A stratigraphic section made of Quaternary alluvial–lacustrine sediments belonging to the Baza Formation (South Spain) has been logged and studied for paleomagnetism, rock magnetic cyclostratigraphy, and electron spin resonance (ESR) quartz dating. Our results indicate that the section, which is found in the vicinity of a number of paleontological and archaeological localities, falls within the mid-Early Pleistocene (Calabrian), within the Matuyama Chron, and runs to the Jaramillo Subchron, encompassing the Cobb Mountain Subchron. The magnetostratigraphic results combined with rock magnetic cyclostratigraphy and ESR provide solid timelines, which allow gross accumulation rates to be estimated, and revealing an upsection decrease of sedimentation in accordance with the lithological and paleodepositional changes. Our study furnishes new chronologies to better understand the timing of the latest stages of endorheic sedimentation that precedes the capture of the Baza Basin by the Gualdalquivir River in the Middle Pleistocene.

In this article, I examine the history of the concept of herd immunity, beginning with British epidemiologists in the 1920s and ending with the controversy surrounding it during the COVID-19 pandemic. I argue that competing historical and contemporary understandings of herd immunity reveal an underlying tension between observing the effects of infection-acquired herd immunity on the population dynamics of infectious diseases and actively cultivating it through immunisation. Originally offering an explanatory mechanism for the rise and fall of epidemics, the concept soon became entangled with strategies of disease control and technologies for producing immunity, particularly as mass vaccination became more common in the postwar era. This tension between observing herd immunity and cultivating it has produced diverse interpretations ranging from the temporary abatement of an outbreak due to the accumulation of infection-acquired immunity to the principle undergirding disease elimination through mass vaccination. I close by suggesting that the scientific debates and uncertainties regarding the relevance of herd immunity to public health strategies during the COVID-19 pandemic reflect this long-running tension between observing and cultivating immunity in populations.

We prove that when the Aubry set for a Lipschitz continuous potential is a subshift of finite type, then the pressure function converges exponentially fast to its asymptote as the temperature goes to 0. The speed of convergence turns out to be the unique eigenvalue for the matrix whose entries are the costs between the different irreducible pieces of the Aubry set. For a special case of Walters potential, we show that perturbations of that potential that go faster to zero than the pressure do not change the selection, neither for the subaction nor for the limit measure, a zero temperature.

Diet can affect health directly or by altering the gut microbiota; thus, there are strong interrelationships between the gut immune system, gut microbiota, and diet. This study examined the effects of ingesting AIN-93M purified diet on gut immune function and gut microbiota in DO11.10 mice, in which T cell–dependent and –independent IgA can be analysed separately. Ingestion of the purified diet for 2 weeks reduced both T cell–dependent and –independent secretory IgA in the faeces compared with non-purified diet, whereas the diet did not affect T cell–dependent and –independent serum IgA. Ingestion of the purified diet had no effect on systemic immune system splenocyte responses. Ingestion of the purified diet reduced intestinal tissue expression levels of BAFF and APRIL, cytokines involved in T cell–independent IgA production, and pIgR, which transports IgA into the intestinal lumen. Co-abundance group analysis of the intestinal microbiota was conducted based on correlations between changes in the abundance of bacterial genera, and the correlations between co-abundance groups and IgA were determined. The Allobaculum-dominated co-abundance group expanded following ingestion of the purified diet, accompanied by an inverse correlation with the decrease in faecal IgA, whereas the Lactobacillus-dominated co-abundance group shrank relative to the Allobaculum-dominated co-abundance group. These results suggest that T cell–independent IgA suppresses the expansion of some intestinal bacteria and that ingestion of the purified diet induces dysbiosis via impaired IgA secretion into the intestinal lumen.

Head circumference (HC) is a low-cost proxy for early brain development, yet few studies have examined its predictive value for specific neurocognitive outcomes in low- and middle-income countries. This study investigated whether trajectories of HC growth from 1 to 24 months predict executive function and fluid cognitive skills at age 4 in a Kenyan cohort (N = 182). Using latent growth curve modeling, we found that greater HC growth was significantly associated with better EF and fluid cognitive skills, independent of initial HC and sociodemographic factors. These associations were robust across subgroups defined by prenatal exposure to HIV and atypical physical growth (i.e., extreme values for weight-for-length, underweight, or HC). Moreover, the predictive association between early HC and later neurocognition was evident within the first 15 months of life. This study highlights the value of monitoring changes in HC as one aspect of early child health and wellbeing. Infants who do not exhibit normative increases in HC in infancy may benefit from early neurocognitive assessments and/or the receipt of early intervention services.

