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Understanding microbial adaptations to the extreme conditions of space is crucial for both astronaut health and the integrity of spacecraft materials. This study comparatively analyses the cosmic radiation resistance and growth responses to simulated microgravity (SMG) of a wild-type strain and an International Space Station (ISS) isolate of Penicillium rubens. Resistance to helium- and iron-ion radiation was determined, alongside growth under SMG using clinorotation. The results revealed that the ISS isolate exhibited higher resistance to both helium- and iron-ion radiation than the wild-type strain, suggesting adaptive mechanisms that enhance survival in space environments. Additionally, while the ISS isolate demonstrated significantly increased growth in SMG compared to normal gravity conditions, the wild-type strain showed no difference between the two conditions. These findings indicate that prolonged exposure to the space environment may select for traits that enhance resistance to cosmic radiation and alter growth dynamics under microgravity. Such adaptations could have implications for microbial monitoring in space habitats, planetary protection policies, and potential biotechnological applications in space. Further investigations into the genetic and metabolic differences between both strains may provide deeper insights into fungal adaptation to space environments.
This study characterises the radio luminosity functions (RLFs) for star forming galaxies (SFGs) and active galactic nuclei (AGN) using statistical redshift estimation in the absence of comprehensive spectroscopic data. Sensitive radio surveys over large areas detect many sources with faint optical and infrared counterparts, for which redshifts and spectra are unavailable. This challenges our attempt to understand the population of radio sources. Statistical tools are often used to model parameters (such as redshift) as an alternative to observational data. Using the data from GAMA G23 and EMU early science observations, we explore simple statistical techniques to estimate the redshifts in order to measure the RLFs of the G23 radio sources as a whole and for SFGs and AGN separately. Redshifts and AGN/SFG classifications are assigned statistically for those radio sources without spectroscopic data. The calculated RLFs are compared with existing studies, and the results suggest that the RLFs match remarkably well for low redshift galaxies with an optical counterpart. We use a more realistic high redshift distribution to model the redshifts of (most likely) high redshift radio sources and find that the LFs from our approach match well with measured LFs. We also look at strategies to compare the RLFs of radio sources without an optical counterpart to existing studies.
We present the Evolutionary Map of the Universe (EMU) survey conducted with the Australian Square Kilometre Array Pathfinder (ASKAP). EMU aims to deliver the touchstone radio atlas of the southern hemisphere. We introduce EMU and review its science drivers and key science goals, updated and tailored to the current ASKAP five-year survey plan. The development of the survey strategy and planned sky coverage is presented, along with the operational aspects of the survey and associated data analysis, together with a selection of diagnostics demonstrating the imaging quality and data characteristics. We give a general description of the value-added data pipeline and data products before concluding with a discussion of links to other surveys and projects and an outline of EMU’s legacy value.
The World Health Organization (WHO) Emergency Medical Team (EMT) Minimum Data Set (MDS) consists of a package of selected medical data items for recording and reporting patient encounters during sudden onset disaster. The MDS is primarily tailored for trauma and surgical care, and its effectiveness, particularly in contexts where other levels of care are needed, namely primary health care (PHC), has been strongly debated.
Objectives:
This study aims to analyze medical data from three UK-MED/UK-EMT deployments, compare the current MDS tool with its context-adapted versions, and explore potential improvements to enhance the effectiveness and adaptability of medical reporting.
Method/Description:
We conducted a statistical analysis of medical data collected and reported in three types of settings: a) Ukraine (conflict), b) Malawi (outbreak), and c) Türkiye (earthquake).
Results/Outcomes:
The analysis of data from recent deployments in Ukraine, Malawi, and Türkiye reveals that non-trauma medical encounters are often categorized as “other” indicating that the current MDS lacks adaptability to various disaster types (non-trauma), local contexts, and specific medical needs. In addition, the tool generates extensive data with low granularity which has proven unhelpful in supporting health programming decision-making and for analysis of disaggregated data during and post-deployment.
Conclusion:
We advocate for a comprehensive revision of the MDS, emphasizing the development of a modular data collection approach that can be tailored to specific local contexts and health services. This revised approach will enhance the utility of collected data for both immediate response efforts and long-term health system improvements, without adding extra data collection burden on clinicians.
