Conduct problems and head injuries increase the risk of delinquency and share a bidirectional association. However, how they link across development is unknown. The present study aimed to identify their linked developmental pathways and associated risk factors. Latent class analysis was modeled from Millennium Cohort Study data (n = 8,600) to identify linked pathways of conduct problem symptoms and head injuries. Head injuries were parent-reported from ages 3 to 14 and conduct problems from ages 3 to 17 using the Strengths and Difficulties Questionnaire (SDQ). Multinomial logistic regression then identified various risk factors associated with pathway membership. Four distinct pathways were identified. Most participants displayed low-level conduct problem symptoms and head injuries (n = 6,422; 74.7%). Three groups were characterized by clinically relevant levels of conduct problem symptoms and high-risk head injuries in childhood (n = 1,422; 16.5%), adolescence (n = 567; 6.6%), or persistent across development (n = 189; 2.2%). These clinically relevant pathways were associated with negative maternal parenting styles. These findings demonstrate how pathways of conduct problem symptoms are uniquely linked with distinct head injury pathways. Suggestions for general preventative intervention targets include early maternal negative parenting styles. Pathway-specific interventions are also required targeting cumulative risk at different ecological levels.

Using data from a 15-year longitudinal follow-up of a randomized controlled trial of a parenting-focused preventive intervention for divorced families (N = 240) with children aged 9–12, the current study examined alternative cascading pathways through which the intervention led to improvements in offspring’s perceived health problems, BMI, and cigarette smoking in emerging adulthood. It was hypothesized that the program would lead to improvements in these health-related outcomes during emerging adulthood through progressive associations between program-induced changes in parenting and offspring outcomes, including mental health problems, substance use, and competencies. Intervention-induced improvements in positive parenting at posttest led to improvements in mental health problems in late childhood/early adolescence, which led to lower levels of mental health and substance use problems as well as higher levels of competencies in adolescence, which led to improvements in the health-related outcomes. Academic performance predicted all three health-related outcomes and other aspects of adolescent functioning showed different relations across outcomes. Results highlight the potential for intervention effects of preventive parenting interventions in childhood to cascade over time to affect health-related outcomes in emerging adulthood.

This study examines associations between early childhood attachment security and adolescent personality functioning in a high-risk sample within a developmental psychopathology framework. Data from 2,268 children (1165 male; 1103 female) and caregivers participating in Future of Families and Child Well-Being Study (FFCWS) were used to examine (1) effects of genetic polymorphisms of the serotonin transporter (5-HTTLPR) and dopamine D4 receptor (DRD4) genes and adverse childhood experiences (ACEs) on attachment security and emotional and behavioral dysregulation in early childhood and (2) longitudinal associations and transactional relationships among attachment security, dysregulation, negative parenting attitudes and behaviors, social competence, and adolescent personality functioning. Results revealed that ACEs predicted attachment security over and above sex or the genetic risk, and gene × environment interactions did not increment prediction. Results of cascade models showed that greater early childhood attachment security predicted higher adolescent level of personality functioning via pathways through intermediary variables. Limitations and future research directions are discussed.

While there is evidence that childhood maltreatment (CM) is positively associated with drug use (DU), the strength and difference of the association between CM and its subtypes (hereafter CM + ST) and DU remains to be further explored. A multilevel meta-analysis was conducted on 101 independent studies reporting 333 effect sizes (N = 132,341; Mage = 24.65; 43.80%males). Results showed significantly positive correlations between CM + ST and DU (range from 0.109 to 0.185). The results of the subgroup analysis revealed notable disparities in the correlations between distinct CM subtypes and DU (F = 5.358, P<0.01). Specifically, the effect size for childhood sexual abuse (CSA) was significantly lower than childhood emotional maltreatment (CEM) and childhood physical maltreatment (CPM), while no significant difference was noted between the CEM and CPM groups. These effect sizes also varied across regions, drug types, gender, detection rate of CM, the presence or absence of alcohol in substances, publication status and measurement method. The significant yet differing correlations between different subtypes of CM and DU to some extent support the principle of equality in psychopathology. These findings help explain the relationship between CM + ST and DU laying the groundwork for further research into the intricate and complex associations between CM and DU.

