The diagnosis of central nervous system tumours has been transformed in recent years from a microscopic morphology-based process to one dominated by the identification of somatic genetic alterations in tumour cells. This switch requires implementing radically different methods, for which appropriate training and financial resources must be allocated. The Canadian Association of Neuropathologists (CANP) has followed a process based on the scientific literature and consensus to develop recommendations for molecular testing of tumours of the brain and spinal cord, aiming to balance the need for treatment-determinant accurate diagnosis and the current limitations inherent in the transition to a new paradigm. The Professional Affairs Committee was charged with this task. A draft was discussed during the CANP general assembly, along with presentations from groups who had implemented molecular technologies, as well as others who relied on external laboratories. The Professional Affairs Committee summarised the consensus and submitted their recommendation to the CANP’s Executive Committee. A final report was posted on the CANP website for a month to allow all members to comment. The recommendations below apply to intrinsic tumours of the central nervous system and do not include metastatic disease or tumours impinging upon the nervous system from outside. These recommendations should be considered clinically relevant, as the results have direct consequences on the patient’s treatment, either through the use of targeted therapies or the trial-proven best application of radiation and/or chemotherapy.

We combine newly collected election data with records of public denials of the results of the 2020 election to estimate the degree to which election-denying Republican candidates over- or underperformed other Republicans in 2022 in statewide and federal elections. We find that the average vote share of election-denying Republicans in statewide races was approximately 3.2 percentage points lower than their co-partisans after accounting for state-level partisanship. However, we find no such underperformance on aggregate for U.S. House elections, perhaps due to the more-partisan nature of many House districts. Together, the results suggest that the types of candidates in American elections who take more-extreme positions tend to underperform, but that these performance gaps are relatively small in the present, polarized political environment.

Onion is sensitive to soil water stress and nitrogen limitations, causing a marked reduction in yield and bulb quality. A field trial was set in the winter seasons of 2016–17 and 2017–18 to evaluate the effects of three micro-sprinkler irrigation levels at 0.6, 0.9 and 1.2 ratios of crop evapotranspiration (ETc) and four nitrogen levels at 0, 75, 100 and 120% of the recommended nitrogen dose (RDN), including surface irrigation at 40 mm cumulative pan evaporation (CPE) with 100% RDN (SN) using an augmented strip plot design on water and N distribution in soil, their productivities, onion yield and economics. Results indicated that the root zone water content increased by 5.2% for 1.2 ETc, and 1.4% for 0.9 ETc over the cropping period, but declined by 1.5% for 0.6 ETc with micro-sprinkler irrigation compared to surface irrigation with nitrogen fertilization (SN). The largest total root zone water depletion was in 1.2 ETc (16.7%), followed by SN (15.3%) and 0.9 ETc (15.0%). The high irrigation regime produced the maximum yield and nitrogen productivity, whereas deficit irrigation displayed the greatest water productivity. However, the coupling of micro-sprinkler irrigation at 1.2 ETc and 120% RDN led to an increase of onion bulb yield (22.6%), water productivity (42.7%), plant N uptake (29.0%) and net income (30.6%) with maximum benefit-cost ratio (3.19) compared to SN. However, as this study was only based on two seasons, more field trials will be needed to confirm the optimum amount of water and nitrogen for winter onion.

Although the relationship between gaming addiction (GA) and attention deficit hyperactivity disorder (ADHD) is well established, the causal mechanism of this relationship remains ambiguous. We aimed to investigate whether common genetic and/or environmental factors explain the GA-ADHD relationship. We recruited 1413 South Korean adult twins (837 monozygotic [MZ], 326 same-sex dizygotic [DZ], and 250 opposite-sex DZ twins; mean age = 23.1 ± 2.8 years) who completed an online survey on GA and related traits. Correlational analysis and bivariate model-fitting analysis were conducted. Phenotypic correlation between GA and ADHD in the present sample was 0.55 (95% CI [0.51, 0.59]). Bivariate model-fitting analysis revealed that genetic variances were 69% (95% CI [64%, 73%]) and 68% (95% CI [63%, 72%]) for ADHD and GA respectively. The remaining variances (ADHD: 31%; GA: 32%) were associated with nonshared environmental variances, including measurement error. Genetic and nonshared environmental correlations between ADHD and GA were 0.68 (95% CI [0.62, 0.74]) and 0.22 (95% CI [0.13, 0.30]) respectively, which indicates that shared genes can explain 82% of the phenotypic correlation between ADHD and GA. Our study demonstrated that the ADHD-GA association was largely due to shared genetic vulnerability.