A new temporal vortex tracking algorithm allows the first long-term temporal observation of the lives of the intense vorticity structures (IVS). The algorithm is applied to direct numerical simulations of statistically stationary isotropic turbulence, with Taylor-based Reynolds numbers in the range $54 \leqslant Re_{\lambda } \leqslant 239$. In the highest Reynolds number case, the continuous time tracking of millions of ‘worms’ is achieved for more than seven integral time scales and close to 200 Kolmogorov time scales. Within an integral scale volume, more than 66 structures exist, and approximately 20 new structures are created per Kolmogorov time. More than $80\, \%$ of the structures live a solitary ‘life’ without any visible interaction with the other structures, while approximately $15\, \%$ break into new structures. Less than $2\, \%$ of the structures merge with others to form new vortices. A ‘population model’ is developed to estimate the numbers of existing vortices for very long simulated times, and it is observed that the birth rate density of these structures slowly increases with the Reynolds number. The survival functions of the IVS lives exhibit an exponential distribution, with some structures living for more than $35$ Kolmogorov time scales (more than four integral time scales). The mean lifetime of the IVS scales with the mean turnover time scale of the worms, defined by their radii and tangential velocity, attaining $\approx 6.5$ turnover time scales at high Reynolds numbers.
This study aimed to investigate the association between family characteristics and adherence to the EAT-Lancet dietary recommendations in 7-year-old children. This is a prospective birth cohort study with 2125 children from Generation XXI (Porto, Portugal), who provided 3-day food diaries at age 7, used to assess habitual food consumption. At the age of 4, maternal diet was assessed using a Food Frequency Questionnaire, and a diet quality score was calculated (higher scores indicating a better maternal diet), and parental–child feeding practices were assessed with the Child Feeding Questionnaire. Adherence to the EAT-Lancet dietary recommendations was evaluated using the World Index for Sustainability and Health (WISH) at the age of 7 years, previously adapted to paediatric age. Hierarchical linear regression models (consecutive addition of blocks of variables based on a theoretical framework) were employed to evaluate the associations between family characteristics and adherence to the WISH at age 7 (β regression coefficients and the respective 95 % confidence intervals (95 % CI)). Higher maternal age and education at child’s birth were associated with increased adherence to the WISH at age 7 (β = 0·018, 95 % CI 0·005, 0·031; β = 0·038, 95 % CI 0·024, 0·053, respectively). A better maternal diet quality and using more restrictive practices on child’s diet, at 4 years old, were both associated with higher scoring in the WISH at 7 years old (β = 0·033, 95 % CI 0·018, 0·049; β = 0·067, 95 % CI 0·009, 0·125, respectively). Early maternal sociodemographic and diet quality play a significant role in influencing the adherence to a healthy and environmentally sustainable dietary pattern at school-age.
Clastic sedimentary systems and their characteristics are assumed not to have been modified by carbonate bioclastic grains until the Phanerozoic. Here, we show that the presence of carbonate bioclasts produced by disintegrated biomineralizing metazoans modified fine-grained siliciclastic facies in the Late Ediacaran Tamengo Formation, Brazil, ca. 555–542 Ma. The analysis of both polished sections and thin sections shows that sand-sized carbonate bioclasts (< 2 mm) derived from the Ediacaran metazoan Corumbella created diverse sedimentary features later found in the Phanerozoic record, such as bioclastic-rich horizontal and low-angle cross-laminations, erosive pods and lenses, bioclastic syneresis cracks, ripples preserved by bioclastic caps, microbial lamination eroded and filled with bioclasts, and entrapped bioclasts within microbial mats. These sedimentary features would have hardly been recorded in fine siliciclastic facies without the sand-sized bioclasts. Based on these features, together with other sedimentary evidence, Corumbella depositional settings in the Tamengo Fm. are reinterpreted as mid-ramp, subtidal settings. The multi-component organization of the skeleton of Corumbella favoured disarticulation to yield a sand-sized bioclast, so in turn creating a new complexity to shallow marine clastic settings typical of Phanerozoic marine depositional systems.
