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Music was important in John Stuart Mill’s life. He was an accomplished pianist and a talented improviser. His works include treatments of various philosophical aspects of music, including its metaphysics, its epistemology, the sources and nature of its value, and its aesthetics. Some of his ideas on musical aesthetics are still of interest. This applies to his distinction between those reactions to music that are based on associations with non-musical experiences and those that are based on properties of the music itself. It also applies to his concepts of poetic and oratorical modes of musical expression. In addition to his other achievements, he should be recognized as a philosopher of music.
We examine whether intellectual property protection facilitates the greater incorporation of firm-specific information into the stock price. Employing the staggered, country-level adoption of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), we find that after adoption, stock prices become less synchronous, consistent with more firm-specific information being impounded into the stock price. We further show that this effect is more pronounced for more innovative firms, firms in countries with stronger law enforcement, and firms with more financial analyst coverage. Finally, we document that TRIPS induces a richer information environment characterized by more management forecasts and media coverage.
The Statute of Uses enacted radical reform which can still be felt across the common law world. It was from exceptions to the statute’s execution of uses to perform last wills that the modern trust emerged. Our understanding of the passage of the statute has been shaped by the survival of several draft bills and ancillary documents. It has been argued that a draft bill introduced in 1529 was rejected by the Commons in March 1532. This in turn inspired the landmark litigation in Dacre’s Case (1533–35), which paved the way for the subsequent enactment of the Statute of Uses. This chapter challenges that orthodox position by demonstrating that there were in fact three early drafts which were considered. It then considers what this tells us about the role of the crown, parliament and the courts during this pivotal period in our legal history.
We study the impact of opioid abuse on real estate prices. We document that opioid death rates and excess prescription rates are negatively associated with house prices. Exploiting the staggered passage of opioid-limiting legislation, we find that a decrease in opioid abuse results in higher county-level house prices. This effect is due to fewer mortgage delinquencies, lower vacancy rates, more home improvement loans, and increased population inflow. Our findings are consistent with improved real estate conditions and a rise in local demand. These results highlight the importance of public health policy in mitigating the economic costs of the opioid epidemic.
This scoping review aims to synthesize the literature on pediatric health technology assessments (HTAs) and map out the challenges of assessing new technologies for use in children, with a particular focus on pharmaceutical interventions.
Methods
Conducted in accordance with the Joanna Briggs Institute Methodology, this scoping review addressed HTAs in the pediatric domain through searches of PubMed, Embase, Web of Science Core Collection, and EconLit through 22 January 2024, as well as the gray literature. Sources were excluded if they (i) were a clinical trial investigating a specific technology or an HTA of that technology, (ii) did not address the challenges of HTAs, or (iii) had no relevance to pediatrics. Two authors performed screening and data extraction independently and in duplicate.
Results
One hundred and three reports were included. Of these, sixty were full journal articles, twenty-three were conference abstracts, and twenty were guidelines, reports, and other documents. Two important themes emerged from this work. The first was the unique position of children within society and the resulting difficulty of incorporating them within a population-wide HTA system. The second was the uncertainty that characterized pediatric HTAs due to data constraints and either a lack of guidance by HTA bodies or variations in guidance between bodies.
Conclusions
Many factors inherent to children, including the heterogeneity of pediatric disease populations, long-term outcomes, and children’s distinct social positions, render conducting pediatric HTAs challenging. Innovative approaches are required to address these challenges and respond to the needs of pediatric populations.
This study investigates the influence of multiple jet parameters on the flow field of translating impinging inclined water jets. We conducted full-scale stereoscopic particle image velocimetry and pressure measurements and three-dimensional computational fluid dynamics simulations for Reynolds numbers in the range of $Re = 23{,}000{-}43{,}750$. Considering the complex mechanism of a translating impinging jet, a good concordance is observed between the experimental and numerical results. The translation-to-jet velocity ratio ($R$) is identified as a critical parameter in determining whether the jet flow predominantly exhibits impinging characteristics or behaves as a jet in cross-flow. It is found that, for $R \gt 0.22$, jet impingement is minimal. The stand-off distance to nozzle diameter ratio ($H/D$) determines the relative influence of the cross-flow on the jet flow. The effect of $H/D$ is similar to a stationary impinging jet, with the potential core extending up to $H/D \approx 4$, but entrainment is enhanced by the relative cross-flow. For an inclined jet, i.e. jet angle $\theta \neq 90^{\circ}$, the direction of the jet, either backward or forward, governs the deflection of the flow. Higher pressures are recorded for a backward directed jet compared with a forward directed jet for supplementary angles.
