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When considering the implications of the shareholder-stakeholder debate in defining the purpose of a company, epistemological clarity is vital in this emerging theory of the firm. Such clarity can prevent recurrence based solely on rephrasing key terms. To understand how various stakeholders develop and interpret a shared purpose, I argue for the necessity of a pragmatist approach that is normative and process-oriented. Mental models play a crucial role in interpretive processes that define decision-making, where individual perspectives converge. The figures of Milton Friedman and Ed Freeman serve as “beacons,” as artefacts, in the transmission of knowledge through which we, as individuals, shape a shared understanding. In current societies, profound polarization obstructs solutions to grand challenges. Pragmatism starts by questioning the underlying values of everyone involved. It assumes that sound deliberative processes are the only way to reach real solutions—not only for the mind but, above all, for the heart.
Arctic human settlements experience formidable challenges from accelerating climate change and environmental transformations. While these towns have demonstrated adaptive resilience, the looming threat of local climate extremes raises concerns about the results of adaptation and mitigation efforts. With the further development of Arctic settlements, it is necessary to consider changes in local climatic conditions, shifting the adaptation focus from regional to local scales. The local climate perspective in this literature synthesis study is built upon constraints from physical climatology, focused on the climate and environment within and around the town of Longyearbyen, Svalbard. The study provides insights into Longyearbyen’s local climate dynamics, including physical mechanisms, climate localisation, factors and trends, as well as their implications. Three model pathways for development are discussed, centred on (1) industrial development, (2) public services, and (3) tourism and conservation. This categorisation is introduced to distinguish development scenario sensitivity to the local climate effects. The synthesis indicates that any development concentrated spatially will amplify local warming and climate change, as positive climate feedback predominate. The study emphasises the need for a comprehensive understanding of the environmental factors sustaining local climatic anomalies.
Tryptophan (Trp) is an essential amino acid acting as a key nutrition factor regulating animal growth and development. But how Trp modulates food intake in pigs is still not well known. Here, we investigated the effect of dietary supplementation of Trp with different levels on food intake of growing pigs. The data showed that dietary Trp supplementation with the standardised ileal digestibility (SID) Trp to lysine (Lys) ratio at both 0·18 and 0·20 significantly increased the food intake by activating the expression of orexigenic gene agouti-related peptide (AgRP) and inhibiting the expression of anorexigenic gene pro-opiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART) and melanocortin receptor 4 (MC4R) in the hypothalamus. Meanwhile, the level of anorexigenic hormones appetite-regulating peptide YY (PYY) in the duodenum and serum and leptin receptor in the duodenum were also significantly decreased. Importantly, both the kynurenine and serotonin metabolic pathways were activated upon dietary Trp supplementation to downregulate MC4R expression in the hypothalamus. Further mechanistic studies revealed that the reduced MC4R expression activated the hypothalamic AMP-activated protein kinase (AMPK) pathway, which in turn inhibited the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) activity to stimulate food intake. Together, our study unravels the orexigenic effect of dietary Trp supplementation in pigs and expands its potential application in developing nutrition intervention strategy in pig production.
We construct a reflexive Banach space $X_{\mathcal {D}}$ with an unconditional basis such that all spreading models admitted by normalized block sequences in $X_{\mathcal {D}}$ are uniformly equivalent to the unit vector basis of $\ell _1$, yet every infinite-dimensional closed subspace of $X_{\mathcal {D}}$ fails the Lebesgue property. This is a new result in a program initiated by Odell in 2002 concerning the strong separation of asymptotic properties in Banach spaces.
A new diosaccin species, Paramphiascella aestuarii n. sp., was found in sediment samples from a shallow estuary in north-western Mexico. The morphological distinction between the new species and its congeners is discussed. The new species is morphologically close to P. calcarifer (Sewell, 1940) from the Maldivian Archipelago. However, P. calcarifer differs from the new species in the proximal and subdistal outer spiniform processes on the female second antennulary segment. Bayesian inference based upon molecular characterization (nuclear 18S ribosomal DNA and the mitochondrial cytochrome oxidase subunit I genes) places the new species within a large group of Diosaccinae Sars G.O., 1906, for which molecular sequences are available, composed of Typhlamphiascus typhlops (Sars G.O., 1906), Rhyncholagena cuspis Yeom and Lee, 2023, Robertgurneya jejuensis Yeom and Lee, 2022, and Amphiascoides Nicholls, 1941. The close relationship with Amphiascoides as its sister genus, only morphologically distinct in the structure of the second endopodal segment of the male second swimming leg, is also confirmed.
