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This article combines book history and urban history to examine the spread of the print trade and facilities for reading in Scotland by the 1820s, using a Scotland-wide trade directory as its main source. The article demonstrates how support for reading, including printers, bookshops and venues for reading, extended far and wide within the Scottish urban hierarchy – from the largest cities to the smallest towns and villages. Variations between different types of towns are discussed, and local case studies provide further insights. The article provides fresh perspectives on Scottish urbanization, through its snapshot view of Scotland’s towns in the mid-1820s.
Antimicrobial resistance (AMR) is a global health challenge, highlighting the need for antibiotic stewardship policies. We evaluated the impact of the National Action Plan to Contain Antimicrobial Resistance (2022–2025) on antibiotic use among primary healthcare institutions (PHIs) in Central China.
Design:
A segmented interrupted time-series analysis from January 2021 to December 2023.
Methods:
We collected data from 1510 PHIs, by region, types of healthcare institutions and medication type, assessing antibiotic consumption using defined daily doses per 1000 inhabitants per day and the quality by the percentage of broad-spectrum antibiotics.
Results:
Post-intervention, antibiotic consumption declined by −35.96% (95%CI: –49.34 to –22.57), and the proportion of broad-spectrum antibiotic use decreased by –41.97% (–61.74 to –22.20). Consumption dropped significantly in both moderately developed areas and underdeveloped areas, while highly developed areas saw the largest reduction in broad-spectrum antibiotic use. Rural PHIs also showed notable declines in both overall antibiotic consumption and broad-spectrum usage.
Conclusions:
The policy was associated with a reduction in antibiotic use across PHIs, though regional disparities in its implementation suggest uneven benefits.
We study the local limit in distribution of Bienaymé–Galton–Watson trees conditioned on having large sub-populations. Assuming a generic and aperiodic condition on the offspring distribution, we prove the existence of a limit given by a Kesten’s tree associated with a certain critical offspring distribution.
Admission to shared hospital rooms are a risk factor of healthcare-associated (HA) SARS-CoV-2. Quantifying the impact of engineering controls such as ventilation and filtration is essential to informing resource utilization and infection prevention guidelines.
Methods:
Multicenter test-negative study of patients exposed to SARS-CoV-2 in shared rooms across five hospitals between January and October, 2022. Independent variables tested were measured air changes per hour (ACH), presence of any room mechanical ventilation (RMV), or portable high-efficiency particulate air (HEPA) filter. Covariates included facility (number of beds in room, outbreak status of unit), source patient (presence of symptoms, RT-PCR cycle threshold (Ct) value), and exposed patient factors (age, sex, time from last SARS-CoV-2 vaccine, previous SARS-CoV-2 infection, exposure duration). Multilevel logistic mixed models used to estimate the impact of engineering controls on transmission.
Results:
Among 468 exposed patients, secondary attack rate was 26.3% (range 7.5–33.3% across hospitals). In multivariable analysis, increased ACH was associated with decreased odds of infection (adjusted odds ratio (aOR) 0.88, 95% CI 0.78–1.00; p=.046) as were exposure duration and Ct value of source patient. Presence of RMV was also associated with decreased odds of infection (aOR 0.51, 95% CI 0.27–0.95; p=.034) while use of portable HEPA filter was not significant (aOR 0.58, 95% CI 0.26–1.31; p=.18).
Conclusions:
Improved ventilation was independently associated with lower odds of SARS-CoV-2 infection among exposed roommates. Ensuring RMV is present and optimizing ACH may significantly mitigate the risk of HA-SARS-CoV-2. Future prospective studies should assess optimal ACH thresholds and the impact of portable HEPA filters.
Despite a long tradition of research on dominant party systems (DPS), comparative analysis remains limited by conceptual ambiguities, regional and historical biases, and the absence of accessible data. This research note introduces the Global Dominant Party Systems (GDPS) Dataset, which includes 187 cases of executive dominance across 106 independent countries from 1900 to 2024, addressing the regional and historical biases that have traditionally plagued the literature. Drawing on foundational theories and refined concepts, the dataset differentiates between dominant parties and DPS and develops the minimal definition of DPS that focuses on executive arena and at least minimally contested elections. The dataset identifies cases with mechanical properties typical of DPS, that is those in which one party (or coalition) consistently monopolizes executive power and electoral competition fails to produce changes in government leadership. Despite setting permissive minimal criteria, the dataset also offers a broad range of variables on democracy, corruption and institutional features which can be used to set different criteria for case selection and conduct robustness checks. The dataset also includes variables on ethnic and opposition fragmentation, voter turnout, economy and population size, enabling researchers to investigate the institutional and socio-economic foundations of dominance across regime types and world regions. Finally, the proposed model of DPS evolution and change can serve as a useful guide for qualitative research on unpacking causal mechanisms. While limited to positive cases of dominance, the dataset offers new potential for cross-regional hypothesis testing and theory development on executive power, party system change, and democratic resilience.
In an observational study, healthcare personnel often entered contact precautions rooms without contacting patients or the environment. An approach requiring gloves and gowns based on actual contacts rather than for all room entries would reduce personal protective equipment donning and doffing time, cost, and carbon footprint by more than half.