This retrospective cohort study examined prosocial skills development in child welfare-involved children, how intimate partner violence (IPV) exposure explained heterogeneity in children’s trajectories of prosocial skill development, and the degree to which protective factors across children’s ecologies promoted prosocial skill development. Data were from 1,678 children from the National Survey of Child and Adolescent Well-being I, collected between 1999 and 2007. Cohort-sequential growth mixture models were estimated to identify patterns of prosocial skill development between the ages of 3 to 10 years. Four diverse pathways were identified, including two groups that started high (high subtle-decreasing; high decreasing-to-increasing) and two groups that started low (low stable; low increasing-to-decreasing). Children with prior history of child welfare involvement, preschool-age IPV exposure, school-age IPV exposure, or family income below the federal poverty level had higher odds of being in the high decreasing-to-increasing group compared with the high subtle-decreasing group. Children with a mother with greater than high school education or higher maternal responsiveness had higher odds of being in the low increasing-to-decreasing group compared with the low stable group. The importance of maternal responsiveness in fostering prosocial skill development underlines the need for further assessment and intervention. Recommendations for clinical assessment and parenting programs are provided.

Longitudinal studies exploring the role of early personality vulnerabilities as risk factors for later NSSI dynamics are scarce. In this study, we assess how pre-adolescent borderline personality pathology (BPP) traits (assessed at mean age 12.78; SDage = 1.38, age range = 7.17–14.78) shape dynamic links between daily socio-emotional dysregulation and NSSI thoughts during emerging adulthood (Mage = 20.96, SDage = 1.63). Mothers of 131 children completed questionnaires about their child’s BPP traits in pre-adolescence. These children were re-assessed eight years later and were asked to complete a daily diary for 14 consecutive days. During these 14 days, behavioral and emotional dysregulation as well as NSSI thoughts were self-reported. Multilevel structural equation modeling was used (1) to examine dynamic links between socio-emotional dysregulation manifestations and NSSI thoughts in early adulthood, and (2) to explore the role of pre-adolescent BPP traits in moderating these early-adult dynamic associations. Our findings suggest that young adults who were described by their mothers as high on BPP traits (especially anxious and paranoid traits) during pre-adolescence, tended to respond more with NSSI thoughts when experiencing dysregulation or when perceiving others as rejecting in young adulthood. Results are discussed in terms of potential targets for indicated prevention of NSSI development.

This study investigates whether lower self-regulation (SR) facets are risk factors for internalizing symptoms (vulnerability models), consequences of these symptoms (scar models), or develop along the same continuum and thus share common causes (spectrum models) during middle childhood. To analyze these models simultaneously, a random intercept cross-lagged panel model was estimated using Mplus. Data were assessed at three measurement time points in a community-based sample of N = 1657 (52.2% female) children in Germany, aged 6–13. Internalizing symptoms were measured via parent report by the emotional problems scale of the Strengths and Difficulties Questionnaire. Seven SR facets were assessed behaviorally, via parent report and teacher report. At the within-person level, internalizing symptoms were concurrently associated with emotional reactivity at all measurement time points, while no cross-lagged paths reached significance. At the between-person level, internalizing symptoms were associated with working memory updating (r = −.29, p < .001), inhibitory control (r = −.29, p < .001), planning behavior (r = −.49, p < .001), and emotional reactivity (r = .59, p < .001). As internalizing symptoms and SR facets were primarily associated at the between-person level, the results lend support to spectrum models suggesting common causes of internalizing symptoms and impaired SR.