The bright radio source, GLEAM J091734$-$001243 (hereafter GLEAM J0917$-$0012), was previously selected as a candidate ultra-high redshift ($z \gt 5$) radio galaxy due to its compact radio size and faint magnitude ($K(\mathrm{AB})=22.7$). Its redshift was not conclusively determined from follow-up millimetre and near-infrared spectroscopy. Here we present new HST WFC3 G141 grism observations which reveal several emission lines including [NeIII]$\lambda$3867, [NeV]$\lambda$3426 and an extended ($\approx 4.8\,$kpc), [OII]$\lambda$3727 line which confirm a redshift of $3.004\pm0.001$. The extended component of the [OII]$\lambda$3727 line is co-spatial with one of two components seen at 2.276 GHz in high resolution ($60\times 20\,$mas) Long Baseline Array data, reminiscent of the alignments seen in local compact radio galaxies. The BEAGLE stellar mass ($\approx 2\times 10^{11}\,\textit{M}_\odot$) and radio luminosity ($L_{\mathrm{500MHz}}\approx 10^{28}\,$W Hz$^{-1}$) put GLEAM J0917$-$0012 within the distribution of the brightest high-redshift radio galaxies at similar redshifts. However, it is more compact than all of them. Modelling of the radio jet demonstrates that this is a young, $\approx 50\,$kyr old, but powerful, $\approx 10^{39}\,$W, compact steep spectrum radio source. The weak constraint on the active galactic nucleus bolometric luminosity from the [NeV]$\lambda$3426 line combined with the modelled jet power tentatively implies a large black hole mass, $\ge 10^9\,\textit{M}_\odot$, and a low, advection-dominated accretion rate, i.e. an Eddington ratio $\le 0.03$. The [NeV]$\lambda$3426/[NeIII]$\lambda$3867 vs [OII]$\lambda$3727/[NeIII]$\lambda$3867 line ratios are most easily explained by radiative shock models with precursor photoionisation. Hence, we infer that the line emission is directly caused by the shocks from the jet and that this radio source is one of the youngest and most powerful known at cosmic noon. We speculate that the star-formation in GLEAM J0917$-$0012 could be on its way to becoming quenched by the jet.
Following the growing interest in using behavioral theory and choice architecture in the public sector, several new studies have looked at how changes in the choice architecture of budget simulations influence the participants’ budgetary decisions. These studies have also introduced the possible problem that participants may make inappropriate choices in the budget simulation, like creating a budget with unacceptably high budget surpluses. Building on Thaler and Sunstein’s NUDGES framework, we seek to answer the question, ‘How can budgetary choice architects correct for errors such as large ending surpluses at the end of the budget simulation?’ We replicate earlier results on budget starting conditions. Additionally, we test a budget treatment that encourages participants to reduce ending budget surpluses. The budget treatment works as intended and suggests that the large ending budget surpluses stem from errors made by participants in the simulation rather than loss aversion. The need to both nudge and budge participants is important for practicing choice architects, like public budgeters who have to design and implement tools that inform citizens and reveal accurate preferences that conform with legal requirements.
Temperature increase may cause some regions in the world to become marginal or unsuitable for Arabica coffee cultivation, due to either heat and/or marked water deficit. The feasibility of sustainable coffee production in these regions promotes good opportunity of income and value addition for rural producers within an expanding market. This study aimed to identify short-stature Arabica coffee cultivars with the best agronomic and qualitative performance in a low-altitude region. The experiment was located in northeastern São Paulo state, Brazil, at 565 m above sea level. During the experimental period (2014–2018) the average annual and November temperatures were 23.0 and 24.3°C, respectively, with an average annual water deficit of 109 mm. The experimental design was randomized blocks, with four replicates, and the treatments consisted of 17 short-stature cultivars. The cultivars Catuaí Amarelo IAC 62, Catuaí Vermelho IAC 99, IAC Ouro Amarelo, Obatã IAC 1669-20, Obatã IAC 4739, Tupi IAC 1699-33, IAC 125 RN and IPR 100 stood out in terms of yield, reaching approximately 50 bags/ha. The appropriate choice of Arabica coffee cultivar in a low-altitude region may result in yield increment of up to 74%. The cultivars Catuaí Vermelho IAC 99, Tupi IAC 1699-33 and IAC 125 RN produced grains with the best quality and highest hundred-grain weight, processing yield and percentage of grains retained on sieve 17. Therefore, it is possible for an Arabica coffee cultivar to have high yield and high grain and beverage quality in a low-altitude region, promoting production alternatives for farmers.
