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Molecular analyses of geographically dispersed Fasciola spp. isolates based on ribosomal, mitochondrial and nuclear molecular markers have revealed high levels of genetic diversity within liver fluke populations. To investigate the Fasciola population substructure across Pakistan 4 molecular markers were compared (fatty acid binding protein, fabp; phosphoenolpyruvate carboxykinase, pepck; random amplified polymorphic DNA, RAPD; mitochondrial NADH dehydrogenase, mt-nd1). Adult parasites (n = 595) were collected from buffalo and cattle across 4 provinces in Pakistan (Baluchistan, Gilgit Baltistan, Khyber Pakhtunkhwa, Punjab). Species classification of all 595 parasites was confirmed by the 3 gel-based markers (pepck, fabp and RAPD) as F. gigantica, except for the fabp marker which unexpectedly could not be amplified in 274 parasites (46%). Analysis of a subset of samples indicates the potential for mis-priming due to multiple genomic loci that match the fabp primer sequences resulting in negative PCR products in some cases. Sequence analysis of the mt-nd1 PCR products identified 29 haplotypes within the samples from Pakistan, the majority of which are unique to this study. None of the 29 haplotype sequences were identified in samples from Africa, highlighting the genetic diversity between geographically disparate liver fluke populations. Inconsistencies between Fasciola spp. molecular markers in this study highlights the need for multiple markers, validated on large numbers of geographically disparate parasites, to generate robust analyses of liver fluke genetic diversity. This study echoes other Fasciola spp. population studies and highlights the genetic diversity of F. gigantica populations in Pakistan that is comparable to observations of diversity throughout Asia.
Tackling climate change requires long-term commitment to action, yet an array of influential parties with vested interests stand opposed to this. How best to engage and balance these positions for positive change is of increasing concern for advocates and policy makers. Exploring a discord within climate change policy and politics, this insightful volume critically examines the competing assumptions and arguments underpinning political 'stability' versus 're/politicization' as a means of securing effective, long-term climate action. A range of cases exemplify the different political systems and power structures that underpin this antagonism, spanning geographical approaches, examples of non-governmental action, and key industries in the global economy. Authored by an international team of scholars, this book will be of interest to researchers of local, national, and international legislation, specialists on climate governance policy, and other scholars involved in climate action. This title is also available as Open Access on Cambridge Core.
Enforced Disappearances: On Universal Responses to a Worldwide Phenomenon discusses the UN human rights (both treaty bodies and special procedures) response to the key challenges of missing persons and enforced disappearances, including reparations, family rights, involvement of non-state actors, and the migration context. The book also includes several illustrative case studies from Latin America, Africa, Mexico, Western Balkans, and the Asia-Pacific region, which demonstrate the current challenges and problems relating to enforced disappearances in domestic or regional settings. The book includes contributions from experts in this issue working across a global range of jurisdictions. This title is also available as open access on Cambridge Core.
This book examines the intersection of professional tennis and legal regulation, unveiling a fascinating world where tennis meets domestic, international and transnational law, and showing the many ways these legal frameworks impact tennis. Filled with firsthand accounts of the legal landscape and its implication on tennis, the work provides an accessible, engaging portrait of the tennis ecosystem that is equally suited for academics, athletes, sports lawyers and journalists. It is an essential read for those working within sports law generally, and the tennis industry specifically. This title is also available as Open Access on Cambridge Core.
Light access is the primary factor affecting yields in cacao-based agroforestry systems (CAFS). While CAFS ecosystem services provision is extensively documented, research on improving light access in CAFS remains scarce. Shade canopy pruning, a developing technique in Latin America, is part of the long-term SysCom Bolivia trial. It is undertaken twice a year, at the start of the rainy and dry seasons. This paper presents the results of a 5-year study on the relationship between CAFS canopy cover, flowering levels, cocoa yields, and pruning events from this trial.
