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We present the first results from the COS-EDGES survey, targeting the kinematic connection between the interstellar medium and multi-phase circumgalactic medium (CGM) in nine isolated, near-edge-on galaxies at z ∼ 0.2, each probed along its major axis by a background quasar at impact parameters of D = 13 – 38 kpc. Using VLT/UVES and HST/COS quasar spectra, we analyse Mgi, Mgii, Hi, Cii, Ciii, and OVi absorption relative to galaxy rotation curves from Keck/LRIS and Magellan/MagE spectra. We find that low ionisation absorption for 8/9 galaxies lies below the halo escape velocity, indicating bound inflow or recycling gas, while 6/9 galaxies have high ionisation gas reaching above the halo escape velocity, suggesting some unbound material. We find that at lower D/Rvir (0.12 ≤D/Rvir≤ 0.20), over 80% of absorption in all ions lies on the side of systemic velocity matching disk rotation, and the optical-depth–weighted median velocity (vabs) is consistent with the peak rotation speed. At higher D/Rvir (0.21 ≤D/Rvir≤ 0.31), the kinematics diverge by ionisation state: For the low ionisation gas, the amount of co-rotating absorption remains above 80%, yet vabs drops to roughly 60% of the galaxy rotation speed. For the high ionisation gas (OVi), only 60% of the absorption is consistent with co-rotation and vabs drops to 20% of the galaxy rotation speed. Furthermore, the velocity widths, corresponding to 50% of the total optical depth (∆v50) for low ionisation gas is up to 1.8 times larger in the inner halo than at larger radii, while for Ciii and OVi∆v50 remains unchanged with distance. The 90% optical-depth width (∆v90) shows a modest decline with radius for low ionisation gas but remains constant Ciii and OVi. At high D/Rvir both ∆v50 and ∆v90 increase with ionisation potential. These results suggest a radially dependent CGM kinematic structure: the inner halo hosts cool, dynamically broad gas tightly coupled to disk rotation, whereas beyond ≳ 0.2Rvir, particularly traced by OVi and Hi, the CGM shows weaker rotational alignment and lower relative velocity dispersion. Therefore, low-ionisation gas likely traces extended co-rotating gas, inflows and/or recycled accretion, while high-ionisation gas reflects a mixture of co-rotating, lagging, discrete collisionally ionised structures and volume-filling warm halo, indicating a complex kinematic stratification of the multi-phase CGM.
Chapter 4 explores how American policymakers expanded housing programs from the late 1960s to the early 1990s to address economic challenges such as rising inflation, unemployment, and deindustrialization. When high interest rates threatened mortgage lending and housing activity, policymakers created a government-backed mortgage-backed securities market with the quasi-public agencies Fannie Mae and Freddie Mac at its center. These actions aimed at restoring housing-based growth by attracting capital into housing and expanding mortgage lending at affordable rates. Moreover, policymakers expanded tax subsidies for homeownership, notably through the Tax Reform Act of 1986, and extended housing programs to stimulate economic activity in marginalized communities previously excluded from the benefits of housing-based growth. These programs contributed to the financialization of the American housing market and economy: They made the US mortgage market even more dependent on government support and tied the demand-led economy more closely to housing, as homeowners increasingly borrowed against their homes for consumer spending - further entrapping policymakers into supporting the housing sector as a growth strategy for decades to come.
Chapter 1 introduces the reader to the black geographies of New Granada in the eighteenth century, with the structure following the routes of African captives from the Caribbean region across to the mines of the Pacific. It explores how Caribbean New Granada was connected to Antioquia and the Pacific region by the mobilities of people of African descent and thereby offers an alternative geography of colonial Colombia that nuances traditional understandings of region in Colombian history. The chapter outlines the demographics of New Granada’s provinces, demonstrating the central importance of the jurisdiction’s black population to colonial history, and how New Granada was a society governed through slavery. Rivers and slave caravan routes that connected the Caribbean to the interior and the Pacific. Following an analysis of provenance zones of captives arriving in Cartagena de Indias, the chapter sketches the black geographies of the provinces of the Caribbean coastal cities of Cartagena de Indias and Santa Marta and their forested interior before casting its gaze across to the gold mines of southwestern Colombia. Elites ruled the region from temperate cities upon the backs of black and indigenous labourers.
This study aimed to evaluate the predictive accuracy of Paediatric Risk of Mortality-III, Paediatric Index of Mortality-II, and Paediatric Logistic Organ Dysfunction scoring systems for major adverse events following congenital heart surgery.
Methods:
This prospective observational study included patients under 18 years of age who were admitted to the ICU for at least 24 hours postoperatively following congenital heart surgery. Major adverse events were defined as a composite of 30-day mortality, ICU readmission, reintubation, acute neurologic events, requirement for extracorporeal membrane oxygenation, cardiac arrest requiring cardiopulmonary resuscitation, need for a permanent pacemaker, acute kidney injury, or unplanned reoperation.
Results:
A total of 116 patients, with a median age of 17.5 months (interquartile range: 5.4–60.0) were included in the study. Major adverse events occurred in 34 patients (29.3%). Paediatric Risk of Mortality-III (11.5 [8.0–18.8] vs. 7.0 [2.3–11.0]; p = 0.001), Paediatric Index of Mortality-II (3.8 [2.8–6.6] vs. 2.2 [1.7–2.8]; p < 0.001), and Paediatric Logistic Organ Dysfunction (12.0 [10.0–21.0] vs. 1.0 [1.0-10.0]; p < 0.001) scores were significantly higher in patients with major adverse events than in those without. The Paediatric Logistic Organ Dysfunction score (area under the curve 0.83; 95% confidence interval: 0.74–0.92) demonstrated the highest discrimination capacity compared to Paediatric Risk of Mortality-III (area under the curve 0.70; 95% confidence interval: 0.60–0.81) and Paediatric Index of Mortality-II (area under the curve 0.77; 95% confidence interval: 0.66–0.88) with good calibration (Hosmer–Lemeshow p > 0.05 for all). Based on the logistic regression model evaluation metrics, Paediatric Logistic Organ Dysfunction demonstrated better performance in predicting major adverse events compared with Paediatric Risk of Mortality-III and Paediatric Index of Mortality-II.
