Schizophrenia affects approximately 1% of the population aIts treatment is mainly based on antipsychotics, although therapeutic non-compliance is common due to lack of illness insight and side effects. Long-acting injectable antipsychotics emerged as an alternative to improve treatment adherence. This study investigates relapses in patients with severe mental illnesses treated with long-acting injectable antipsychotics, originating from the province of Salamanca.

To evaluate and compare the efficacy of different long-acting injectable treatments available in the market in preventing relapses in patients with Severe Mental Disorder (SMD), through retrospective analysis of epidemiological, clinical, and treatment data obtained from electronic medical records.

This is an observational, retrospective, and comparative study using anonymized data extracted from electronic medical records of patients diagnosed with Severe Mental Disorder (SMD) who have been treated with Long-Acting Injectable (LAI) medications. The study period covers from January 2018 to December 2022.

The study contains information from 161 patients, with a uniform distribution by age and sex. The main group presents psychotic disorders (74.5%), followed by bipolar disorder (18%). Monthly Long Acting aripiprazole is the most used injectable antipsychotic (39.8%). Side effects were recorded, such as extrapyramidal symptoms (11.9%) and sexual dysfunction (8.8%). Antipsychotic switching occurred in 19.5% of patients. The absence of relapses was higher for six-month long-acting paliperidone palmitate (80%) and lower for Monthly Long Acting aripiprazole (69.4%), a survival analysis was performed using the Kaplan-Meier method.

The comparative study reflects that, although Abilify Maintena was the most used, no significant differences were found in relapse prevention among different treatments. Survival analysis also did not yield conclusive results. Although the study has some limitations, such as a small sample size and missing data in some medical records, it provides a starting point for future research.Despite the limitations of this study due to the small sample size and lack of statistically significant results regarding the efficacy of injectable antipsychotics, the study provides information on the use of these treatments in patients with Severe Mental Disorder. Although Monthly Long Acting aripiprazole was the most used, side effects do not seem to be related to its efficacy. The results suggest that there are no significant differences between long-acting injectable antipsychotics available in the market. However, it is important to note the significance of this research topic for the future, given its clinical implications.

None Declared

The continuous exploration of new treatments in the field of psychopharmacology has brought a new light on psychedelics, raising the provocative question of how these drugs of abuse (DOA) may become useful in clinical practice. Psychedelics are included in the category of “psychoplastogens”, substances that are known for their effects of enhancing neuroplasticity in the nervous central system via the modulation of Brain-derived Neurotrophic Factor (BDNF) signaling. However, psychedelics were originally known as DOA; therefore, ascribing them to therapeutic use for patients with psychiatric disorders may seem largely counterintuitive.

To review the current data on the benefits and risks of psychoplastogens in patients with psychiatric disorders.

A literature review was conducted in four electronic databases (PubMed, EMBASE, Cochrane, and Clarivate/Web of Science) and the US National Library of Medicine database for clinical trials (www.clinicaltrials.gov) to find clinical and preclinical sources published between January 2000 and September 2024. The keywords used were “psychoplastogens,” “neuroplastogens,” “neuroplasticity,” “psychoactive drugs,” “drugs in the pipeline,” and all the main psychiatric diagnosis categories. Both primary and secondary reports were allowed, but only those published in English were selected.

Ketamine and each of its stereoisomers, as well as psilocybin, are the most extensively explored drugs in this class, but also MDMA, DMT, psilocin (ELE-101), CYB003 (a psilocybin analog), and lisuride have received increased attention in the last decade. Such agents are investigated for indications such as treatment-resistant major depression, posttraumatic stress disorder, binge eating disorder, and substance use disorders. One important direction of research is the evaluation of psilocybin in patients with cancer-related depression and/or anxiety. Hallucinations and altered states of consciousness that may receive mystical interpretations are typical for high doses of psychedelics, raising questions about the use of these drugs in clinical populations with already severe mood, thought and perceptual disturbances. Safety and tolerability aspects are extremely important in deciding when, to whom, and how much psychoplastogens may be recommended for different psychiatric disorders. Creating psychoplastogens with less or no psychotomimetic activity is expected to increase the interest of clinicians in the use of such agents for patients with psychiatric disorders, especially in treatment-resistant cases.

Although expected to be a paradigm-shifter in psychiatry, the exploration of psychoplastogens should consider not only the potential benefits, which require further and extensive studies, but also their adverse events. For this purpose, long-term studies are needed with both efficacy and tolerability outcomes carefully monitored.