It is a reasonable worry that God would not truly love us and want our salvation if He fixed a definite point after which He will no longer offer us the graces to repent of our sins. I propose that Thomas Aquinas succeeds in showing us that God would not be cruel or arbitrary in setting up a world where embodied agents end up after death in a state where they will inevitably fail to repent of their sins. Aquinas proposes that being disembodied is to be in a state where a person cannot be mistaken about what they want, given that they know themselves perfectly. If the disembodied state were like this, it would not be surprising that being in that state makes repentance impossible, since a soul would become fully integrated around whatever one desired, without any conflicting desires that could prompt repentance. Thus, humans would persist in whatever desires they had at the moment of death and disembodiment. I conclude by arguing that, while this scenario stands in need of fuller theodicy, Aquinas’s scenario is helpful in defending a view that God is not cruel or arbitrary for creating a world in which post-mortem repentance is impossible.

Paternal exposures (and other non-maternal factors) around pregnancy could have important effects on offspring health. One challenge is that data on partners are usually from a subgroup of mothers with data, potentially introducing selection bias, limiting generalisability of findings. We aimed to investigate the potential for selection bias in studies using partner data.

We characterise availability of data on father/partner and mother health behaviours (smoking, alcohol, caffeine and physical activity) around pregnancy from three UK cohort studies: the Avon Longitudinal Study of Parents and Children (ALSPAC), Born in Bradford and the Millennium Cohort Study. We assess the extent of sample selection by comparing characteristics of families where fathers/partners do and do not participate. Using the association of parental smoking during pregnancy and child birthweight as an example, we perform simulations to investigate the extent to which missing father/partner data may induce bias in analyses conducted only in families with participating fathers/partners.

In all cohorts, father/partner data were less detailed and collected at fewer timepoints than mothers. Partners with a lower socio-economic position were less likely to participate. In simulations based on ALSPAC data, there was little evidence of selection bias in associations of maternal smoking with birthweight, and bias for father/partner smoking was relatively small. Missing partner data can induce selection bias. In our example analyses of the effect of parental smoking on offspring birthweight, the bias had a relatively small impact. In practice, the impact of selection bias will depend on both the analysis model and the selection mechanism.

The crystal structure of cariprazine dihydrochloride has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Cariprazine dihydrochloride crystallizes in space group P21/n (#14) with a = 27.26430(14), b = 7.29241(1), c = 12.80879(4) Å, β = 99.5963(2)°, V = 2511.038(8) Å3, and Z = 4 at 295 K. The crystal structure consists of layers of cations parallel to the bc-plane. The cations stack along the b-axis. Each H atom on the two protonated N atoms participates in a discrete N–H⋯Cl hydrogen bond. One Cl anion acts as an acceptor in two of these bonds, while the other Cl is an acceptor in only one bond. The result is to link the cations and anions into columns parallel to the b-axis. The powder pattern has been submitted to the ICDD for inclusion in the Powder Diffraction File™ (PDF®).

In 1853, a Taiping army infiltrated North China, threatening Beijing and the Qing dynasty itself. Though this army never reached Beijing, its northern siege had acute and lasting impacts on communities in the capital region (jifu 畿輔). Attention to the capital region invites reflection on the temporality and strategic nature of commemoration. Focusing on Cangzhou 滄州, I examine how capital region communities memorialized the northern chapter of the Taiping Civil War, even as for the rest of the empire, the war remained unfinished until 1864. In gazetteers, private histories, and commemorative records, local authors reframed ambiguous realities to write their localities into a story of northern victory, regardless of the fate of the south. The timeline for commemoration in Cangzhou was interrupted, not seamless, and took place over decades. Initially addressed to Beijing and elites along the Grand Canal, Cangzhou's commemorative project was later brought into the orbit of ascendant Tianjin.

This study employs social cognitive theory to examine the dynamics of ethical climate, environmental passion, and low-carbon behaviours among Malaysian public servants based on data from 407 employees across 37 departments. Although ethical climate did not have a direct impact on low-carbon behaviour, a significant association with environmental passion was observed. Additionally, environmental passion exhibited a noteworthy relationship with low-carbon behaviour, and emerged as a mediator between ethical climate and low-carbon behaviour, with green mindfulness moderating this relationship. These findings underscore the importance of nurturing environmental passion and green mindfulness to promote low-carbon behaviour among employees and aid organisations in addressing environmental challenges. By addressing these empirical gaps, this study contributes to the literature on low-carbon behaviour and offers both theoretical insights and practical implications for sustainability initiatives.