To examine if the COVID-19 pandemic had a differential impact longitudinally over four years on psychological and functional impact in individuals with a pre-existing anxiety, bipolar or emotionally unstable personality Disorder (EUPD).
Methods:
Semi-structured interviews were conducted with 52 patients attending the Galway-Roscommon Mental Health Services with an International Classification of Diseases (ICD)-10 diagnosis of an anxiety disorder (n = 21), bipolar disorder (n = 18), or EUPD (n = 13) at four time points over a four-year period. Patients’ impression of the impact of the COVID-19 pandemic was assessed in relation to anxiety and mood symptoms, social and occupational functioning and quality of life utilising psychometric instruments and Likert scale data, with qualitative data assessing participants’ subjective experiences.
Results:
Individuals with EUPD exhibited higher anxiety (BAI) symptoms compared to individuals with bipolar disorders and anxiety disorders (F = 9.63, p = 0.001), with a more deleterious impact on social functioning and quality of life also noted at all time points. Themes attained from qualitative data included isolation resulting from COVID-19 mandated restrictions (N = 22), and these same restrictions allowing greater appreciation of family (n = 19) and hobbies/nature (n = 13).
Conclusions:
Individuals with EUPD reported increased symptomatology and reduced functioning and quality of life as a consequence of the COVID-19 pandemic over a four-year period compared to individuals with either an anxiety or bipolar disorder. This could be related to the differing interaction of the COVID-19 pandemic’s restrictions on the symptoms and support requirements of this cohort.
We study the structure of infinite discrete sets D definable in expansions of ordered Abelian groups whose theories are strong and definably complete, with a particular emphasis on the set $D'$ comprised of differences between successive elements. In particular, if the burden of the structure is at most n, then the result of applying the operation $D \mapsto D'\ n$ times must be a finite set (Theorem 1.1). In the case when the structure is densely ordered and has burden $2$, we show that any definable unary discrete set must be definable in some elementary extension of the structure $\langle \mathbb{R}; <, +, \mathbb{Z} \rangle $ (Theorem 1.3).
We study possible Scott sentence complexities of linear orderings using two approaches. First, we investigate the effect of the Friedman–Stanley embedding on Scott sentence complexity and show that it only preserves $\Pi ^{\mathrm {in}}_{\alpha }$ complexities. We then take a more direct approach and exhibit linear orderings of all Scott sentence complexities except $\Sigma ^{\mathrm {in}}_{3}$ and $\Sigma ^{\mathrm {in}}_{\lambda +1}$ for $\lambda $ a limit ordinal. We show that the former cannot be the Scott sentence complexity of a linear ordering. In the process we develop new techniques which appear to be helpful to calculate the Scott sentence complexities of structures.
The 1814 memoir of missionary wife Harriet Newell was important for awakening the early nineteenth-century American Evangelical imagination on behalf of the burgeoning missionary cause. As young women ‘read the self’ and patterned their lives according to the literary examples they encountered, Newell's memoir used the language of ‘usefulness’ as a powerful theological plot. This article hopes to address the lacuna of scholarship regarding the theological aspects of Newell's writing and how it was those aspects in particular which subsequent generations venerated in the creation of missionary wife memoirs.
This paper explores the use of mediation in medical treatment disputes through the lens of therapeutic justice (TJ), a concept developed in the 1990s to consider the therapeutic and anti-therapeutic effects of justice systems. The paper argues that mediation may be a mechanism for achieving therapeutic effects for people involved in medical treatment disputes. In doing so, the paper highlights the conflict that can often arise between healthcare professionals, family members and patients in medical treatment disputes and the related difficulties with using litigation to resolve this type of conflict. It has been suggested by judges, academics and policy-makers that mediation might be a better way of resolving conflict in these cases. While mediation and TJ have much in common, the paper explores the many tensions between them, considering ways in which mediation might need to be done differently to achieve therapeutic aims. Finally, the paper identifies six TJ features against which mediation can be tested to consider whether it can live up to the claims that it can be used to resolve medical treatment disputes more therapeutically.
