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Mental health disorders are the leading cause of ill-health and disability, with depression and anxiety being among the most prevalent(1). There is a growing body of evidence to indicate that optimal nutrition can help to promote better mental health, while suboptimal dietary patterns or status of specific nutrients have been associated with a greater risk of depression and anxiety, but the evidence is conflicting(2,3,4,5). Therefore, the aim was to conduct a systematic review with metaanalyses to investigate the effect of interventions with specific nutrients or dietary patterns on mental health outcomes in adults.
Searches were conducted using the electronic bibliographic databases: MEDLINE, EMBASE and PsycINFO. The inclusion criteria were randomised controlled trials or controlled dietary interventions; study duration ≥ 12 weeks; participants aged ≥ 18 years old; outcome measures of depression or anxiety. The meta-analysis was conducted using Cochrane Review Manager Software (RevMan), version 5.4. The Risk of Bias and Quality of Evidence were assessed utilising the Cochrane Risk of Bias 2 tool and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework, respectively.
A total of 68 studies met the inclusion criteria: 5 investigated dietary patterns, while 63 were nutrient interventions, involving omega-3 (n = 22), vitamin D (n = 18), B-vitamins (n = 10), zinc (n = 7), iron (n = 1), vitamin D combined with calcium (n = 4), and omega-3 combined with vitamin D (n = 1). Insufficient studies were available to conduct a meta-analysis for any nutrient in relation to anxiety; all results relate to depression. Meta-analysis results showed that zinc intervention significantly reduced depression (standardised mean difference (SMD) in depression scores was −0.67; 95% Confidence Interval (95% CI) −0.96, −0.37); 4 studies, GRADE: moderate certainty). No significant effects on depression were reported in response to intervention with omega-3 fatty acids [SMD 0.26 (95% CI −0.64, 0.12); 10 studies, GRADE: moderate certainty] or vitamin D [SMD 0.07 (95% CI 0.34, 0.47); 10 studies, GRADE: moderate certainty], while there were insufficient studies to perform a meta-analysis for B-vitamins and depression. There was also no significant effect of the Mediterranean Diet on depression [SMD −0.95 (95% CI -1.90, 0.01); 3 studies, GRADE: high certainty], and insufficient studies for analysis of the Dietary Approaches to Stop Hypertension (DASH) diet.
The results indicate that zinc supplementation has beneficial effects on depression, but there were no significant effects of intervention with the Mediterranean Diet, omega-3 fatty acids or vitamin D. These meta-analyses are however based on a limited number of intervention studies and therefore no firm conclusions can be reached. Further intervention trials are required to fully investigate the effects of specific nutritional factors on mental health.
In the present study, the spatiotemporal distribution and community structure of surface copepods were investigated in Chabahar Bay, Gulf of Oman, through a year-long sampling programme divided into four distinct periods: post-monsoon (POM), northeast monsoon, pre-monsoon (PRM), and southwest monsoon (SWM). Sampling was conducted at five locations using a horizontal plankton net with a 100 μm mesh size, from the midnight to dawn period. Environmental parameters (temperature, salinity, pH, and total dissolved solids) were also recorded, revealing significant differences (P < 0.0005) across seasons and locations. A total of 38 copepod genera, belonging to five orders and 22 families, were identified, accounting for 66% of the total zooplankton population, while the remaining 34% consisted of non-copepod organisms. The highest and lowest mean abundances of copepods were recorded during the PRM and POM periods, respectively. Excluding copepod larvae, Cyclopoida and Calanoida exhibited the highest annual mean abundances, while Monstrilloida had the lowest. Results show the highest annual mean abundance belongs to the genera Oithona with 167,382 ± 11,089 ind. m−3, Temora with 52,250 ± 3691 ind. m−3, Paracalanus with 40,041 ± 2256 ind. m−3, Acartia with 34,822 ± 3876 ind. m−3, Euterpina with 34,313 ± 1542 ind. m−3, and Oncea with 34,033 ± 2951 ind. m−3. However, the lowest value of 794 ± 259 ind. m−3 belonged to the genus Cymbasoma. The highest mean diversity index (H′) was observed in SWM and POM, while the highest mean species richness index (D) was observed in POM and SWM, and the highest mean Pielou's evenness (J′) was observed in SWM and POM.