None Declared

Methamphetamine (MA) is one of the most addictive drugs globally. Among its harmful consequences, methamphetamine use disorder (MUD) and methamphetamine-induced psychosis (MAP) are prevalent and increase the burden of mental health worldwide. Recent studies highlighted the relationship of the disorders and various factors including patterns of MA consumption and adverse childhood experiences (ACEs). Understanding the association between these factors and MUD and MAP is essential for advancing our knowledge and improving healthcare for our patients.

To investigate the association of MA use patterns, ACEs and the development of MUD and MAP.

This study analyzed data from a survey using the ThaiMIND questionnaire (September 2023 – June 2024). We collected participants’ socio-demographic details (including gender, age, income, employment, marital status, education), mental health history, other substances use, MA use patterns, ACEs, psychotic symptoms and their onset. The diagnosis of MUD and MAP were based on DSM-5 criteria. Univariate logistic regression was employed to examine the relationships, adjusting for socio-demographics and mental health history for MUD models, and adding other substances use and MUD diagnosis for MAP models.

In this study of 2,524 participants, 1,987 (78.72%) met the criteria for MUD, and 876 (34.71%) met the criteria for MAP. The use of yaba (MA or speed pill) reduced the risk of MAP compared to ice (crystalline MA)(OR = 0.32 [0.12 – 0.85]) while combining two types of MA raised the risk of MAP compared to ice alone (OR = 1.96 [1.37 – 2.81]). For MUD, more frequent MA use, compared to monthly or less, increased the risk with OR = 1.81 [1.34 – 2.43] (2-4 times/month), 2.27 [1.58 – 3.27] (2-3 times/week), and 4.00 [2.87 – 5.59] (4 or more times/week). Similarly, for MAP, using MA 2-3 times/week raised the risk (OR = 1.59 [1.14 – 2.22]), and using it more than 4 times/week further increased the risk (OR = 2.16 [1.62 – 2.87]). Additionally, MA injection significantly heightened the risk of MUD (OR = 6.29 [3.28 – 12.04]). Emotional abuse (OR = 1.84 [1.36 – 2.47]) and physical abuse (OR = 1.71 [1.29 – 2.27]) were linked to a higher risk of developing MUD. In addition, physical neglect (OR = 1.29 [1.02 – 1.65]), emotional neglect (OR = 1.47 [1.13 – 1.90]), and sexual abuse (OR = 1.46 [1.05 – 2.03]) were associated with an increased risk of MAP. The total number of ACEs also increased the risk of both MUD (OR = 1.28 [1.17 – 1.40]) and MAP (OR = 1.14 [1.05 – 1.24]).

The study demonstrates that MA use patterns and adverse childhood experiences significantly impact the risk of developing MA use disorder and MA-induced psychosis.

None Declared

In humanitarian settings, populations face extreme adversity, and women in the perinatal period are particularly vulnerable, often at heightened risk of depression. This impacts not only their mental health but also their ability to care for themselves and their newborns, presenting a serious challenge for maternal and nfant well-being.

This project aimed to reduce the risk of perinatal depression while strengthening infant care practices and parenting skills, ensuring that mothers, despite living in distressing and hostile environments, can be in the best possible state of mind to care for their babies.

As part of Action contre la Faim’s psychosocial support projects, we adapted the WHO’s “Thinking Healthy” (TH) protocol specifically for low- and middle-income countries (LAMIC), focusing on cultural sensitivity and the unique challenges of the intervention areas. The standard manual was condensed into three sessions, with additional cultural adaptations and the inclusion of two projective sessions (protolanguage approach) to allow women more freedom to express their specific challenges. The protocol was delivered to groups of up to eight women, separated based on whether they were pregnant or breastfeeding to better target their unique needs. Due to logistical and security constraints, the TH protocol required further adaptation to fit each context’s specific limitations.

Over the past three years, the adapted TH protocol has been implemented in three countries across Central Africa, including both humanitarian crisis zones and more stable developmental settings. The programme reached approximately 5,000 preganant women, mothers, and their babies. It was delivered not only in healthcare centres but also directly in communities and internally displaced person (IDP) camps, providing wider access. Results demonstrated significant reductions in psychological distress and depressive symptoms, with improved mother-infant interactions. The programme also helped train healthcare workers, including midwives, enhancing local capacity for long-term support. Quantitative and qualitative results, along with details of cultural adaptations, will be presented.

