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Intermediaries are communication experts who facilitate communication between individuals with communication needs and the criminal justice system. In executing the role, intermediaries interact with police, lawyers, judges and other criminal justice professionals. But is the intermediary a professional in its own right? This article argues that a more useful question to ask is whether intermediaries engage in what Andrew Abbott terms ‘professional work’. It reveals how the role tussles for legitimate control over its work tasks through the staking of ‘jurisdictional claims’. Intermediaries do so through the performance of ‘boundary work’ which involves the construction and negotiating of boundaries that mediate interaction. This article presents findings from thirty-one in-depth, semi-structured interviews with intermediaries and judges in England and Wales and Northern Ireland. It concludes that the future of the intermediary role and its work depends largely on the type of ‘jurisdictional settlement’ which its practitioners seek to carve out.
The model eukaryotic microalgae Chlamydomonas reinhardtii is well known for its ability to generate bioconvection flows that are associated to intricate concentration patterns. Recently, it was demonstrated that the propensity of these algae to move toward a light source – a phenomenon termed phototaxis – can be exploited to locally concentrate micro-organisms and induce (photo)-bioconvection in algal suspensions by inducing a localised excess of density. In the present study we show experimentally that a cell population in a thin liquid layer self-organises in the presence of a heterogeneous light field and displays remarkable symmetry-breaking instabilities that are ruled by both the width of the light beam and the photo-bioconvection Rayleigh number. Beside circular stable states, fingers, dendrites and wave instabilities are reported, quantified and classified in a general phase diagram. Next, we use lubrication theory to develop an asymptotic model for bioconvection in a thin liquid layer, that includes the influences of both gyrotaxis and phototaxis. We obtain a single nonlinear anisotropic diffusion–drift equation describing the spatiotemporal evolution of the depth-averaged algal population. Analytical and numerical solutions are presented and show a very good agreement with the experimental results. In particular, we show that the dendrite instability arises as a result of a subtle coupling between the nonlinearity of the phototactic response, the gyrotactic effect and the self-induced bioconvective flows. Such complex flow fields might find applications in photo-bioreactors, through the efficient stirring of the harvested biomass.
We present numerical and analytical predictions of mucociliary clearance based on the continuum description of a viscoelastic mucus film, where momentum transfer from the beating cilia is represented via a Navier-slip boundary condition introduced by Bottier et al. (PLoS Comput. Biol., vol. 13, issue 7, 2017a, e1005552). Mucus viscoelasticity is represented via the Oldroyd-B model, where the relaxation time and the viscosity ratio have been fitted to experimental data for the storage and loss moduli of different types of real mucus, ranging from healthy to diseased conditions. We solve numerically the fully nonlinear governing equations for inertialess flow, and develop analytical solutions via asymptotic expansion in two limits: (i) weak viscoelasticity, i.e. low Deborah number; (ii) low cilia beat amplitude (CBA). All our approaches predict a drop in the mucus flow rate in relation to the Newtonian reference value, as the cilia beat frequency is increased. This relative drop increases with decreasing CBA and slip length. In diseased conditions, e.g. mucus properties characteristic of cystic fibrosis, the drop reaches 30 % in the physiological frequency range. In the case of healthy mucus, no significant drop is observed, even at very high frequency. This contrasts with the deterioration of microorganism propulsion predicted by the low-amplitude theory of Lauga (Phys. Fluids, vol. 19, issue 8, 2007, 083104), and is due to the larger beat amplitude and slip length associated with mucociliary clearance. In the physiological range of the cilia beat frequency, the low-amplitude prediction is accurate for both healthy and diseased conditions. Finally, we find that shear-thinning, modelled via a multi-mode Giesekus model, does not significantly alter our weakly viscoelastic and low-amplitude predictions based on the Oldroyd-B model.
The linear and nonlinear stability of two concentric jets separated by a duct wall is analysed by means of global linear stability and weakly nonlinear analysis. Three governing parameters are considered, the Reynolds number based on the inner jet, the inner-to-outer jet velocity ratio ($\delta _u$) and the length of the duct wall ($L$) separating the jet streams. Global linear stability analysis demonstrates the existence of unsteady modes of inherent convective nature, and symmetry-breaking modes that lead to a new non-axisymmetric steady state with a single or double helix. Additionally, we highlight the existence of multiple steady states, as a result of a series of saddle-node bifurcations and its connection to the changes in the topology of the flow. The neutral lines of stability have been computed for inner-to-outer velocity ratios within the range $0 < \delta _u < 2$ and duct wall distances in the interval $0.5 < L < 4$. They reveal the existence of hysteresis, and mode switching between two symmetry-breaking modes with azimuthal wavenumbers $1:2$. Finally, the mode interaction is analysed, highlighting the presence of travelling waves emerging from the resonant interaction of the two steady states, and the existence of robust heteroclinic cycles that are asymptotically stable.