This chapter explores the roles of different generations of lawyers in Estonia’s post-1991 democratic transformation. Focused on young, progressive lawyers familiar with Western legal culture and established leaders educated under the Soviet regime, the study draws on extensive interviews and document analysis to trace how these actors shaped the nation’s transition from Soviet legal structures to a contemporary democratic framework. The findings highlight the critical importance of individual efforts in redefining legal practices, emphasising the dual impact of innovative youth and experienced mentors in driving significant legal and institutional reforms. The study enhances understanding of the dynamics of legal transitions in post-Soviet states, highlighting the essential blend of innovation and experience necessary for successful legal reform.
Dietary phytosterols exert hypocholesterolemic effects by inhibiting cholesterol absorption in the small intestine. However, oxidised phytosterols exert harmful effects. In this study, we compared the effects of dietary stigmasterol or oxidised stigmasterol (OS) on cholesterol absorption and metabolism in mice. Institute of Cancer Research (ICR) male mice were fed one of the following diets: a standard American Institute of Nutrition (AIN) diet; the standard diet plus 0·25 % cholesterol; the standard diet plus 0·25 % cholesterol and 0·25 % stigmasterol or the standard diet plus 0·25 % cholesterol and 0·25 % OS. Stigmasterol, but not OS, decreased plasma total cholesterol levels. Unlike stigmasterol, dietary OS increased the cholesterol levels in micellar solutions. Thus, OS could not exert hypocholesterolemic effects as it could not displace cholesterol in micellar solutions. In contrast, dietary OS downregulates the mRNA expression of genes involved in cholesterol synthesis and upregulates the mRNA expression of genes involved in cholesterol catabolism in mice fed cholesterol. In addition, dietary stigmasterol and OS increased the levels of faecal-neutral steroids by downregulating the mRNA expression of Niemann-Pick C1-like 1 protein (NPC1L1) in the small intestine. Dietary stigmasterol may directly regulate the mRNA expression of NPC1L1, whereas dietary OS may reduce the mRNA expression of sterol regulatory element-binding protein 2 and act as a Liver X receptor α agonist, reducing the mRNA expression of NPC1L1. Therefore, OS may affect cholesterol absorption and metabolism through a mechanism different from that of stigmasterol.
Skinfold callipers are used internationally in research, clinical and field settings to assess body composition and nutritional status. Notably, currently available instruments differ in important specificities that impact measurement. In this sense, this report proposes a methodological approach that organises skinfold callipers into three categories (Original, Generic and Hybrid) and three configurations (Type A, Type B and Type C) based on physical-mechanical properties and characteristics. Therefore, this concept provides technical support for choosing the most appropriate skinfold calliper in different contexts.
Carbon-14 (14C) is an important contributor to the collective effective dose to the public due to releases from nuclear power plants (NPPs). In Sweden, only airborne emissions of 14C from NPPs are currently routinely monitored, and the existing data on waterborne 14C discharges are limited. A recent study of 14C in brown algae (Fucus spp.) in Swedish coastal waters showed higher F14C values collected at Ringhals NPP, on the Swedish west coast, than expected. Therefore, this study aimed at assessing if blue mussels (Mytilus edulis) could be used to retrospectively estimate the 14C concentration of dissolved inorganic carbon (DIC) in seawater at three sites. A method was developed to extract the fibrous layer that forms visible annual structures in the shells. All samples were analyzed with accelerator mass spectrometry and the results compared with 14C data from Fucus spp. For one of the analyzed shells (structures from 1974–1978), from the site Särdal, F14C in Fucus spp. and M. edulis agreed very well. For another shell (1972–1978), shell structures from some of the earlier years displayed up to 6% lower F14C than Fucus spp. F14C in one shell from a remote site, Båteviken, only had small annual variations (2017–2022: F14C = 1.070 ± 0.015 (1 σ)). Two shells from Ringhals NPP had higher average F14C, and a significant temporal variability (2014–2022: F14C = 1.427 ± 0.268 (1 σ)). Difficulties in unambiguous identification of the annual structures in the shells, as well as the future potential of this method, are discussed.
In 1636, a set of nine paintings was installed on the ceiling of the Banqueting Hall in Whitehall Palace. Three central and six side panels. The set had arrived from the studio of Peter Paul Rubens in Antwerp, and had been commissioned by King Charles I in honour of his father James. They were intended to summate three aspirations which defined James’s reign. The three central panels were entitled The Apotheosis of King James, The Peaceful Reign of King James, and The Union of Crowns. Each spoke to a matter of constitutional urgency, then and now; respectively, the nature of monarchy, relations with the rest of Europe, and the possibility of forging a union between England and Scotland. The purpose of this chapter is to revisit the reign of King James I and see if we can spot some resonances.
