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This study investigated sex differences in Fe status, and associations between Fe status and endurance and musculoskeletal outcomes, in military training. In total, 2277 British Army trainees (581 women) participated. Fe markers and endurance performance (2·4 km run) were measured at the start (week 1) and end (week 13) of training. Whole-body areal body mineral density (aBMD) and markers of bone metabolism were measured at week 1. Injuries during training were recorded. Training decreased Hb in men and women (mean change (–0·1 (95 % CI –0·2, –0·0) and –0·7 (95 % CI –0·9, –0·6) g/dl, both P < 0·001) but more so in women (P < 0·001). Ferritin decreased in men and women (–27 (95 % CI –28, –23) and –5 (95 % CI –8, –1) µg/l, both P ≤ 0·001) but more so in men (P < 0·001). Soluble transferrin receptor increased in men and women (2·9 (95 % CI 2·3, 3·6) and 3·8 (95 % CI 2·7, 4·9) nmol/l, both P < 0·001), with no difference between sexes (P = 0·872). Erythrocyte distribution width increased in men (0·3 (95 % CI 0·2, 0·4)%, P < 0·001) but not in women (0·1 (95 % CI –0·1, 0·2)%, P = 0·956). Mean corpuscular volume decreased in men (–1·5 (95 % CI –1·8, –1·1) fL, P < 0·001) but not in women (0·4 (95 % CI –0·4, 1·3) fL, P = 0·087). Lower ferritin was associated with slower 2·4 km run time (P = 0·018), sustaining a lower limb overuse injury (P = 0·048), lower aBMD (P = 0·021) and higher beta C-telopeptide cross-links of type 1 collagen and procollagen type 1 N-terminal propeptide (both P < 0·001) controlling for sex. Improving Fe stores before training may protect Hb in women and improve endurance and protect against injury.
The transfer of momentum between the atmosphere and oceanic motions affected by the Earth's rotation occurs through the thin surface Ekman layer. The exchange depends on the surface wind stress, which produces the Ekman pumping of fluid to the ocean upper layer. The Ekman pumping mainly depends on: (i) the curl of the wind stress and (ii) the advection of vorticity due to the Ekman transport. The wind stress is usually parametrised as a quadratic function of the relative speed between the wind and the ocean currents, providing a feedback mechanism between the two fluids. Under steady and spatially uniform wind conditions over mesoscale vortices, the first mechanism generates vertical motions that induce the vortex decay (top drag), while the second promotes the horizontal advection of vorticity in the Ekman transport direction. This study examines the nonlinear effects of both mechanisms in cyclonic and anticyclonic vortices. The analyses consist of simple analytical approximations and nonlinear numerical simulations of quasi-two-dimensional vortices. When considering only the top drag mechanism, it is found that anticyclones decay faster than cyclones. By considering only the vorticity-advection effect, the vortices acquire horizontal momentum and drift; furthermore, anticyclones are reinforced while cyclones are weakened. The joint action of both mechanisms and the possible consequences on vertical transport properties are also discussed.
We study the locations of complex zeroes of independence polynomials of bounded-degree hypergraphs. For graphs, this is a long-studied subject with applications to statistical physics, algorithms, and combinatorics. Results on zero-free regions for bounded-degree graphs include Shearer’s result on the optimal zero-free disc, along with several recent results on other zero-free regions. Much less is known for hypergraphs. We make some steps towards an understanding of zero-free regions for bounded-degree hypergaphs by proving that all hypergraphs of maximum degree $\Delta$ have a zero-free disc almost as large as the optimal disc for graphs of maximum degree $\Delta$ established by Shearer (of radius $\sim 1/(e \Delta )$). Up to logarithmic factors in $\Delta$ this is optimal, even for hypergraphs with all edge sizes strictly greater than $2$. We conjecture that for $k\ge 3$, $k$-uniform linear hypergraphs have a much larger zero-free disc of radius $\Omega (\Delta ^{- \frac{1}{k-1}} )$. We establish this in the case of linear hypertrees.
We aimed to understand the facilitators to developing and sustaining high-quality services for people with young onset dementia (YOD) and their families/supporters.
Design:
This qualitative study used semi-structured interviews with commissioners and service managers, analyzed using inductive thematic analysis.
Setting:
A purposive sample of providers was selected from diverse areas and contrasting YOD services.
Participants:
Eighteen senior staff from YOD services and two dementia service commissioners took part.
Measurements:
For commissioners, key interview topics were experiences of commissioning YOD services, perceived facilitators or barriers, and how future guidance should be structured for ease of use. For service providers, key topics explored experiences of delivering YOD services; what was achievable or challenging; how the service was funded; how it linked with broader provision for YOD in the area; and how guidance should be structured.
Results:
Recorded interviews lasted 30–40 minutes. Seven key facilitators to the development and sustaining of YOD services were identified: having knowledgeable, committed local champions; involvement of people living with YOD and family supporters; initial delivery within existing resources; partnership working within and between sectors; having a reflective, supportive organizational culture; gathering evidence of impact; and having wider support and guidance.