A thin liquid droplet spreads on a soft viscoelastic substrate with arbitrary rheology. Lubrication theory is applied to the governing field equations in the liquid and solid domains, which are coupled through the free boundary at the solid–liquid interface, to derive a set of reduced equations that describe the spreading dynamics. Fourier transform techniques and the finite difference method are used to construct a solution for the dynamic liquid–gas and solid–liquid interface shapes, as well as the macroscopic contact angle. Substrate properties affect the spreading dynamics through the contact angle and internal droplet flow fields, and these mechanisms are revealed. Increased substrate softness increases the spreading rate, whereas increased viscoelasticity decreases the spreading rate. For the case of a purely elastic substrate, the spreading power-law exponent recovers Tanner's law in the rigid limit and increases with substrate softness.
While partisanship in American politics has been historically tied to racial identity and racial attitudes, most studies of Latino partisanship do not incorporate these factors into understanding their partisan attachments. I argue that the concepts of race, color, and mestizaje as they are understood within Latino communities in the United States can influence political attitudes and partisanship among Latinos themselves. Using six consecutive Cooperative Election Study (formerly Cooperative Congressional Election Study) surveys I examine how self-identification as white, racial resentment, and color-blind attitudes influence Latino partisanship. I find that white racial identity has a small but significant positive association with Republican partisanship among Latinos, and a negative association with Democratic partisanship. Additionally, negative racial attitudes among Latinos are strongly related to identification as Republican, even when controlling for ideology and other factors like immigrant generation and religion. These results have important implications for understanding current and future Latino voting patterns.
We present a theoretical asymptotic solution for high-speed transient flow through microporous media in this work by addressing the inertia effect in the high-pressure-difference pulse-decay process. The capillaric model is adopted, in which a bundle of straight circular tubes with a high length–radius ratio is used to represent the internal flow paths of microporous media so that the flow is described by a simplified incompressible Navier–Stokes equation based on the mean density, capturing the major characteristics of mass flow rate. By order-of-magnitude analysis and asymptotic perturbation, the inertial solution with its dimensionless criterion for the high-pressure-difference pulse-decay process is derived. To be compared with experimental data, the theoretical solution involves all three related effects, including the inertia effect, the slippage effect and the compressibility effect. A self-built experimental platform is therefore established to measure the permeability of microporous media by both pulse-decay and steady-state methods to validate the theoretical solution. The results indicate that the relative difference between two methods is less than 30 % even for permeability at as low as $48.2$ nD $(10^{-21}\,{\rm m}^2)$, and the present theoretical solution can accurately capture the inertia effect in the high-pressure-difference pulse-decay process, which significantly accelerates the measurements for ultra-low-permeability samples.
Universities are expected to play a pivotal role in promoting environmental conservation goals, yet a comprehensive analysis of their actual contributions remains limited. This study delves into the perceptions of socio-environmental responsibility among faculty members within Iran’s top 13 universities. Using random cluster sampling, we collected 410 questionnaires from these institutions, evaluating socio-environmental responsibility through eight distinct variables. The outcomes unveil widespread deficiencies in responsibility across all universities, with 66% exhibiting low levels of engagement. Notably, Gorgan University of Agricultural Sciences and Natural Resources displays the lowest level, while Bu-Ali Sina University ranks highest. The research variables exhibit significant positive correlations, elucidating the interconnectedness of different aspects of socio-environmental responsibility. Furthermore, the study identifies a significant disparity in mean university socio-environmental responsibility concerning gender, although no significant relationships are found with factors such as professors’ academic rank, employment status or age. Sixteen codes are highlighted based on qualitative analysis. These findings underscore the urgency for universities to redefine their roles within the community and prioritize community empowerment, stakeholder engagement, capacity building and environmental education. By addressing these facets, universities can elevate their levels of socio-environmental responsibility and contribute more effectively to environmental conservation efforts.
The purpose of this study is to evaluate the incidence and outcomes regarding tachyarrhythmia in patients after total cavopulmonary connection.
Methods:
A retrospective analysis of 620 patients who underwent total cavopulmonary connection between 1994 and 2021 at our institution was performed. Incidence of tachyarrhythmia was depicted, and results after onset of tachyarrhythmia were evaluated. Factors associated with the onset of tachyarrhythmia were identified.