The adaptation of the Thinking Healthy protocol for low-resource, high-stress environments proved to be an effective and scalable approach for addressing perinatal depression. By tailoring the intervention to fit the cultural and logistical realities of Central Africa, we were able to provide meaningful support to thousands of families. The programme not only reduced depressive symptoms but also fostered stronger maternal-infant bonds and built local healthcare capacity. This model can serve as a reference for implementing mental health interventions in similar contexts globally.

None Declared

The ongoing armed conflict in Ukraine has significantly destabilized Europe’s geopolitical and economic situation, leading to a war-inflation crisis that may substantially affect the mental health of women during the perinatal period.

Our primary objective was to investigate the prevalence of depressive symptoms and assess the role of resilience as a protective factor against anxiety and depression in Polish perinatal women during the war-inflation crisis. We analyzed the percentage of women experiencing anxiety related to childbirth and the war-economic crisis, as well as their relationship with perinatal depression. The study also aimed to identify risk factors for perinatal depression and various types of anxiety, including those related to childbirth, war, and the global situation.

152 women participated in three online surveys – two conducted during pregnancy and one after childbirth. To evaluate mental well-being and the intensity of depressive and anxiety symptoms, we utilized the Edinburgh Postnatal Depression Scale (EPDS), Beck Depression Inventory (BDI-2), Labour Anxiety Questionnaire (LAQ), along with research team-developed questionnaires assessing anxiety related to the war (WAQ) and global situation (GSAQ). Resilience was assessed using the Resilience Measure Questionnaire (KOP-26).

About 32.2% of perinatal women were diagnosed with depression based on the EPDS scale with a cutoff of ≥14. Nearly 70% scored 14 or higher on the LAQ scale, indicating a significant rise in labour-related anxiety. Additionally, 24.3% experienced high levels of anxiety due to the war, while 25% faced severe anxiety related to the global situation. The Kruskal-Wallis analysis, with resilience as the independent variable, revealed statistically significant differences in the distribution of depression (F=28.302; df=2; p<0.001) and global situation anxiety (F=7.183; df=2; p<0.028) variables between the groups. Post hoc analysis showed differences in the severity of depressive symptoms and global situation anxiety between the low and high resilience groups. The correlation heat map between psychometric scores at the start of the study is presented in Table 1.

The prevalence of depressive disorders among women in the perinatal period may increase during crises caused by war and inflation, compared to periods of geopolitical and economic stability. This is a strong argument for improving the screening system for perinatal depression in Poland. A lower level of resilience during pregnancy may be a significant predictor of increased severity of depressive symptoms and higher levels of anxiety related to global situation among the perinatal population.

None Declared

The borderline pattern is an optional diagnostic specification in ICD 11 that includes the diagnostic criteria for borderline disorder. With the introduction of the dimensional diagnosis of personality disorders by grading the severity of the disorder and determining the pathological traits, a debate has been opened about the need for the borderline pattern specifier.

The objective of the study is to determine the relationship of the borderline pattern with the level of personality functionality and its role in the differentiation of patients with and without personality disorder.

An analytical cross-sectional study was conducted to determine the degree of severity of personality disorder and borderline pattern in patients diagnosed with personality disorder according to ICD 10 compared to healthy individuals. LPFS-BF-2.0 was used to assess the degree of personality functioning, and BPS was used to assess the existence and intensity of a borderline pattern.

Two groups between the ages of 18 and 65 were included in the study, the first of 17 people (N 17, 41% women) (mean age 34.29, SD 13.85) with a diagnosed personality disorder according to ICD 10 and the second a control group of 22 healthy subjects (N 22, 59% female) (mean age 33.18 years, SD 11.76). The first respondent group had LPFS-BF-2.0 scores of 29.88 (SD 4.93) and BPS 38.06 (SD 7.3). The control group had LPFS-BF-2.0 scores of 17.22 (SD 3.99) and BPS 20.09 (SD 6.05). A high correlation was found between LPFS-BF-2.0 and BPS, r(39)=0.82 p=0.0000. The differences between the two groups were high both according to the level of personality functionality t(37)=8.849 p<0.00001 and according to the intensity of the borderline pattern t(37)=8.401 p<0.00001.

According to the obtained results for the high correlation between the intensity of the borderline pattern and the level of functionality of the person, it is concluded that the borderline pattern is an indicator of the degree of severity of a personality disorder. The significant difference between the levels of personality functionality and the borderline pattern in both groups can be used in the differential diagnosis of persons with and without personality disorder and other mental disorders, which would have implications for the therapy plan.

