The war in Ukraine raises concerns for potential hazards of radiological and nuclear incidents. Children are particularly vulnerable in these incidents and may need pharmaceutical countermeasures, including antidotes and cytokines. Searches found no published study comparing pediatric indications and dosing among standard references detailing pediatric medications for these incidents. This study addresses this gap by collecting, tabulating, and disseminating this information to healthcare professionals caring for children. Expert consensus chose the following references to compare their pediatric indications and dosing of medical countermeasures for radiation exposure and internal contamination with radioactive materials: Advanced Hazmat Life Support (AHLS) for Radiological Incidents and Terrorism, DailyMed, Internal Contamination Clinical Reference, Medical Aspects of Radiation Incidents, and Medical Management of Radiological Casualties, as well as Micromedex, POISINDEX, and Radiation Emergency Medical Management (REMM). This is the first study comparing pediatric indications and dosing for medical countermeasures among commonly used references for radiological and nuclear incidents.

Cette étude se penche sur la communication du Parti conservateur du Québec (PCQ) sur Facebook et X au cours de l'année précédant l’élection générale québécoise de 2022. Basée sur une analyse de contenu d'un échantillon de 800 messages diffusés sur Facebook et X par le parti et son chef Éric Duhaime, l'analyse relève les éléments populistes des publications de même que les objectifs politiques de sa communication en ligne. L'article démontre comment le parti a utilisé ces plateformes numériques afin de tenter de mobiliser une base d’électeurs en contournant les filtres médiatiques traditionnels et en s'adressant directement aux électeurs afin de tirer profit du contexte médiatique hybride québécois. Deux conclusions découlent de nos analyses. Premièrement, le PCQ semble avoir employé un discours populiste à caractère antiélitiste de manière à exploiter une grogne pandémique présente au Québec. Deuxièmement, le parti a utilisé les fonctions de mobilisations qu'offrent les médias socionumériques afin de constituer une coalition d’électeurs.

Monism and pluralism are not only used to describe the ways in which international law becomes part of a domestic legal system but can also be applied to scholarship that seeks to explain the messiness of discrimination. According to Sophia Moreau's pluralist theory, the wrongfulness of discrimination can be summarized as three types of treatment: subordination, restriction, and exclusion. In this contribution, I will explore the role that power plays in her theory; while power is explicitly discussed in relation to subordination, it is less apparent from restriction and exclusion. However, as I will argue, power is a crucial element underpinning all forms of discrimination and all protected grounds.

From 1965 to 2020, the National Science Foundation constituted the single largest funding source for political science research. As such, the NSF played a central role in defining the cutting-edge of our discipline. This study draws on historical records of the American Political Science Association to examine the political and administrative contexts that shaped the funding priorities of the NSF Political Science Program. Additionally, the study presents a new dataset and analysis of the nearly three thousand projects funded over the 55-year life of the program. The dataset shows that NSF funding was principally channeled toward quantitative research, whereas qualitative methods received little support, and work advancing normative, critical, or interpretive approaches received virtually no support. The archival record and awards-level data make visible the material forces that shaped knowledge production, and they underline the NSF’s instrumental role in consolidating behavioralism and marginalizing non-positivist approaches. The study sheds new light on the history of the discipline and helps to contextualize some of the distinctive features of American political science.

Given maps $f_1,\ldots ,f_n:X\to Y$ between (finite and connected) graphs, with $n\geq 3$ (the case $n=2$ is well known), we say that they are loose if they can be deformed by homotopy to coincidence free maps, and totally loose if they can be deformed by homotopy to maps which are two by two coincidence free. We prove that: (i) if Y is not homeomorphic to the circle, then any maps are totally loose; (ii) otherwise, any maps are loose and they are totally loose if and only if they are homotopic.

This note highlights an original echo between two passages of Seneca's Troades that draws attention to one of Andromache's personality traits.

While it is known that vitamin D deficiency is associated with adverse bone outcomes, it remains unclear whether low vitamin D status may increase the risk of a wider range of health outcomes. We had the opportunity to explore the association between common genetic variants associated with both 25 hydroxyvitamin D (25OHD) and the vitamin D binding protein (DBP, encoded by the GC gene) with a comprehensive range of health disorders and laboratory tests in a large academic medical center. We used summary statistics for 25OHD and DBP to generate polygenic scores (PGS) for 66,482 participants with primarily European ancestry and 13,285 participants with primarily African ancestry from the Vanderbilt University Medical Center Biobank (BioVU). We examined the predictive properties of PGS25OHD, and two scores related to DBP concentration with respect to 1322 health-related phenotypes and 315 laboratory-measured phenotypes from electronic health records. In those with European ancestry: (a) the PGS25OHD and PGSDBP scores, and individual SNPs rs4588 and rs7041 were associated with both 25OHD concentration and 1,25 dihydroxyvitamin D concentrations; (b) higher PGS25OHD was associated with decreased concentrations of triglycerides and cholesterol, and reduced risks of vitamin D deficiency, disorders of lipid metabolism, and diabetes. In general, the findings for the African ancestry group were consistent with findings from the European ancestry analyses. Our study confirms the utility of PGS and two key variants within the GC gene (rs4588 and rs7041) to predict the risk of vitamin D deficiency in clinical settings and highlights the shared biology between vitamin D-related genetic pathways a range of health outcomes.

This article traces a speculative and critical engagement with histories of health care disparity and medical exploitation shared across fictions by Ralph Ellison and Toni Morrison, and the artwork of Ellen Gallagher. It argues that insistent returns to racialized experimentation and scientific modes of looking form a significant interrogation of a wider set of US promises and attritions. Specifically, it asks how postwar African American culture takes up scopic questions to address dominant accounts of progress and the modern, both via reference to visual orders and technologies, and via formal choices regarding iteration, perspective and scale.

Sustainability of DBT programmes and the factors which potentially influence this has received little attention from researchers. In this article, we review the literature reporting on sustainability of DBT programmes in outpatient settings. We also seek to advance the limited knowledge on this topic by reporting on the sustainability of DBT programmes delivered by teams that trained via a coordinated implementation approach in Ireland. As part of this perspective piece we conducted a systematic literature search which identified four studies reporting on DBT programme sustainability. All four reported on programmes delivered by teams that had received training as per the DBT Intensive Training Model. The findings of these studies are summarised and we consider the effect on DBT programme sustainability of introducing a coordinated implementation approach in Ireland.