Results:
A total of 52 (8%) patients presented with tachyarrhythmia that required medical therapy. Onset during hospital stay was observed in 27 patients, and onset after hospital discharge was observed in 32 patients. Freedom from late tachyarrhythmia following total cavopulmonary connection at 5, 10, and 15 years was 97, 95, and 91%, respectively. The most prevalent late tachyarrhythmia was atrial flutter (50%), followed by supraventricular tachycardia (25%) and ventricular tachycardia (25%). Direct current cardioversion was required in 12 patients, and 7 patients underwent electrophysiological study. Freedom from Fontan circulatory failure after onset of tachyarrhythmia at 10 and 15 years was 78% and 49%, respectively. Freedom from occurrence of decreased ventricular systolic function after the onset of tachyarrhythmia at 5 years was 85%. Independent factors associated with late tachyarrhythmia were dominant right ventricle (hazard ratio, 2.52, p = 0.02) and weight at total cavopulmonary connection (hazard ratio, 1.03 per kilogram; p = 0.04). Type of total cavopulmonary connection at total cavopulmonary connection was not identified as risk.
Conclusions:
In our large cohort of 620 patients following total cavopulmonary connection, the incidence of late tachyarrhythmia was low. Patients with dominant right ventricle and late total cavopulmonary connection were at increased risk for late tachyarrhythmia following total cavopulmonary connection.
We consider the moduli space of genus 4 curves endowed with a $g^1_3$ (which maps with degree 2 onto the moduli space of genus 4 curves). We prove that it defines a degree $\frac {1}{2}(3^{10}-1)$ cover of the nine-dimensional Deligne–Mostow ball quotient such that the natural divisors that live on that moduli space become totally geodesic (their normalizations are eight-dimensional ball quotients). This isomorphism differs from the one considered by S. Kondō, and its construction is perhaps more elementary, as it does not involve K3 surfaces and their Torelli theorem: the Deligne–Mostow ball quotient parametrizes certain cyclic covers of degree 6 of a projective line and we show how a level structure on such a cover produces a degree 3 cover of that line with the same discriminant, yielding a genus 4 curve endowed with a $g^1_3$.
In the vast Neotropic seasonal environment, the most diverse family of bats, the Phyllostomidae (leaf-nosed bats), includes up to 93 species. As the quality and quantity of food resources fluctuate in the habitats, diet heterogeneity is observed among bat species and regions of the Neotropics. In this study, we investigated by faecal analyses, how the dietary niche (DN) of eight Phyllostomidae bat species (Artibeus planirostris, A. fimbriatus, Carollia brevicauda, C. perspicillata, Chiroderma villosum, Glossophaga soricina, Platyrrhinus lineatus, and Sturnira lilium) that occur in a karstic area in the Midwest region of Minas Gerais, Brazil, change in response to seasonal food availability. We recorded the consumption of insects and nine plant families. Moraceae was the most frequent, followed by Piperaceae. Given that seasonal dietary changes can be subtle and hardly noticeable along with fluctuating habitat conditions, we performed the DN decomposition of the eight bats species into subniches, by analysing the data with the WitOMI, which is a decomposition of the niche into temporal subniches. By improving the accuracy and details of the results, we assessed the effects of abiotic (precipitation and environmental temperature) and biotic (quantity and quality of food resources) interactions within the phyllostomid bat community. For each species, we compared niche breadth and overlap and found higher values for the dry season among morphologically similar species. The results of our study suggest that ecologically similar bat species coexist occupying different DNs.
The demise of the value-free ideal constitutes a threat to public trust in science. One proposal is that, whenever making value judgments, scientists rely only on democratic values. Because the influence of democratic values on scientific claims and recommendations is legitimate, public trust in science is warranted. I challenge this proposal. Appealing to democratic values will not suffice to secure trust because of at least two obstacles: polarization and marginalization.
The purpose of the present article is to describe the current state of sex and gender data collection in nutrition science research, discuss the effects of flawed data collection practices, highlight considerations for transgender and gender non-conforming populations and propose a sex- and gender-informed approach to human subjects research. Sex and gender are separate constructs that are often conflated in nutrition research and practice. Current nutrition surveillance programmes in the United States, United Kingdom and Ireland do not accurately capture sex and gender data, which undermines the accuracy of the analyses and excludes gender minorities. Transgender and gender non-conforming populations have distinct clinical and psychosocial nutrition considerations that require further research to inform nutrition policy and practice, such as anthropometric and biochemical changes with hormone therapy, eating disorders, food insecurity and nutrition as a source of empowerment or expression of gender identity. Researchers can apply a sex- and gender-informed approach to human subjects research by treating sex and gender as separate, relevant demographic data, appreciating gender as a fluid construct, and approaching data collection on gender minorities with sensitivity to privacy and confidentiality.