We present deep near-infrared $K_\textrm{s}$-band imaging for 35 of the 53 sources from the high-redshift ($z \gt 2$) radio galaxy candidate sample defined in Broderick et al. (2022, PASA, 39, e061). These images were obtained using the High-Acuity Widefield K-band Imager (HAWK-I) on the Very Large Telescope. Host galaxies are detected for 27 of the sources, with $K_\textrm{s} \approx 21.6$–23.0 mag (2$^{\prime\prime}$ diameter apertures; AB). The remaining eight targets are not detected to a median $3\unicode{x03C3}$ depth of $K_\textrm{s} \approx 23.3$ mag (2$^{\prime\prime}$ diameter apertures). We examine the radio and near-infrared flux densities of the 35 sources, comparing them to the known $z \gt 3$ powerful radio galaxies with 500-MHz radio luminosities $L_{500\,\textrm{MHz}} \gt 10^{27}$ W Hz$^{-1}$. By plotting 150-MHz flux density versus $K_\textrm{s}$-band flux density, we find that, similar to the sources from the literature, these new targets have large radio to near-infrared flux density ratios, but extending the distribution to fainter flux densities. Five of the eight HAWK-I deep non-detections have a median $3\unicode{x03C3}$ lower limit of $K_\textrm{s} \gtrsim 23.8$ mag (1$.\!^{\prime\prime}$5 diameter apertures); these five targets, along with a further source from Broderick et al. (2022, PASA, 39, e061) with a deep non-detection ($K_\textrm{s} \gtrsim 23.7$ mag; $3\unicode{x03C3}$; 2$^{\prime\prime}$ diameter aperture) in the Southern H-ATLAS Regions $K_\textrm{s}$-band Survey, are considered candidates to be ultra-high-redshift ($z \gt 5$) radio galaxies. The extreme radio to near-infrared flux density ratios ($\gt 10^5$) for these six sources are comparable to TN J0924$-$2201, GLEAM J0856$+$0223 and TGSS J1530$+$1049, the three known powerful radio galaxies at $z \gt 5$. For a selection of galaxy templates with different stellar masses, we show that $z \gtrsim 4.2$ is a plausible scenario for our ultra-high-redshift candidates if the stellar mass $M_\textrm{*} \gtrsim 10^{10.5}$ M$_\odot$. In general, the 35 targets studied have properties consistent with the previously known class of infrared-faint radio sources. We also discuss the prospects for finding more UHzRG candidates from wide and deep near-infrared surveys.
Neurodevelopmental delay is common in children who undergo surgery for Congenital Heart Disease (CHD) in infancy. Cardiac surgery associated acute kidney injury (CS-AKI) occurs frequently in the paediatric cardiac Intensive care unit (ICU). Cardiac surgery associated acute kidney injury (CS-AKI) is associated with worse neurodevelopmental scores and delay in cognitive, language, and motor domains in children with CHD. No known data exist regarding the association of CS-AKI and motor and language subscales. In this study, we explored the relationship between CS-AKI and receptive and expressive language, as well as gross and fine motor delay.
Methods:
This was a single centre retrospective observational cohort study. Children who underwent surgery for CHD and developed recurrent CS-AKI in the first year of life who had follow-up neurodevelopmental testing using the Bayley Scale of Infant Development Version III were included. Neurodevelopmental delay subscales assessed included: receptive and expressive language, fine and motor skills.
Results:
The study cohort included 203 children. Recurrent CS-AKI was significantly associated with lower scores in receptive and expressive language, as well as fine and gross motor on unadjusted analyses. On adjusted analyses, recurrent CS-AKI was significantly associated with severe receptive language delay.