None Declared

Anxious depression (AxD) as an independent diagnostic has been controversial, with many suggesting it as a transient state and others highlighting evidence of a worse outcome, severity, and increased suicide risk. The International Classification of Diseases (ICD-11) lists a related concept under 6A73, Mixed depressive and anxiety disorder. Previous literature on ketamine’s efficacy has mainly focused on either anxiety or depression, with limited comparison of both groups. Given their high comorbidity and shared pathophysiology, we aimed to assess ketamine’s efficacy in these populations.

This meta-analysis aimed to consolidate evidence from clinical trials evaluating ketamine therapy in AxD and Non-Anxious Depression (NAxD).

A search for published clinical trials in indexed journals and databases was conducted on August 11, 2024. Keywords included ketamine, anxiety, comorbidity, and depression, with no restrictions on language or publication date. Studies on bipolar or psychotic depression were excluded. A random-effects model accounted for variability, and subgroup analyses were performed.

Eight studies involving 536 participants (mean age = 39.0 years) were preselected. Seven studies defined “anxious depression” as a score of 7 or higher on the HAMD-AS, with AxD mean of 8.74 (±0.56) and NAxD mean of 5.83 (±1.9). MADRS scores were 35.18 (±2.22) for AxD and 31.97 (±2.29) for NAxD. The effect size of improvement in depressive symptom severity (as assessed by the MADRS) was not significantly different between the groups either 13 days after treatment (SMD = -0.07[-0.69, 0.55], p = 0.82, I2 = 73%) or 26-28 days after treatment (SMD = -0.30[-0.64, 0.04], p = 0.09, I2 = 21%). The overall depression response also did not significantly differ between the groups (odds ratio = 0.84 [0.50, 1.41], p = 0.52, I² = 13%). Insufficient data were available for remission rates.

Ketamine shows comparable efficacy in reducing depressive symptoms and achieving response in both groups. The group classified as AxD parallels previous reports of increased severity when reviewing baseline scores MADRS and other available scores. Thus, ketamine should be considered a viable treatment for patients with AxD, as they may have lower response rates to traditional antidepressants. This analysis was limited by the small number of studies, small sample sizes, and moderate heterogeneity. Differences in baseline depressive symptom severity and varying definitions of MDD with anxiety also constrained our analysis. Given the severity of symptoms in this population, we recommend developing better classification instruments for AxD. Further research is needed to explore remission differences in AxD and refine treatment strategies.

I. Borja De Oliveira: None Declared, A. Stephany: None Declared, M. Geremias: None Declared, D. Xavier: None Declared, F. Wagner: None Declared, A. Balduino de Souza: None Declared, M. O. Pozzolo Pedro: None Declared, D. Soler Lopes: None Declared, M. Carbajal Tamez: None Declared, J. Quevedo Shareolder of: Instituto de Neurociencias Dr. Joao Quevedo, Grant / Research support from: LivaNova; and receives copyrights from Artmed Editora, Artmed Panamericana, and Elsevier/Academic Press, Consultant of: EMS, Libbs, and Eurofarma, Speakers bureau of: Myriad Neuroscience and AbbVie., M. Teranishi: None Declared

Autistic spectrum disorders belong to the group of neurodevelopmental disorders, where the manifestations of the disorder differ depending on the severity of the autistic condition. These disorders are often associated with intellectual impairments and structural language disorders. In his patients, Asperger described cases with above-average intelligence as well as cases with low language and intellectual abilities. What they had in common was that they had significant disorders in social and affective communication. The diagnosis of autism spectrum disorders is usually made in childhood, but there are also cases where the diagnosis is made at an older age due to the later manifestation of symptoms.

To present a case report of 18 years old girl who was diagnosed with moderate intellectual disability in childhood, while later established with symptoms of Asperger’s syndrome and mild intellectual disability.

Psychiatric interview, medical history, psychological testing

An 18-year-old girl, accompanied by her mother, presented herself to psychiatrist for the first time due to affective disorders that manifested in the form of increased nervousness and outbursts of anger. Early psychomotor development was slow, she started walking at the age of 1.5 years and spoke at the age of two. From early childhood, stereotypies in movements and hypervigilant attention were observed, along with very poor social interactions. Due to difficulties at school, she was categorized at the age of 12 as having moderate intellectual insufficiency and IQ of 35. She underwent long-term speech therapy treatment and finished elementary and high school with the help of teaching assistant. Somewhere in high school, the patient’s pronounced talent for drawing was noticed. Observation during the psychiatric examination reveals emotional immaturity, stereotypes and rigidity in social interactions. The patient is referred again for psychological testing, results show IQ of 88 with a lag in emotional development and development of basic social skills. The patient is referred to another psychiatrist for an additional opinion, who agrees with diagnose of Asperger’s syndrome. Low dose of lamotrigine was included in therapy, after which affective state stabilized. The patient is referred again for categorization.

