Childhood and puberty can affect metabolism, leading to tissue injury and malfunction later in life. The consumption of high-processed foods rich in salt and sugar is increasing in middle- and high-income countries, especially among young people. It is necessary to evaluate the effects of high salt and sugar levels in the youth on most injured organs during metabolic challenges. We aimed to investigate whether high-salt/sucrose intake affects whole-body development and leads to end-organ injury. Weaned male Wistar rats were divided into two groups: a control group fed a standard diet and tap water, and an experimental group (SS) fed a standard diet and a beverage containing 1·8 % NaCl and 20 % sucrose instead of tap water. The animals were treated for 60 d, starting after weaning at 21 d of age, after which the animals were subjected to glucose and insulin tolerance tests, urine collection and heart rate monitoring and euthanised for sample collection at 81 d of age. SS showed reduced body weight gain and increased food intake of sodium/sucrose solution. Interestingly, high-salt/sucrose intake led to increased body adiposity, liver lipid inclusion, heart rate and renal dysfunction. SS exhibits increased levels of PPAR alpha to counterbalance the hypertrophy of brown adipose tissue. Our findings reveal that the SS rat model exhibits non-obvious obesity with end-organ damage and preserved brown adipose tissue function. This model closely parallels human conditions with normal BMI but elevated visceral adiposity, providing a relevant tool for studying atypical metabolic disorders.

The concurrent challenges of the COVID-19 pandemic and a significant earthquake in Izmir on October 30, 2020, presented a unique scenario for disaster management and response. This study focuses on the impact of the earthquake, which resulted in 117 fatalities, including 1 due to drowning, and injured 1034 individuals, alongside widespread structural damage including to the Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital. The objective is to assess the activation and implementation of the hospital disaster plan amidst the ongoing pandemic. Through a retrospective evaluation of all actions undertaken as per the Hospital Disaster Emergency Plan within the Disaster Management cycle, this study examines the decision-making process for the hospital evacuation on October 30, 2020, the evacuation of COVID-19 patients, and the strategies employed to increase hospital capacity. Of 216 patients hospitalized at the time of the earthquake, 65 were transferred to other facilities under COVID-19 protocols. The prolonged nature of pandemics and the likelihood of secondary disasters underscore the importance of comprehensive risk assessments and dynamic disaster planning, considering simultaneous multiple hazards. This study suggests the inclusion of multi hazard scenarios and diverse evacuation methods by using types of ambulances, such as ground, helicopter, and boat.

The fruit fly Ceratitis capitata is a successful generalist due to the trade-off between different variables in its life history traits. The present study aimed to assess some life history traits of C. capitata recovered from peach, plum and fig, three key host species, under the climatic conditions of an irrigation oasis in the arid province of San Juan, Argentina. Pupal abundance, sex ratio and morphometric parameters such as pupal and adult weight, pupal volume, wingspan and head-caudal length were influenced by the host in which the larvae were reared. Sexual maturity, measured as the peak of calling (pheromone emission), was homogeneous on the sixth and seventh days after emergence, but males recovered from fig showed early calling activity on the third day after emergence. The plasticity of C. capitata to adapt its life history traits to specific nutrient variations within the larval environment allows it to colonise and establish populations where key hosts, as those studied here, are available. The knowledge of the interactions between host fruit trees and C. capitata populations provides helpful information for planning the management of local orchards and urban fruit plantations within irrigation oases, taking into consideration the concept of key hosts as peach and fig.

In a context promoting partners’ active participation in their divorce or dissolution, family lawyers often put their clients to work – from stating goals and supplying information for the written file, to embodying the case at the hearing. This article focuses on the coproduction of legal work between family lawyers and their clients, based on long-term collective research on family law in mainland France: interviews with attorneys, observations of encounters between lawyers and clients in lawyer offices and in courts, as well as a “3,000 family cases” database. Using a relational, materialist, structural, and intersectional theoretical approach, we show that coproduction of legal work and its meaning varies greatly depending on the power dynamics between lawyers and clients, – on a spectrum that goes from exploitation to empowerment of the client. Coproduced legal work varies according to configurations of class, race, gender, and age on both side of the desk, as well as according to the structure of the legal market. Interactions between lawyers and their clients thus contribute to shape inequality before the law.

We study the exact Hausdorff and packing dimensions of the prime Cantor set, $\Lambda _P$, which comprises the irrationals whose continued fraction entries are prime numbers. We prove that the Hausdorff measure of the prime Cantor set cannot be finite and positive with respect to any sufficiently regular dimension function, thus negatively answering a question of Mauldin and Urbański (1999) and Mauldin (2013) for this class of dimension functions. By contrast, under a reasonable number-theoretic conjecture we prove that the packing measure of the conformal measure on the prime Cantor set is in fact positive and finite with respect to the dimension function $\psi (r) = r^\delta \log ^{-2\delta }\log (1/r)$, where $\delta $ is the dimension (conformal, Hausdorff, and packing) of the prime Cantor set.