Parents involved with child protective services (CPS) often face stressors that compromise their parenting; thus, it is critical to identify sources of resilience at multiple ecological levels. This study leveraged cross-sectional data from a study of CPS-involved parent-child dyads (N = 129). Most parents identified as having a minoritized racial/ethnic identity and as having low income. Parent responsive involvement, constructive discipline, and problematic discipline were coded from observations of parent-child interactions when children were approximately 4 years old (M = 4.19 years, SD = .34; 45.7% female). Neighborhood resource availability was assessed using the Childhood Opportunity Index, a publicly available measure of resources in a given census tract. Parental attachment was coded from the Adult Attachment Interview. Greater neighborhood resource availability and secure-autonomous parental attachment were associated with reduced problematic discipline. Additionally, parental attachment moderated the link between neighborhood resource availability and responsive involvement, such that autonomous parents in more resourced neighborhoods demonstrated strengths in positive, warm parenting. These findings highlight the potential of neighborhood resources and secure attachment to strengthen parenting, even in the face of adversity, supporting the resilience of families in marginalized communities.

The proopiomelanocortin (POMC) molecule has been implicated in models of self-injurious behavior (SIB) in neurodevelopmental disorders, but it has never been specifically sequenced in search of base specific polymorphisms. The empirical focus of this preliminary study was to sequence the POMC gene in 11 children (mean age = 41.8 months, range = 12–60 months; 73% male) with clinical concerns regarding global developmental delay, 5 with reported self-injury. Genomic DNA was extracted from blood samples, and the POMC gene was amplified by specific oligonucleotide primers via polymerase chain reaction. The amplified gene products were sequenced by the University of Minnesota Genomic Center, and the results were analyzed using Sequencher software. A single nucleotide polymorphism (SNP), 1130 C>T, was found in the 3’ untranslated region (UTR) of two samples (one of whom had SIB). The program TargetScanHuman was used to predict the function of this mutation. Variant c.1130 C<T was predicted to be located in the target site of two microRNAs (miRNAs; hsa-mir-3715 and hsa-mir-1909), and the variant allele T may result in an increased minimum free energy for the two miRNAs. Further work with much larger samples is needed to continue the investigation of POMC’s possible function as a risk factor for the development of SIB in children with developmental delay/disability. The findings presented in this study show that the SNP found in the 3’ UTR could alter the binding of miRNAs to POMC 3'UTR, thus, increasing POMC expression and affecting several biological systems with high relevance to the biology of self-injury. There was a significant difference in β-endorphin levels between SIB (M = 169.25 pg/mL) and no SIB (M = 273.5 pg/mL, SD = 15.2) cases (p < .01). Intervention implications are tied to prior observations of individual differences among SIB responders and nonresponders to treatment with the opioid antagonist naltrexone. Stratifying individuals with SIB by POMC mutation status may provide a potential tailoring-like variable to guide the selection of who is more (or less) likely to respond to opiate antagonist treatment. Currently, opioid antagonistic treatment for SIB is empiric (trial and error).

Suicide rates are increasing rapidly among Black children and adolescents, calling for novel approaches to understanding their unique risk factors. The Structural Racism and Suicide Prevention Systems Framework offers a new culturally responsive theory that structural racism is an underlying mechanism for disparities in suicide among ethnoracial marginalized youth. Thus, a deeper analysis of the intersection of racism and systems to better understand suicide risk and create more effective targeted interventions for Black youth is imperative. The current systematic review comprehensively evaluated and synthesized the empirical literature regarding the relationship between structural racism and suicide risk among Black youth. 17 studies from 3 database searches, published between 2013 and 2024 are presented. Results revealed a positive relationship between structural racism and suicidal thoughts and behaviors among Black youth. Systems that particularly facilitate the perpetration of racism toward Black youth include schools, criminal justice, and income inequality. Findings serve as a call to action to incorporate more socioecological models into suicide prevention research focused on Black youth. Understanding the depth and scope of how racism contributes to suicide risk provides key targets for prevention and intervention strategies that are specific to individuals belonging to this group at disparate risk for suicide.

