based use of pharmacological treatment including antidepressants and adjuncts, adverse effects of commonly used medications, management of treatment-resistant depression.