Anaemia affects more than 36 % of all pregnancies globally and is associated with significant maternal and neonatal morbidity and mortality. Iron deficiency is widely recognised as the most common nutritional cause of anaemia but other nutrient deficiencies are also implicated, including the B vitamin riboflavin, albeit its role is largely under-investigated and thus typically overlooked. Riboflavin, in its co-factor forms flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), is required for numerous oxidation-reduction reactions, antioxidant function and in the metabolism of other B vitamins and iron. While clinical deficiency of riboflavin is largely confined to low-income countries, sub-clinical (functional) deficiency is much more widespread, including in high-income countries, and is particularly common among women of reproductive age and during pregnancy. Limited observational evidence from high-income populations suggests that suboptimal riboflavin status contributes to an increased risk of anaemia. Furthermore, randomised controlled trials in pregnant women from low- and middle-income countries have demonstrated beneficial effects of riboflavin on haematological status and anaemia. Various mechanisms have been proposed to explain the contribution of riboflavin deficiency to anaemia, with the strongest evidence pointing to an adverse effect on iron metabolism, given that riboflavin co-factors are required for the release of iron from storage ferritin in the production of red blood cells. Overall, this review investigates riboflavin intakes and status during pregnancy in different populations and evaluates the available evidence for the under-recognised role of riboflavin in the maintenance of haemoglobin concentrations together with its potential to protect against the development of anaemia during pregnancy.

Graffiti are often seen as providing a window into the emotions of ancient peoples. However, Byzantine graffiti has been viewed as an exception, with the formulaic Greek texts written between 300 and 1500 taken as evidence of communal identity, rather than individual expressiveness. However, variations in these texts can reveal much about an individual author and their personal experiences. In particular, certain formula suggest the dangerous situation an author survived, including incarceration and sea travel. This paper focuses on Corinth, Syros, and Tinos where individuals experienced danger, and how their fears and needs were manifested in the graffiti they left behind.

How does interior immigration enforcement affect how undocumented immigrants describe their interactions with state and societal institutions? Although there is some evidence that points to a broad range of chilling effects that result when local law enforcement officials work with U.S. Immigration and Customs Enforcement (ICE) on federal immigration enforcement, there is no systematic study that collectively examines the impacts that may result with such enforcement efforts. We situate our paper as evidence of the homeland security state and show how contemporary interior immigration enforcement subjugates undocumented immigrants in nearly all facets of their interactions with state and societal institutions. To illustrate this, we embedded an experiment in a survey (n = 594) drawn from a probability-based sample of undocumented immigrants. When respondents are told that local law enforcement officials are working with ICE on federal immigration enforcement, they report that they would be less likely to report crimes they witness or are victims of to the police, use public services that require them to disclose their personal contact information, do business that requires them to disclose their personal contact information, and participate in public events where the police may be present, among other main findings.

You can never really get tired of Italian politics. Over the last 30 years, we have seen many turning points, the most memorable of which was undoubtedly Silvio Berlusconi's unexpected ‘descent into the field’ in 1994. Nor have we been deprived of colourful characters, such as Matteo Renzi or Matteo Salvini, who, as their careers took off, ended up burning their wings. And after many unsuccessful attempts, imagination has finally come to power (as they used to say in the 1960s), although the 1968 generation has nothing to do with it. Indeed, all the credit goes to the Movimento 5 Stelle (M5S), whose activists were seen carrying their leader Beppe Grillo – sitting in a dinghy – through the streets of Bologna during a procession of sorts. The general elections of 25 September 2022 added an important chapter to recent Italian political history, which has sometimes taken on a dramatic tone but more often that of a comedy or even a farce. All in all, nothing out of the ordinary; in the society of the spectacle, this is how the Darwinian struggle for political survival can also be played out.

A number of important studies have documented gender gaps in the effectiveness or performance of individual representatives. Yet whether these differences are observable when it comes to responsiveness to public opinion is unclear. In this article, I examine the degree to which representatives use social media to dynamically respond to shifts in issue salience among the electorate. After combining nearly 400 bi-weekly repeated public opinion surveys from YouGov asking voters about their issue priorities, I trained a large language model to classify the universe of elected U.S. and UK representatives’ social media messages on Twitter to the same issues. Findings reveal that women representatives demonstrate greater responsiveness than their male counterparts to shifts in issue salience according to both women and men constituents. Despite an overall bias toward male constituents, female representatives play a crucial role in narrowing the gender gap by consistently aligning their attention with the issues prioritized by female constituents. These findings not only contribute to our understanding of elite-voter responsiveness but also underscore the substantive benefits that women representatives provide for all constituents.

In this essay, I argue for a reinterpretation of F. H. Bradley's theory of feeling based on the underemphasized influence of Hegel's phenomenology on Bradley's philosophy. While traditional interpretations of Bradleyan feeling often understand it to have strong metaphysical connotations, I argue that such interpretations result in an important distortion of the overall structure of Bradley's thought. Contra the metaphysical interpretation, I argue that Bradley's account of feeling can only be properly understood by interpreting his theory in light of his own explicit attributions of the theory to Hegel. By taking Bradley at his word that feeling truly is derived from Hegel, I argue that we are better able to understand the overall structure of Bradley's thought and the way in which he belongs to the neo-Hegelian tradition of philosophy. Through explaining the debt that Bradley owes to Hegel regarding feeling, an important source of disagreement between Bradley and Hegel will become apparent, namely, the ability for feeling to be subsumed within thought, thereby differentiating Bradley's and Hegel's ultimate characterizations of reality.