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Chapter 57 - Congenital Viral, Bacterial, and Parasitic Infections

from In Utero Infections

Published online by Cambridge University Press:  07 August 2021

Mirna Lechpammer ,
Marc Del Bigio  and
Rebecca Folkerth
By
Marc Del Bigio
Mirna Lechpammer
Affiliation:
New York University School of Medicine
Marc Del Bigio
Affiliation:
University of Manitoba, Canada
Rebecca Folkerth
Affiliation:
New York University School of Medicine
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Summary

Adverse neurological effects of maternal infection, in particular syphilis, on the developing fetus has been recognized for centuries (1). In 1971, Nahmius and coworkers proposed the acronym TORCH, in recognition of the fact that Toxoplasma gondii, rubella, cytomegalovirus, and herpes simplex virus infections could produce a similar spectrum of abnormalities (2). The acronym was later expanded to STORCH to include syphilis, with the “O” including others. In this chapter, we will address the maternal infections that can be associated with congenital brain damage.

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Perinatal Neuropathology , pp. 339 - 358
Publisher: Cambridge University Press
Print publication year: 2021

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