Childbirth influences maternal and new-born’s future health, with the Epigenetic Impact of Childbirth (EPIIC) hypothesis proposing that labour stress affects foetal gene expression. This study explores how birth experiences relate to DNA methylation in infants, breastfeeding and mother-infant bonding. Data from the Avon Longitudinal Study of Parents and Children was used, including 14,541 pregnant women. The ARIES subset of 1,022 mother-child pairs provided DNA methylation profiles. Maternal birth experience (MBE) was evaluated, with mother-infant bonding and breastfeeding. Statistical analysis involved linear regression and epigenome-wide association study. Half of the mothers reported at least one negative childbirth event, with 7% experiencing three or more adverse events. Negative MBE correlated with shorter breastfeeding duration and weaker mother-infant bonding. No significant CpG associations with MBE were found. While positive MBE is linked to improved mother-infant bonding and breastfeeding, no significant changes in DNA methylation profiles were observed in the offspring. Further research is needed to understand MBE’s long-term impact on child health.

We introduce a generalization of sequential compactness using barriers on $\omega $ extending naturally the notion introduced in [W. Kubiś and P. Szeptycki, On a topological Ramsey theorem, Canad. Math. Bull., 66 (2023), 156–165]. We improve results from [C. Corral and O. Guzmán and C. López-Callejas, High dimensional sequential compactness, Fund. Math.] by building spaces that are ${\mathcal {B}}$-sequentially compact but not ${\mathcal {C}}$-sequentially compact when the barriers ${\mathcal {B}}$ and ${\mathcal {C}}$ satisfy certain rank assumption which turns out to be equivalent to a Katětov-order assumption. Such examples are constructed under the assumption ${\mathfrak {b}} ={\mathfrak {c}}$. We also exhibit some classes of spaces that are ${\mathcal {B}}$-sequentially compact for every barrier ${\mathcal {B}}$, including some classical classes of compact spaces from functional analysis, and as a byproduct, we obtain some results on angelic spaces. Finally, we introduce and compute some cardinal invariants naturally associated to barriers.

Uterus transplants (UTx) provide women without a uterus the possibility of experiencing gestational motherhood. This paper delineates the complex bioethical landscape surrounding UTx, focusing on the critical aspects of informed consent, risk–benefit analysis, justice considerations, and the distinct challenges encountered by both donors and recipients. While not discussing UTx directly, John Harris’ seminal work, The Value of Life: An Introduction to Medical Ethics (1985) in its advocacy for reproductive freedom and informed consent provides an informative starting point for the discussion.

As an example, UTx is analyzed within the socio-political context of Mexico. The impact of the Mexican healthcare and legal systems on UTx procedures is discussed and the regulatory measures necessary to ensure that UTx is conducted ethically and equitably are outlined.

There is an increasing gap between the policy cycle’s speed and that of technological and social change. This gap is becoming broader and more prominent in robotics, that is, movable machines that perform tasks either automatically or with a degree of autonomy. This is because current legislation was unprepared for machine learning and autonomous agents. As a result, the law often lags behind and does not adequately frame robot technologies. This state of affairs inevitably increases legal uncertainty. It is unclear what regulatory frameworks developers have to follow to comply, often resulting in technology that does not perform well in the wild, is unsafe, and can exacerbate biases and lead to discrimination. This paper explores these issues and considers the background, key findings, and lessons learned of the LIAISON project, which stands for “Liaising robot development and policymaking,” and aims to ideate an alignment model for robots’ legal appraisal channeling robot policy development from a hybrid top-down/bottom-up perspective to solve this mismatch. As such, LIAISON seeks to uncover to what extent compliance tools could be used as data generators for robot policy purposes to unravel an optimal regulatory framing for existing and emerging robot technologies.

From exoskeletons to lightweight robotic suits, wearable robots are changing dynamically and rapidly, challenging the timeliness of laws and regulatory standards that were not prepared for robots that would help wheelchair users walk again. In this context, equipping regulators with technical knowledge on technologies could solve information asymmetries among developers and policymakers and avoid the problem of regulatory disconnection. This article introduces pushing robot development for lawmaking (PROPELLING), an financial support to third parties from the Horizon 2020 EUROBENCH project that explores how robot testing facilities could generate policy-relevant knowledge and support optimized regulations for robot technologies. With ISO 13482:2014 as a case study, PROPELLING investigates how robot testbeds could be used as data generators to improve the regulation for lower-limb exoskeletons. Specifically, the article discusses how robot testbeds could help regulators tackle hazards like fear of falling, instability in collisions, or define the safe scenarios for avoiding any adverse consequences generated by abrupt protective stops. The article’s central point is that testbeds offer a promising setting to bring policymakers closer to research and development to make policies more attuned to societal needs. In this way, these approximations can be harnessed to unravel an optimal regulatory framework for emerging technologies, such as robots and artificial intelligence, based on science and evidence.