The seasonality and peak periods of flowering and pod production were independent from the cropping system, underlining both climatic- and genetically determined production patterns. Yet, flowering levels depended on canopy cover levels during the rainy season, which translated into different pod production levels in the following months. Average annual yields were 1300 kg ha-1 for full sun cacao, 780 kg ha-1 for agroforestry systems (AF), and 640 kg ha-1 for dynamic agroforestry systems (DAF), with rainy season canopy covers maintained at 25–35% for AF and 40–60% for DAF.
The relationships between canopy cover, flowering, and cocoa yield were found to be exponential, indicating that the lower the canopy cover, the greater the yield increase could be expected from pruning. The lower levels of cover obtained in AF after the ‘flowering’ pruning triggered better flowering levels in comparison to DAF. However, these did not systematically translate into significantly higher yields, underlining the probable significance of the ‘ripening pruning’ for DAF’s cocoa yield. Overall, our results show (i) the great potential of timely shade canopy pruning and (ii) the need to adapt such a technique to systems’ diversity and density to make it cost/labour-effective and support its scalability.
This chapter delves into the concept of paradata with the dual aim to link paradata’s notable complexity to broad utility, and to provide groundwork for exploring paradata in the subsequent chapters of this volume. The concept of paradata is investigated in several ways, including explaining the etymology of paradata and reviewing paradata definitions in survey research, archaeology, and heritage visualisation research – three domains where paradata use is most well-established. The chapter then moves on to discuss metadata and provenance data, two key related terms that are used to further interrogate the concept of paradata. The chapter shows that the concept of paradata encompasses a range of meanings and definitions, and that these share several common characteristics and correspondences, but also notable differences. To conclude, the chapter outlines two approaches to grasping and utilising the concept of paradata. The many definitions of and approaches to paradata are discussed as being, in some respects, an obstacle for understanding and employing the concept. The chapter, however, also underlines the complexities of the concept of paradata as a useful resource when building connectivities across its many possible domains of use and application.
Using an explicit Eichler–Shimura–Harder isomorphism, we establish the analog of Manin’s rationality theorem for Bianchi periods and hence special values of L-functions of Bianchi cusp forms. This gives a new short proof of a result of Hida in the case of Euclidean imaginary quadratic fields. In particular, we give an explicit proof using the space of Bianchi period polynomials constructed by Karabulut and describe the action of Hecke operators.
The chapter examines the application of intersectionality theory to feminist judgment writing at the International Criminal Court (ICC), questioning whose feminism is centered and which intersections matter. Drawing on Black feminist scholarship, Dawuni evaluates both the merits and limitations of intersectionality as a framework for judicial decision-making in international criminal law. The chapter argues that while intersectionality can illuminate how multiple identities shape experiences of victimisation and access to justice, careful attention must be paid to avoid reproducing marginalisation through oversimplified applications. It critiques the continued impact of coloniality on the ICC’s operations and questions the homogenisation of African experiences in international law. The analysis concludes with recommendations for judges, registry staff, and researchers, emphasising the need for continuous education on intersectionality, greater institutional diversity, and constant self-reflection about positionality and privilege. Dawuni argues that true intersectional justice requires transforming both the composition and operational culture of international criminal institutions.
The Introduction introduces the central research questions of the study and summarizes the main arguments. It also lays out the research design and discusses the key concepts and how it measures them. Finally, it provides summaries of all of the chapters in the book.
We investigate flow-induced choking in soft Hele-Shaw cells comprising a fluid-filled gap in between a rigid plate and a confined block of elastomer. Fluid injected from the centre of the circular rigid plate flows radially outwards, causing the elastomeric block to deform, before exiting through the cell rim. The pressure in the fluid deforms the elastomer, increasing the size of the gap near the inlet, and decreasing the gap near the cell rim, because of volume conservation of the solid. At a critical injection flow rate, the magnitude of the deformation becomes large enough that the flow is occluded entirely at the rim. Here, we explore the influence of elastomer geometry on flow-induced choking and, in particular, the case of a thick block with radius smaller than its depth. We show that choking can still occur with small-aspect-ratio elastomers, even though the confining influence of the back wall that bounds the elastomer becomes negligible; in this case, the deformation length scale is set by the radial size of the cell rather than the depth of the block. Additionally, we reveal a distinction between flow-induced choking in flow-rate-controlled flows and flow-rate-limiting behaviour in pressure-controlled flows.