The current study represents the first records of elusive cardinalfish, Apogon fugax Gon et al., 2020 and twinbar cardinalfish, Apogonichthyoides sialis (Jordan and Thompson, 1914) from the Gujarat coast, northwestern India. During February 2024, regular fishing surveys were conducted to document a bycatch species assemblage. In the course of this study, a total three specimens of A. fugax and a single specimen of A. sialis were procured from Veraval Fishing Harbour, Gujarat, India. Apogon fugax is reported for the first time from Indian waters, while A. sialis is recorded for the first time from northwestern India. Herein, detailed meristic counts, morphometric measurements and the distribution of the species are described.
Does the situation in Afghanistan amount to persecution due to the accumulation of repressive measures enacted against women and is it sufficient that women are affected by such measures merely on the basis of their gender? While these two questions remain in front of the Court of Justice of the EU, several EU member states have moved to grant asylum to women and girls from Afghanistan on general risks of gender-based persecution. This dynamism in asylum regulations across the EU has occurred alongside renewed discussions around gender-based persecution and gender apartheid in international criminal law in light of the ongoing process for a Crimes Against Humanity Treaty. In this article, I put these developments into conversation through case study method and legal-institutional analysis, and argue that the historical link between international refugee law and international criminal law provides a space to envision an integrated system of protection around gender-related claims. To this end, I offer three outlooks for establishing general risks of gender-based persecution in international refugee law and the relationship between gender apartheid and asylum.
The Dutch parliamentary far right has been considered a relatively liberal outlier to the gender politics of the European far right, yet recent years have shown the increasing anti-gender mobilization of the party Forum voor Democratie(FvD). Based on a theoretical framework of anti-gender mobilization, the far right, and politics of knowledge, this article explores anti-gender politics as a form of alternative knowledge production through a qualitative content analysis of the FvD’s online presence. Through applying Verloo’s concept of the episteme, this article’s findings show that the FvD mobilizes against epistemic institutions by claiming they disseminate dangerous knowledge about gender, which they argue presents a fundamental threat to society, captured in conspiratorial terms like “transgender ideology” and “woke.” Simultaneously, the party promotes illiberal gender politics through the establishment of alternative epistemic institutions. This article shows how far-right actors may promote anti-gender politics by presenting themselves as “alternative intellectuals” who seek to carve out an epistemic niche alongside the mainstream.
This experimental study employs Bayesian optimisation to maximise the cross-flow (transverse) flow-induced vibration (FIV) of an elastically mounted thin elliptical cylinder by implementing axial (or angular) flapping motions. The flapping amplitude was in proportion to the vibration amplitude, with a relative phase angle imposed between the angular and transverse displacements of the cylinder. The control parameter space spanned over the ranges of proportional gain and phase difference of $0 \leq K_p^* \leq 5$ and $0 \leq \phi _d \leq 360^\circ$, respectively, over a reduced velocity range of $3.0 \leqslant {U^*} = U/({{f_{nw}}} b) \leqslant 8.5$. The corresponding Reynolds number range was $1250 \leqslant {{Re}} =(U b)/\nu \leqslant 3580$. Here, $U$ is the free stream velocity, $b$ is the major cross-sectional diameter of the cylinder, ${{f_{nw}}}$ is the natural frequency of the system in quiescent fluid (water) and $\nu$ is the kinematic viscosity of the fluid. It was found that the controlled body rotation extended the wake-body synchronisation across the entire ${U^*}$ range tested, with a larger amplitude response than the non-rotating case for all flow speeds. Interestingly, two new wake-body synchronisation regimes were identified, which have not been reported in previous studies. As this geometry acts as a ‘hard-oscillator’ for ${U^*} \geqslant 6.3$, an adaptive gain (i.e. one that varies as a function of oscillation amplitude) was also implemented, allowing the body vibration, achieved for a non-rotating cylinder using increasing ${U^*}$ increments, to be excited from rest. The findings of the present study hold potential implications for the use of FIV as a means to efficiently extract energy from free-flowing water sources, a topic of increasing interest over the last decade.