Este trabajo explica los orígenes y evolución de un preámbulo diplomático que fue común en los documentos de compraventa y donación que se redactaban entre mediados del siglo XII y mediados del XIII en la ciudad de Oviedo, al norte del antiguo reino de León. Merece estudio por su larga perduración en el tiempo, ya que fue pasando de unos escribanos a otros y alcanzó la época de la implantación del notariado público. Asimismo, interesa desde el punto de vista lingüístico, ya que comenzó su trayectoria como una composición latina que, en una fase avanzada de su trayectoria, dio lugar a una fórmula romance original. Pero sobre todo llama la atención por la extrañeza de hallar un discurso estructurado sobre las ideas de equitas y ratio en una zona con vida urbana débil, carente de instituciones de enseñanza sólidas, y en general considerada periférica en el reino, más aún a escala europea. En fin, el modo en que habla de la memoria puede aportar matices interesantes a un objeto de estudio que en la Edad Media leonesa ha buscado más la crítica de autenticidad de los cartularios, y luego la comprensión de los mismos, que el papel de lo escrito en la conformación de los derechos de propiedad.

Dairy fat is rich in SFA such as palmitic acid (16:0) but low in linoleic acid (18:2n-6). The natural carbon 13 enrichment (δ13C) of 16:0 is higher in dairy fat than in most of the food supply. In adults, serum levels of pentadecanoic acid (15:0) and heptadecanoic acid (17:0) are recognised as biomarkers of dairy intake. In adolescents, no study has evaluated serum fatty acid levels or δ13C in response to chronic dairy consumption. The objectives of this study were to evaluate whether increased dairy product consumption can modulate (1) serum fatty acid levels and (2) 16:0 δ13C in adolescents with overweight/obesity who followed a 12-week weight management programme. This secondary analysis of a randomised control trial included two groups of adolescent females: recommended dairy (RDa; n 23) and low dairy (LDa; n 23). The RDa group was given 4 servings/d of dairy products while the LDa group maintained dairy intakes at ≤ 2 servings/d. Blood was sampled before and after the intervention. Lipids were extracted and separated, and fatty acids were quantified by GC. Isotope ratio MS was used to assess 16:0 δ13C. There were no group differences on serum changes of 15:0 or 17:0. Within TAG, 18:2n-6 was lowered by 7·4 % only in the RDa group (P = 0·040). The difference in delta 16:0 δ13C between the LDa and RDa groups did not reach statistical significance (P = 0·070). Reductions in serum 18:2n-6 by dairy consumption could have positive health implications, but more studies are needed to confirm this assertion.

Wild and domestic populations of waterfowl garner economic benefits, as they are hunted for human consumption or as a recreational activity. Waterfowl migrate to their wintering grounds in Mexican wetlands where habitat conditions are more favourable. In this study, we present a list of helminth species sampled from the gastrointestinal tract of 59 wild birds belonging to the family Anatidae in three localities of Mexico, and a checklist of the helminth parasite fauna of the members of the family in the whole country, built from literature records. After helminthological examination, 25 taxa were identified: eight trematodes; four cestodes; 12 nematodes; and one acanthocephalan. Obtained records dated from 1943 to 2019. Our literature search yielded 563 records corresponding to 95 parasite taxa: 38 trematodes, 24 cestodes, 23 nematodes and ten acanthocephalans. In Mexico, 17 anatid species have been studied for helminths. Records correspond to 55 locations from 20 Mexican states. An insight gained from the collated literature and recent records was that trematodes represent the most diverse parasite group in anatids in Mexico. We briefly discuss that the information about helminths parasitizing waterfowl will be useful for understanding the effect of habitat loss and pollution of wetlands where migratory birds spend the breeding season, for addressing ecological programs aimed to guarantee the health and conservation of North American migratory birds or the effect of bird migration in the composition of the helminth parasite communities, and for freshwater biologists interested in the understanding of freshwater ecosystem health.