This case report that a diagnosis established in childhood period does not have to be definitive and that revision of diagnosis is necessary over time and as necessary, initially due to increase of patient’s IQ, as well as due to the later presentation of symptoms characteristic of certain disorder.

None Declared

Cognitive impairments often hinder daily functioning in people with severe mental illness (SMI). Cognitive Adaptation Training (CAT) is an effective psychosocial intervention that reduces this impact. However, barriers such as the two-day training and lack of neuropsychological expertise in some professionals hinder CAT implementation.

To make CAT more accessible to healthcare professionals and relatives of people with SMI by developing a web application (House-CAT) that guides users through the intervention.

For the development, User Centered Design (UCD) is used: a design process where close cooperation with future users (healthcare professionals, relatives, service users) is important to make sure that their needs are met. Although UCD is circular and iterative, three phases can be distinguished: analysis, design, and evaluation. In the analysis phase, users’ needs are identified and translated into design criteria. A testable prototype of House-CAT is created (design phase), followed by implementation and evaluation on efficiency, acceptability, and user-friendliness (evaluation phase).

Three focus groups were conducted in the analysis phase: CAT-experienced professionals (n=5); professionals unfamiliar with CAT (n=4); and relatives (n=5). Further, individual meetings with family members (n=8), and professionals (n=6) were conducted. Design criteria included the app’s ability to (1) support with setting up individual goals; (2) find personalized strategies or tools; (3) improve communication between professionals; (4) encourage cooperation between professionals, relatives, and service users; (5) be available in hybrid form; (6) use simple language. The design- and evaluation phase are currently in process: the web app and results from the evaluation phase will be presented at the conference.

House-CAT should support users in creating individual goals and personalized strategies, stimulate contact between professionals, relatives and service users, and be simple to use.

None Declared

Adverse childhood events have been associated with immune aberrations. Herpes simplex virus 1 (HSV1), a neurotropic pathogen, establishes persistent infection after primary exposure. Elevated HSV1 immunoglobulin (IgG) levels have been found in HSV1-infected patients with severe mental illness (SMI), which likely reflects immune dysregulation.

We assessed childhood maltreatment and HSV1 IgG concentrations in adult patients with SMI and healthy controls. We hypothesized that maltreatment would be associated with elevated HSV1 IgG concentrations reflecting a failure in immune competence, and that such a putative association would be stronger in or even restricted to patients.

We included 448 adult patients with SMI (mean age=31 years, 48% women, 46% HSV1 seropositive), i.e., 259 patients with schizophrenia spectrum and 189 patients with bipolar disorders, and 271 adult healthy controls (mean age=32, 41% women, 46% HSV1 seropositive). We assessed childhood maltreatment with the Childhood Trauma Questionnaire (CTQ), a 28-item retrospective self-report scale. We evaluated circulatory HSV1 IgG concentrations, expressed as continuous and dichotomous measures. In our main analyses, we applied sex- and age-adjusted multiple regressions on HSV1 IgG concentrations.

In patients with SMI (p=0.002) but not in healthy controls (p=0.203), CTQ total score was associated with HSV1 IgG seropositivity. Among seropositive patients (p<0.001) but not healthy controls (p=0.957), CTQ total score was associated with increased HSV1 IgG concentrations. Post-hoc analysis among seropositive patients showed that the five subscale scores for physical (p=0.002), sexual (p=0.019) and emotional abuse (p=0.002), and physical (p=0.012) and emotional neglect (p=0.016) were all associated with increased HSV1 IgG concentrations.

Among patients with SMI, childhood maltreatment is associated with an increased risk of HSV1 infection. Further, among HSV1-infected patients, maltreatment is associated with elevated HSV1 antibody concentrations which may reflect a link between childhood adverse experiences and an immune system dysregulation.