The seminal Krajewski–Kotlarski–Lachlan theorem (1981) states that every countable recursively saturated model of $\mathsf {PA}$ (Peano arithmetic) carries a full satisfaction class. This result implies that the compositional theory of truth over $\mathsf {PA}$ commonly known as $\mathsf {CT}^{-}[\mathsf {PA}]$ is conservative over $\mathsf {PA}$. In contrast, Pakhomov and Enayat (2019) showed that the addition of the so-called axiom of disjunctive correctness (that asserts that a finite disjunction is true iff one of its disjuncts is true) to $\mathsf {CT}^{-}[\mathsf {PA}]$ axiomatizes the theory of truth $\mathsf {CT}_{0}[\mathsf {PA}]$ that was shown by Wcisło and Łełyk (2017) to be nonconservative over $\mathsf {PA}$. The main result of this paper (Theorem 3.12) provides a foil to the Pakhomov–Enayat theorem by constructing full satisfaction classes over arbitrary countable recursively saturated models of $\mathsf {PA}$ that satisfy arbitrarily large approximations of disjunctive correctness. This shows that in the Pakhomov–Enayat theorem the assumption of disjunctive correctness cannot be replaced with any of its approximations.
The role of editorial staff in shaping early climate change narratives has been underexplored and deserves more attention. During the 1970s, the epistemological underpinnings of the production of knowledge on climate change were contested between scientists who favoured computer-based atmospheric simulations and those who were more interested in investigating the long-term history of climatic changes. Although the former group later became predominant in the Intergovernmental Panel on Climate Change during the 1980s, the latter had a sizable influence over climate discourse during the 1970s. Of these, one of the key popularizers of climate discourse during the 1970s was the British climatologist Hubert Lamb (1913–97). The correspondence between Lamb and journal editors who gatekept and curated different audiences helped craft resonant messages about climate change and its potential effects, and we explore Lamb's interactions with editors of Nature, the UNESCO Courier, The Ecologist and Development Forum in the 1973–4 period. Through understanding how climate change discussion was influenced by editors, we gain an insight into how such narratives had to be adjusted to fit into pre-existing discourses before their importance was more widely established, and how these adjustments helped shape conceptualizations of climate change as a global, human-caused phenomenon and a source of universal threat.
This study aimed to demonstrate the utilization value of 1PN embryos. The 1PN zygotes collected from December 2021 to September 2022 were included in this study. The embryo development, the pronuclear characteristics, and the genetic constitutions were investigated. The overall blastocyst formation and good-quality blastocyst rates in 1PN zygotes were 22.94 and 16.24%, significantly lower than those of 2PN zygotes (63.25 and 50.23%, respectively, P = 0.000). The pronuclear characteristics were found to be correlated with the developmental potential. When comparing 1PN zygotes that developed into blastocysts to those that arrested, the former exhibited a significantly larger area (749.49 ± 142.77 vs. 634.00 ± 119.05, P = 0.000), a longer diameter of pronuclear (29.81 ± 3.08 vs. 27.30 ± 3.00, P = 0.000), and a greater number of nucleolar precursor body (NPB) (11.56 ± 3.84 vs. 7.19 ± 2.73, P = 0.000). Among the tested embryos, the diploidy euploidy rate was significantly higher in blastocysts in comparison with the arrested embryos (66.67 vs. 11.76%, P = 0.000), which was also significantly higher in IVF-1PN blastocysts than in ICSI-1PN blastocysts (75.44 vs. 25.00%, P = 0.001). However, the pronuclear characteristics were not found to be linked to the chromosomal ploidy once they formed blastocysts.