In January 1852, as searches continued for Sir John Franklin’s missing Arctic expedition, large quantities of preserved (that is, canned) meats supplied to the Royal Navy were found putrid and caused concern that the expedition had received similar meats with fatal consequences. Whilst a Parliamentary enquiry concluded correctly that the expedition had received good-quality meats, it neglected the fact that some 5% of all canned meats were condemned on ships due to damage and corrosion. As the Franklin expedition would be no exception, the study applies recent evidence of the expedition’s victualling schedule to estimate the number of cans condemned by the time at Beechey Island when a decision would be made whether enough remained to sustain the mission. It also estimates the vitamin B1 (thiamine) content of the meat because high temperatures during canning would have degraded or destroyed that vitamin, and vitamin C, both being essential to health. Any reduction in general rations would add to the decline in the quality of the diet. The expedition’s unique circumstances of long entrapment without recourse to hunting to supplement such deficiencies, or to escape, would prove fatal regardless of the good quality of the canned provisions.

This article analyzes how Poland’s Law and Justice (PiS) weaponized migration anxiety as a populist strategy during the 2023 general elections. Using a comparative qualitative case-study approach (George and Bennett 2005), the article examines how PiS leveraged anti-immigration rhetoric to mobilize voters, deepen social polarization, and legitimize its governance. The study draws comparisons with Hungary’s 2016 referendum on European Union (EU) refugee quotas to explore how populist governments in Central and Eastern Europe (CEE) use fear-based narratives to consolidate power. It also demonstrates how PiS emulated Viktor Orbán’s 2022 strategy of holding a referendum alongside parliamentary elections to retain power. The study finds that PiS framed migration as an existential threat, using the referendum as a tool to divert attention from democratic backsliding. This strategy mirrored Orbán’s use of anti-immigration campaigns to strengthen his electoral support and resist EU pressures. By expanding on the concept of “populist polarizing referendum,” the study contributes to research on populist electoral strategies, institutional manipulation, and the role of migration-related fear in political mobilization. It highlights the broader implications of such tactics for democracy and governance in the CEE region, demonstrating how populist leaders instrumentalize migration crises to sustain electoral dominance.

We introduce Displayed Type Theory (dTT), a multi-modal homotopy type theory with discrete and simplicial modes. In the intended semantics, the discrete mode is interpreted by a model for an arbitrary $\infty$-topos, while the simplicial mode is interpreted by Reedy fibrant augmented semi-simplicial diagrams in that model. This simplicial structure is represented inside the theory by a primitive notion of display or dependency, guarded by modalities, yielding a partially-internal form of unary parametricity. Using the display primitive, we then give a coinductive definition, at the simplicial mode, of a type of semi-simplicial types. Roughly speaking, a semi-simplicial type consists of a type together with, for each , a displayed semi-simplicial type over . This mimics how simplices can be generated geometrically through repeated cones, and is made possible by the display primitive at the simplicial mode. The discrete part of then yields the usual infinite indexed definition of semi-simplicial types, both semantically and syntactically. Thus, dTT enables working with semi-simplicial types in full semantic generality.

The increasing focus on longevity and cellular health has brought into the spotlight two key compounds, urolithin A (UroA) and spermidine, for their promising roles in autophagy and mitophagy. Urolithin A, a natural metabolite derived from ellagitannins, stimulates mitophagy through pathways such as PTEN induced kinase 1 (PINK1)/ Parkin RBR E3 ubiquitin protein ligase (PRKN), leading to improved mitochondrial health and enhanced muscle function. On the other hand, spermidine, a polyamine found in various food sources, induces autophagy by regulating key signaling pathways such as 5' AMP-activated protein kinase (AMPK) and sirtuin 1, thus mitigating age-related cellular decline and promoting cardiovascular and cognitive health. While both UroA and spermidine target cellular maintenance, they affect overlapping as well as distinct signaling pathways. Thus, they do not have completely identical effects, although they overlap in many ways, and offer varying benefits in terms of metabolic function, oxidative stress reduction, and longevity. This review article aims to describe the mechanisms of action of UroA and spermidine not only on the maintenance of cellular health, which is mediated by the induction and maintenance of autophagy and mitophagy, but also on their potential clinical relevance. The analysis presented here suggests that although both compounds are safe and offer substantial health benefits and are involved in both autophagy and mitophagy, the role of UroA in mitophagy places it as a targeted intervention for mitochondrial health, whereas the broader influence of spermidine on autophagy and metabolic regulation may provide more comprehensive anti-aging effects.

