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We report a lab experiment to study subjects’ preferences over their ordinal rank in an earnings distribution. Following an assignment of unequal earnings, subjects can select a monetary transfer from exactly one individual to another, not including themselves. This can potentially change their own position in the distribution, as well as influence overall inequality. The experiment varies whether the initial earnings assignment is random or is affected by preliminary competition. It also varies the reference group from a complete to a partial network. A majority of observed transfers reduce inequality by moving earnings from those with the highest rank to the lowest rank in the distribution. Rank-improving transfers are substantially more common for preliminary competition losers than winners. Transfers to individuals outside of the reference group are not uncommon, and they usually target as the source the individuals high in the income distribution. While generally weak overall, own rank preferences appear to be more common among men than women.
Identifying actionable stewardship targets in immunocompromised patients is challenging due to limited data and high morbidity. One approach could be targeting therapy with limited evidence, like cytomegalovirus immune globulin (CMV-IGIV). We implemented a drug restriction program that increased appropriate use of CMV-IGIV, highlighting a unique stewardship opportunity in immunocompromised populations.
The tattoos of the Pazyryk ice mummies are of paramount importance for the archaeology of Iron Age Siberia and are often discussed from a broad stylistic and symbolic perspective. However, deeper investigations into this cultural practice were hindered by the inaccessibility of quality data. Here, the authors use high-resolution, near-infrared data in conjunction with experimental evidence to re-examine the tools and techniques employed in Early Iron Age tattooing. The high-quality data allow for the previously unfeasible distinction of artist hands and enable us to put the individual back into the picture of a widespread but rarely preserved prehistoric practice.
This editorial explores dual harm – the co-occurrence of self-harm and aggression – particularly among forensic populations. Historically approached as two separate and even opposing behaviours, emerging evidence shows that those who engage in self-harm and aggression experience greater adversity and poorer outcomes. This underscores the importance of enhancing our understanding of dual harm. We review key developments within the field, including how dual harm may be best conceptualised and managed, and identify critical gaps in the literature. In order to improve the care and outcomes of those who engage in self-harm and aggression, emphasis is placed on adopting more integrated approaches that consider the duality of these behaviours, as well as the complex needs of this high-risk group, within research and practice.
The concept of total suffering is widely recognized in palliative care (PC), encompassing a range of interconnected and complex factors that collectively shape the evolving and individualized experience of a patient’s illness journey. Studies on will to live (WtL) in terminally ill patients have demonstrated its variability over time and various factors that influence these changes.
Methods
To objectively investigate the concept of total suffering and WtL; including their fluctuation over time and associations with sociodemographic, clinical, physical, and psychological symptoms in a sample of individuals with life-limiting conditions receiving PC. This multicenter Iberian study involved 3 centers in Portugal and 1 in Spain. A total of 107 individuals with life-limiting conditions consented to participate. To capture the dynamic and multifaceted components of total suffering, we had each participant completed the Edmonton Symptom Assessment Scale (ESAS) along an additional WtL visual analogue once daily over a 30-day period.
Results
WtL demonstrated various patterns over time. While some patterns reflected relative stability, other demonstrated substantive fluctuation during the course of illness. Significant correlations were observed between WtL and all other ESAS items. Moderate positive correlations were found between WtL and total ESAS score and its physical and psychological sub-scores. Spearman’s correlation coefficients between all physical and psychosocial items on the ESAS were statistically significant across all 45 correlations performed, with only 5 showing moderate strength; the remaining correlations were weaker.
Significance of results
Evidence-based understanding of WtL is critical to improving care for patients who experience suffering toward end-of-life and their families. Further research is needed to inform and refine interventions targeting total suffering.
Chapter 18 offers a critical analysis of the types of remedies sought in climate cases and examines their implications within the legal landscape. Drawing on a comprehensive analysis of climate lawsuits from around the world, the authors provide insights into the diverse range of remedies that have been sought to address the adverse impacts of climate change. They then shed light on the different considerations and approaches that courts have taken when determining appropriate remedies. In their exploration of emerging best practices, the authors highlight instances where courts have adopted innovative and transformative approaches to remedies in climate litigation. They examine creative legal mechanisms that go beyond traditional compensatory measures and explore the potential of remedies such as injunctive relief, restitution, and declaratory judgments to address the multifaceted challenges posed by climate change.