Conclusions:
The Paediatric Logistic Organ Dysfunction score outperformed the Paediatric Index of Mortality-II and Paediatric Risk of Mortality-III scores in predicting major adverse events in paediatric patients admitted to the ICU after congenital heart surgery.
Part II of this book is deliberately called "Lenses and Lessons: Towards more Global Perspectives" as it takes the reader on a journey from Pacific social work across to East Africa and into Europe. It explicity acknowledges the interdependence of the local with the global and that social work is a profession which is shaped by and in turn shapes these geopolitical and socioeconomic contexts. Framed by multiple global crises such as wars in Ukraine and the Middle East, a once-in-a-century pandemic, widespread economic turmoil, a reckoning on race, mass illegal migration, rising inequality, post- and anti-colonial views on social work and much more, the reaffirmation of positive and purposeful and socially relevant social work is illuminated and justified. The issues in Part II can be set against the International Federation of Social Workers definition of social work as “a practice-based profession and an academic discipline that facilitates social change and development, social cohesion, and the empowerment and liberation of people.” In Part II there are implications for social work education, practices, and policy.
This chapter first considers some correlations between memetic constructions and select figurative meanings, showing how our approach differs from existing multimodal metaphor approaches. As a case in point, the chapter presents an analysis of when-memes as relying on similative patterns of meaning, and also extends this discussion to include the family of If 2020 Was X memes.
This essay explores two movements that developed in reaction to naturalism and its mimetic logic of stage realism at the turn of the twentieth century. Symbolism sought to represent the unrepresentable essence of the human experience, turning to allegories, fables, and mystical images to conjure spirits from both the natural and supernatural realms. Expressionism likewise aimed at an alternative aesthetic for representing the unrepresentable but did so with an eye towards the epistemological uncertainty of knowing oneself in relation to the modern world. It featured an abstract palette of skewed lines and woodcut shadows to depict the anxious experience of unpredictability, ironically projecting movement as stasis onto an increasingly stylised mis-en-scène.
In 1812, the courts were again thrust into the center of international conflict. Decades of resentment over British domination prompted the United States to embark upon what many Americans thought of as the nation’s “second war for independence.” It was one the United States was unprepared to fight. Longstanding distrust of permanent military establishments left the nation unable to counter British armed might, especially on the water. Privateers were a potential solution, but Congress and the Madison administration were unequal to the task of regulating the United States’ private navy. Responsibility fell to the judiciary, even though Jeffersonians had spent the previous decade attacking the courts for their supposed undermining of republican principles. As the revolutionary generation had learned, judicial enforcement of the laws of maritime war was critical to maintaining the nation’s international credibility. And the courts’ disposition of ships and goods captured by American privateers kept the nation’s war machine running. By marrying government authority to private enterprise, judges made it possible for the United States to reassert its standing as a sovereign and independent nation.
Individuals with a family history of bipolar disorder are at increased risk of developing affective psychopathology. Longitudinal imaging studies in young people with familial risk have been limited, and cortical developmental trajectories in the progression towards illness remain obscure.
Aims
To establish high-resolution longitudinal differences in cortical structure that are associated with risk of bipolar disorder.
Method
Using structural magnetic resonance imaging data from 217 unrelated ‘Bipolar Kids and Sibs study’ participants (baseline n = 217, follow-up n = 152), we examined changes over a 2-year period in cortical area, thickness and volume, measured at each vertex across the cortical surface. Groups comprised 105 ‘high-risk’ participants with a first-degree relative with bipolar disorder (female n = 64; age in years: M (mean) = 20.9, s.d. = 5.5) and 112 controls with no familial psychiatric history (females n = 60; age in years: M = 22.4, s.d. = 3.7).
Results
Accelerated thickness and volume reductions over time were observed in ‘high-risk’ individuals across multiple cortical regions, relative to controls, including right lateral orbitofrontal thickness (β = 0.033, P < 0.001) and inferior frontal volume (β = 0.021, P < 0.001). These differences were observed after controlling for age, sex, ancestry, current medication status, lifetime psychiatric diagnoses and measures of gross brain morphology.
Conclusions
Longitudinal group differences suggest the presence of thicker cortex in familial ‘high-risk’ individuals at earlier developmental stages, followed by accelerated thinning towards the typical age of bipolar disorder onset. Future examination of genetic and environmental components of familial risk and the mechanistic nature (pathological or protective) of cortical-trajectory differences over time may facilitate the identification of prodromal biomarkers and opportunities for early clinical intervention.
Anxiety and depression symptoms and disorders are the leading child mental health problems in western societies. This systematic review evaluated how parental emotion socialization (ES) relates to children’s internalizing problems (from birth to age 18 years). Three meta-analyses, evaluating supportive (k = 50, N = 10,698), nonsupportive ES behaviors (k = 47, N = 10,970), and elaboration (k = 6, N = 867) were conducted. Supportive ES behaviors had a very small negative association with children’s internalizing problems (r = −.06), nonsupportive ES behaviors had a medium positive association with internalizing problems (r = .18), and elaboration had a small negative association with internalizing problems (r = −.11). Very few significant moderators emerged, and no differences based on parent gender were found. The results suggest that incorporating an ES framework in intervention and preventive efforts might be beneficial for children at risk of experiencing internalizing problems.