The blow-up of the anticanonical base point on a del Pezzo surface S of degree 1 gives rise to a rational elliptic surface $\mathscr {E}$ with only irreducible fibers. The sections of minimal height of $\mathscr {E}$ are in correspondence with the $240$ exceptional curves on S. A natural question arises when studying the configuration of these curves: if a point on S is contained in “many” exceptional curves, is it torsion on its fiber on $\mathscr {E}$? In 2005, Kuwata proved for the analogous question on del Pezzo surfaces of degree $2$, where there are 56 exceptional curves, that if “many” equals $4$ or more, the answer is yes. In this paper, we prove that for del Pezzo surfaces of degree 1, the answer is yes if ‘many’ equals $9$ or more. Moreover, we give counterexamples where a non-torsion point lies in the intersection of $7$ exceptional curves. We give partial results for the still open case of 8 intersecting exceptional curves.
The so-called “Prakhon Chai Hoard” is one of Southeast Asia’s most infamous cases of looting. The story begins in 1964 when a cache of Buddhist bronzes from Northeast Thailand appeared on the international art market via the auction house Spink & Son, London. They quickly ended up in museums and private collections throughout the US and Europe. The exact findspot was unclear but soon became associated with an unidentified temple in Prakhon Chai district in Buriram province. The moniker “Prakhon Chai Hoard/bronzes” subsequently took hold, becoming commonplace in museum displays, dealer/auction house catalogs, and art historical discourse. However, in 2002, it was revealed the temple in question was Plai Bat II in Lahan Sai district.
This article untangles the many myths and misunderstandings surrounding this act of looting. It does so by reviewing the extant literature in light of information revealed by criminal investigations into the late Douglas Latchford from 2012 onwards, and presenting conclusions drawn from our decade-long documentation of villager testimonies at Plai Bat II (2014–2024).
Since Cannon, inspired by Bernard’s discussion of the conditions required for free and independent life, introduced the term homeostasis, many have embraced it as the main theoretical principle guiding physiology and medicine. Nonetheless, critics have argued that homeostasis is too limiting and have advanced a variety of alternative concepts such as heterostasis, rheostasis, and allostasis. We argue that the critics target a much narrower understanding of homeostasis put forward by the cyberneticists and that Bernard and Cannon embraced a far broader understanding that can accommodate the alternatives advanced by the critics and provide an integrated theoretical framework for physiology.
We continue our study of exponent semigroups of rational matrices. Our main result is that the matricial dimension of a numerical semigroup is at most its multiplicity (the least generator), greatly improving upon the previous upper bound (the conductor). For many numerical semigroups, including all symmetric numerical semigroups, our upper bound is tight. Our construction uses combinatorially structured matrices and is parametrised by Kunz coordinates, which are central to enumerative problems in the study of numerical semigroups.
This paper advances a theory of disease as domino dysfunction. It is often argued that diseases are biological dysfunctions. However, a theory of disease as biological dysfunction is complicated by some plausible cases of dysfunction that seem clearly non-pathological. I argue that pathological conditions are not just dysfunctions but domino dysfunctions, and that domino dysfunctions can be distinguished on principled biological grounds from non-pathological dysfunctions. I then show how this theory can make sense of the problem cases; they are not diseases because they are not domino dysfunctions.
In this study, we propose hierarchical inconsistency among family-member top leaders as a novel structural reason for nonfamily executives' high compensation in family firms. Hierarchical inconsistency among family-member top leaders is observed when the head in the formal business hierarchy is not ranked the highest among family-member executives and directors in the informal family hierarchy. We argue that this structure triggers contestations between the heads of the two hierarchies, adding complexity and challenges to nonfamily executives' jobs. Family firms with hierarchical inconsistency among family-member top leaders need to offer higher compensation to make up for the demanding features of these professional managers' work. The positive relationship between hierarchical inconsistency and nonfamily executives' compensation is weaker when the proportion of female family-member executives and directors is high and when the formal head's tenure is long. We use data from publicly listed family firms in China to test our arguments. Our study contributes to family business research by suggesting how the interplay between family relationships and formal organizational structures influences job features and compensation decisions.