The article examines the drivers of migrant atypical employment in the manufacturing sector of Emilia-Romagna, an Italian region that is well known for its high-quality manufacturing productions and industrial relations. By drawing on administrative data based on mandatory communications, we document that, even in such an institutional context, migrants have a disproportionately higher likelihood of being hired through either fixed-term or agency contracts than native workers. We interpret this evidence through a set of different theories, including human capital theory, dual labour market processes, the use of precarious contracts as screening devices, and institutional segmentation theories. The empirical analysis reveals that while migrant employment through fixed-term contracts is consistent with dual processes and screening practices, the hiring of migrants with agency contracts is driven by processes of institutional segmentation, through which employers shift the costs of flexibility to the most vulnerable and less organized segments within the labour force, such as migrants. Managerial and policy implications are discussed.

Background: Efgartigimod, a human immunoglobulin (Ig)G1 antibody Fc fragment, blocks the neonatal Fc receptor, reducing IgGs involved in chronic inflammatory demyelinating polyneuropathy (CIDP). The multi-stage, double-blinded, placebo-controlled ADHERE (NCT04281472) and open-label extension ADHERE+ (NCT04280718) trials (interim analysis cutoff: February 16, 2024) assessed efgartigimod PH20 SC in participants with CIDP. Methods: Participants with active CIDP received open-label, weekly efgartigimod PH20 SC 1000 mg during ≤12-week run-in (stage-A). Responders were randomized (1:1) to efgartigimod or placebo for ≤48 weeks (stage-B). Participants with clinical deterioration in stage-B or who completed ADHERE entered ADHERE+. Week 36 changes from run-in baseline (CFB) in adjusted Inflammatory Neuropathy Cause and Treatment (aINCAT), Inflammatory Rasch-built Overall Disability Scale (I-RODS), and grip strength scores were evaluated. Results: Of 322 stage-A participants, 221 were randomized and treated in stage-B, and 99% entered ADHERE+. Mean CFB (SE) in aINCAT, I-RODS, and grip strength scores were -1.2 (0.15) and 8.8 (1.46) and 17.5 (2.02), respectively, at ADHERE+ Week 36 (N=150). Half the participants with clinical deterioration during ADHERE stage-B restabilized on efgartigimod from ADHERE+ Week 4. Conclusions: Interim results from ADHERE+ indicate long-term effectiveness of efgartigimod PH20 SC in clinical outcomes in participants with CIDP.

Background: Efgartigimod, a human immunoglobulin (Ig)G1 antibody Fc fragment, blocks the neonatal Fc receptor, reducing IgGs involved in chronic inflammatory demyelinating polyneuropathy (CIDP), a rare, progressive, immune-mediated disease that can lead to irreversible disability. The multi-stage, double-blinded, placebo-controlled ADHERE (NCT04281472) trial assessed efgartigimod PH20 SC in participants with CIDP. Methods: Participants with active CIDP received open-label, weekly efgartigimod PH20 SC 1000 mg during ≤12-week run-in (stage-A). Responders were randomized (1:1) to weekly efgartigimod or placebo for ≤48 weeks (stage-B). This posthoc analysis evaluated changes from run-in baseline (study enrollment) to stage-B last assessment and items of the Inflammatory Rasch-built Overall Disability Scale (I-RODS). Results: Of 322 participants who entered stage-A, 221 were randomized and treated in stage-B, and 191/221 had data for run-in baseline and post–stage-B timepoints. Mean (SE) I-RODS change at stage-B last assessment vs run-in baseline was 5.7 (1.88) and -4.9 (1.82) in participants randomized to efgartigimod and placebo, respectively. 37/97 (38.1%) and 24/92 (26.1%) participants randomized to efgartigimod and placebo, respectively, experienced ≥4-point improvements in I-RODS score. Efgartigimod-treated participants improved ≥1 point in I-RODS items of clinical interest. Conclusions: Participants who received efgartigimod in stage-B experienced improvements in I-RODS score from study enrollment to stage-B last assessment.

The water buffalo farm with intensive breeding techniques promotes the spread of lice (Haematopinus tuberculatus), leading to a reduction in meat and milk productions. Current control measures include the use of chemicals, which in the long-term lead to the development of resistance. Given the lack of alternative solutions, the aim of this study was to evaluate the repellent effect of a low impact by-product, the wood vinegar (WV), against H. tuberculatus using a new in vitro bioassay test. The test consisted of a glass Petri dishes subdivided in 3 separate areas. WV was tested at different concentrations (100%, 75%, 50%, 25%). Each of the 3 replicates was performed with 10 adults, at 27 °C and 75% relative humidity. Observations were made 5, 15, 30, 60, 90, 120 and 180 min after application to evaluate movement, the living/dead ratio and the ability to overcome the obstacle area of the lice, in terms of comparative avoidance (%). Additional in vitro cytotoxicity tests were performed. The test performed showed a repellent effect of 77% for the 100% WV concentration against lice of both sexes 30 min after exposure, similar (P < 0.05) to the repellent effect of deltamethrin (77%). The in vitro bioassay developed during the experiment proved to be reliable and can be used to evaluate the repellent effect of new molecules against lice before testing them in vivo. Furthermore, WV has a potential to be a valid tool for the control of buffalo pediculosis, although in vivo studies have to be undertaken.

The widespread use of artificial intelligence technologies in border management throughout the European Union has significant human rights implications that extend beyond the commonly examined issues of privacy, non-discrimination and data protection. This article explores these overlooked impacts through three critical frameworks: the erosion of freedom of thought, the disempowerment of individuals and the politicization of human dignity. In uncovering these dynamics, the article argues for a broader conception of human rights to prevent their gradual erosion and safeguard the core principle of protecting human dignity.