D. Andreou: None Declared, N. E. Steen: None Declared, K. N. Jørgensen: None Declared, T. Ueland: None Declared, I. Drabløs: None Declared, L. Wortinger: None Declared, O. Andreassen Consultant of: HealthLytix, Speakers bureau of: Speaker’s honoraria from Lundbeck and Sunovion, R. Yolken: None Declared, I. Agartz Speakers bureau of: Speaker’s honoraria from Lundbeck

In persons with severe mental illness (SMI) in long-term care, cognitive impairments may be severe and pervasive. However, it remains unclear how cognitive impairments specifically impact daily life and how these effects are reflected in their everyday functioning. Collection of such data is complicated by the fact that these individuals are often excluded from scientific research and tend to drop out more frequently due to the severity and complexity of their mental health issues. This calls for a different approach, one that makes greater use of the available structured and unstructured data from electronic patient records (EPRs).

The goals of this research are to assess how cognitive impairments and their impact on daily life in persons with SMI are qualitatively addressed in EPRs and to assess whether and how such data may be systematically evaluated.

We will conduct an explorative, retrospective EPR study focused on persons with SMI who use long-term care services within Lentis Psychiatric Institute, Department of Rehabilitation. EPRs contain qualitative (such as written reports) as well as quantitative (such as Routine Outcome Measures) data. To ensure patient privacy, the data in the obtained files will be de-identified. Indicators of cognitive impairments and their impact on daily life will be operationalized in collaboration with health care professionals and clustered in the domains of working memory, attention, verbal learning and memory, reasoning and problem solving, processing speed and social cognition. Using these operationalizations, natural language processing, an innovative machine-learning technique used to understand and interpret human language, will be used to identify patterns (such as, potentially, gender differences) with respect to cognitive impairments and their impact on daily life functioning from the qualitative EPR data.

As the study is work in progress, preliminary results are currently not yet available and will be presented at the conference.

EPRs are a potentially vital but underused source of data for persons with SMI in long-term care. By analysing data from EPRs we may gain a broader insight into cognitive impairments and their impact on daily life in persons with SMI. Such insights are essential to aid recovery for persons with SMI in long-term care.

None Declared

Balint groups are recognized for preventing burn-out and ehanced empathy by general practionners. Since few years, they are also identified for enhancing empathy by medical students for difficult patients. With the introduction of a six weeks psychiatric internship during the master medical studies at Fribourg University, a compulsory participation in four Balint Group sessions was implemented for medical trainees during there clinical psychiatric rotation.

Hilighting main psychiatric topics concerns by medical trainees during the first and the second years of implementation Hypothesing about imposition participation for medical trainees versus a freely participation.

An intervision space between group leaders take place to supervising this new design..Each group leader made a presentation about the groupal dynamic and the broached subjets during their session with medical trainees.

These finding were wrintig, discussed beteween and compiled, in order to target a future enquiry’s questions.

The fisrt year, main topics concern psychiatry’s foundations: what to do when a relative or friend is hospitalized? How to manage relational distance? How far should one be empathetic towards suicidal patients or directive with the setting of care? It was noticed an emotionally context where the tendency of students to identify with the patient was prevalent.

In consequence’s, the groupal dynamic required a great attention on the part of the moderators, to enhancing and building the medical identity of the trainees.

During the second year, in contrast, the emotional climate was quieter, the cases presented in a more balanced way.Trainees were distanced from the patient’s position as victim and accept better identify to the therapists.

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Balint group for medical student during their immersion in the psychiatry field are useful to help students to improve empathy in the patient relationship and to better understanding the specificity of the doctor relationship in psychiatry. But the confrontation with the mental illness and their treatment, especially seclusion treatment, asked a lot of questions from the trainees. The students during the first year of Balint introduction showed a great identification with the patient, essentially catched by the manifest speech and complaints. We observed some changes between the both year, with some hypothesis: better prepared students with previous teaching but also the better frame for their attend by the medical staff in hospital or in ambulatory services.

Further studies must be conducted with qualitative items (satisfaction enquiry by the students, and quantitative findings.

None Declared

People with schizophrenia have a higher prevalence of type 2 diabetes than the background population due to adverse effects from antipsychotics, lifestyle, and genetics.

This study aims to explore the illness and treatment burden, mental well-being, and received support for illness management among people with schizophrenia and type 2 diabetes.

62 Danish adults recruited from psychiatric outpatient clinics participated in this cross-sectional study using a survey developed for this specific purpose. The survey included measures of burden of illness and treatment (daily impact of diabetes and schizophrenia, multimorbidity treatment burden, diabetes empowerment), mental well-being (general well-being and diabetes distress), and social relations and support (general and illness-specific support). Descriptive analyses of survey data were conducted.