Impairments in social interaction are common symptoms of dementia and necessitate the use of validated neuropsychological instruments to measure social cognition. We aim to investigate the Hinting Task – Dutch version (HT-NL), which measures the ability to infer intentions behind indirect speech to assess Theory of Mind, in dementia.
Method:
Sixty-six patients with dementia, of whom 22 had behavioral variant frontotemporal dementia (bvFTD), 21 had primary progressive aphasia, and 23 had Alzheimer’s disease (AD), and 99 healthy control participants were included. We examined the HT-NL’s psychometric properties, including internal consistency, between-group differences using analyses of covariance with Bonferroni-adjusted post hoc comparisons, discriminative ability and concurrent validity using the area under the receiver operating characteristic curve (AUC), and construct validity using Spearman rank correlations with other cognitive tests.
Results:
Internal consistency was acceptable (Cronbach’s α = 0.74). All patient groups scored lower on the HT-NL than the control group. Patients with bvFTD scored lower than patients with AD dementia. The HT-NL showed excellent discriminative ability (AUC = 0.83), comparable to a test of emotion recognition (ΔAUC = 0.03, p = .67). The HT-NL correlated significantly with a test for emotion recognition (r = .45), and with measures of memory and language (r = [.31, .40]), but not with measures of information processing speed, executive functioning, or working memory (r = [.00, .17]). Preliminary normative data are provided.
Conclusions:
The HT-NL is a psychometrically sound and valid instrument and is useful for identifying Theory of Mind impairments in patients with dementia.
At the time of writing in 2023, it was four years since the Office of the Prosecutor commenced an investigation into the situation in Bangladesh/Myanmar in accordance with Article 15(4) of the Rome Statute. It was also six years since the mass displacement of Rohingyas from Rakhine state in Myanmar, which Pre-Trial Chamber III held may amount to the crimes against humanity of deportation and persecution on the ground of religion and/or ethnicity. According to the United Nations, around 10,000 people were killed in an alleged genocidal operation, and more than 700,000 people fled to Bangladesh. Most of these people have found themselves in the Kutupalong-Balukhali expansion site in Cox’s Bazar – the largest and most densely populated refugee camp in the world. Living conditions in the camp are challenging. Shelters are built from bamboo and tarpaulin and are closely packed together. Access to clean water, sanitation, healthcare, and education is limited. Residents must contend with overcrowding, outbreaks of disease, fires, monsoons, and cyclones. The COVID-19 pandemic added another layer of complexity to the crisis. The future for refugees in the camp remains uncertain, with limited prospects for safe and voluntary return to Myanmar, local integration in Bangladesh, or resettlement to a third country.
Edited by
Marietta Auer, Max Planck Institute for Legal History and Legal Theory,Paul B. Miller, University of Notre Dame, Indiana,Henry E. Smith, Harvard Law School, Massachusetts,James Toomey, University of Iowa
Reduction in mobility due to gait impairment is a critical consequence of diseases affecting the neuromusculoskeletal system, making detecting anomalies in a person’s gait a key area of interest. This challenge is compounded by within-subject and between-subject variability, further emphasized in individuals with multiple sclerosis (MS), where gait patterns exhibit significant heterogeneity. This study introduces a novel perspective on modeling kinematic gait patterns, recognizing the inherent hierarchical structure of the data, which is gathered from contralateral limbs, individuals, and groups of individuals comprising a population, using wearable sensors. Rather than summarizing features, this approach models the entire gait cycle functionally, including its variation. A Hierarchical Variational Sparse Heteroscedastic Gaussian Process was used to model the shank angular velocity across 28 MS and 28 healthy individuals. The utility of this methodology was underscored by its granular analysis capabilities. This facilitated a range of quantifiable comparisons, spanning from group-level assessments to patient-specific analyses, addressing the complexity of pathological gait patterns and offering a robust methodology for kinematic pattern characterization for large datasets. The group-level analysis highlighted notable differences during the swing phase and towards the end of the stance phase, aligning with previously established literature findings. Moreover, the study identified the heteroscedastic gait pattern variability as a distinguishing feature of MS gait. Additionally, a novel approach for lower limb gait asymmetry quantification has been proposed. The use of probabilistic hierarchical modeling facilitated a better understanding of the impaired gait pattern, while also expressing potential for extrapolation to other pathological conditions affecting gait.