Internalising disorders are highly prevalent emotional dysregulations during preadolescence but clinical decision-making is hampered by high heterogeneity. During this period impulsivity represents a major risk factor for psychopathological trajectories and may act on this heterogeneity given the controversial anxiety–impulsivity relationships. However, how impulsivity contributes to the heterogeneous symptomatology, neurobiology, neurocognition and clinical trajectories in preadolescent internalising disorders remains unclear.
Aims
The aim was to determine impulsivity-dependent subtypes in preadolescent internalising disorders that demonstrate distinct anxiety–impulsivity relationships, neurobiological, genetic, cognitive and clinical trajectory signatures.
Method
We applied a data-driven strategy to determine impulsivity-related subtypes in 2430 preadolescents with internalising disorders from the Adolescent Brain Cognitive Development study. Cross-sectional and longitudinal analyses were employed to examine subtype-specific signatures of the anxiety–impulsivity relationship, brain morphology, cognition and clinical trajectory from age 10 to 12 years.
Results
We identified two distinct subtypes of patients who internalise with comparably high anxiety yet distinguishable levels of impulsivity, i.e. enhanced (subtype 1) or decreased (subtype 2) compared with control participants. The two subtypes exhibited opposing anxiety–impulsivity relationships: higher anxiety at baseline was associated with higher lack of perseverance in subtype 1 but lower sensation seeking in subtype 2 at baseline/follow-up. Subtype 1 demonstrated thicker prefrontal and temporal cortices, and genes enriched in immune-related diseases and glutamatergic and GABAergic neurons. Subtype 1 exhibited cognitive deficits and a detrimental trajectory characterised by increasing emotional/behavioural dysregulations and suicide risks during follow-up.
Conclusions
Our results indicate impulsivity-dependent subtypes in preadolescent internalising disorders and unify past controversies about the anxiety–impulsivity interaction. Clinically, individuals with a high-impulsivity subtype exhibit a detrimental trajectory, thus early interventions are warranted.
This study has selected Codex Sinaiticus and Mark 1:1 as a test case to propose a new way for Greek New Testament editions and translations to present textual uncertainties in manuscripts. The article suggests that editors and translators use a partial cancellation type of erasure in a continuous line over problematic text. This method draws inspiration from a technique used by Martin Heidegger and Jacques Derrida known as sous rature (under erasure). This form of limited cancellation aims to expel indifference and elicit a visceral reaction in the reader. The technique also has a philosophical and theological aim, namely, to work within Heidegger’s view of truth as a process of hiding and revealing. Finally, the limited cancellation, which both conceals and shows, fits with the theme of “messianic secret” in Mark’s Gospel, wherein Jesus both reveals and hides his identity.
This article seeks to ascertain the difference between the agreements forbidden by law under section 24(a) and those intended to defeat the law under section 24(b) of the Malaysian Contracts Act 1950. Even though both subsections (a) and (b) cater to different types of illegality, the courts in Malaysia have often been applying them together without giving reasons why they do so. Their conjoined application prevails perhaps because there has been no convincing explanation of their differences, particularly when considered in the context of the common law doctrine of sham. This article attempts to fill that gap. The article suggests that 24(a) deals with the agreements that are expressly or impliedly forbidden by law, while 24(b) applies to sham contracts. This proposition is based on the analysis of the common law doctrine of sham and recent court decisions.
We consider the attractor $\Lambda $ of a piecewise contracting map f defined on a compact interval. If f is injective, we show that it is possible to estimate the topological entropy of f (according to Bowen’s formula) and the Hausdorff dimension of $\Lambda $ via the complexity associated with the orbits of the system. Specifically, we prove that both numbers are zero.
We make some remarks on the Euler–Lagrange equation of energy functional $I(u)=\int _\Omega f(\det Du)\,{\rm d}x,$ where $f\in C^1(\mathbb {R}).$ For certain weak solutions $u$ we show that the function $f'(\det Du)$ must be a constant over the domain $\Omega$ and thus, when $f$ is convex, all such solutions are an energy minimizer of $I(u).$ However, other weak solutions exist such that $f'(\det Du)$ is not constant on $\Omega.$ We also prove some results concerning the homeomorphism solutions, non-quasimonotonicity and radial solutions, and finally we prove some stability results and discuss some related questions concerning certain approximate solutions in the 2-Dimensional cases.