Acute rheumatic fever is a systemic autoimmune disease resulting from an abnormal immune response to group A streptococcal pharyngitis. Cardiac findings are an important part of acute rheumatic fever and usually manifest as electrocardiographic abnormalities. The most common arrhythmia is first-degree atrioventricular block; however, in rare cases, complete atrioventricular block may occur. In this article, we present the case of an 11-year-old child who presented with complaints of knee pain and limited movement, in whom the diagnosis of acute rheumatic fever was suspected based on clinical, echocardiographic, and laboratory findings, and in whom complete atrioventricular block was detected on electrocardiographic. The patient’s electrocardiographic initially showed complete atrioventricular block, but with the treatment process, different levels of complete atrioventricular block were observed, and the electrocardiographic findings returned to normal. Particularly in patients who develop complete atrioventricular block, the response to treatment should be evaluated before making rapid decisions for pacemaker implantation, taking into account that the arrhythmia may be transient and can be corrected with medical treatment. This article emphasises that electrocardiographic abnormalities should not be ignored when diagnosing acute rheumatic fever and that patients should be evaluated in a holistic manner.

To advance the understanding of how e-government resources drive e-participation, the current research conducts a meta-analysis on the relationship above from the perspective of citizen experience. This meta-analysis synthesizes 517 effect sizes from 126 empirical studies to examine how e-government resources influence citizens’ e-participation intention. The findings highlight several key variables that moderate this effect. Specifically: (1) From the perspective of the experience channel, e-government resources are more effective in facilitating citizen e-participation intention when delivered through social (vs. official) channels. (2) From the perspective of the experience affair, e-government resources exert a stronger impact on citizen e-participation intention when targeting specific (vs. general) public affairs and when focusing on regional (vs. national) government affairs. (3) From the perspective of the experience environment, the effect of e-government resources on e-participation intention is stronger in developing (vs. developed) countries. Based on these findings, this study offers implications for governments and researchers and suggests directions for future research.

Anisakis pegreffii (Nematoda: Anisakidae) is a marine parasitic nematode responsible for anisakiasis, a zoonotic disease acquired through the consumption of raw or undercooked fish. With the rising popularity of dishes such as sushi and sashimi, the risk of infection has grown, prompting the need for effective food-safety measures. This study investigates the nematocidal effects of commercial wasabi substitute paste (WSP) and its bioactive compound, allyl isothiocyanate (AITC), on third-stage larvae (L3) of A. pegreffii, and explores their associated stress-response mechanisms. WSP at 1 g/mL and 2 g/mL significantly reduced larval viability, with hazard rates of 3.1% and 3.8% per minute and mean lethal times of 45 and 30 minutes, respectively (p < 0.0001). AITC, tested at a 10-fold dilution, exhibited stronger activity, inducing 50% mortality in 16 minutes with a hazard rate of 13.45%/min. Expression analyses revealed that WSP robustly upregulated HSP70 mRNA and protein in a time-dependent manner, whereas AITC caused only a modest increase in HSP70 mRNA without a significant protein-level rise over the same exposure window. Conversely, HSP90 expression showed early, transient upregulation followed by suppression or downregulation, suggesting differential regulation of heat shock pathways under chemical stress. These findings demonstrate that WSP and AITC exert potent, rapid nematocidal effects on A. pegreffii larvae and elicit distinctive molecular stress responses. The data support the potential of wasabi-derived compounds as safe, natural agents for reducing anisakiasis risk in raw seafood consumption.

Contrary to the dominant literature on autocracies, this article argues and demonstrates that dictators, in addition to being office-seeking, often are driven by policy-seeking motivation—that is, broader beliefs and ideology. The empirical investigation enlists new original data, based on obituaries, about dictators’ political motives. The dataset contains information on 297 deceased dictators who held power at some point during the period 1945–2008. The results reveal that the dictators had a variety of different motives for being in power. Many were strongly ideologically motivated, several were primarily motivated by money and power ambitions, and others held power to create stability and democratize. Thus, dictators’ motives seem to be substantially more diverse than typically assumed, and the data make it possible to measure motivation. This is key to investigating the direct as well as the conditional impact on political dynamics in autocracies.