Participants reported very negative daily impact from living with schizophrenia. However, diabetes also negatively impacted physical health, emotional well-being, and feelings about their future. 55% reported high treatment burden, 74% reported low/moderate diabetes empowerment. Approximately 30% had high levels of diabetes distress and 49% reported low general well-being. Half of the participants reported needing support for managing type 2 diabetes equal to schizophrenia.

Living with schizophrenia and type 2 diabetes often involves high burden of illness and treatment, low diabetes empowerment, high levels of diabetes distress and low general well-being. This study highlights a need for engaging mental health professionals, care coordinators, family and friends in daily diabetes management in future interventional studies and clinical practice.

None Declared

The follow-up of patients with severe mental disorders and disruptive behaviors poses a significant challenge, particularly when there is a history of high impulsivity and risk of escape. Effective coordination among mental health teams, support institutions, and families is essential to provide a safe therapeutic environment and facilitate rehabilitation. This case illustrates the complexity of managing a patient with conduct disorder and borderline intellectual functioning following a prolonged escape from a long-term psychiatric care center.

To describe the clinical and outpatient management of a patient who escaped from a long-term psychiatric care facility. To evaluate the importance of multidisciplinary and inter-institutional coordination in the planning and follow-up of treatment to optimize the clinical and functional stability of the patient.

We present the case of a 26-year-old male with a history of conduct disorder and borderline intellectual functioning (IQ=60), problematic cannabis use, and gambling addiction. The patient was admitted to a Long-term Psychiatric Care Unit (UCPP) due to impulsive behaviors, aggression, and threats towards family members. The patient escaped and remained missing for 8 months. After being located and returning to the clinic, an outpatient intervention was initiated in coordination with the Madrid Agency for Support to People with Disabilities (AMAPAD) and the Regional Office of Mental Health and Addictions (ORSMA), assessing his readiness for re-admission and the adequacy of the treatment plan.

Upon re-admission, the patient initially appeared cooperative, minimizing the behaviors that led to his previous admission. As the intervention progressed, signs of irritability and hostility emerged, with overvalued/delusional ideas of persecution from family and UCPP staff, and limited introspective capacity. Intensive treatment at the UCPP led to better acceptance of limits and reduced impulsivity, although deficiencies in awareness of his limitations persisted. A transfer to another long-term care unit, the recently inaugurated Recovery and Community Reintegration Unit (URCC), was planned, with intensive rehabilitation goals tailored to the patient’s needs.

Proper coordination among institutions and flexibility in the therapeutic approach are essential for managing patients with severe mental disorders and high-risk behaviors. This case underscores the importance of a multimodal approach and adapting therapeutic strategies to the patient’s clinical evolution, always prioritizing the safety and well-being of both the individual and their family environment.

None Declared

The increasing prevalence of shift work, particularly night shifts, in modern industrial settings has raised concerns about its potential detrimental effects on workers’ health. Disruptions to circadian rhythms, sleep deprivation, and social isolation associated with night shift work have been linked to a range of physical and mental health problems.

This study aims to investigate the specific impact of night shift work on the mental health outcomes of Tunisian industrial workers.

This is a cross-sectional study carried out during 3 years among active workers working in the inter-company occupational health services of Sousse. All participants had a fixed night work schedule. Data collection was based on a pre-established anonymous questionnaire. Job strain was assessed with Karazek questionnaire.

A total of 453 employees were included in our study. Mean age was 32.12 ± 7.68 years. Half of the participants were women (52%). Sixty percent of participants were not married. Tobacco consumption was identified among 26% of the participants. The most affected sector of activity was the electronic one (63%). The average occupational seniority was 7.78 ± 6.407. Job strain was revealed in 23.4% of employees. High psychological demand was noted among 46.5% of cases. Low job control was identified among 57,4% of participants. Low social support was noted among 68% of participants.

These results underscore the need for targeted interventions to protect the health and well-being of night shift workers. Future research should explore the effectiveness of various strategies, such as scheduling modifications, workplace accommodations, and health promotion programs, in mitigating the negative impacts of night shift work.

None Declared

Background and aims: There is a lack of research regarding the topic of childhood sexual abuse trauma on men population. Childhood experiences and traumas can have a great impact on various life domains, including mental state and addictions.

This study examines the impact of childhood sexual abuse on men diagnosed with schizophrenia – regarding the age of the disease’s appearance, the appearance of additional PTSD diagnosis and substance use throughout life.

This study can contribute to the development of more effective treatment and prevention strategies for men who have experienced childhood sexual abuse and are diagnosed with schizophrenia.

Participants: 60 Male patients hospitalized in the closed wards for men, aged 18-50 at ‘Merhavim’ - Mental Health Center.