This introduction grounds the middle-income (MI) trap by looking at the empirical realities of firms, sectors, national, and subnational institutions embedded in global value chains (GVCs). While MI-trap scholarship has shed light on macro-structural constraints, it often overlooks international production structures and micro-level agency. GVC research, in turn, captures firm strategies and governance structures but tends to underplay the role of domestic institutions and political coalitions. This Special Issue brings these two traditions into dialogue in order to examine how upgrading is (partially) attained—or how it fails—in MI countries.
The articles in the Issue focus on six countries—Argentina, Brazil, Chile, China, Malaysia, and Mexico—to analyze how public and private actors pursue upgrading strategies under MI-trap conditions. We develop a typology of Actors’ Upgrading Strategies along two dimensions: loci of agency (state vs. firm/chain) and modes of action (transformative vs. adaptive). This yields four conceptual categories: Transformative Policy Entrepreneurs, Adaptive Policy Implementers, Transformative Firm Upgraders, and Incremental Firm Repositioners. Collectively, the contributions offer a more textured and politically attuned understanding of upgrading under the MI trap in a world of GVCs, and bring us closer to understanding what it means to be caught in—or to find pathways out of—the trap.
Delving into fraternal succession, intermarriage practices, and levirate marriages of the Northern Qi dynasty (550–577), this article demonstrates that these practices served as pillars of stability for the imperial family. In this exploration, Empress Dowager Lou 婁太后 (501–562) emerges as the central figure behind these practices, playing a pivotal role in their implementation and wielding immense power as kingmaker. Starting from before the official reign of the Northern Qi, she personally chose her husband, laid the groundwork for him to become regent of the preceding Eastern Wei (534–550) court, and controlled the succession system to seat her own sons as emperors of the Northern Qi. Drawing on her Xianbei 鮮卑 roots, Empress Dowager Lou enforced an agenda of Inner Asian practices and politics in her pursuit to consolidate the rule and identity of the Northern Qi imperial family.
Generative AI systems’ output as speech – Constitutional coverage for AI speech in the absence of a (human) speaker – Right of individuals to receive information as a perspective for framing constitutional coverage of generative AI output – Implications of constitutional coverage for content policing and content moderation by private platforms – Trends in the interpretation of existing content moderation regimes and their applicability to generative AI systems.
This paper is a single-project meta-analysis of four experiments that model charitable giving as individual contributions to a multiplicity of competing threshold public goods. We pool 17,136 observations at the individual level to summarize the project and investigate the role of learning, gender, and risk attitude, since the included studies are inconclusive in this regard. We find that equally effective coordination devices are the existence of a single contribution option that stands out on its merits, learning, and delegation as long as the intermediary is formally obliged to pass along a high enough percentage of the transferred resources. Women delegate less than men, and consequently prefer direct contributions. Risk tolerance increases overall donations but decreases individual earnings. We discuss possible implications of our findings.
The article explores the interplay between imperialism and ethnonationalism, revealing how these seemingly conflicting ideologies coalesced in Russian political thought. The period of 1989–1994 saw a struggle between civic nationalism, which sought to redefine Russia within its existing borders, and imperialist-nationalist currents that viewed Soviet disintegration as a geopolitical catastrophe. Within this ideological conflict, the “time bomb” metaphor emerged as a potent rhetorical device, encapsulating anxieties about territorial fragmentation and national decline. The study identifies Russian émigré intellectual Gleb Rahr as a key figure in introducing the metaphor, later popularized by figures such as Dmitry Rogozin and Vladimir Putin.
Chapter 10 on International Atmospheric Trust cases investigates the application of the public trust doctrine in climate litigation. Historically, under this doctrine courts have maintained that certain natural and cultural resources should be held in trust for the public, with the government acting as a trustee. The authors explain the practical application and interpretation of this doctrine in climate litigation, examining key cases (through 2022) across various jurisdictions, including the United States, Canada, India, Pakistan, and Uganda. The effect is to produce a Restatement of best practices in climate litigation revealing the successes and challenges encountered when invoking the public trust doctrine in climate litigation. This review of the case law reveals an emerging distinction between the U.S., which has seen the erection of procedural barriers in federal and state courts to avoid deciding cases on the merits, and international courts, who have reached the merits of several cases, ordering remedial actions. The chapter underscores the potential of this doctrine to induce more robust climate action among the political branches of government, reflecting a growing recognition among courts outside the U.S. of their own role in safeguarding the atmosphere.