In summary, while the developmental potential of 1PN zygotes is reduced, our study shows that, in addition to the reported pronuclear area and diameter, the number of NPB is also associated with their developmental potential. The 1PN blastocysts exhibit a high diploidy euploidy rate, are recommend to be clinically used post genetic testing, especially for patients who do not have other 2PN embryos available.
In an enticing article for the Neue Zeitschrift für Musik, Hans von Bülow suggested that Joseph Joachim would be well suited to achieve a reform of violin playing in the 1850s, which would effectively close the door behind Virtuosentum. The Golden Age of virtuosity had been on its way out for several years, impacting also violin performance. And yet, violin programming in the musical metropolises London and Paris was slow to adapt. As recent work on Joachim's virtuoso years has shown, his repertoire during the 1840s encompassed far more than German classics. It accommodated plenty of virtuoso music by H.W. Ernst, de Bériot, Ferdinand David, and Vieuxtemps, as well as his own substantial, virtuoso compositions, composed for his London tours in the 1840s. As this article argues, Joachim's programming did not change overnight: the shift from performing and composing virtuoso pieces to identifying himself with lofty and serious works happened gradually. One vehicle through which Joachim transformed the state of ‘violin playing’ of the 1840s was the violin romance. Joachim, who spent three months in Paris in early 1850, used the aesthetic of the romance to transform not only the state of violin playing but also the violin romance itself. Two simple romances he composed in 1850 were followed by a third romance in 1857. The third was, in effect, a Bravourstück in disguise, exhibiting none of the older virtuoso tricks such as flying bow strokes that had fallen out of favour. Rather, in Joachim's third romance, the conspicuous, ‘1840s’ virtuosity merged into ‘shape-oriented virtuosity’, a term used in a 1854 review of Joachim's playing. Many later nineteenth-century composers of violin romances from Bruch to Sibelius adopted Joachim's romance model, negotiating between melodic simplicity and violinistic demand, resulting in lyrical pieces in which virtuosity was an undercurrent, hidden but present.
During the Syrian war, many archaeological sites were subjected to systematic looting and destruction, often on a massive scale. Among the casualties of this looting is a colossal basalt statue of a lion that was located at the archaeological site of Ain Dara in northwest Syria. The lion of Ain Dara is a prominent local symbol and of great importance for the collective memory of northwest Syria, especially for the people of Wadi Afrin. Its disappearance will also have serious repercussions for the local economy as it was, in the past, an important tourist attraction. In this article, we investigate how the statue was stolen, why it was stolen, and where it is now. By using the lion statue of Ain Dara as a case study, we aim to shed more general light on the networks responsible for looting and trafficking Syrian antiquities, the factors that have enabled their growth during the conflict, and the role of civil society organizations in reducing their harmful impact on the cultural community of the Syrian people.
In this article, a dual-sense triband circularly polarized modified slot antenna loaded with metamaterial structures such as split-ring resonator and cross strips is proposed. The first resonant frequency is generated using the modified square slot which produces the two degenerative modes required to achieve circular polarization (CP). The corners of slot antenna are extended to obtain the orthogonal modes. The second resonant band is obtained using the single split-ring resonator. Two micro-splits in Split Ring Resonator (SRR) orthogonal to each other produces CP due to electric field generated by the micro-splits. The third resonance band is obtained due to loading of cross strips. The orthogonal phase is adjusted by varying the length of cross strips, so that the CP is achieved. All resonance bands are tuned independently. The measured impedance bandwidth of 31.68%, 4.55%, and 8.6% is obtained in first, second, and third bands respectively. The axial ratio bandwidth of 13.04%, 2.7%, 8.6% and peak gain of 3.8 dBic, 3.9 dBic, 3.7 dBic are obtained respectively. The simulated radiation efficiencies of above 80% is achieved in all bands. The left-hand CP is obtained in first two band as co-polarization and right-hand CP is obtained at the third band as co-polarization with respect to cross-polarization radiation. The cross-polarization of minimum −10 dB is obtained in all three bands. The proposed design is well suitable for the Bluetooth, n78 and n79 5G applications.