Conclusion:
The independent association of recurrent CS-AKI with severe language delay in children who undergo surgery for CHD in infancy is novel. Our findings may contribute to the understanding of language impairment in this population. Further studies are required to better understand this relationship and any potentially modifiable factors.
Sexuality, although an essential component of human health, remains a controversial topic shrouded in stigma, particularly in the context of neurodiversity, which includes autism spectrum disorder (ASD), where the expression of sexuality presents unique challenges. Autism and sexuality is a complex and multifaceted topic that involves understanding the unique ways in which individuals on the autism spectrum experience and express their sexuality.
Objectives
The purpose of this work is to address the complexity of the biopsychosocial sexuality components of people with autism, promoting a shift in the medical perspective, societal attitudes, and supporting greater inclusion of these individuals in current discussions regarding this area of human behavior and experience.
Methods
Evidence-based review, through research conducted on PubMed and selection of the most relevant studies on this topic, published in the last decade.
Results
Sexuality in autism is now recognized as a normative and integral aspect of development and functioning. Existing research suggests that most individuals with ASD display a clear interest in sexuality and relationships, with a study reviling that 96% of the ASD sample expressed an interest in sexuality. Individuals with high autistic traits tended to identify themselves more times as bisexual or presented a sexuality not definable within the categories of heterosexual. The relationship between autism and gender dysphoria is an area of ongoing research and discussion. Studies have suggested a higher prevalence of gender diverse identities and experiences within the autism community compared to the general population. Various hypotheses have been proposed to explain the increased gender and sexual diversity among individuals with autism. People with ASD may face unique challenges when it comes to their sexuality. The impairments in social skills and communication central to ASD potentially impact an autistic individual’s expression and experience of sexuality by affecting their abilities to understand and interpret social cues, emotions, and nonverbal behaviors of others. Importantly, such individuals may be more vulnerable, as they may have different or even limited understanding of boundaries and consent. To address these challenges, it is important to acknowledge and respect the diversity of sexual experiences and desires among individuals with neuro(bio)logical differences. This can be done by providing accurate and inclusive sex education, creating safe spaces for such individuals to explore and express their sexuality, and working to address discrimination and abuse in intimate contexts.
Conclusions
Recognizing and respecting this diversity and fostering inclusive and accepting environments, we can help individuals with neurological differences to fully express and explore their sexuality and have satisfying sexual lives.
The population ageing is a reality associated with an increase in prevalence of Dementia. The use of benzodiazepines is often postulated as a risk factor in these syndromes.
Contrary to recommendations for its short-time use, long-term and chronic use are common, with an estimated 8,7% of elderly people in the US taking benzodiazepines.
Objectives
To clarify the most recent evidence on the use of benzodiazepines and the risk of developing dementia.
Methods
Non-systematic review of literature, using PubMed as database and filtering the results for meta-analysis.
Results
Four articles were included in this review.
Zhong G et al. concluded that risk of dementia increased in consumers of benzodiazepines and it was associated with higher doses.
In turn, AlDawasari A et al., when trying to clarify the use of different sedative-hypnotic drugs, found and increased risk with the consumption of benzodiazepines. After exclusion of articles with confounders and adjustment for protopathic bias, the risk was not maintained.
Lucchetta RC et al. concluded that the risk exists but without inferring differences between doses or duration of action.
Finally, Penninkilampi R e Eslick GD investigated this association, after controlling for the protopathic bias, concluding, contrary to AlDawasari et al., that the association benzodiazepines consumption and dementia do not result from this bias.
Conclusions
We cannot draw robust and concrete conclusions between benzodiazepines consumption and the pathogenesis of dementia because not only is the literature limited, but results are also heterogeneous.
However, these prescriptions must be carried out cautiously, especially in the elderly, due to the known adverse effects associated with them.