Consider a subcritical branching Markov chain. Let $Z_n$ denote the counting measure of particles of generation n. Under some conditions, we give a probabilistic proof for the existence of the Yaglom limit of $(Z_n)_{n\in\mathbb{N}}$ by the moment method, based on the spinal decomposition and the many-to-few formula. As a result, we give explicit integral representations of all quasi-stationary distributions of $(Z_n)_{n\in\mathbb{N}}$, whose proofs are direct and probabilistic, and do not rely on Martin boundary theory.
This paper presents a new problem for the inference rule commonly known as Inference to the Best Explanation (IBE). The problem is that uncertainty about parts of one’s evidence may undermine the inferrability of a hypothesis that would provide the best explanation of that evidence, especially in cases where there is an alternative hypothesis that would provide a better explanation of only the more certain pieces of evidence. A potential solution to the problem is sketched, in which IBE is generalized to handle uncertain evidence by invoking a notion of evidential robustness.
The utility of routine environmental sampling to monitor the airborne fungal load (AFL) in healthcare settings is uncertain.
Methods:
AFL was measured by monthly cultures at a tertiary-care pediatric hospital from November 2018 through October 2023 on eleven units caring for patients at risk for invasive mold infection (IMI). Surveillance for healthcare-associated IMI was conducted for all patients in the healthcare system using locally developed definitions for possible, probable, and definite hospital-onset infections. Poisson regression was used to analyze the association between AFL and monthly IMI rates.
Results:
78 cases of IMI were identified during the period of AFL monitoring. Of these, 51 infections were classified as healthcare-associated probable or proven IMI and were tested for association with AFL measurements. There was not a significant facility-wide association between the average monthly AFL and the overall IMI rate. On units where hematology/oncology patients were treated, however, an increase in average monthly local AFL for opportunistic fungal pathogens of 1 CFU/m3 was associated with a 1.48-fold increase in the IMI rate for these patients (95% CI 1.00–2.19, P = .05). The AFL for Aspergillus species on these units showed a particularly strong association with the hematology/oncology IMI rate (15.9-fold elevation for an increase of 1 CFU/m3 [95% CI 2.8–90.7, P = .002]). Neither hematology/oncology nor facility-wide IMI rates showed comparable associations with changes of the AFL in outdoor air.
Conclusions:
Regular monitoring of AFL on targeted hospital units may identify periods when hematology/oncology patients are at increased risk for IMI.
In recent scholarship on the Ottoman Mediterranean, it has become commonplace to challenge narratives of heroic discovery and cultural superiority expounded in publications by European travellers. Rather than taking a polished, published account as its starting point, this paper discusses the travels of Edward Falkener (1814–96), a lesser-known Victorian architect and writer whose extensive tour around Anatolia (1844–5) was never communicated to a broader audience. If Falkener is remembered today, it is usually as the author of the first anglophone monograph on ancient Ephesus and editor of the first British academic journal devoted to classical art and architecture. This paper reviews Falkener’s career, but instead of these publications, the focus is on his remarkable personal archive of diaries, sketchbooks, watercolours, contracts and notes for an incomplete book about his tour of Anatolia. Drawing on this collection, it explores his fluctuating interests in heritage from different periods of Anatolia’s history and well-documented interactions with a variety of local actors who helped or hindered his meandering tour. Representing the first attempt to study Falkener’s journey, this paper explores the utility of his archive for understanding the challenges and contingencies of Victorian travel in the Ottoman Empire.
Public service internships are a staple in contemporary political science curricula. Research shows that internships produce better thinkers, employees, and citizens. Yet, political science interns are on the frontlines in observing the firsthand trauma, stress, and mental health challenges of many people seeking support and services from government. In turn, students may internalize this stress and trauma, a phenomenon recognized as secondary traumatic stress (STS). This study addresses a significant gap in the discipline’s understanding of the frequency and severity of STS experienced by political science interns in their fieldwork. We relied on surveys and written assessments from students enrolled in internship courses at two public universities. We find that interns report increased exposure to STS at the end of the semester. Furthermore, STS vulnerability varies among interns, with higher incidence rates among those with a history of primary trauma, older students, and women. We outline coping strategies for students, propose adaptations to experiential learning to enhance support, and emphasize the need for further research on this issue.
Today’s field of spatialisation in acousmatic music is very heterogeneous. Composers tend to develop their own technologies and techniques for spatialisation, and often the differences in how multichannel systems are addressed may influence both the musical appreciation and the future reproducibility of a piece. Moreover, the analytical and musicological perspectives of spatialisation are both fragmented and underdeveloped, with a lack of a shared framework for their study. This article focuses on these problems and tries to give a coherent and consistent view of spatialisation practice, from both technological and musicological perspectives. It will also act as a bedrock for the development of the musicological side of spatialisation, an aspect too often overlooked. ‘Spatial reduced listening’ and ‘spatial relativism’ will be introduced as analytical perspectives to shine a light on the composed spatial traits of sound, and not only on its spectromorphological and technological features.