Children with developmental language disorder (DLD) often struggle with theory of mind (ToM). This study explored the link between parental reflective functioning (PRF) and children’s ToM, focusing on the mediating role of parental stress (PS). A total of 80 children aged 4–7 years (40 with DLD and 40 with typical language development, TLD) and their parents were included for analysis. Assessments included the WPPSI-IV, NEPSY-II, TEC, and ELT for children and the PRFQ and PSI-SF4 for parents. Results showed that children with DLD performed similarly to their TLD peers in terms of nonverbal intelligence but faced difficulties with cognitive and affective ToM and understanding of emotional terms (UET). Parents of DLD children exhibited low interest and curiosity (PRF components) and high PS, particularly due to dysfunctional interactions and challenging behaviors. Mediation analysis revealed that low parental interest and curiosity negatively affected children’s cognitive ToM and UET through increased PS from dysfunctional interactions. These findings highlight the need for early interventions to enhance ToM in children with DLD and support parents in better understanding and interacting with their child. Such interventions can reduce parent–child stress and promote ToM development of children with DLD, aligning with bioecological models of development.

Exposure to maternal depressive symptoms (MDS) may have a pertinent role in shaping children’s emotional development. However, little is known about how these processes emerge in the early postpartum period. The current study examined the direct and interactive associations between MDS and cry-processing cognitions in the prediction of infant negative emotionality and affective concern. Participants were 130 mother-child dyads (50% female) assessed at three time points. During the second trimester of pregnancy, expectant mothers completed a procedure to assess responses to video clips of distressed infants and reported about MDS. Mothers also reported about MDS at 1- and 3-months postpartum. At age 3 months, infants’ negative emotionality and affective concern responses were observed and rated. We found no direct associations between MDS and both measures of infant emotional reactivity. However, MDS interacted with cry-processing cognitions to predict affective concern and negative emotionality. Overall, MDS were related to increased affective concern and decreased negative emotionality when mothers held cognitions that were more focused on their own emotions in the face of the infant’s cry rather than the infant’s emotional state and needs. Clinical implications for early screening and intervention are discussed.

Higher levels of parental reflective functioning are associated with normatively developing children’s secure attachment and better socioemotional functioning. Children with autism spectrum disorder (ASD) exhibit more severe behavioral problems than normatively developing children, which hinder social adaptation and impose significant parenting challenges. However, the relationship between parental reflective functioning and behavioral problems in children with ASD remains underexplored, with most studies being cross-sectional. The present study examined reciprocal associations between parental reflective functioning and behavioral problems over a 6-month period across three timepoints in a sample of 180 Chinese parents of children with ASD using cross-lagged panel analyses. The result revealed a bidirectional relationship between parental reflective functioning and children’s internalizing behavioral problems. Higher level of pre-mentalizing predicted increased internalizing behavioral problems at the subsequent time point, and vice versa. A child-driven effect was found in the association between externalizing behavioral problems and parental reflective functioning. A higher level of children’s externalizing behaviors was correlated with increased parental pre-mentalizing and decreased certainty about mental states, as well as reduced parental interest and curiosity, at subsequent time points. The results underscore the importance of developing parenting interventions aimed at enhancing parental reflective functioning to mitigate behavioral problems in children with ASD.

The moderating roles of friendship and contextual variables on associations between social withdrawal and peer exclusion and growth curves of depressed affect were studied with a three-wave multilevel longitudinal design. Participants were 313 boys and girls aged 10–12 from Canada (n = 139), mostly of European and North African descent, and Colombia (n = 174), mostly mestizo, afrocolombian, and European descent. Depressed affect, peer exclusion, social withdrawal and friendship were assessed with peer-reports, and collectivism and individualism with self-reports. Group-level scores included gender, place and means of social withdrawal, peer exclusion, friendship, collectivism and individualism for each child’s same-gender classroom peer-group. Results indicated that being friended weakened associations between peer exclusion and social withdrawal and depressed affect. The strength of this effect varied across peer-group contexts.