Hand hygiene (HH) is the paramount measure used to prevent healthcare-associated infections. A repeated cross-sectional study was undertaken with direct observation of the degree of compliance on HH of healthcare personnel during the SARS-CoV-2 pandemic. Between, 2018–2019, 9,083 HH opportunities were considered, and 5,821 in 2020–2022. Chi squared tests were used to identify associations. The crude and adjusted odds ratios were used along with a logistic regression model for statistical analyses. Compliance on HH increased significantly (p < 0.001) from 54.5% (95% CI: 53.5, 55.5) to 70.1% (95% CI: 68.9, 71.2) during the COVID-19 pandemic. This increase was observed in four of the five key moments of HH established by the World Health Organization (WHO) (p < 0.05), except at moment 4. The factors that were significantly and independently associated with compliance were the time period considered, type of healthcare-personnel, attendance at training sessions, knowledge of HH and WHO guidelines, and availability of hand disinfectant alcoholic solution in pocket format. Highest HH compliance occurred during the COVID-19 pandemic, reflecting a positive change in healthcare-personnel’s behaviour regarding HH recommendations.
The current study explores the interplay between central and peripheral processes in second language (L2) handwriting among bilinguals with diverse orthographic backgrounds. Our investigation delves into the cross-linguistic transfer effect in Spanish–English and Chinese–English bilinguals, emphasizing lexical frequency and phoneme-grapheme (P-O) consistency in spelling-to-dictation and immediate copying tasks. Results reveal that the interaction between central and peripheral processes in L2 handwritten production is shaped by the bilinguals' native language (L1) orthographic characteristics. Spanish–English bilinguals exhibited sensitivity to P-O consistency and the spread of this effect from central to peripheral processes throughout both tasks. Conversely, Chinese–English bilinguals showed heightened sensitivity to lexical frequency during orthographic planning and motor execution, particularly in the immediate copying task. In a broader context, these findings suggest that the parallel and cascading coordination of the L2 writing system is modulated by cross-linguistic variations. The implications of our findings hold relevance for handwriting production and bilingualism research.
We propose a new method for identifying active galactic nuclei (AGN) in low mass ($\mathrm{M}_*\leq10^{10}\mathrm{M}_\odot$) galaxies. This method relies on spectral energy distribution (SED) fitting to identify galaxies whose radio flux density has an excess over that expected from star formation alone. Combining data in the Galaxy and Mass Assembly (GAMA) G23 region from GAMA, Evolutionary Map of the Universe (EMU) early science observations, and Wide-field Infrared Survey Explorer (WISE), we compare this technique with a selection of different AGN diagnostics to explore the similarities and differences in AGN classification. We find that diagnostics based on optical and near-infrared criteria (the standard BPT diagram, the WISE colour criterion, and the mass-excitation, or MEx diagram) tend to favour detection of AGN in high mass, high luminosity systems, while the “ProSpect” SED fitting tool can identify AGN efficiently in low mass systems. We investigate an explanation for this result in the context of proportionally lower mass black holes in lower mass galaxies compared to higher mass galaxies and differing proportions of emission from AGN and star formation dominating the light at optical and infrared wavelengths as a function of galaxy stellar mass. We conclude that SED-derived AGN classification is an efficient approach to identify low mass hosts with low radio luminosity AGN.
Although the losses associated with aging activate additional psychological resilience resources, dependency settings, which often require admission to Residential Care Facilities (RCF's), need adequate care so that the person can maintain his/her dignity and quality of life. The activation of mechanisms for regulating losses and the preservation of the identity and autonomy of the person respecting his/her decision-making capacity are central for the preservation of the well-being of people with dependence. Portuguese RCF's are mainly based on care models that are opposed to the models of attention centered on the person, which value the person's potential and decision-making capacity. The COVID-19 pandemic has tested RCF's, highlighting their weaknesses and limitations.
Objective:
This study aimed to identify ways to improve the provision of care in RCF's during the pandemic.
Method:
This is a qualitative study, with data collection through an online questionnaire. Participants were invited to indicate strategies to improve the provision of care to elderly residents in RCF's. The study included 198 RCF ́s workers during the COVID-19 pandemic. Content analysis of the collected data was performed.