Conclusions:
Improvements in provision for those with YOD and their families need to be built on understanding of service-level and interpersonal influences as well as on understanding of YOD itself. Our findings highlight a set of facilitators which need to be in place to establish and sustain high-quality YOD services that fit the local context.
In John 7:8–9, Jesus tells his brothers he will not “go up” to Jerusalem, but in the very next scene, he makes the ascent in secret. This essay interprets Jesus’s unusual, and seemingly deceptive, behavior in the episode as a symbolic action akin to others structuring the first half of the Gospel. The episode immediately precedes a dialogue in which Jesus predicts his imminent departure from the world. Jesus insists that he will soon “go” to God so that unbelievers “will seek” him “but … not find” him (7:33–34; cf. 20:17). Foreshadowing this future, Jesus “goes up” to Judea but in such a way that leaves unbelievers unaware of his whereabouts, leaving them to ask, “Where is he?” (7:10–11). The article highlights half-truth as an important speech device in the episode and dialogue that follows. It also concludes that the episode is key to interpreting other scenes sharing a motif of misdirection, delay, and secret reversal.
While scholars have traditionally taken Revelation’s “letters to the seven churches” (Rev 2–3) as documentation for the experiences of the Christ-movement in those cities, this article argues that the letters amount to a fictional device—that the Apocalypse appropriates epistolary forms in response to the increasing authority of early Pauline collections among the late first-century Asia Minor Christ-movements. With its divine epistolary authority and heavenly sevenfold “collection,” the Apocalypse attempts to exceed and denigrate Pauline authority in the Christ-movement, and it elevates a Jewish Christ-devotion based in priestly apocalyptic traditions. In the end, we can see John of Patmos both as a competitor to the Pauline tradition and as a witness to the earliest circulation of Pauline collections.
Studies on Indonesia–China relations have emphasized the central role of Indonesia's domestic politics in shaping its foreign policy toward China. However, there has been little discussion on the context in which and the extent to which internal struggles for power have contributed to shape Indonesia's China policy. Contributing to such a discussion, this article specifically focuses on the roles of Indonesian Islamist groups in affecting Jakarta–Beijing ties. It examines their political maneuvers in responses to the attitudes and policies of two governments, the Susilo Bambang Yudhoyono (2004–2014) administration and that of Joko “Jokowi” Widodo (2014–), on China-related foreign policy issues. Both Yudhoyono's and Jokowi's governments display the same friendly attitude toward China. On the South China Sea issues, nevertheless, Jokowi's government adopts tougher measures against China's maneuvers. Despite Jokowi's implementation of such policy, the Islamists put up considerable resistance to his China policy, even compared to his predecessor. This article finds that the extent of power sharing between the Islamists and the regime in power determines the former's responses toward the latter's China policy. This suggests that in the management of bilateral relations, the Islamists are not a hindrance per se in Indonesia–China relations.
Historians are playing an important role in Macedonian society. Their understanding of history and their focus of research interest revolves around the national identity of Macedonians and differentiating them from Others. In recent decades, the political debates in the Republic of (North) Macedonia and its relations with Bulgaria and Greece have had important impact on historiographic production and the new (revisionist) interpretations of the past. History has become an essential element in contemporary politics that is key for framing the national identity of the Macedonians. In this new political context historians are even more engaged in political campaigns and debates, thus making them and their historiographical work one of the sources for symbolic division in the country.
Liberty of conscience, encompassing free speech, a free press, and freedom of religion, has a rich history in Anglo-American political thought, long predating the drafting of the First Amendment to the United States Constitution in 1789. The debate over licensing acts in seventeenth-century England; the advancement of principles of toleration by John Milton, Algernon Sidney, and John Locke in the same period; the renowned, impassioned, and highly influential essays of John Trenchard and Thomas Gordon in Cato’s Letters; the flourishing of a relatively free press and free church in eighteenth-century colonial America; and the liberty-championing assertions in the several declarations of rights in the newly independent states of America all played a critical role in shaping and inspiring the popular views in America that made the First Amendment possible.
Family caregivers are essential inpatient pediatric care partners, yet their handwashing knowledge and compliance are rarely studied. Through hand hygiene audits and self-administered questionnaires, we observed 9% compliance, significantly lower than self-reported practice. We suggest interventions to improve caregiver handwashing behaviors to decrease infection transmission risk to hospitalized children.
Moving more deeply into the 21st century and acknowledging the ongoing patterned needs of children, there continues to be broadly voiced sentiments about the importance of all children’s thriving, adaptive coping, and resiliency. This paper notes that social science more broadly and developmental science specifically is a major resource determinative of the nature of remedies conceptualized, designed, and implemented. Evident is that the harms experienced by children and the solutions implemented by delivery systems are frequently unaligned. Efficacy and impact do not appear to be improved by multisystem integration delivery. This paper explores the benefits of incorporating inclusive and shared human development theory. As well, it examines the need to question the character virtue of the multisystem integration efforts intended to afford supportive solutions required for youths’ thriving and resiliency. Specifically, it addresses whether democratic and equity relevant character values are integrated into public and privately funded intended supportive systems. The position taken is that whether considered under conditions of trauma illustrated by the global COVID pandemic or the efficacy of systems intended to aid the most vulnerable youngsters, the character of the content of support and its delivery matter and can benefit from inclusive human development interrogation and theorizing.