Radiation exposure and the effect of anti-scatter grids are not well studied in premature infants during transcatheter patent ductus arteriosus closure.
This study aimed to investigate whether the use of anti-scatter grids altered the level of radiation exposure to premature infants undergoing transcatheter patent ductus arteriosus closure.
Methods and Results:
Demographic and radiation exposure data for premature infants who underwent transcatheter patent ductus arteriosus closure at the Stead Family Children’s Hospital from 10/2019 to 10/2021 were retrospectively reviewed and analyzed. Twenty-four patients (41%) underwent transcatheter patent ductus arteriosus closure with anti-scatter grids, while 34 (59%) underwent the procedure without using anti-scatter grids. At the time of catheterization, the median age, corrected age, and weight were 4.3 weeks (3.4–6), 29 weeks (28.1–30.9), and 1200g (1000-1600), respectively. Total radiation exposures for the dose area product and air kerma were 2.73 µGy.m2 (1.65–4.16), and 1.63 mGy (1.15–2.58), respectively. Radiation doses were higher in the group in whom the anti-scatter grids were utilized with dose area product of 3.33 µGy.m2 (2.39–5.43) and air kerma of 2.27 mGy (1.41–3.06) versus 1.86 µGy.m2 (1.46–3.60) and air kerma of 1.40 mGy (1.08–1.92). When radiation doses were adjusted to the radiation time, no difference in radiation exposure was noticed between the groups.
Conclusions:
Transcatheter patent ductus arteriosus closure in premature infants can be safely performed with minimal radiation exposure. In the authors’ laboratory, the use of anti-scatter grids does not impact radiation exposure in premature infants.
Soft robots show an advantage when conducting tasks in complex environments due to their enormous flexibility and adaptability. However, soft robots suffer interactions and nonlinear deformation when interacting with soft and fluid materials. The reason behind is the free boundary interactions, which refers to undetermined contact between soft materials, specifically containing nonlinear deformation in air and nonlinear interactions in fluid for soft robot simulation. Therefore, we propose a new approach using material point method (MPM), which can solve the free boundary interactions problem, to simulate soft robots under such environments. The proposed approach can autonomously predict the flexible and versatile behaviors of soft robots. Our approach entails incorporating automatic differentiation into the algorithm of MPM to simplify the computation and implement an efficient implicit time integration algorithm. We perform two groups of experiments with an ordinary pneumatic soft finger in different free boundary interactions. The results indicate that it is possible to simulate soft robots with nonlinear interactions and deformation, and such environmental effects on soft robots can be restored.
We experimentally investigate the effect of Reynolds number ($Re$) on the turbulence induced by the motion of bubbles in a quiescent Newtonian fluid at small $Re$. The energy spectra, $E(k)$, are determined from the decaying turbulence behind the bubble swarm obtained using particle image velocimetry. We show that when $Re \sim O(100)$, the slope of the normalized energy spectra is no longer independent of the gas volume fraction and the $k^{-3}$ subrange is significantly narrower, where $k$ is the wavenumber. This is further corroborated using second-order longitudinal velocity structure function and spatial correlation of the velocity behind the bubble swarm. On further decreasing the bubble Reynolds number ($O(1) < Re < O(10)$), the signature $k^{-3}$ of the energy spectra for the bubble-induced turbulence is replaced by $k^{-5/3}$ scaling. Thus, we provide experimental evidence to the claim by Mazzitelli et al. (Phys. Fluids, vol. 15, 2003, pp. L5–L8) that at low Reynolds numbers the normalized energy spectra of the bubble-induced turbulence will no longer show the $k^{-3}$ scaling because of the absence of bubble wake and that the energy spectra will depend on the number of bubbles, thus being non-universal.