Preliminary results on the ongoing study: The results indicate that the strategies that RCF´s workers consider most necessary are at the level of human resources, also highlighting the need for greater proximity, affection and attention to residents, the personalization of care and the valorization of the resident person and his/her opinions. These are considered by the participants as central strategies for the quality of care and satisfaction of RCF ́s workers.
Conclusion:
The needs identified are in line with the guiding principles of Person-Centered Care. The use of reminiscence as a strategy for valuing the person and his/her identity, as well as the promotion of self-determination, evaluating and allowing the person to make decisions may be central to meeting the needs identified at the level of care. The necessary transition from RCF's in Portugal to paradigms of centered care is thus reinforced by the results of this study.
Interventions aimed to optimize cognitive function and functionality in individuals at risk of dementia were scarce in validity studies. While some RCTs have been developed in cognitive training interventions, studies of multicomponent interventions (cognitive, social, and behavioral) integrating intervention targeting psychosocial risk factors (social isolation, depression, low cognitive reserve) is absent. Additionally, few efforts have been made to develop such validity studies with individuals at higher risk of dementia who still do not present objective cognitive decline, despite current recommendations in this regard. We aimed to start the validation of a 20-session multicomponent intervention – REMINDER program - with a feasibility test and a preliminary efficacy testing using a comprehensive outcome assessment protocol.
Methods:
A feasibility randomized controlled trial (RCT) was conducted, recruiting community-dwelling individuals between 60 to 75 years old with increased risk of dementia (LIBRA dementia risk score). Fifteen participants took part in twice-a-week sessions of the REMINDER program, during twelve weeks. Data on the acceptability, satisfaction and adherence to the REMINDER program was collected, and an association between pre and post intervention motivation and knowledge about dementia risk was examined. For the preliminary efficacy testing we considered as primary outcome a performance-based functionality measure (UPSA) and secondary outcomes will include global cognition, emotional status, and lifestyle habits, tested prior and after the intervention.
Results:
Rates of satisfaction throughout the REMINDER program sessions were high (75%, mean) as well as the adherences that was superior to the main dementia risk reduction programs referred in literature. (83%). Post-intervention efficacy testing is ongoing, however, levels of knowledge about dementia risk increased 12% compared with pre-intervention (34% pre-intervention, to 46% post intervention; p=.045)
Discussion:
Preliminary data on feasibility and efficacy of the REMINDER program suggests this program is an engaging and motivating tool for dementia risk reduction, justifying the future implementation of a large-scale RCT. We expect that, with a larger efficacy study we can demonstrate the REMINDER program effects in behavior change and in the adoption of protective lifestyles for dementia prevention, and that the comprehensive outcome assessment proves to be effective and, therefore, replicable in further studies.
Broad variations in dietary and physical activity patterns are part of nutritional transition concept. An additional nutritional transition has as main characteristic the change of consumption of processed foods for ultra-processed foods (UPF). This study aims to evaluate trends of UPF availability in Portuguese population and its association with diet-related non-communicable diseases (NCD) health indicators. This ecological study used data from the Household Budget Surveys conducted by the National Statistics Institute each 5 years within a national representative sample of households. The percentage of UPF was calculated based on the total daily amount of food and beverages available per capita (in grams). Data from the years 1990, 1995, 2000 and 2005 were used, which were retrieved from DAFNE-Anemos Software. NCD age-standardised mortality, prevalence and incidence were obtained from the Global Burden of Disease database, for the years 2000, 2005, 2010 and 2015. Between 1990 and 2005, the UPF availability increased from 3·9 % to 13·8 %. Over the years, almost all food and beverages categories increased the UPF availability contribution, mainly noticeable for milk, sugar, cereal and meat products. Positive correlations were observed between UPF availability and digestive diseases both in prevalence (r = 0·062; P = 0·037) and incidence (r = 0·005; P = 0·010) measures. Neoplasms incidence also showed positive correlation with UPF availability (r = 0·002; P = 0·012). Trends in UPF availability in Portugal increased exponentially. At the same time, there is a trend towards a decrease in unprocessed and processed food availability. The Portuguese population should be made aware of the health risks resulting from excessive consumption of UPF.