Chapter 2 uses an original database on historical elections in South America to explore when and where democracy first emerged in the region. Scholars traditionally portrayed nineteenth-century elections in Latin America as farces, but in recent years historians have challenged this view. This chapter shows that many South American elections in the nineteenth century involved significant participation and competition, and a few were even free and fair. Nevertheless, authoritarian rule predominated. Most elections were non-competitive, numerous restrictions on the franchise existed, and voter turnout tended to be low in comparison to Europe and the United States. Moreover, the few democratic episodes in the nineteenth century proved to be quite brief, as the freely elected presidents were either overthrown or subverted democracy to perpetuate themselves or their allies in power. However, in the first three decades of the twentieth century, a great divide occurred. A few South American countries, namely Argentina, Chile, Colombia, and Uruguay, established democratic regimes that lasted a dozen years or more. By contrast, authoritarian rule deepened in the other six countries of the region
Edited by
Marietta Auer, Max Planck Institute for Legal History and Legal Theory,Paul B. Miller, University of Notre Dame, Indiana,Henry E. Smith, Harvard Law School, Massachusetts,James Toomey, University of Iowa
Ever since the beginning of opera, the scenografo’s role has fluctuated between invention and execution, conceptual creation and manual realisation. Initially considered an art in the old, Latin sense of the word – a craft or trade – the profession gradually gained social and aesthetic respectability, shedding its associations with the technical skills of artisans and acquiring the prestige of modern artistic expression. By the early 1800s, prominent scenografi were hailed as ‘men of genius’, although their ennoblement was never quite as complete as some renowned commentators seemed to suggest. Indeed, while we may be tempted to view the scenografo’s transformation from craftsman to artist as an uninterrupted, linear development, the debates on operatic staging that accompanied the 1930s Maggio Musicale Fiorentino challenge this inclination.
This article examines the role and status of operatic scenografi in 1930s Italy, with a particular focus on Florence and the intersection between cultural and institutional histories of the profession. What was Italian operatic set design at the time? What did this theatrical art mean, represent, produce in Tuscany’s foremost Renaissance city? Is it possible to develop a specifically urban approach to the history of set design before World War II, and where might this leave our understanding of opera production labour both during the Fascist period and today?
Amid profoundly unstable and vulnerable times, conventional education systems continue to reflect the dominant ideology in modernity that has contributed to the current global polycrisis. This study explores how educators engage in vernacular pedagogical practices, locally grounded, relational and often situated outside standard curricula, that act as counterpoints to the conventional constraints using a Place-Based Education (PBE) approach. Drawing on semi-structured interviews with 14 educators from the Southeast Michigan Stewardship (SEMIS) Coalition, the research investigates how educators experience job satisfaction, define their roles and navigate tensions between dominant norms and community-rooted learning. Findings suggest that educators embrace indeterminism as a source of creativity, responsiveness and growth, weaving together interlaced strands of personal, cultural and ecological meaning in their vernacular pedagogical practices. Educators carve out alternative ways of knowing and relating, positioning PBE as a cultural stance that enables responsive, locally rooted reform amid today’s complex, uncertain and interconnected crises.