Defects of Neural Tube Closure and Axial Mesodermal Defects

Mirna Lechpammer; Marc Del Bigio; Rebecca Folkerth

doi:10.1017/9781316671863.038

Chapter 37 - Defects of Neural Tube Closure and Axial Mesodermal Defects

from Neural Tube Defects and Patterning Defects

Published online by Cambridge University Press: 07 August 2021

Marc Del Bigio and

Mirna Lechpammer: Affiliation:
New York University School of Medicine
Marc Del Bigio: Affiliation:
University of Manitoba, Canada
Rebecca Folkerth: Affiliation:
New York University School of Medicine

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Summary

One of the critical early steps in the development of the central nervous system (CNS) is the closure of the neural tube and subsequent coverage by mesenchymal and epithelial components. Failure of these steps results in dorsal axis anomalies of the CNS (1). Furthermore, coverage of the CNS by mesenchymal and epithelial components is necessary for the development of the skull and vertebral column, which are in turn necessary for the protection of the CNS. It is not always clear if the main abnormality is one of actual neural tube closure, or a failure of the CNS coverings to properly form and contain the CNS. Factors external to the fetus, such as adherent amniotic membranes, can cause injury or malformation to the developing CNS.

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Type: Chapter
Information: Perinatal Neuropathology , pp. 211 - 222

DOI: https://doi.org/10.1017/9781316671863.038 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2021

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