Neurodevelopmental challenges are the most prevalent comorbidity associated with a diagnosis of critical CHD, and there is a high incidence of gross and fine motor delays noted in early infancy. The frequency of motor delays in hospitalised infants with critical CHD requires close monitoring from developmental therapies (physical therapists, occupational therapists, and speech-language pathologists) to optimise motor development. Currently, minimal literature defines developmental therapists’ role in caring for infants with critical CHD in intensive or acute care hospital units.
Purpose:
This article describes typical infant motor skill development, how the hospital environment and events surrounding early cardiac surgical interventions impact those skills, and how developmental therapists support motor skill acquisition in infants with critical CHD. Recommendations for healthcare professionals and those who provide medical or developmental support in promotion of optimal motor skill development in hospitalised infants with critical CHD are discussed.
Conclusions:
Infants with critical CHD requiring neonatal surgical intervention experience interrupted motor skill interactions and developmental trajectories. As part of the interdisciplinary team working in intensive and acute care settings, developmental therapists assess, guide motor intervention, promote optimal motor skill acquisition, and support the infant’s overall development.
During the Civil War, many Americans were prepared for censorship if free speech undermined preserving the Union. Journalists were unable to obtain timely accurate information on the military campaigns either for fear of helping the enemy or depressing morale at home. Self-censorship was far more important than official suppression of free speech, as spontaneous popular pressure curtailed freedom of expression at the beginning of the war and later on the army performed a similar function. For Federals, commitment to preserving the Union required treating Confederates as ubiquitous seditious conspirators. Combatting this internal enemy, in turn, especially in the Border States, required extensive suppression of free speech. Later in the conflict and right across the Union, the critical and urgent need to fill the ranks led to official censorship of any words that might discourage volunteering, and this conflicted with freedom of religion as well as speech and the press.
We aimed to investigate the effectiveness of n-3 fatty acids supplementation on the risk of developing depression, depressive symptoms and remission of depression. We searched PubMed, Scopus and Web of Science from inception to December 2022 to find randomised trials of n-3 fatty acids supplementation in adults. We conducted random-effects meta-analyses to estimate standardised mean differences (SMD) and 95 % CI for continuous outcomes and risk difference and 95 % CI for binary outcomes. A total of sixty-seven trials were included. Each 1 g/d n-3 fatty acids supplementation significantly improved depressive symptoms in adults with and without depression (moderate-certainty evidence), with a larger improvement in patients with existing depression. Dose–response analyses indicated a U-shaped effect in patients with existing depression, with the greatest improvement at 1·5 g/d. The analysis showed that n-3 fatty acid supplementation significantly increased depression remission by 19 more per 100 in patients with depression (low-certainty evidence). Supplementation with n-3 fatty acids did not reduce the risk of developing depression among the general population, but it did improve the severity of depression among patients with existing depression.
This article examines how Jews and Judaism are envisioned in the Catholic imagination, through a critical reading of contemporary Catholic discourse on Judaism. It identifies three problematic areas. The first concerns the tendency of Catholic discourse to project a specifically Christian vision of salvation history onto the Jewish people, which reflects Christian rather than Jewish self-understanding. Second, this article analyzes patterns in language and imagery in Vatican documents about Judaism, alert to troubling allusions implicit in the texts. The third area concerns a hermeneutical obstacle to deep interreligious understanding, one which may be ultimately insurmountable: namely, the challenges of understanding the religious other according to its own self-understanding. This article reaches an ambivalent conclusion, conceding that the goal of recognizing the self-understanding of another religious tradition may ultimately be impossible.
In the Sejarah Melayu or Malay Annals, the fall of Singapura is widely appraised as an act of divine retribution unleashed upon rulers who have committed injustice. Implicit in this theodicy is the promise of moral justice enshrined in the Bukit Siguntang covenant, which ensures mutual reciprocity between the rulers and the ruled. But a cautious approach to the narrative of Singapura's demise reveals how justice is suspended, rather than upheld, in service of power. Enabling this suspension of morality is the transformative capacity of violence. This article performs a close reading on three consecutive episodes of unjust violence inflicted on a foreigner, a child, and a concubine, respectively, prior to the sacking of Singapura by Majapahit. In scrutinising the symbolic significance of these victims as persecuted by injudicious rulers, this article posits that violence functions as a rhetorical trope in the retelling of a Malay history. As victims are made scapegoats, unjust violence brings about the fall of Singapura and, by the same token, necessitates the birth of Melaka. Violence impels the forward movement of a royal genealogy by permitting an uninterrupted sequence of reigns through a sequence of crises.