Soluble Intercellular Adhesion Molecule-1 (sICAM-1) has emerged as an inflammatory biomarker of many essential functions. We investigated the level of sICAM-1 influenced by Clonorchis sinensis (C. sinensis) co-infection in chronic hepatitis B (CHB) patients to explore the degree of liver tissue inflammation and liver function damage after co-infection. The study included data from patients with C. sinensis mono-infection (n=27), hepatitis B virus (HBV) mono-infection (n=32), C. sinensis and HBV co-infection (n=24), post-hepatitis B liver cirrhosis (n=18), post-hepatitis B liver cirrhosis co-infected with C. sinensis (n=16), and healthy controls (n=39). The level of sICAM-1 was measured with specific enzyme-linked immunosorbent assay method. Compared to the healthy control group, all the experimental groups had significantly higher serum sICAM-1 levels. The levels of sICAM-1 in co-infected groups were significantly higher compared to the mono-infection groups and were positively correlated with the levels of glutamate aminotransferase (ALT) and aspartate aminotransferase (AST). Our research findings confirmed that co-infection could exacerbate liver tissue inflammation and liver function damage in patients, could raise the sICAM-1 level, and may lead to the chronicity of HBV infection. These results provide clues for pathological mechanism study and formulating treatment plans.

We report on a 7-month-old boy (4.2 kg/60 cm) with severe immunodeficiency disorder and bacterial septicaemia who was referred for an infected atrial thrombus secondary to a jugular central line. The echocardiogram showed a teardrop-shaped thrombus with a wide base adherent to the interatrial wall and a flimsy tail moving freely in the right atrium. Chest CT scan showed multiple lesions in both lungs consistent with infected micro-thrombi. The thrombus increased in size despite 2 weeks of antibiotics and anticoagulation. We applied the Indigo® Lightning® 7 aspiration system from Penumbra® (Alameda, USA) and removed percutaneously the thrombus under transoesophageal ultrasound and biplane fluoroscopic guidance. At 6 weeks of follow-up, the patient is alive, under enoxaparin with no procedure-related complication.

This article aims to evaluate the sociodemographic determinants of ultra-processed foods (UPF) consumption in the Brazilian population ≥ 10 years of age. The study used data from the personal and resident food consumption module of the Family Budget Surveys, grouping foods according to the NOVA classification of food processing. The classification and regression tree (CART) was used to identify the factors determining the lowest to highest percentage participation of UPF in the Brazilian population. UPF accounted for 37·0 % of energy content in 2017–2018. In the end, eight nodes of UPF consumption were identified, with household situation, education in years, age in years and per capita family income being the determining factors identified in the CART. The lowest consumption of UPF occurred among individuals living in rural areas with less than 4 years of education (23·78 %), while the highest consumption occurred among individuals living in urban areas, < 30 years of age and with per capita income ≥ US$257 (46·27 %). The determining factors identified in CART expose the diverse pattern of UPF consumption in the Brazilian population, especially conditions directly associated with access to these products, such as penetration in urban/rural regions. Through the results of this study, it may be possible to identify focal points for action in policies and actions to mitigate UPF consumption.

Using the special value at $u=1$ of Artin–Ihara L-functions, we associate to every $\mathbb {Z}$-cover of a finite connected graph a polynomial, which we call the Ihara polynomial. We show that the number of spanning trees for the finite intermediate graphs of such a cover can be expressed in terms of the Pierce–Lehmer sequence associated to a factor of the Ihara polynomial. This allows us to express the asymptotic growth of the number of spanning trees in terms of the Mahler measure of this polynomial. Specialising to the situation where the base graph is a bouquet or the dumbbell graph gives us back previous results in the literature for circulant and I-graphs (including the generalised Petersen graphs). We also express the p-adic valuation of the number of spanning trees of the finite intermediate graphs in terms of the p-adic Mahler measure of the Ihara polynomial. When applied to a particular $\mathbb {Z}$-cover, our result gives us back Lengyel’s calculation of the p-adic valuations of Fibonacci numbers.

Descriptions of various subsets of $\mathbb{SO}(3)$ are encountered frequently in robotics, for example, in the context of specifying the orientation workspaces of manipulators. Often, the Cartesian concept of a cuboid is extended into the domain of Euler angles, notwithstanding the fact that the physical implications of this practice are not documented. Motivated by this lacuna in the existing literature, this article focuses on studying sets of rotations described by such cuboids by mapping them to the space of Rodrigues parameters, where a physically meaningful measure of distance from the origin is available and the spherical geometry is intrinsically pertinent. It is established that the planar faces of the said cuboid transform into hyperboloids of one sheet and hence, the cuboid itself maps into a solid of complicated non-convex shape. To quantify the extents of these solids, the largest spheres contained within them are computed analytically. It is expected that this study would help in the process of design and path planning of spatial robots, especially those of parallel architecture, due to a better and quantitative understanding of their orientation workspaces.