This chapter deals with child labour in value chains, whether global value chains (GVCs) or domestic value chains (DVCs). This chapter goes beyond the usual question of the regulation of child labour in value chains to consider the conditions necessary for the elimination of child labour. This chapter is the product of many years of research on this topic by the two authors, sometimes jointly and at times along with other researchers. The empirical base of the analysis in this chapter comprises the various studies carried out by the authors, jointly or separately, of child labour in the garment GVCs in Delhi (Bhaskaran et al., 2010); in the global and DVCs of handicrafts in Jaipur, matches in Sivakasi, stone quarries in Rajasthan, brick kilns in Malda, West Bengal, knitwear and fireworks in Tirupur, Tamil Nadu (Nathan and George, 2012); cotton production in Punjab and Haryana (IHD and Save the Children, 2014); and of gems, lac bangles, and embroidered garments in Jaipur (The Freedom Fund, 2018). One of the authors (Varsha Joshi) led the Child Helpline, which is the key agency in the identification and rescue of child labour in Jaipur, so we were able to use the insights gathered in the course of her work in rescuing child labourers. While the data leading to the chapter's analysis are mainly from Indian cases, the analysis itself is applicable to other, developing countries in the Global South where child labour still exists in serious dimensions. The chapter's policy prescription of combining higher adult earnings at the base of the labour force pyramid with compulsory and quality education is relevant to all developing countries of the Global South.
After this introduction, the next section deals with types of child labour and the implications for different types of interventions. This is followed by a summary of the different types of interventions of both public and private regulation that have been undertaken to eliminate child labour in value chains, both global and domestic. The elimination of child labour involves a change in the business strategy of both the lead firm or principal employer and the supplier.
This chapter provides an account of the Public Records Office of Ireland as a legal repository, before its destruction in 1922 as an early ‘casualty’ of the Irish Civil War. The chapter supplies a succinct account of Ireland’s historic courts and their record-keeping, providing an overview of the legal contents of the Public Record Office of Ireland at the moment of its destruction. Using several case studies, the chapter then illustrates the process of archival reconstruction through the use of substitute and replacement sources, spanning the late medieval period up to the end of the nineteenth century. It argues that attempting to reconstruct these lost legal archives constitutes a powerful method of historical reappraisal, revealing how many of Ireland’s historic courts were created, evolved and disappeared.
Some arboreal monocotyledons, such as the dragon trees (Dracaena sp.), can develop impressive trunks (>5 m perimeter) through a lateral meristem, but their ages are difficult to determine. We report here a series of calibrated radiocarbon (14C) dates obtained from a stem section of Dracaena draco (L.) L. subsp. draco growing on the island of Tenerife, Canary Islands, Spain. This radial section, about 40 cm long, was cut on October 18, 2023, from a large (∼60 cm diameter) branch that had fallen off the main stem of a privately owned dragon tree. In order to apply 14C calibration, and given the lack of clearly defined growth layers, we collected 33 sequential samples at ∼1-cm intervals along this radial section. A first attempt at wiggle-matching resulted in a calibrated dating of ∼1787 CE for the innermost sample. Because we only knew the spatial distance, but not the time interval, between 14C dates, we further applied calibration tools commonly used for sedimentary sequences. The Poisson-process deposition model in the software OxCal resulted in a calibrated age for the innermost sample of 1776–1798 CE (2σ). The classic and Bayesian age-depth deposition models available as R packages dated the innermost sample to, respectively, 1775–1862 and 1768–1813 CE. Because the branch was at a height of ∼3 m from the ground, and its section did not reach the pith, our results suggest that this dragon tree was ∼300 years old in 2023.
For any integer $t \geq 2$, we prove a local limit theorem (LLT) with an explicit convergence rate for the number of parts in a uniformly chosen t-regular partition. When $t = 2$, this recovers the LLT for partitions into distinct parts, as previously established in the work of Szekeres [‘Asymptotic distributions of the number and size of parts in unequal partitions’, Bull. Aust. Math. Soc.36 (1987), 89–97].
Supersonic jets impinging on a ground plane produce a highly unsteady jet shear layer, often resulting in extremely high noise level. The widely accepted mechanism for this jet resonance involves a feedback loop consisting of downstream-travelling coherent structures and upstream-propagating acoustic waves. Despite the importance of coherent structures, often referred to as disturbances, that travel downstream, a comprehensive discussion on the disturbance convection velocity has been limited due to the challenges posed by non-intrusive measurement requirements. To determine the convection velocity of disturbances in the jet shear layer, a high-speed schlieren flow visualisation is carried out, and phase-averaged wave diagrams are constructed from the image sets. The experiments are conducted using a Mach 1.5 jet under various nozzle pressure ratios and across a range of impingement distances. A parametric analysis is performed to examine the influence of nozzle pressure ratio on the convection velocity and phase lead/lag at specific impingement distances. The results reveal that impingement tonal frequency is nearly independent of the disturbance convection velocity, except in cases of staging behaviour. They also demonstrated that slower downstream convection velocity of the disturbance corresponds to larger coherent structures, resulting in increased noise levels. Based on the observation of acoustic standing waves, an acoustic speed-based frequency model has been proposed. With the help of the allowable frequency range calculated from the vortex-sheet model, this model can provide a good approximation for the majority of axisymmetric impingement tonal frequencies.