The bibliography on the Spanish Civil War is almost unattainable, but the matter continues to elicit such interest that it remains open to new historiographic trends. For example, the ‘classic’ military history of the conflict, cultivated prominently in recent years by Gabriel Cardona, Jorge Martínez Reverte and Anthony Beevor, does not renounce the microhistory or cultural perspective. These constitute the theoretical framework of the New Military History and its corollary the New Combat History, which combine philological, anthropological, psychological and historiographical perspectives to various degrees. In the specific field of the war experiences pioneered by George L. Mosse, the concepts of brutalisation, barbarisation and demodernisation of military operations, coined by Omer Bartov to describe the particularities of the Eastern campaign during the Second World War, are being used by Spanish historians dedicated to the study of the violence and atrocities of the civil war and post-war. Focusing on the field of political history, government management or diplomacy has been studied almost exhaustively, but this is not the case for the principal phenomenon of political violence in the 1930s in Europe, namely paramilitarisation. It is surprising that the latest studies on the issue at the European level (Robert Gerwarth, John Horne, Chris Millington and Kevin Passmore) do not include any essays on the enormous incidence of paramilitary violence in Spain before, during and after the civil war.

Gestational stress is associated with many maternal and child complications, however, this association must be taken with care, since there are studies that find inconsistent results between stress measures and maternal complications. It is believed that the lack of convergence is due to the way in which gestational stress is evaluated.

The aim of the present study was to design and validate an instrument based on a bio-psycho-social model of gestational stress. The design and validation process of the inventory was divided into four phases: (a) Construction of the items bank and content validity, (b) construct validity, (c) inventory reliability and (d) convergent and discriminant validity with psychometric instruments that have been used in other investigations to evaluate gestational stress.

A valid and reliable Stressors and Modulators of Gestational Stress Inventory (SMGSI) conformed by two scales was developed: (a) Gestational stressors, which is formed by two factors, the psychological stressors and social stressors with a variance of 48.5% and 51.8% and a reliability of .79 and .67, respectively; and (b) gestational stress modulators integrated by 8 items that explain 55.2% of the variance and with a reliability of .92. In conclusion, a valid and reliable tool was obtained that measures gestational stress from a bio-psycho-social perspective. This inventory allows for the identification of allostatic and pantostatic stress, making it useful as a diagnostic tool to prevent maternal and childhood complications that are associated with chronic gestational stress.

Nowadays there is considerable agreement among educators that learning mathematics fundamentally involves making mathematics [1]. Students learn mathematics while working on tasks that they consider meaningful and worthwhile, and their interest is aroused when they can see the point of what they are being asked to do. Given that learning mathematics involves a process of meaning-making - the use of mathematical language, symbols and representations as learners negotiate ideas – activities should provide students with a variety of challenging experiences through which they can actively construct mathematical meanings for themselves.

The World Health Organisation (2016) recommends exclusive breastfeeding up to 6 months of age and the introduction of complementary foods at around 6 months. International literature suggests that although knowledge of the guidelines is high, only a minority of parents wait until 6 months to wean and sub-optimal weaning practices are common. The aim of this study was to assess breastfeeding and weaning practices and to evaluate the effect of socio-economic determinants on such behaviours in a Mediterranean setting.

A cross-sectional study design was used. One-time short interviews with 250 consenting mothers having 8 month old infants were conducted using a structured questionnaire. Mothers attending all the well baby clinics in the primary health care centres of the Maltese Islands for a period of two months were included in the study. The questionnaire included socio-economic and demographic data, details on the initiation and duration of breastfeeding, weaning practices and a short assessment of the infant's usual diet at 8 months.

Mothers between 25–34 years old (26%) and mothers with a high level of education (25%) were more likely to breastfeed only during the first 8 months of life without using any other type of milk, compared to younger (6.5%) or older (21%) mothers, and to mothers with a lower level of education (16%). The level of education was also positively associated with the continuation of breastfeeding, with the mean duration of breastfeeding for higher educated mothers being 4 months compared to 2.6 months in less educated mothers. Mothers with a lower level of education and mothers who are house-wives are more likely to give their infants only ready-made foods however associations were in this case borderline significant. On the other hand, appropriateness of weaning age was not associated with any socio-economic factors.

The length of breastfeeding and the introduction of complementary foods varied widely between mothers. Compliance with infant feeding guidelines was poor. The mother's age, level of education and employment status all have an impact on breastfeeding and weaning practices. The provision of professional advice and a supportive environment for mothers, together with interventions for increasing awareness may promote maternal adherence to WHO guideline.