Penicillin allergies are reported in 10–15% of the US population, but the actual rate is less than 1%. Inappropriate penicillin allergies are associated with adverse patient outcomes, poor antimicrobial stewardship, and increased healthcare costs. Direct oral provocation testing (DOPT) is a safe and cost-effective way to remove false penicillin allergy labels (PAL). However, widespread implementation is currently limited due to inadequate safety data and protocol variations. This systematic review evaluates the safety of single-dose, nongraded DOPT by the nonallergist.
Design:
Systematic review. MEDLINE, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials were searched from inception to May 2025.
Setting:
Inpatient (Intensive care unit (ICU) and general medical ward) and outpatient
Participants:
Adults with self-reported penicillin allergies deemed low risk by a validated scoring system.
Interventions:
DOPT by nonallergists with single-dose oral amoxicillin 250 mg with a 60-minute observation period.
Results:
3 352 studies were identified, 15 were included in the analysis. Of the 1786 patients who completed DOPT, 66 (3.7%) experienced any reaction: 27 (1.5%) immediate rashes, 24 (1.3%) delayed rashes, and 15 (.8%) other reactions. No cases of anaphylaxis, angioedema, or epinephrine use were reported.
Conclusion:
The use of single-dose DOPT in patients deemed low risk, using a validated risk scoring tool, is safe, with low rates of mild reactions and no serious adverse events. A nonallergist can significantly improve penicillin delabeling rates and patient outcomes using this approach.
This study presents high-power mode-selective operation in a large-mode-area (LMA) fiber laser. A spatial mode-adaptive control system incorporating a 5×1 photonic lantern was employed to facilitate mode conversion between the LP01 and LP11 modes. The coherence length between the five single-mode arms and the stimulated Brillouin scattering threshold in the amplifier were well balanced by tuning the seed linewidth. In addition, the specific design of the fiber amplifier’s bending radius enabled stable mode-selective output with high mode purity. Consequently, a near-fundamental mode control was achieved in a 42-μm LMA fiber laser, yielding a beam quality M2 factor of 1.97 at an output power of 1 kW. Subsequently, a stable LP11 mode laser output with an output power of 219 W and an optical conversion efficiency of 75% was obtained. This research provides a significant technical foundation for the mode-selective operation of high-power LMA fiber lasers.
Acanthocephalans, which are in the family Polymorphidae, are a globally distributed group of endoparasites whose adults reside in the intestines of fish-eating birds, waterfowl and marine mammals. Adults of Polymorphus brevis and Pseudocorynosoma constrictum are endoparasites of fish-eating birds (Ardeids) and waterfowl (Anatidae), respectively, and are considered one of the most abundant and widely distributed species of polymorphids in freshwater systems from the Nearctic and Neotropical regions of Mexico and the USA. In the present study, sequences of cytochrome c oxidase subunit 1 (cox1) from mitochondrial DNA were generated from 67 specimens of P. brevis and 32 of Ps. constrictum from 12 localities on 6 biogeographic provinces in Mexico (the Trans-Mexican Volcanic Belt, Pacific Lowlands, Veracruzan, Californian, Sierra Madre Occidental, and Sonoran), plus the Temperate Prairies biogeographical province in the USA. The phylogeographic analyses indicated that the populations of both species lacked phylogeographic structure and exhibited high haplotype diversity, low nucleotide diversity and low Fst values among the biogeographic provinces; in combination with negative values in the neutrality test, these findings suggest that the populations of both species of acanthocephalan are undergoing expansion. The current evidence indicates that the biology of the definitive hosts, in combination with their migration patterns, could play a key role in shaping the distribution of haplotypes and the population genetic structure of the studied 2 acanthocephalan species.
Chapter 7 dissects how human rights laws have been harnessed in climate cases, scrutinising key judgments that have applied human rights frameworks to climate change and the implications of these legal strategies for both claimants and defendants. The authors’ analysis of emerging best practice reveals a growing acceptance of the notion that a State’s failure to take adequate action to address climate change constitutes a breach of human rights obligations, and this recognition is shaping legal strategies in climate litigation at the national and international levels. The authors also highlight how recent jurisprudence further suggests that corporations have important obligations to respect human rights in the face of climate change. Although jurisdictional disparities exist, the growing body of case law demonstrates the adaptability and replicability of rights-based reasoning, thereby contributing to the establishment of a consistent and coherent framework for ‘transnational’ climate law.