Data Collection: A one-time meeting with the research team, which included completing several questionnaires regarding their current state and childhood experiences.

The influence of childhood sexual abuse was significant in all subjects we examined. Patients of suffered from sexual abuse in their childhood were more likely to develop PTSD or develop schizophrenia at a much younger age. Also, they were more likely to suffer from substance abuse throughout their life.

- Childhood sexual abuse has a significant impact on the onset of schizophrenia symptoms (age of first hospitalization), PTSD symptoms and substance abuse throughout life.

- Traumatic childhood experiences have a significant impact on mental symptoms that appear in adulthood as well as on various behaviors throughout life.

None Declared

Digital wearable devices, such as smartphones and smartwatches, have shown potential for passively monitoring mental and physical health in individuals with Severe Mental Illness (SMI), such as schizophrenia and bipolar disorder. While research-grade devices are well studied, consumer-grade wearables could offer a more accessible alternative, though their utility in this specific context remains underexplored.

We conducted a systematic review to assess the utility of data from consumer-grade wearables in tracking and predicting changes in mental and physical health among adults with SMI. We focused on passively collected physiological data, such as sleep patterns, physical activity, and heart rate. We sought to a) identify relationships between data streams and both mental and physical health outcomes and b) recommendations for future digital phenotyping research.

A systematic review of multiple databases (Cochrane Central Register of Controlled Trials, APA PsycINFO, Embase, MEDLINE, and IEEE XPlore) was conducted in May 2024. Studies that collected passive physiological data for at least three days were included. Narrative methods were used to synthesise results across three key phenotypes: physical activity, sleep and circadian rhythms, and heart rate. Studies using invasive, or research-specific devices were excluded.

In total, 23 studies met the inclusion criteria, representing data from 12 distinct studies and more than 500 participants with SMI, mostly from high-income countries. The majority of studies used smartphones (N=15), with only eight utilizing smartwatches or other wrist-worn wearables. Eighteen studies focused on physical activity, 14 on sleep and/or circadian rhythms, and six on heart rate. We explore the findings of this study, focusing on practical recommendations for future research in the following areas: exploiting opportunities to promote physical health outcomes in SMI; greater standardization of reporting and methodologies; fine tuning longitudinal data collection and feature definition; and comparing alternative data analysis strategies.

Consumer-grade wearables hold significant promise for the passive monitoring of both mental and physical health in individuals with SMI, though current research focuses largely on psychiatric relapse prevention. The findings of this systematic review provide insights into research gaps and future research directions, including tackling physical comorbidities in this population.

L. Hassan: None Declared, C. Sawyer: None Declared, A. Milton: None Declared, J. Torous Grant / Research support from: Otsuka , Consultant of: Precision Mental Wellness, A. Casson: None Declared, A. Davies: None Declared, B. Ruiz-Yu: None Declared, J. Firth Consultant of: Atheneum, Informa, Bayer, HedoniaUSA, Strive Coaching, Angelini, ParachuteBH, and the Richmond Foundation.

The present study aimed to investigate the causal relationships among cognitive impairment, psychopathology, and real-life functioning in a large sample of people with schizophrenia, using a data-driven causal discovery procedure based on partial ancestral graphs (PAGs).

This method may provide additional insights for identifying potential targets of therapeutic interventions to promote recovery in people with chronic schizophrenia.

State-of-the-art instruments were used to assess the study variables. Two PAGs were generated at baseline and after 4 years of follow-up to explain the nature of the causal relationships linking psychopathology, cognition, and functioning.

The study sample was composed of 612 clinically stable patients with schizophrenia at baseline and 602 at follow-up. The PAGs suggested that working memory deficit is the first ancestor of the causal links, influencing all the other neurocognitive domains, social cognition, and functional capacity, which in turn affects everyday life functioning. From this domain of functioning a causal link is directed to disorganization and positive symptoms, and another to work skills and interpersonal relationships domains; the latter had a direct link to asociality and the other domains of negative symptoms. The structure of the PAGs did not differ significantly between baseline and follow-up, indicating the stability of the causal relationships.

The role of working memory deficits in the pathways to functional outcomes in schizophrenia highlights the importance of implementing integrated pharmacological and cognitive remediation interventions targeting neurocognition. The impact of everyday life and interpersonal functioning on the clinical presentation of schizophrenia suggests that integrated and personalized treatments, promoting relevant skills to improve these functional outcomes, may have a beneficial impact on clinical outcomes.

None Declared