Childhood adversity is associated with increased engagement in health risk behaviors (HRBs), such as substance use, violence, and risky sexual behaviors during adolescence, which contribute to leading causes of death and disability throughout the lifespan. Threat and deprivation are two dimensions of adversity that impact health and wellbeing through partially distinct developmental pathways, but no studies have examined if and how HRBs differ by adversity dimension. This pre-registered network analysis examined the independent associations between threat, deprivation, and adolescent HRBs using data from the 2023 Youth Risk Behavior Survey. We hypothesized that both adversity dimensions would be associated with HRBs, with stronger associations for threat compared to deprivation. Participants were U.S. high school students (N = 7,691; 52% male, 48% female). Forty-six percent were white, 26% multiple races, 12% Black, 7% American Indian/Alaska Native, 4% Asian, < 1% Native Hawaiian/Other Pacific Islander, and 20% Hispanic. Consistent with our hypotheses, network structures revealed that both threat and deprivation were associated with HRBs, the patterns of such associations varied by dimension, and the overall strength and number of HRB associations was greater for threat. Findings support the utility of dimensional models in linking childhood adversity to adolescent HRBs, with implications for research and clinical practice.

Dante Cicchetti, the architect of developmental psychopathology, has influenced so many of us in profound ways. One of his many contributions was in demonstrating the power of randomized controlled trials (RCTs) to study the effects of Child–Parent Psychotherapy (CPP). These RCTs have shed light on causal mechanisms in development. Following Cicchetti and colleagues’ work, we designed a brief home visiting program, Attachment and Biobehavioral Catch-up (ABC), to help parents respond in sensitive, nurturing ways, so as to enhance children’s attachment and self-regulatory capabilities. In the current study, we assessed adolescents’ reports of the closeness of their relationships with their mothers 12 years after their mothers completed the intervention. A total of 142 adolescents participated (47 randomized to ABC, 45 randomized to a control intervention, and 50 from a low-risk comparison group). Adolescents whose mothers had been randomized to ABC reported closer relationships with their mothers than adolescents randomized to the control condition, with significant differences seen on approval, support, companionship, and emotional support subscales. Consistent with Cicchetti et al.’s work, these results provide powerful evidence of the long-term effects of an early parenting intervention.

The present study examined several distinct indicators of regulation (i.e., task-based executive function, surveyed child effortful control, and surveyed household chaos) as moderators of longitudinal bidirectional links between developmental changes in harsh parenting (HP) and child externalizing behaviors (EXT) from age 9 to 14 years. The sample included 311 children (50.4% female; 111 White or European American; 97 Hispanic or Latino; 103 Black or African American). We conducted cross-lagged panel analyses and utilized multiple reporters (mother, father, and child). Regarding bidirectionality between HP and EXT, findings were mixed depending on informant, but overall more child effects than parent effects or bidirectional effects emerged. Child and household regulation moderated certain effects, providing initial evidence of the potential role of regulations in bidirectional links between HP and EXT. The present study adds impetus to considering child self-regulation and household chaos as critical features influencing the bidirectional link between parenting and child functioning.

Early childhood trauma has been linked to neurocognitive and emotional processing deficits in older children, yet much less is known about these associations in young children. Early childhood is an important developmental period in which to examine relations between trauma and executive functioning/emotion reactivity, given that these capacities are rapidly developing and are potential transdiagnostic factors implicated in the development of psychopathology. This cross-sectional study examined associations between cumulative trauma, interpersonal trauma, and components of executive functioning, episodic memory, and emotion reactivity, conceptualized using the RDoC framework and assessed with observational and performance-based measures, in a sample of 90 children (ages 4–7) admitted to a partial hospital program. Children who had experienced two or more categories of trauma had lower scores in episodic memory, global cognition, and inhibitory control as measured in a relational (but not computerized) task, when compared to children with less or no trauma. Interpersonal trauma was similarly associated with global cognition and relational inhibitory control. Family contextual factors did not moderate associations. Findings support examining inhibitory control in both relationally significant and decontextualized paradigms in early childhood, and underscore the importance of investigating multiple neurocognitive and emotional processes simultaneously to identify potential targets for early intervention.